Determining the timing of respiratory syncytial virus (RSV) epidemics: a systematic review, 2016 to 2021; method categorisation and identification of influencing factors
ConclusionMethods and assessment characteristics used to define RSV seasonality are heterogeneous. Our categorisation of methods and proposed framework of factors may assist in choosing RSV seasonality methods and interpretating results.PMID:38304952 | PMC:PMC10835753 | DOI:10.2807/1560-7917.ES.2024.29.5.2300244 (Source: Euro Surveill)
Source: Euro Surveill - February 2, 2024 Category: Infectious Diseases Authors: Lisa Staadegaard Michel D ückers Jojanneke van Summeren Rob van Gameren Clarisse Demont Mathieu Bangert You Li Jean-Sebastien Casalegno Saverio Caini John Paget Source Type: research
Determining the timing of respiratory syncytial virus (RSV) epidemics: a systematic review, 2016 to 2021; method categorisation and identification of influencing factors
ConclusionMethods and assessment characteristics used to define RSV seasonality are heterogeneous. Our categorisation of methods and proposed framework of factors may assist in choosing RSV seasonality methods and interpretating results. (Source: Eurosurveillance)
Source: Eurosurveillance - February 1, 2024 Category: Infectious Diseases Authors: Lisa Staadegaard, Michel D ückers, Jojanneke van Summeren, Rob van Gameren, Clarisse Demont, Mathieu Bangert, You Li, Jean-Sebastien Casalegno, Saverio Caini and John Paget Source Type: research
Extramammary Paget ’s disease of the vulva
is a rare dermatologic condition that presents in areas where there are apocrine sweat glands including the vulva, perineum and perianal skin. It presents are erythematous well-demarcated plaques that can become erosive, ulcerated, scaly or eczematous. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Silvaine Dalli, Mario Refalo, Mark Sant, Yves Muscat Baron Source Type: research
Mammary Paget disease
Med Clin (Barc). 2024 Jan 28:S0025-7753(23)00758-3. doi: 10.1016/j.medcli.2023.11.022. Online ahead of print.NO ABSTRACTPMID:38286721 | DOI:10.1016/j.medcli.2023.11.022 (Source: Medicina Clinica)
Source: Medicina Clinica - January 29, 2024 Category: General Medicine Authors: Mag í Brufau-Cochs Claudia Guilarte-Cadavide Montserrat Ferrer-Artola Source Type: research
Untargeted metabolomics yields insight into extramammary Paget ’s disease mechanisms
ConclusionIn conclusion, this study was the first to reveal the metabolome profile of EMPD. Our results demonstrate that IDO1/TDO2-initialized KYN metabolic pathway may play a vital role in the development and progression of EMPD, which may serve as a potential therapeutic target for treating EMPD. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - January 29, 2024 Category: Cancer & Oncology Source Type: research
Paget's disease of the breast: Presentation, treatment, and outcomes in a modern cohort
This study aims to assess outcomes of PD patients based on procedure type and determine the reliability of imaging in estimating disease extent. (Source: American Journal of Surgery)
Source: American Journal of Surgery - January 24, 2024 Category: Surgery Authors: Dorsa Mousa-Doust, Rebecca Warburton, Jin-Si Pao, Carol Dingee, Amy Bazzarelli, Jieun Newman-Bremang, Elaine McKevitt Tags: Featured Article Source Type: research
Extramammary Paget ’s Disease of the Penis and Scrotum
AbstractExtramammary Paget ’s disease (EMPD) is an adenocarcinoma arising from the skin or skin appendages which is sometimes associated with an underlying malignancy. EMPD is most commonly seen in the vulva, followed by perianal region, and the male genitalia. In most cases, patient presents with eczematous lesion persisti ng for long duration. A 77-year-old gentleman had a history of chronic eczematous lesion over penis and scrotum for the last 10 years. Examination revealed an erythematous plaque like eczematous lesion over the penis and scrotum. Biopsy with IHC of lesion is suggestive of EMPD. Wide local excision of...
Source: Indian Journal of Surgical Oncology - January 23, 2024 Category: Cancer & Oncology Source Type: research
Man with swollen arm
Clinical Introduction A previously healthy 39-year-old male presented to the emergency department with intermittent right arm swelling for 1 month, which worsened over 4 days (figure 1). He is a right-handed chef and often raised his right arm at work. He denied fever or recent trauma. On examination, radial artery pulse was palpable. There was no cervical or axillary lymphadenopathy. His vital signs were stable, while the other physical and neurologic examinations were unremarkable. Question What is the most likely diagnosis? Compartment syndrome. Lymphedema. ‘Paget-Schroetter’ syndrome. Dermatomyositis. Answe...
