Novel Glial Cells Missing-2 (GCM2) Variants in Parathyroid Disorders
CONCLUSIONS: We provide evidence that 2 novel GCM2 R67C inactivating mutations with inability to bind DNA are causative of hypoparathyroidism. Additionally, we provide evidence that two novel GCM2 variants increased transactivation of the PTH promoter in vitro and are associated with FIHP. Furthermore, our studies suggest that activating GCM2 variants may contribute to facilitating more aggressive parathyroid disease.PMID:35038313 | DOI:10.1530/EJE-21-0433 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 17, 2022 Category: Endocrinology Authors: Lucie Canaff Vito Guarnieri Yoojung Kim Betty Y L Wong Alexis Nolin-Lapalme David E C Cole Salvatore Minisola Cristina Eller-Vainicher Filomena Cetani Andrea Repaci Daniela Turchetti Sabrina Corbetta Alfredo Scillitani David Goltzman Source Type: research

Novel Glial Cells Missing-2 (GCM2) Variants in Parathyroid Disorders
CONCLUSIONS: We provide evidence that 2 novel GCM2 R67C inactivating mutations with inability to bind DNA are causative of hypoparathyroidism. Additionally, we provide evidence that two novel GCM2 variants increased transactivation of the PTH promoter in vitro and are associated with FIHP. Furthermore, our studies suggest that activating GCM2 variants may contribute to facilitating more aggressive parathyroid disease.PMID:35038313 | DOI:10.1530/EJE-21-0433 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - January 17, 2022 Category: Endocrinology Authors: Lucie Canaff Vito Guarnieri Yoojung Kim Betty Y L Wong Alexis Nolin-Lapalme David E C Cole Salvatore Minisola Cristina Eller-Vainicher Filomena Cetani Andrea Repaci Daniela Turchetti Sabrina Corbetta Alfredo Scillitani David Goltzman Source Type: research

Clinical Presentation, Treatment, and Outcome of Parathyroid Carcinoma: Results of the NEKAR Retrospective International Multicenter Study
Objective: In this retrospective cohort study, we describe the clinical presentation and workup of parathyroid carcinoma (PC) and determine its clinical prognostic parameters. Primary outcome was recurrence free survival. Summary Background Data: PC is an orphan malignancy for which diagnostic workup and treatment is not established. Methods: Eighty-three patients were diagnosed with PC between 1986 and 2018. Disease-specific and recurrence-free survivals were estimated with the Kaplan-Meier method. Risk factors for recurrence were identified by binary logistic regression with adjustment for age and sex. ...
Source: Annals of Surgery - January 11, 2022 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

A Case of Brown Tumor on 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT
A 50-year-old man presented with right chest pain and persistent increased parathyroid hormone after parathyroidectomy for parathyroid carcinoma. 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT were performed consecutively for restaging to determine subsequent treatment strategy. An osteolytic lesion on the right sixth rib showed increased uptake on both 68Ga-DOTATATE and 18F-FDG PET/CT. Subsequent biopsy confirmed it to be a brown tumor. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - December 16, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Case Report and Systematic Review: Sarcomatoid Parathyroid Carcinoma —A Rare, Highly Malignant Subtype
ConclusionSaPC is a very rare pathologic subtype of PC and appears to be much more easily misdiagnosed as a thyroid tumor. Spindle cell areas or transitional zones are highly possible to be pathological features in its sarcomatoid components. Despite many similarities, there are some differences between SaPC and general PC—SaPC does not show the obvious endocrine feature but stronger aggressiveness. Surgical treatment of SaPC does relieve life-threatening symptoms and improve quality of life even with recurrence in the short term. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - December 15, 2021 Category: Endocrinology Source Type: research

