Cancers, Vol. 14, Pages 4004: Patterns and Predictors of Cervical Lymph Node Metastasis in Parathyroid Carcinoma
Conclusion: Most PCs were slow-growing, but lymph node metastasis was not rare. For patients planning to undergo remedial surgery after previous local resection of PC, central LND is suggested for tumors with high-risk Schulte staging or CDC73 abnormalities. (Source: Cancers)
Source: Cancers - August 19, 2022 Category: Cancer & Oncology Authors: Ya Hu Ming Cui Xiaoyan Chang Ou Wang Tianqi Chen Jinheng Xiao Mengyi Wang Surong Hua Quan Liao Tags: Article Source Type: research
Tumor size rather than the thyroid invasion affects the prognosis of parathyroid carcinoma without lymph node or distant metastasis
ConclusionThyroid invasion, which was the criterion forT1 andT2 staging criteria of parathyroid carcinoma according to the AJCC, did not affect the prognosis of patients with parathyroid carcinoma without local lymph node or distant metastasis. Our study indicates that a tumor size ≥ 4 cm may be an appropriate indicator ofT1 andT2 cancer staging. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - August 9, 2022 Category: ENT & OMF Source Type: research
Label-Free Mass Spectrometry-Based Quantitative Proteomics to Evaluate the Effects of the Calcium-Sensing Receptor Agonist Cinacalcet on Protein Expression in Rat Brains and Livers
CONCLUSIONS These findings indicate that long-term cinacalcet therapy can impair phase II of enzymatic detoxication and can cause disturbances in blood hemostasis, lipid metabolism, and inflammatory mediators or contribute to the acceleration of cognitive dysfunction; therefore, appropriate patient monitoring should be considered.PMID:35941808 | DOI:10.12659/MSM.937338 (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 9, 2022 Category: Research Authors: Ewa Bulska Andrzej Gawor Anna Konopka Grzegorz Wryk Bo żena Czarkowska-Pączek Zdzis ław Gajewski Leszek P ączek Source Type: research
Intrathyroidal parathyroid carcinoma presenting as thyroid nodule: Case report of unusual location
We report a case of intrathyroidal PC that was taken for a suspicious thyroid nodule, with a literature review.PRESENTATION OF THE CASE: Our case is an asymptomatic intrathyroidal PC imitating a suspicious thyroid nodule, in a 54-year-old woman. A literature review was performed about clinical, radiological features, histopathological findings, and therapeutic options.DISCUSSION: The diagnosis of asymptomatic intrathyroidal parathyroid carcinoma, similar to our case report, is even more difficult, our patient had no symptoms of hypercalcemia. Surgery is the cornerstone of the treatment. A better chance to cure this disease...
Source: Annals of Medicine - July 21, 2022 Category: Internal Medicine Authors: Anajar Said Allaoui Abire Laidi Soukaina Alatawna Hind Taali Loubna Tahiri Ilias Hajjij Amal Saadi Mustapha Zalakh Mohammed Benariba Fouad Source Type: research
Parathyroid Carcinoma All-In-One, a Rare Life-Threatening Case With Multiple Systemic Manifestations: Case Report and Review of the Literature
We report an exceptionally unusual case of life-threatening PC, associated with several systemic manifestations: moderate pancreatitis, portal thrombosis, kidney stones, brown tumors, osteoporosis, hungry bone syndrome (HBS), chondrocalcinosis, neuropathy, and depression. The clinical case also represents an opportunity to provide a review of the recent literature, associated with a complete evaluation of the main diagnostic and therapeutic approaches. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - July 7, 2022 Category: Endocrinology Source Type: research
Non-Linear Correlation Between Tumor Size and Survival Outcomes for Parathyroid Carcinoma: A SEER Population-Based Cohort Study
ConclusionsA non-linear correlation between tumor size and death risk has been identified in patients with PC, along with an accurate size threshold at which survival rates sharply decrease. Further investigation is needed to determine if these trends are seen in other malignancies with promising prognoses. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - July 1, 2022 Category: Endocrinology Source Type: research
Giant intrathyroidal parathyroid carcinoma: A case report and literature review
Asian J Surg. 2022 Jun 17:S1015-9584(22)00751-5. doi: 10.1016/j.asjsur.2022.06.003. Online ahead of print.NO ABSTRACTPMID:35725792 | DOI:10.1016/j.asjsur.2022.06.003 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - June 20, 2022 Category: Surgery Authors: Tingting Yu Shike Li Zhuo Zhang Source Type: research
Fine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis
AbstractMalignancy-related hypercalcemia is a leading cause of hypercalcemia among hospitalized patients that carries poor prognosis. Parathyroid carcinoma is a rare form of primary hyperparathyroidism that may be associated with PTH dependent hypercalcemia. Severe hypercalcemia is life-threatening and may require management in an intensive care unit by means of medical therapy consisting of volume expansion, loop diuretics, cinacalcet, calcitonin and bisphosphonates. Renal replacement therapy such as intermittent hemodialysis has been successfully used among patients with severe hypercalcemia who become refractory to medi...