Source: Emergency Medicine Journal - January 22, 2024 Category: Emergency Medicine Authors: Yang, S.-C., Lee, C.-W. Tags: EMJ Image Challenge Source Type: research
Management of Paget-Schroetter Syndrome: a Systematic Review and Meta-Analysis
The objective was to summarise the current evidence for management of PSS with explicit attention to the clinical outcomes of different management strategies. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - January 18, 2024 Category: Surgery Authors: F. Hoexum, M. Hoebink, H.M.E. Coveliers, W. Wisselink, V. Jongkind, K.K. Yeung Tags: Systematic Review Source Type: research
Radiologic Evaluation of Conductive Hearing Loss
In the presence of an intact tympanic membrane, conductive hearing loss may be due to a wide range of conditions, include congenital or acquired ossicular chain abnormalities, complications from chronic inflammation including cholesteatoma or tympanosclerosis, neoplasms or vascular lesions in the middle ear, bone dysplasia including Paget disease or otosclerosis, or third window lesions. Imaging with CT and MRI has evolved as a powerful tool in the diagnosis and surgical planning in the evaluation of conductive hearing loss. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
Source: Operative Techniques in Otolaryngology - Head and Neck Surgery - January 16, 2024 Category: ENT & OMF Authors: Yuh-Shin Chang, Katherine L. Reinshagen Source Type: research
Safety and effectiveness of risedronate in Paget ’s disease of bone: postmarketing surveillance study in Japan
ConclusionTo conclude, risedronate 17.5 mg/day is safe and effective for treating patients with PDB in daily practice. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 10, 2024 Category: Orthopaedics Source Type: research
Understanding organotropism in cancer metastasis using microphysiological systems
Lab Chip. 2024 Jan 9. doi: 10.1039/d3lc00889d. Online ahead of print.ABSTRACTCancer metastasis, the leading cause of cancer-related deaths, remains a complex challenge in medical science. Stephen Paget's "seed and soil theory" introduced the concept of organotropism, suggesting that metastatic success depends on specific organ microenvironments. Understanding organotropism not only offers potential for curbing metastasis but also novel treatment strategies. Microphysiological systems (MPS), especially organ-on-a-chip models, have emerged as transformative tools in this quest. These systems, blending microfluidics, biology,...
Source: Cancer Control - January 9, 2024 Category: Cancer & Oncology Authors: Jihoon Ko Jiyoung Song Yedam Lee Nakwon Choi Hong Nam Kim Source Type: research
Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases
AbstractGlycosylation changes of cancer cells are known to be associated with malignant progression and metastases and potentially determine the organ-selective nature of metastasis as theorized by Paget (Lancet 1:571 –573, 1889). Cellular glycans play a variety of roles in the processes of metastasis and may be unique to the cells that metastasize to different organs. We analyzed the glycosylation profiles of the primary tumor and tumors metastasized to lymph node, liver, lung, brain, bone, thyroid, kidney, ad renal, small intestine and pancreas in an autopsy case of breast cancer employing a lectin microarray with 45 l...
Source: Clinical and Experimental Metastasis - January 9, 2024 Category: Cancer & Oncology Source Type: research
Primary melanoma of the nipple: Report of 10 cases including coexistence with Paget's disease
Pathol Res Pract. 2023 Dec 22;253:155058. doi: 10.1016/j.prp.2023.155058. Online ahead of print.ABSTRACTPrimary melanoma of the nipple (PMN) is exceedingly rare, with only single cases reported to date. We identified 10 patients with PMN: 5 females, 5 males, median age 55.5 years (range 29-66) at diagnosis of melanoma in situ (4 cases) or invasive melanoma (6 cases, Breslow depth 0.2 mm to 3.5 mm). Follow-up was available for all 10 patients (median 19 months, range 1-183). Nine patients had no evidence of disease; one patient died of disease (13.5 months) after presenting with a nodal metastasis. One case was exceptional,...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Carina A Dehner Emma F Johnson Margot S Peters Ruifeng Ray Guo Source Type: research
Primary melanoma of the nipple: Report of 10 cases including coexistence with Paget's disease
Pathol Res Pract. 2023 Dec 22;253:155058. doi: 10.1016/j.prp.2023.155058. Online ahead of print.ABSTRACTPrimary melanoma of the nipple (PMN) is exceedingly rare, with only single cases reported to date. We identified 10 patients with PMN: 5 females, 5 males, median age 55.5 years (range 29-66) at diagnosis of melanoma in situ (4 cases) or invasive melanoma (6 cases, Breslow depth 0.2 mm to 3.5 mm). Follow-up was available for all 10 patients (median 19 months, range 1-183). Nine patients had no evidence of disease; one patient died of disease (13.5 months) after presenting with a nodal metastasis. One case was exceptional,...
Source: Pathology, Research and Practice - January 5, 2024 Category: Pathology Authors: Carina A Dehner Emma F Johnson Margot S Peters Ruifeng Ray Guo Source Type: research