18F Choline PET/CT in a patient with HRPT2 mutation: Detecting parathyroid carcinoma recurrence and concomitant breast carcinoma
Nuklearmedizin. 2021 Nov 29. doi: 10.1055/a-1670-9315. Online ahead of print.NO ABSTRACTPMID:34844271 | DOI:10.1055/a-1670-9315 (Source: Nuklearmedizin)
Source: Nuklearmedizin - November 29, 2021 Category: Radiology Authors: Konrad Christof Radzikowski Gundula Rendl Mohsen Beheshti Christian Pirich Source Type: research

18F Choline PET/CT in a patient with HRPT2 mutation: Detecting parathyroid carcinoma recurrence and concomitant breast carcinoma
Nuklearmedizin. 2021 Nov 29. doi: 10.1055/a-1670-9315. Online ahead of print.NO ABSTRACTPMID:34844271 | DOI:10.1055/a-1670-9315 (Source: Nuklearmedizin)
Source: Nuklearmedizin - November 29, 2021 Category: Radiology Authors: Konrad Christof Radzikowski Gundula Rendl Mohsen Beheshti Christian Pirich Source Type: research

Imaging of Treated Thyroid and Parathyroid Disease
The thyroid and parathyroid glands are endocrine structures located in the visceral space of the infrahyoid neck. Imaging plays a critical role in the evaluation of patients with thyroid cancer, both in the pre and posttreatment setting. Disorders of thyroid function, that is, hyperthyroidism and hypothyroidism, are also fairly common, although imaging utilization is less frequent with these conditions. Parathyroid dysfunction results in disordered calcium metabolism. Imaging is frequently applied in the preoperative assessment of these patients undergoing parathyroidectomy; however, routine imaging in the postoperative se...
Source: Neuroimaging Clinics - November 20, 2021 Category: Radiology Authors: Kalen Riley, Yoshimi Anzai Source Type: research

Parathyroid Carcinoma and Ectopic Secretion of Parathyroid hormone
Endocrinol Metab Clin North Am. 2021 Dec;50(4):683-709. doi: 10.1016/j.ecl.2021.07.001.ABSTRACTThe most common causes of hypercalcemia are primary hyperparathyroidism (PHPT) and malignancy. Parathyroid carcinoma (PC), causing a severe PHPT, is the rarest parathyroid tumor. A diagnosis of PC is challenging because the clinical profile overlaps with that of benign counterpart. Surgery is the mainstay treatment. CDC73 mutations have been detected in up to 80% of sporadic PCs. Ectopic production of parathyroid hormone (PTH) by malignant nonparathyroid tumors is a rare condition accounting for less than 1% of hypercalcemia of m...
Source: The Medical Clinics of North America - November 14, 2021 Category: General Medicine Authors: Filomena Cetani Elena Pardi Claudio Marcocci Source Type: research

ASO Visual Abstract: Extended En Bloc Reoperation for Recurrent or Persistent Parathyroid Carcinoma-Analysis of 31 Cases in a Single-Institution Experience
Ann Surg Oncol. 2021 Nov 13. doi: 10.1245/s10434-021-11064-0. Online ahead of print.NO ABSTRACTPMID:34775546 | DOI:10.1245/s10434-021-11064-0 (Source: Ann Oncol)
Source: Ann Oncol - November 14, 2021 Category: Cancer & Oncology Authors: Bojun Wei Teng Zhao Hong Shen Mulan Jin Quan Zhou Xing Liu Jiacheng Wang Qian Wang Source Type: research

ASO Visual Abstract: Extended En Bloc Reoperation for Recurrent or Persistent Parathyroid Carcinoma-Analysis of 31 Cases in a Single-Institution Experience
Ann Surg Oncol. 2021 Nov 13. doi: 10.1245/s10434-021-11064-0. Online ahead of print.NO ABSTRACTPMID:34775546 | DOI:10.1245/s10434-021-11064-0 (Source: Ann Oncol)
Source: Ann Oncol - November 14, 2021 Category: Cancer & Oncology Authors: Bojun Wei Teng Zhao Hong Shen Mulan Jin Quan Zhou Xing Liu Jiacheng Wang Qian Wang Source Type: research

