Intrathyroidal Parathyroid Carcinoma: Case Report and Literature Review
We present a case of a 31-year-old male with a history of hyperparathyroidism who was found to have intrathyroidal PC upon review of immunostains along with a review of the current literature. A systematic review of the literature utilizing the PubMed database identified 24 relevant, full-text articles. 25 cases were analyzed, including our own report. The case of a 31-year-old man with a history of hyperparathyroidism managed with subtotal thyroidectomy and subtotal parathyroidectomy who had persistent hypercalcemia and elevated parathyroid hormone. Abnormal radiotracer uptake was noted in the left thyroid gland. Neck exp...
Source: Ear, Nose and Throat Journal - April 11, 2022 Category: ENT & OMF Authors: Hannah Daniel Pranati Pillutla Cynthia Schwartz Tam Nguyen Source Type: research
A Case of Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma
Intern Med. 2022 Apr 2. doi: 10.2169/internalmedicine.9261-21. Online ahead of print.ABSTRACTParathyroid carcinoma (PC) is a rare type of endocrine cancer. Recurrence and metastasis are common after surgery, and refractory hypercalcemia often leads to a poor prognosis. However, there are currently no specific strategies for PC recurrence. We herein report a 61-year-old Japanese man with metastatic PC who was treated with sorafenib, a multikinase inhibitor. In this case, the serum calcium level was under control for 10 months after the initiation of sorafenib. This case suggests that combination therapy with sorafenib, evoc...
Source: Cancer Control - April 4, 2022 Category: Cancer & Oncology Authors: Hirofumi Makino Masakazu Notsu Itsuko Asayama Hazuki Otani Miwa Morita Masahiro Yamamoto Mika Yamauchi Mika Nakao Hitomi Miyake Asuka Araki Shinya Uchino Keizo Kanasaki Source Type: research
A Case of Successful Control of Hypercalcemia with Sorafenib, Evocalcet, and Denosumab Combination Therapy for Recurrent Parathyroid Carcinoma
Intern Med. 2022 Apr 2. doi: 10.2169/internalmedicine.9261-21. Online ahead of print.ABSTRACTParathyroid carcinoma (PC) is a rare type of endocrine cancer. Recurrence and metastasis are common after surgery, and refractory hypercalcemia often leads to a poor prognosis. However, there are currently no specific strategies for PC recurrence. We herein report a 61-year-old Japanese man with metastatic PC who was treated with sorafenib, a multikinase inhibitor. In this case, the serum calcium level was under control for 10 months after the initiation of sorafenib. This case suggests that combination therapy with sorafenib, evoc...
Source: Internal Medicine - April 4, 2022 Category: Internal Medicine Authors: Hirofumi Makino Masakazu Notsu Itsuko Asayama Hazuki Otani Miwa Morita Masahiro Yamamoto Mika Yamauchi Mika Nakao Hitomi Miyake Asuka Araki Shinya Uchino Keizo Kanasaki Source Type: research
Parathyroid Disorders
Am Fam Physician. 2022 Mar 1;105(3):289-298.ABSTRACTParathyroid disorders are most often identified incidentally by abnormalities in serum calcium levels when screening for renal or bone disease or other conditions. Parathyroid hormone, which is released by the parathyroid glands primarily in response to low calcium levels, stimulates osteoclastic bone resorption and serum calcium elevation, reduces renal calcium clearance, and stimulates intestinal calcium absorption through synthesis of 1,25-dihydroxyvitamin D. Primary hyperparathyroidism, in which calcium levels are elevated without appropriate suppression of parathyroi...
Source: American Family Physician - March 15, 2022 Category: Primary Care Authors: Jarrett Sell Sarah Ramirez Michael Partin Source Type: research
Parathyroid Disorders
Am Fam Physician. 2022 Mar 1;105(3):289-298.ABSTRACTParathyroid disorders are most often identified incidentally by abnormalities in serum calcium levels when screening for renal or bone disease or other conditions. Parathyroid hormone, which is released by the parathyroid glands primarily in response to low calcium levels, stimulates osteoclastic bone resorption and serum calcium elevation, reduces renal calcium clearance, and stimulates intestinal calcium absorption through synthesis of 1,25-dihydroxyvitamin D. Primary hyperparathyroidism, in which calcium levels are elevated without appropriate suppression of parathyroi...
