Phenotypic Profiling and Molecular Mechanisms in Hyperparathyroidism-Jaw Tumor Syndrome
CONCLUSIONS: Multiple, recurrent atypical adenomyomatous uterine polyps appear to be enriched in women with HPT-JT and appear characteristic of the disease. Patients with CDC73 variants at p.M1 residue appear predisposed to kidney tumors.PMID:37339334 | DOI:10.1210/clinem/dgad368 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - June 20, 2023 Category: Endocrinology Authors: Rana Tora James Welch Jian Sun Sunita K Agarwal Debra A Bell Maria Merino Lee S Weinstein William F Simonds Smita Jha Source Type: research
Mediastinal parathyroid carcinoma: a case report and review of the literature
Parathyroid carcinoma (PC) is an uncommon cause of primary hyperparathyroidism (PHPT) and particularly rare in the mediastinum. Herein, we present a case of mediastinal PC and conduct a related literature review. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - June 6, 2023 Category: Endocrinology Authors: Yan Bao, Ganjun Kang, Xiaoyan Wu, Jing Li, Yan Huang and Ye Wang Tags: Case report Source Type: research
Single ‐cell transcriptomic atlas of parathyroid adenoma and parathyroid carcinoma
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 16, 2023 Category: Orthopaedics Authors: Lihui Chen,
Ci Shan,
Shuqin Xu,
Xianzhao Deng,
Bomin Guo,
Qiong Jiao,
Li Zhang,
Youben Fan,
Hua Yue,
Zhenlin Zhang Tags: Research Article Source Type: research
Single-cell transcriptomic atlas of parathyroid adenoma and parathyroid carcinoma
This article is protected by copyright. All rights reserved.PMID:37191193 | DOI:10.1002/jbmr.4824 (Source: Cell Research)
Source: Cell Research - May 16, 2023 Category: Cytology Authors: Lihui Chen Ci Shan Shuqin Xu Xianzhao Deng Bomin Guo Qiong Jiao Li Zhang Youben Fan Hua Yue Zhenlin Zhang Source Type: research
Left parathyroid carcinoma with secondary hyperparathyroidism: a case report
Parathyroid carcinoma is a rare disease with a frequency of 0.005% of all malignancies [1, 2]. Various aspects of its pathogenesis, diagnosis, and treatment remain poorly understood. Furthermore, cases with se... (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - May 16, 2023 Category: Endocrinology Authors: Ko Yokoyama, Nobuyasu Suganuma and Yasushi Rino Tags: Case Report Source Type: research
Parathyroid carcinoma: molecular therapeutic targets
AbstractParathyroid carcinoma (PC) is an extremely rare malignant tumor of the parathyroid glands, accounting for less than 1% of primary hyperparathyroidism, commonly characterized by severe and unmanageable hypercalcemia, aggressive behavior, high metastatic potential, and poor prognosis. PC manifests prevalently as a sporadic tumor and only occasionally it is part of congenital syndromic and non-syndromic endocrine diseases. Molecular pathogenesis of this form of parathyroid tumor is not fully elucidated and it appears to be caused by multiple genetic and epigenetic drivers, differing among affected patients and not yet...
Source: Endocrine - May 9, 2023 Category: Endocrinology Source Type: research
A case of parathyroid carcinoma discovered at post-mortem
We present a post-mortem (PM) case of a patient who died from complications of a previously undiagnosed parathyroid carcinoma (PC). The typical clinical signs and symptoms are highlighted. The histology of PC is reviewed, and we discuss the key genetic alterations, and hereditary conditions, in which it is typically seen. Trainees should be aware of the findings of PC that may be encountered at PM, as well as the implications of PC for surviving first degree family members. (Source: Diagnostic Histopathology)
Source: Diagnostic Histopathology - May 9, 2023 Category: Pathology Authors: Dilek Taze, Hannah Hawrot Tags: Short case Source Type: research
New prospective in the genetic dissection underlying the development of parathyroid cancer
J Clin Endocrinol Metab. 2023 May 7:dgad253. doi: 10.1210/clinem/dgad253. Online ahead of print.NO ABSTRACTPMID:37149780 | DOI:10.1210/clinem/dgad253 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 7, 2023 Category: Endocrinology Authors: Alberto Falchetti Source Type: research
New prospective in the genetic dissection underlying the development of parathyroid cancer
J Clin Endocrinol Metab. 2023 May 7:dgad253. doi: 10.1210/clinem/dgad253. Online ahead of print.NO ABSTRACTPMID:37149780 | DOI:10.1210/clinem/dgad253 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 7, 2023 Category: Endocrinology Authors: Alberto Falchetti Source Type: research
Genomic and transcriptomic profiling reveal molecular characteristics of parathyroid carcinoma
Exp Mol Med. 2023 May 1. doi: 10.1038/s12276-023-00968-4. Online ahead of print.ABSTRACTGenomic and transcriptomic profiling has enhanced the diagnostic and treatment options for many cancers. However, the molecular characteristics of parathyroid cancer remain largely unexplored, thereby limiting the development of new therapeutic interventions. Herein, we conducted genomic and transcriptomic sequencing of 50 parathyroid tissues (12 carcinomas, 28 adenomas, and 10 normal tissues) to investigate the intrinsic and comparative molecular features of parathyroid carcinoma. We confirmed multiple two-hit mutation patterns in cell...
Source: Molecular Medicine - April 30, 2023 Category: Molecular Biology Authors: Se-Young Jo Namki Hong Seunghyun Lee Jong Ju Jeong Jeongsoo Won Jiho Park Gi Jeong Kim Sang Kyum Kim Sangwoo Kim Yumie Rhee Source Type: research
In-depth Proteomic Signature of Parathyroid Carcinoma
CONCLUSION: We identified key proteins differentially expressed between PC and PA using proteomic analyses of parathyroid neoplasms. These findings may help to diagnose PC accurately and elucidate potential therapeutic targets.PMID:36995894 | DOI:10.1093/ejendo/lvad046 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - March 30, 2023 Category: Endocrinology Authors: Sung Hye Kong Joon-Hyop Lee Jeong Mo Bae Namki Hong Hyeyoon Kim So Young Park Yong Jun Choi Sihoon Lee Yumie Rhee Sang Wan Kim Dohyun Han Jung Hee Kim Chan Soo Shin Source Type: research
Comparison of biochemical markers and technetium 99m methoxyisobutylisonitrile imaging in primary and secondary hyperparathyroidism
ConclusionThe proportion of positive findings on 99mTc-MIBI dual-phase planar imaging and the T/NT ratios of 99mTc-MIBI SPECT/CT fusion imaging were higher in PHPT than in SHPT. The volume of parathyroid lesions in SHPT was smaller than in PHPT. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - March 27, 2023 Category: Endocrinology Source Type: research
Molecular and Clinical Spectrum of Primary Hyperparathyroidism
Endocr Rev. 2023 Mar 24:bnad009. doi: 10.1210/endrev/bnad009. Online ahead of print.ABSTRACTRecent data suggest an increase in the overall incidence of parathyroid disorders with primary hyperparathyroidism (PHPT) being the most prevalent parathyroid disorder. PHPT is associated with morbidities (fractures, kidney stones, chronic kidney disease) and increased risk of death. The symptoms of PHPT can be non-specific, potentially delaying the diagnosis. Approximately 15% of patients with PHPT have an underlying heritable form of PHPT which may be associated with extra-parathyroidal manifestations, requiring active surveillanc...
Source: Endocrine Reviews - March 24, 2023 Category: Endocrinology Authors: Smita Jha William F Simonds Source Type: research
