Extramammary Paget Disease. Part II. Evidence-based Approach to Management
Extramammary Paget disease is a rare cutaneous malignancy that most commonly affects the genitals, perianal area, and axilla of elderly patients. Delays in care often lead to high levels of disease burden for patients. Thus, evidence-based recommendations are paramount in mitigating morbidity and mortality for this unique patient population. This 2-part continuing medical education series provides a complete picture of extramammary Paget disease. Part 2 of this continuing medical education series focuses on the complex management of extramammary Paget disease including surgical and non-invasive therapies, as well as novel ...
Source: Journal of the American Academy of Dermatology - April 6, 2024 Category: Dermatology Authors: Rohan R. Shah, Kalee Shah, Britney N. Wilson, Mario M. Leitao, Jan Smogorzewski, Christopher Crane, Samuel A. Funt, Sharif Hosein, Mirabel Dafinone, Anthony Rossi Source Type: research
Long-term effectiveness of zoledronic acid in patients with Paget ’s disease of bone – a retrospective cohort study
ConclusionThe majority of patients with PDB experience a mild disease course, marked by monostotic involvement and a low prevalence of fractures. Zoledronic acid effectively manages PDB, providing sustained biochemical response. The necessity for multiple zoledronic acid injections remains questionable, often implemented due to osteoporosis. (Source: Endocrine)
Source: Endocrine - March 30, 2024 Category: Endocrinology Source Type: research
Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS
(Source: Critical Care)
Source: Critical Care - March 28, 2024 Category: Intensive Care Authors: Antoine Guillon, Youenn Jouan, Arthur Kassa-Sombo, Christophe Paget and Pierre-Fran çois Dequin Tags: Correspondence Source Type: research
Paget Disease of Bone Harboring Bone Metastatic Neuroendocrine Cancer: A Case Report
In conclusion, low back pain in the elderly may require deep investigation to individuate rare diseases. In asymptomatic patients with apparently stable PDB, the sudden appearance of pain or neurologic symptoms may alert the clinician for the possibility of other superimposing diseases, like bone metastases. (Source: Calcified Tissue International)
Source: Calcified Tissue International - March 20, 2024 Category: Orthopaedics Source Type: research
Vulvar Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology
J Natl Compr Canc Netw. 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013.ABSTRACTVulvar cancer is annually diagnosed in an estimated 6,470 individuals and the vast majority are histologically squamous cell carcinomas. Vulvar cancer accounts for 5% to 8% of gynecologic malignancies. Known risk factors for vulvar cancer include increasing age, infection with human papillomavirus, cigarette smoking, inflammatory conditions affecting the vulva, and immunodeficiency. Most vulvar neoplasias are diagnosed at early stages. Rarer histologies exist and include melanoma, extramammary Paget's disease, Bartholin gland adenocarcinom...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - March 19, 2024 Category: Cancer & Oncology Authors: Nadeem R Abu-Rustum Catheryn M Yashar Rebecca Arend Emma Barber Kristin Bradley Rebecca Brooks Susana M Campos Junzo Chino Hye Sook Chon Marta Ann Crispens Shari Damast Christine M Fisher Peter Frederick David K Gaffney Stephanie Gaillard Robert Giuntoli Source Type: research