Parathyroid Carcinoma and Ectopic Secretion of Parathyroid hormone
The most common causes of hypercalcemia are primary hyperparathyroidism (PHPT) and malignancy. Parathyroid carcinoma (PC), causing a severe PHPT, is the rarest parathyroid tumor. A diagnosis of PC is challenging because the clinical profile overlaps with that of benign counterpart. Surgery is the mainstay treatment. CDC73 mutations have been detected in up to 80% of sporadic PCs. Ectopic production of parathyroid hormone (PTH) by malignant nonparathyroid tumors is a rare condition accounting for less than 1% of hypercalcemia of malignancy. PTH secretion can be considered an aberration in the tissue specificity of gene expr...
Source: Endocrinology and Metabolism Clinics of North America - November 11, 2021 Category: Endocrinology Authors: Filomena Cetani, Elena Pardi, Claudio Marcocci Source Type: research

A novel long-range deletion spanning CDC73 and upper-stream genes discovered in a kindred of familial primary hyperparathyroidism
ConclusionsWe discovered a novel 130  kb long-range deletion spanningCDC73 in a family of 5 persons, and the existence of the deletion was related to PHPT and PC. Our discovery validated the role ofCDC73 mutation in the occurrence of PHPT and PC, which provided new information to the genetic studies of PC. (Source: Endocrine)
Source: Endocrine - November 2, 2021 Category: Endocrinology Source Type: research

ASO Author Reflections: Extended En Bloc Reoperation: A Potential Curative Operation for Recurrent or Persistent Parathyroid Carcinoma
Ann Surg Oncol. 2021 Oct 28. doi: 10.1245/s10434-021-10975-2. Online ahead of print.NO ABSTRACTPMID:34709492 | DOI:10.1245/s10434-021-10975-2 (Source: Ann Oncol)
Source: Ann Oncol - October 28, 2021 Category: Cancer & Oncology Authors: Bojun Wei Teng Zhao Hong Shen Mulan Jin Quan Zhou Xing Liu Jiacheng Wang Qian Wang Source Type: research

ASO Author Reflections: Extended En Bloc Reoperation: A Potential Curative Operation for Recurrent or Persistent Parathyroid Carcinoma
Ann Surg Oncol. 2021 Oct 28. doi: 10.1245/s10434-021-10975-2. Online ahead of print.NO ABSTRACTPMID:34709492 | DOI:10.1245/s10434-021-10975-2 (Source: Ann Oncol)
Source: Ann Oncol - October 28, 2021 Category: Cancer & Oncology Authors: Bojun Wei Teng Zhao Hong Shen Mulan Jin Quan Zhou Xing Liu Jiacheng Wang Qian Wang Source Type: research

Extended En Bloc Reoperation for Recurrent or Persistent Parathyroid Carcinoma: Analysis of 31 Cases in a Single Institute Experience
CONCLUSION: EEBRs provide better outcomes than other conventional surgical approaches and might offer a second chance of cure for patients with recurrent or persistent PC in the absence of DM.PMID:34694522 | DOI:10.1245/s10434-021-10962-7 (Source: Ann Oncol)
Source: Ann Oncol - October 25, 2021 Category: Cancer & Oncology Authors: Bojun Wei Teng Zhao Hong Shen Mulan Jin Quan Zhou Xing Liu Jiacheng Wang Qian Wang Source Type: research

Giant parathyroid carcinoma: Diagnostic, difficulties and therapeutic strategies: A case report
CONCLUSION: Parathyroid carcinoma is a rare tumor. This rare entity is often presented with clinicobiological features of severe primary hyperparathyroidism.PMID:34691446 | PMC:PMC8517712 | DOI:10.1016/j.amsu.2021.102919 (Source: Annals of Medicine)
Source: Annals of Medicine - October 25, 2021 Category: Internal Medicine Authors: Laila Bouzayan Mohamed Yassine Mabrouk Hassane Ait Ali Abdelali Guelil Achraf Miry Jabi Rachid Amal Benani Mohammed Bouziane Source Type: research

