Parathyroid carcinoma: Report of 10 patients and literature review
CONCLUSION: Severe bone pain, kidney stones, hypercalcemic crisis, and markedly elevated PTH usually indicate PC. A markedly elevated PTH level, tumor metastasis, and the Ki-67 index ≥ 10% may be indicators of poor prognosis.PMID:36528886 (Source: Neuroendocrinology Letters)
Source: Neuroendocrinology Letters - December 18, 2022 Category: Endocrinology Source Type: research
Para This, Fibromin That
CDC73 alterations are associated with three main parathyroid lesions according to the World Health Organization (WHO) classification of tumors of the endocrine system. These include hyperparathyroidism-jaw tumor (HPT-JT) syndrome-associated adenomas, atypical parathyroid tumors (APTs), and parathyroid carcinomas (PCs). The loss of nuclear parafibromin expression, which serves as a surrogate marker for the underlying CDC73 alteration, encompasses these tumors under the term parafibromin-deficient parathyroid tumors. They have distinct morphologic features of more abundant eosinophilic cytoplasm with perinuclear clearing sur...
Source: Surgical Pathology Clinics - December 9, 2022 Category: Pathology Authors: Emad Ababneh, Vania Nos é Source Type: research
Diagnosis and Treatment of Brown Tumor in the Femur Induced by Parathyroid Carcinoma: A Case Report
We report a case of a 61-year-old woman with brown tumors in both femurs due to parathyroid carcinoma. The patient presented with multiple osteolytic lesions that caused pain in the right thigh. Whole-body computed tomography (CT), including the neck, suspected a parathyroid tumor, and a biopsy of the bone lesion revealed no malignancy. Following parathyroidectomy, she was diagnosed with a brown tumor with hyperparathyroidism due to a very rare parathyroid carcinoma. Although the right femoral lesion was indicated as an impending fracture, conservative treatment was performed because of the instability of her general condi...
Source: Case Reports in Oncology - November 28, 2022 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 14, Pages 5852: Mediastinal Parathyroid Cancer
This study characterizes features of mediastinal parathyroid cancer (MPC) and explores criteria aiding in the pre-operative recognition of malignancy. We assembled data from 502 patients with mediastinal parathyroid neoplasms (MPNs) from a systematic review of the literature 1968–2020 (n = 467) and our own patient cohort (n = 35). Thirty-two of the 502 MPNs (6.4%) exhibited malignancy. Only 23% of MPC patients underwent oncological surgery. Local persistence and early recurrence at a median delay of 24 months were frequent (45.8%), and associated with a 21.7-fold (95%CI 1.3–351.4; p = 0.03) high...
Source: Cancers - November 28, 2022 Category: Cancer & Oncology Authors: Klaus-Martin Schulte Gabriele Galat á Nadia Talat Tags: Article Source Type: research
Shear wave elastography for differentiating parathyroid neoplasms with malignant diagnosis or uncertain malignant potential from parathyroid adenomas: initial experience
This study aims to explore the value of 2D-shear wave elastogr... (Source: Cancer Imaging)
Source: Cancer Imaging - November 22, 2022 Category: Radiology Authors: Ruifeng Liu, Luying Gao, Xinlong Shi, Liyuan Ma, Ou Wang, Weibo Xia, Ya Hu, Yu Xia and Yuxin Jiang Tags: Research article Source Type: research
Advances in Endocrine Surgery
Recent changes in the landscape of endocrine surgery include a shift from total thyroidectomy for almost all patients with papillary thyroid cancer to the incorporation of thyroid lobectomy for well-selected patients with low-risk disease; minimally invasive parathyroidectomy with, and potentially without, intraoperative parathyroid hormone monitoring for patients with well-localized primary hyperparathyroidism; improvement in the management of parathyroid cancer with the incorporation of immune checkpoint blockade and/or targeted therapies; and the incorporation of minimally invasive techniques in the management of patien...
Source: Surgical Oncology Clinics of North America - November 3, 2022 Category: Surgery Authors: Michael S. Lui, Aditya S. Shirali, Bernice L. Huang, Sarah B. Fisher, Nancy D. Perrier Source Type: research
Late Recurrence of Hyperparathyroidism: Parathyromatosis or Recurrent Parathyroid Carcinoma?
A middle-aged woman presented with elevated calcium (10.7 mg/dL [0.28 mmol/L]) and parathyroid hormone (131 pg/mL [4,663.6 pmol/L]) levels. A sestamibi scan exhibited a right upper parathyroid lesion. Parathyroidectomy revealed a 3152 mg right upper parathyroid gland and the intraoperative parathyroid hormone level decreased by 90% (from 27.1 to 2.6 pmol/L; reference range, 1.3-6.8 pmol/L). The lesion was removed intact without any “spillage.” Histology revealed hypercellular parathyroid with intravascular tumor clusters at the periphery of the main lesion. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - November 1, 2022 Category: Internal Medicine Authors: Maria Gubbiotti, Virginia A. Livolsi Tags: Medical image Source Type: research
Predictive a nomogram for overall survival in patients with parathyroid cancer: A novel web-based calculator
CONCLUSION: The developed nomogram can be applied in clinical practice to help clinicians to assess patient prognosis.PMID:36307262 | DOI:10.1016/j.asjsur.2022.10.012 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - October 28, 2022 Category: Surgery Authors: Fangxu Yin Chong Hou Song Wang Xiaohong Wang Zhenlin Yang Source Type: research
