Review on the Role of Paraffin-embedded Margin-controlled Mohs Micrographic Surgery to Treat Skin Tumors
Actas Dermosifiliogr. 2024 Apr 20:S0001-7310(24)00362-4. doi: 10.1016/j.ad.2024.04.019. Online ahead of print.ABSTRACTParaffin-embedded margin-controlled Mohs micrographic surgery (PMMS) includes various procedures such as slow Mohs or deferred Mohs technique, the Muffin and Tübingen techniques, and staged margin excision, or the spaghetti technique. PMMS is a variation of conventional Mohs micrographic surgery (MMS) that allows histopathological examination with delayed margin control. PMMS requires minimum training and may be adopted by any hospital. The setback is that PMMS can require procedures across multiple days. ...
Source: Actas Dermo-Sifiliograficas - April 22, 2024 Category: Dermatology Authors: M Mansilla-Polo D Morgado-Carrasco A Toll Source Type: research
Identifying Current Practice Patterns for the Treatment of Nausea in Advanced Cancer Patients in the Hospice Setting (GP128)
1. Participants will self-report the ability to identify appropriate pharmacological nausea therapies for hospice patients with advanced care.2. Participants will self-report the ability to describe the key factors that affect prescribing patterns for nausea medications in the hospice setting. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - April 19, 2024 Category: Palliative Care Authors: Patrick H. White, Robert Arnold, Elizabeth Blaney, Daniel Paget, Andrea Holthaus, Amy Jacobs Source Type: research
Investigating the role connective tissue fibroblasts play in the altered muscle anatomy associated with the limb abnormality, Radial Dysplasia
J Anat. 2024 Apr 16. doi: 10.1111/joa.14040. Online ahead of print.ABSTRACTRadial dysplasia (RD) is a congenital upper limb birth defect that presents with changes to the upper limb anatomy, including a shortened or absent radius, bowed ulna, thumb malformations, a radially deviated hand and a range of muscle and tendon malformations, including absent or abnormally shaped muscle bundles. Current treatments to address wrist instability caused by a shortened or absent radius frequently require an initial soft tissue distraction intervention followed by a wrist stabilisation procedure. Following these surgical interventions, ...
Source: Cancer Control - April 16, 2024 Category: Cancer & Oncology Authors: George R F Murphy Eleanor Feneck James Paget Branavan Sivakumar Gill Smith Malcolm P O Logan Source Type: research
Investigating the role connective tissue fibroblasts play in the altered muscle anatomy associated with the limb abnormality, Radial Dysplasia
J Anat. 2024 Apr 16. doi: 10.1111/joa.14040. Online ahead of print.ABSTRACTRadial dysplasia (RD) is a congenital upper limb birth defect that presents with changes to the upper limb anatomy, including a shortened or absent radius, bowed ulna, thumb malformations, a radially deviated hand and a range of muscle and tendon malformations, including absent or abnormally shaped muscle bundles. Current treatments to address wrist instability caused by a shortened or absent radius frequently require an initial soft tissue distraction intervention followed by a wrist stabilisation procedure. Following these surgical interventions, ...
Source: Journal of Anatomy - April 16, 2024 Category: Anatomy Authors: George R F Murphy Eleanor Feneck James Paget Branavan Sivakumar Gill Smith Malcolm P O Logan Source Type: research
Global analysis of respiratory viral circulation and timing of epidemics in the pre-COVID-19 and COVID-19 pandemic eras, based on data from the Global Influenza Surveillance and Response System (GISRS)
The emergence of the COVID-19 pandemic, caused by SARS-CoV-2, has undeniably reshaped life on a global scale. As infection rates and fatalities surged to historic proportions, initial strategies to combat the crisis revolved around non-pharmaceutical interventions (NPIs) such as the use of facemasks, physical distancing, travel bans, and lockdowns, considering the absence of available vaccines or targeted therapeutics. Characterized by a spectrum of actions spanning individual precautions to broader societal measures, NPIs aimed to curtail the rapid dissemination of the virus [1]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - April 16, 2024 Category: Infectious Diseases Authors: Marco Del Riccio, Saverio Caini, Guglielmo Bonaccorsi, Chiara Lorini, John Paget, Koos van der Velden, Adam Meijer, Mendel Haag, Ian McGovern, Patrizio Zanobini Source Type: research
Pre-COVID-19-pandemic RSV epidemiology and clinical burden in pediatric primary care in Italy: a comparative analysis across two regions for the 2019/2020 season
This study investigates the epidemiology and burden of RSV in Italian ch... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 11, 2024 Category: Infectious Diseases Authors: Elisabetta Pandolfi, Daniela Loconsole, Maria Chironna, Jojanneke van Summeren, John Paget, Massimiliano Raponi, Luisa Russo, Ilaria Campagna, Ileana Croci, Carlo Concato, Carlo Federico Perno, Alberto Eugenio Tozzi, Giulia Linardos, Veronica Bartolucci, Tags: Research Source Type: research
Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease
Exp Ther Med. 2024 Mar 26;27(5):228. doi: 10.3892/etm.2024.12516. eCollection 2024 May.ABSTRACTGlucose transporter isoform 1 (GLUT1), which is upregulated in a variety of malignant tumors, facilitates cellular glucose uptake to boost rapid tumor growth and progression. In several types of cancer, inhibition of GLUT1 suppresses tumor proliferation and metastasis, indicating that GLUT1 is a potential target of anticancer therapy. The present study performed immunohistochemistry to analyze GLUT1 expression levels in 51 patients with extramammary Paget's disease (EMPD), including 23 with only intraepidermal lesions and 28 with...
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Mika Matsumoto Daiki Rokunohe Takanori Sasaki Yasushi Matsuzaki Hajime Nakano Hiroki Mizukami Eijiro Akasaka Daisuke Sawamura Source Type: research
Extramammary Paget Disease. Part II. Evidence-based Approach to Management
Extramammary Paget disease is a rare cutaneous malignancy that most commonly affects the genitals, perianal area, and axilla of elderly patients. Delays in care often lead to high levels of disease burden for patients. Thus, evidence-based recommendations are paramount in mitigating morbidity and mortality for this unique patient population. This 2-part continuing medical education series provides a complete picture of extramammary Paget disease. Part 2 of this continuing medical education series focuses on the complex management of extramammary Paget disease including surgical and non-invasive therapies, as well as novel ...
Source: Journal of the American Academy of Dermatology - April 6, 2024 Category: Dermatology Authors: Rohan R. Shah, Kalee Shah, Britney N. Wilson, Mario M. Leitao, Jan Smogorzewski, Christopher Crane, Samuel A. Funt, Sharif Hosein, Mirabel Dafinone, Anthony Rossi Source Type: research
Long-term effectiveness of zoledronic acid in patients with Paget ’s disease of bone – a retrospective cohort study
ConclusionThe majority of patients with PDB experience a mild disease course, marked by monostotic involvement and a low prevalence of fractures. Zoledronic acid effectively manages PDB, providing sustained biochemical response. The necessity for multiple zoledronic acid injections remains questionable, often implemented due to osteoporosis. (Source: Endocrine)
Source: Endocrine - March 30, 2024 Category: Endocrinology Source Type: research
Hydrocortisone rapidly and significantly reduces the IL-6 level in blood and lungs of patients with COVID-19-related ARDS
(Source: Critical Care)
Source: Critical Care - March 28, 2024 Category: Intensive Care Authors: Antoine Guillon, Youenn Jouan, Arthur Kassa-Sombo, Christophe Paget and Pierre-Fran çois Dequin Tags: Correspondence Source Type: research