Acute pancreatitis and parathyroid carcinoma: a case report and literature review
CONCLUSIONS: Acute pancreatitis induced by primary hyperparathyroidism due to parathyroid carcinoma is an extremely rare condition. However, when hypercalcemia is found, serum PTH levels should always be determined in order to rule out PHPT and hypercalcemia-induced acute pancreatitis should be suspected in presence of hypercalcemia and abdominal symptoms.PMID:34661256 | DOI:10.26355/eurrev_202110_26874 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - October 18, 2021 Category: Drugs & Pharmacology Authors: I Mignini M Pizzoferrato L Larosa A Gasbarrini G L Rapaccini A Armuzzi Source Type: research

Acute pancreatitis and parathyroid carcinoma: a case report and literature review
CONCLUSIONS: Acute pancreatitis induced by primary hyperparathyroidism due to parathyroid carcinoma is an extremely rare condition. However, when hypercalcemia is found, serum PTH levels should always be determined in order to rule out PHPT and hypercalcemia-induced acute pancreatitis should be suspected in presence of hypercalcemia and abdominal symptoms.PMID:34661256 | DOI:10.26355/eurrev_202110_26874 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - October 18, 2021 Category: Drugs & Pharmacology Authors: I Mignini M Pizzoferrato L Larosa A Gasbarrini G L Rapaccini A Armuzzi Source Type: research

Management and Outcome of Parathyroid Carcinoma-Induced Primary Hyperparathyroidism: A Single-Centre Experience
CONCLUSION: Our study highlights some aspects valuable to suspect PC and differentiate PHPT-PC from benign causes of PHPT preoperatively. Preoperative suspicion of malignancy is essential to guarantee the best course of treatment for patients. Although limited for size and follow-up, the excellent outcome of our series seems to support the value of both surgery extension and risk class according to the Schulte classification as possible prognostic factors for recurrence.PMID:34659402 | PMC:PMC8516565 | DOI:10.1155/2021/5397941 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 18, 2021 Category: Endocrinology Authors: Loredana De Pasquale Antonio Mario Bulfamante Giovanni Felisati Luca Castellani Giorgio Ghilardi Alberto Maria Saibene Source Type: research

Acute pancreatitis and parathyroid carcinoma: a case report and literature review
CONCLUSIONS: Acute pancreatitis induced by primary hyperparathyroidism due to parathyroid carcinoma is an extremely rare condition. However, when hypercalcemia is found, serum PTH levels should always be determined in order to rule out PHPT and hypercalcemia-induced acute pancreatitis should be suspected in presence of hypercalcemia and abdominal symptoms.PMID:34661256 | DOI:10.26355/eurrev_202110_26874 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - October 18, 2021 Category: Drugs & Pharmacology Authors: I Mignini M Pizzoferrato L Larosa A Gasbarrini G L Rapaccini A Armuzzi Source Type: research

Management and Outcome of Parathyroid Carcinoma-Induced Primary Hyperparathyroidism: A Single-Centre Experience
CONCLUSION: Our study highlights some aspects valuable to suspect PC and differentiate PHPT-PC from benign causes of PHPT preoperatively. Preoperative suspicion of malignancy is essential to guarantee the best course of treatment for patients. Although limited for size and follow-up, the excellent outcome of our series seems to support the value of both surgery extension and risk class according to the Schulte classification as possible prognostic factors for recurrence.PMID:34659402 | PMC:PMC8516565 | DOI:10.1155/2021/5397941 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 18, 2021 Category: Endocrinology Authors: Loredana De Pasquale Antonio Mario Bulfamante Giovanni Felisati Luca Castellani Giorgio Ghilardi Alberto Maria Saibene Source Type: research