Source: American Family Physician - March 15, 2022 Category: Primary Care Authors: Jarrett Sell Sarah Ramirez Michael Partin Source Type: research
Parathyroid Disorders
Am Fam Physician. 2022 Mar 1;105(3):289-298.ABSTRACTParathyroid disorders are most often identified incidentally by abnormalities in serum calcium levels when screening for renal or bone disease or other conditions. Parathyroid hormone, which is released by the parathyroid glands primarily in response to low calcium levels, stimulates osteoclastic bone resorption and serum calcium elevation, reduces renal calcium clearance, and stimulates intestinal calcium absorption through synthesis of 1,25-dihydroxyvitamin D. Primary hyperparathyroidism, in which calcium levels are elevated without appropriate suppression of parathyroi...
Source: American Family Physician - March 15, 2022 Category: Primary Care Authors: Jarrett Sell Sarah Ramirez Michael Partin Source Type: research
Parathyroid Disorders
Am Fam Physician. 2022 Mar 1;105(3):289-298.ABSTRACTParathyroid disorders are most often identified incidentally by abnormalities in serum calcium levels when screening for renal or bone disease or other conditions. Parathyroid hormone, which is released by the parathyroid glands primarily in response to low calcium levels, stimulates osteoclastic bone resorption and serum calcium elevation, reduces renal calcium clearance, and stimulates intestinal calcium absorption through synthesis of 1,25-dihydroxyvitamin D. Primary hyperparathyroidism, in which calcium levels are elevated without appropriate suppression of parathyroi...
Source: American Family Physician - March 15, 2022 Category: Primary Care Authors: Jarrett Sell Sarah Ramirez Michael Partin Source Type: research
Parathyroid Disorders
Am Fam Physician. 2022 Mar 1;105(3):289-298.ABSTRACTParathyroid disorders are most often identified incidentally by abnormalities in serum calcium levels when screening for renal or bone disease or other conditions. Parathyroid hormone, which is released by the parathyroid glands primarily in response to low calcium levels, stimulates osteoclastic bone resorption and serum calcium elevation, reduces renal calcium clearance, and stimulates intestinal calcium absorption through synthesis of 1,25-dihydroxyvitamin D. Primary hyperparathyroidism, in which calcium levels are elevated without appropriate suppression of parathyroi...
Source: American Family Physician - March 15, 2022 Category: Primary Care Authors: Jarrett Sell Sarah Ramirez Michael Partin Source Type: research
Parathyroid Disorders
Am Fam Physician. 2022 Mar 1;105(3):289-298.ABSTRACTParathyroid disorders are most often identified incidentally by abnormalities in serum calcium levels when screening for renal or bone disease or other conditions. Parathyroid hormone, which is released by the parathyroid glands primarily in response to low calcium levels, stimulates osteoclastic bone resorption and serum calcium elevation, reduces renal calcium clearance, and stimulates intestinal calcium absorption through synthesis of 1,25-dihydroxyvitamin D. Primary hyperparathyroidism, in which calcium levels are elevated without appropriate suppression of parathyroi...
Source: American Family Physician - March 15, 2022 Category: Primary Care Authors: Jarrett Sell Sarah Ramirez Michael Partin Source Type: research
Parathyroid Disorders
Am Fam Physician. 2022 Mar 1;105(3):289-298.ABSTRACTParathyroid disorders are most often identified incidentally by abnormalities in serum calcium levels when screening for renal or bone disease or other conditions. Parathyroid hormone, which is released by the parathyroid glands primarily in response to low calcium levels, stimulates osteoclastic bone resorption and serum calcium elevation, reduces renal calcium clearance, and stimulates intestinal calcium absorption through synthesis of 1,25-dihydroxyvitamin D. Primary hyperparathyroidism, in which calcium levels are elevated without appropriate suppression of parathyroi...
Source: American Family Physician - March 15, 2022 Category: Primary Care Authors: Jarrett Sell Sarah Ramirez Michael Partin Source Type: research