Source: European Journal of Medical Research - June 8, 2022 Category: Research Source Type: research
A Nomogram Predicting the Overall Survival and Cancer-Specific Survival in Patients with Parathyroid Cancer: A Retrospective Study
ConclusionThe established nomogram application can provide accurate prognostics for patients with PC in the Chinese population, but it must be validated on prospectively collected real-world data. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - May 19, 2022 Category: Endocrinology Source Type: research
Large Parathyroid Tumor 8 Years after Thyroid Surgery: A Case Report
This report represents an unusually large parathyroid carcinoma (PC) mimicking thyroid nodule recurrence after hemithyroidectomy. PC is a rare endocrine malignancy accounting for less than 1% of hyperparathyroidism cases. This is the first case report where contrast-enhanced ultrasound (CEUS) was performed on a PC. A 63-year-old female presented with an enlarged mass on the left side of the neck. In 2012, left-side hemithyroidectomy was done due to a benign goiter. In 2020, laboratory analysis showed markedly elevated parathyroid hormone and calcium. Multiparametric neck ultrasonography was performed including B-mode, colo...
Source: Case Reports in Oncology - May 16, 2022 Category: Cancer & Oncology Source Type: research
The Long Non-Coding BC200 Is a Novel Circulating Biomarker of Parathyroid Carcinoma
Long non-coding RNAs (lncRNAs) are an important class of epigenetic regulators involved in both physiological processes and cancer development. Preliminary evidence suggested that lncRNAs could act as accurate prognostic and diagnostic biomarkers. Parathyroid cancer is a rare endocrine neoplasia, whose management represents a clinical challenge due to the lack of accurate molecular biomarkers. Our previous findings showed that human parathyroid tumors are characterized by a different lncRNAs signature, suggesting heterogeneity through the different histotypes. Particularly, we found that the lncRNA BC200/BCYRN1 could repre...
Source: Frontiers in Endocrinology - May 2, 2022 Category: Endocrinology Source Type: research
Germline Mutations Related to Primary Hyperparathyroidism Identified by Next-Generation Sequencing
In this study, we identified genetic variants that might be responsible for PHPT, including familial PHPT, benign sporadic PHPT, and sporadic parathyroid cancer, using next-generation sequencing (NGS). A total of 107 patients with PHPT who underwent NGS from 2017 to 2021 at Severance Hospital were enrolled. We reviewed the pathogenic variants, likely pathogenic variants, and variants of uncertain significance (VUS) according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology criteria. Of the 107 patients (mean age: 47.6 ± 16.1 years, women 73.8%), 12 patients were diagnose...
Source: Frontiers in Endocrinology - April 28, 2022 Category: Endocrinology Source Type: research
Intrathyroidal Parathyroid Carcinoma: Case Report and Literature Review
We present a case of a 31-year-old male with a history of hyperparathyroidism who was found to have intrathyroidal PC upon review of immunostains along with a review of the current literature. A systematic review of the literature utilizing the PubMed database identified 24 relevant, full-text articles. 25 cases were analyzed, including our own report. The case of a 31-year-old man with a history of hyperparathyroidism managed with subtotal thyroidectomy and subtotal parathyroidectomy who had persistent hypercalcemia and elevated parathyroid hormone. Abnormal radiotracer uptake was noted in the left thyroid gland. Neck exp...
Source: Ear, Nose and Throat Journal - April 11, 2022 Category: ENT & OMF Authors: Hannah Daniel Pranati Pillutla Cynthia Schwartz Tam Nguyen Source Type: research