Acute pancreatitis and parathyroid carcinoma: a case report and literature review
CONCLUSIONS: Acute pancreatitis induced by primary hyperparathyroidism due to parathyroid carcinoma is an extremely rare condition. However, when hypercalcemia is found, serum PTH levels should always be determined in order to rule out PHPT and hypercalcemia-induced acute pancreatitis should be suspected in presence of hypercalcemia and abdominal symptoms.PMID:34661256 | DOI:10.26355/eurrev_202110_26874 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - October 18, 2021 Category: Drugs & Pharmacology Authors: I Mignini M Pizzoferrato L Larosa A Gasbarrini G L Rapaccini A Armuzzi Source Type: research

Management and Outcome of Parathyroid Carcinoma-Induced Primary Hyperparathyroidism: A Single-Centre Experience
CONCLUSION: Our study highlights some aspects valuable to suspect PC and differentiate PHPT-PC from benign causes of PHPT preoperatively. Preoperative suspicion of malignancy is essential to guarantee the best course of treatment for patients. Although limited for size and follow-up, the excellent outcome of our series seems to support the value of both surgery extension and risk class according to the Schulte classification as possible prognostic factors for recurrence.PMID:34659402 | PMC:PMC8516565 | DOI:10.1155/2021/5397941 (Source: International Journal of Endocrinology)
Source: International Journal of Endocrinology - October 18, 2021 Category: Endocrinology Authors: Loredana De Pasquale Antonio Mario Bulfamante Giovanni Felisati Luca Castellani Giorgio Ghilardi Alberto Maria Saibene Source Type: research

Acute pancreatitis and parathyroid carcinoma: a case report and literature review
CONCLUSIONS: Acute pancreatitis induced by primary hyperparathyroidism due to parathyroid carcinoma is an extremely rare condition. However, when hypercalcemia is found, serum PTH levels should always be determined in order to rule out PHPT and hypercalcemia-induced acute pancreatitis should be suspected in presence of hypercalcemia and abdominal symptoms.PMID:34661256 | DOI:10.26355/eurrev_202110_26874 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - October 18, 2021 Category: Drugs & Pharmacology Authors: I Mignini M Pizzoferrato L Larosa A Gasbarrini G L Rapaccini A Armuzzi Source Type: research

Acute pancreatitis and parathyroid carcinoma: a case report and literature review
CONCLUSIONS: Acute pancreatitis induced by primary hyperparathyroidism due to parathyroid carcinoma is an extremely rare condition. However, when hypercalcemia is found, serum PTH levels should always be determined in order to rule out PHPT and hypercalcemia-induced acute pancreatitis should be suspected in presence of hypercalcemia and abdominal symptoms.PMID:34661256 | DOI:10.26355/eurrev_202110_26874 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - October 18, 2021 Category: Drugs & Pharmacology Authors: I Mignini M Pizzoferrato L Larosa A Gasbarrini G L Rapaccini A Armuzzi Source Type: research

A Collision Intrathyroidal Tumor Causing Primary Hyperparathyroidism: Evidence From an: 18: F-Choline PET/CT Study
A 67-year-old man was diagnosed with primary hyperparathyroidism and normofunctioning left nodular goiter. Fine-needle aspiration cytology showed thyroid (Thy) 4 (suspicious of malignancy). After first-line imaging proved negative, integrated 18F-choline PET/4D contrast-enhanced CT revealed uptake by the thyroid nodule and by 3 nodules of the left central compartment. Thyroidectomy and lymphadenectomy were performed. Histopathology revealed a collision tumor (ie, 2 histologically distinct tumors occurring at the same anatomic site) composed of both PTC (papillary thyroid carcinoma) and parathyroid carcinoma within the left...
Source: Clinical Nuclear Medicine - October 12, 2021 Category: Nuclear Medicine Tags: Interesting Images Source Type: research

