Transforming properties of MET receptor exon 14 skipping can be recapitulated by loss of the CBL ubiquitin ligase binding site
While 3% of lung cancers harbor mutations in exon 14 (Ex14) of the MET receptor, its oncogenic capabilities remain elusive, in particular the involvement of several regulatory sites in the juxtamembrane domain. The MET Y1003F mutation fully recapitulates the responses induced by MET exon 14 skipping, suggesting that loss of the CBL ubiquitin ligase binding site is the main factor in the cellular transformation induced by MET Ex14 mutations. MET is a receptor tyrosine kinase that is activated in many cancers through various mechanisms. MET exon 14 (Ex14) skipping occurs in 3% of non-small cell lung tumors. However, the cont...
Source: FEBS Letters - July 20, 2023 Category: Biochemistry Authors: Marie Fernandes,
Sonia Paget,
Zoulika Kherrouche,
Marie ‐José Truong,
Audrey Vinchent,
Jean‐Pascal Meneboo,
Shéhérazade Sebda,
Elisabeth Werkmeister,
Clotilde Descarpentries,
Martin Figeac,
Alexis B Cortot,
David Tulasne Tags: Research Article Source Type: research
Reconstruction of the labia majora using a neurovascular pedicled pudendal thigh flap after extensive vulvectomy for primary extramammary Paget's disease: A case report
Posterior neurovascular pedicled pudendal thigh flaps was applied for the treatment of Extramammary Paget's disease. The flap is based on the branches of the internal pudendal artery, which originate from the internal iliac artery. Key Clinical MessageA neurovascular pedicled pudendal thigh flap was used to reconstruct labial defect after extensive vulvectomy for primary extramammary Paget's disease. The flap was reliable for the superior skin and ideal for large labial defect reconstruction.AbstractExtramammary Paget's disease (EMPD), a rare type of intraepidermal carcinoma, predominantly affects the genitalia. Generally,...
Source: Clinical Case Reports - July 18, 2023 Category: General Medicine Authors: Jiangbo Cui,
Yu Zhang,
Zhou Yu,
Xing Fan,
Xi Zhang,
Li Yang,
Baoqiang Song,
Yang Li Tags: CASE REPORT Source Type: research
KS-EMPD-1: a novel cell line of primary extramammary Paget ’s disease
AbstractExtramammary Paget ’s disease (EMPD) is a rare skin cancer that mainly occurs in apocrine sweat gland-rich areas in elderly people. The prognosis of metastatic EMPD is unfavorable because of the lack of fully effective systemic therapies. However, the difficulty in establishing a model of EMPD has hampered basic res earch for exploring its pathogenesis and optimal treatments. Here, we established for the first time an EMPD cell line (named KS-EMPD-1) from a primary tumor on the left inguinal region of an 86-year-old Japanese male. The cells were successfully maintained for more than 1 year, with a doubling tim e...
Source: Human Cell - July 11, 2023 Category: Cytology Source Type: research
Extramammary Paget Disease: a Therapeutic Challenge, for a Rare Entity
AbstractPurpose of ReviewExtramammary Paget disease (EMPD) is a rare entity which is more frequently localized at the vulva, though it only accounts for 1 –2% of vulvar neoplasms. It is a primary cutaneous adenocarcinoma whose cell of origin is still a matter of controversy: it can either arise from apocrine/eccrine glands or from stem cells. The diagnosis demands a biopsy and entails a histopathological analysis by which cells show similar characte ristics as breast Paget disease.Recent FindingsTreatment approach can entail surgery, radiotherapy, photodynamic therapy, systemic chemotherapy, and topical chemotherapy. For...
Source: Current Oncology Reports - July 8, 2023 Category: Cancer & Oncology Source Type: research
Platelet-Rich Plasma Injections for the Treatment of Ankle Osteoarthritis
CONCLUSION: For patients with ankle osteoarthritis, PRP injections did not improve ankle symptoms and function over 52 weeks compared with placebo injections.REGISTRATION: NTR7261 (Netherlands Trial Register).PMID:37417359 | DOI:10.1177/03635465231182438 (Source: Pain Physician)
Source: Pain Physician - July 7, 2023 Category: Anesthesiology Authors: Liam D A Paget Gustaaf Reurink Robert-Jan de Vos Adam Weir Maarten H Moen Sita M A Bierma-Zeinstra Sjoerd A S Stufkens Simon Goedegebuure Rover Krips Mario Maas Duncan E Meuffels Peter A Nolte J Runhaar Gino M M J Kerkhoffs Johannes L Tol Source Type: research
Platelet-Rich Plasma Injections for the Treatment of Ankle Osteoarthritis
CONCLUSION: For patients with ankle osteoarthritis, PRP injections did not improve ankle symptoms and function over 52 weeks compared with placebo injections.REGISTRATION: NTR7261 (Netherlands Trial Register).PMID:37417359 | DOI:10.1177/03635465231182438 (Source: Pain Physician)
Source: Pain Physician - July 7, 2023 Category: Anesthesiology Authors: Liam D A Paget Gustaaf Reurink Robert-Jan de Vos Adam Weir Maarten H Moen Sita M A Bierma-Zeinstra Sjoerd A S Stufkens Simon Goedegebuure Rover Krips Mario Maas Duncan E Meuffels Peter A Nolte J Runhaar Gino M M J Kerkhoffs Johannes L Tol Source Type: research
Association of PFN1 Gene Polymorphisms with Bone Mineral Density, Bone Turnover Markers, and Osteoporotic Fractures in Chinese Population
This study was performed to investigate the association of Single-Nucleotide Polymorphisms (SNPs) in thePFN1 gene with Bone Mineral Density (BMD) as well as bone turnover markers and osteoporotic fractures in Chinese subjects. A total of 2836 unrelated Chinese subjects comprising 1247 healthy subjects and 1589 osteoporotic fractures patients (Fracture group) were enrolled in this study. Seven tagSNPs (rs117337116, rs238243, rs6559, rs238242, rs78224458, rs4790714, and rs13204) of thePFN1 gene were genotyped. The BMD of the lumbar spine 1 –4 (L1-4), femoral neck, and total hip as well as bone turnover markers, such as β-...
Source: Calcified Tissue International - July 4, 2023 Category: Orthopaedics Source Type: research
Solitary ectopic extramammary Paget ’s disease in the epigastric region
(Source: European Journal of Dermatology)
Source: European Journal of Dermatology - July 1, 2023 Category: Dermatology Source Type: research