Filamin A and Parafibromin Expression in Parathyroid Carcinoma
We examined FLNA, CaSR and parafibromin expression in PCs (n = 32), APTs (n = 44) and PAs (n = 77) and investigated their potential as diagnostic and/or prognostic markers.METHODS: Tissue microarray slides were immunohistochemically stained with FLNA, CaSR and parafibromin. Staining results were correlated with detailed clinical data.RESULTS: All tumours stained positively for CaSR, with two tumours (one PC and one APT) showing diminished expression. Carcinomas were characterized by increased cytoplasmic FLNA expression compared to APTs and PAs (p = 0.004). FLNA expression was not correlated with Ki-67 proliferation index ...
Source: European Journal of Endocrinology - October 4, 2021 Category: Endocrinology Authors: Sara Storvall Helena Leijon Eeva M Ryh änen Tiina Vesterinen Ilkka Heiskanen Camilla Schalin-Jantti Johanna Arola Source Type: research

Filamin A and Parafibromin Expression in Parathyroid Carcinoma
We examined FLNA, CaSR and parafibromin expression in PCs (n = 32), APTs (n = 44) and PAs (n = 77) and investigated their potential as diagnostic and/or prognostic markers.METHODS: Tissue microarray slides were immunohistochemically stained with FLNA, CaSR and parafibromin. Staining results were correlated with detailed clinical data.RESULTS: All tumours stained positively for CaSR, with two tumours (one PC and one APT) showing diminished expression. Carcinomas were characterized by increased cytoplasmic FLNA expression compared to APTs and PAs (p = 0.004). FLNA expression was not correlated with Ki-67 proliferation index ...
Source: European Journal of Endocrinology - October 4, 2021 Category: Endocrinology Authors: Sara Storvall Helena Leijon Eeva M Ryh änen Tiina Vesterinen Ilkka Heiskanen Camilla Schalin-Jantti Johanna Arola Source Type: research

Filamin A and Parafibromin Expression in Parathyroid Carcinoma
We examined FLNA, CaSR and parafibromin expression in PCs (n = 32), APTs (n = 44) and PAs (n = 77) and investigated their potential as diagnostic and/or prognostic markers.METHODS: Tissue microarray slides were immunohistochemically stained with FLNA, CaSR and parafibromin. Staining results were correlated with detailed clinical data.RESULTS: All tumours stained positively for CaSR, with two tumours (one PC and one APT) showing diminished expression. Carcinomas were characterized by increased cytoplasmic FLNA expression compared to APTs and PAs (p = 0.004). FLNA expression was not correlated with Ki-67 proliferation index ...
Source: European Journal of Endocrinology - October 4, 2021 Category: Endocrinology Authors: Sara Storvall Helena Leijon Eeva M Ryh änen Tiina Vesterinen Ilkka Heiskanen Camilla Schalin-Jantti Johanna Arola Source Type: research

Parathyroid carcinoma in chronic renal disease - a case series of three patients and review of literature
CONCLUSION: In patients with secondary hyperparathyroidism, who develop parathyroid carcinoma, surgical resection is the only viable treatment option.PMID:34459368 | DOI:10.1080/00015458.2021.1970438 (Source: Acta Chirurgica Belgica)
Source: Acta Chirurgica Belgica - August 30, 2021 Category: Surgery Authors: Vladan Zivaljevic Rastko Zivic Nikola Slijepcevic Matija Buzejic Dusko Dundjerovic Jasna Trbojevic Stankovic Dejan Stojakov Milan Jovanovic Ivan Paunovic Source Type: research

Epidemiology and prognosis of parathyroid carcinoma: real-world data using nationwide cohort
AbstractPurposeParathyroid carcinoma (PC) is an exceedingly rare endocrine malignancy with a poor prognosis. Due to the rarity, the natural course and prognostic factors of the disease are yet unclear. Therefore, we aimed to identify the incidence, prognosis, and prognostic factors of PC in the nationwide cohort study.MethodsThe study is a nationwide study using the National Health Insurance Services database in Korea from 2002 to 2017. PC was defined as patients with ICD-10 code of PC and a procedural code for parathyroidectomy.ResultsFrom 2002 to 2017, 255 patients were diagnosed with PC whose mean age was 53.2  yea...
Source: Journal of Cancer Research and Clinical Oncology - August 28, 2021 Category: Cancer & Oncology Source Type: research

A large extended family with hyperparathyroidism-jaw tumor syndrome due to deletion of the third exon of CDC73: clinical and molecular features
ConclusionWe report a family carrier of a deletion of exon 3 of theCDC73 gene. This is characterized by a high level of hypercalcemia, deleterious kidney effects and atypical parathyroid adenomas without carcinomas. Onset and intensity of HPT remain unpredictable. The additional somatic mutation found in the parathyroid tumor could lead to these phenotypical variations. (Source: Endocrine)
Source: Endocrine - August 19, 2021 Category: Endocrinology Source Type: research

The input of GATA-3 in the identification of parathyroid carcinoma diagnosis: Case report with review of literature
CONCLUSION: It is concluded that GATA-3 is a very sensitive and relatively specific immunohistochemical marker for parathyroid differentiation that can assist in the differential diagnosis of parathyroid tumours.PMID:34345427 | PMC:PMC8319570 | DOI:10.1016/j.amsu.2021.102571 (Source: Annals of Medicine)
Source: Annals of Medicine - August 4, 2021 Category: Internal Medicine Authors: Zainab Lajmi Ahlem Bdioui Ahlem Bchir None Oussama Belkacem Emene Ben Ammou Nabiha Missaoui Sihem Hmissa Source Type: research

Parathyroid Carcinoma in a Patient With Secondary Hyperparathyroidism and Thyroid Hemiagenesis: A Case Report and Review of the Literature
We report an extremely rare case of parathyroid carcinoma in a patient with secondary hyperparathyroidism and thyroid hemiagenesis. We also present a review of the literature of this rare entity. We also discuss the surgical procedure performed for this patient. Our review of the literature found 34 case reports of parathyroid carcinoma in patients undergoing dialysis due to chronic renal failure; 14 reports of thyroid hemiagenesis with parathyroid disease; and no previous reports of thyroid hemiagenesis with secondary hyperparathyroidism and parathyroid carcinoma. Although surgical treatment of parathyroid carcinoma requi...
Source: Ear, Nose and Throat Journal - July 28, 2021 Category: ENT & OMF Authors: Shinpei Kada Miho Tanaka Akihiro Yasoda Source Type: research

Parathyroid Carcinoma in a Patient With Secondary Hyperparathyroidism and Thyroid Hemiagenesis: A Case Report and Review of the Literature
We report an extremely rare case of parathyroid carcinoma in a patient with secondary hyperparathyroidism and thyroid hemiagenesis. We also present a review of the literature of this rare entity. We also discuss the surgical procedure performed for this patient. Our review of the literature found 34 case reports of parathyroid carcinoma in patients undergoing dialysis due to chronic renal failure; 14 reports of thyroid hemiagenesis with parathyroid disease; and no previous reports of thyroid hemiagenesis with secondary hyperparathyroidism and parathyroid carcinoma. Although surgical treatment of parathyroid carcinoma requi...
Source: Ear, Nose and Throat Journal - July 28, 2021 Category: ENT & OMF Authors: Shinpei Kada Miho Tanaka Akihiro Yasoda Source Type: research

Is extensive surgery really necessary in patients with parathyroid carcinoma? Single-centre experience and a brief review of the literature
CONCLUSIONS: In the presence of PHPT characterized by particularly high preoperative levels of serum PTH and calcium this malignancy should be suspected. On the basis of our experience, we believe that extensive surgery is not always necessary.KEY WORDS: Hyperparathyroidism, Parathyroid carcinoma, Parathyroid surgery.PMID:34312331 (Source: Annali Italiani di Chirurgia)
Source: Annali Italiani di Chirurgia - July 27, 2021 Category: Surgery Authors: Gian Luigi Canu Fabio Medas Federico Cappellacci Stefano Piras Salvatore Sorrenti Enrico Erdas Pietro Giorgio Cal ò Source Type: research