Pathologically Confirmed Subcutaneous Fat and Lymphovascular Invasion of a Hypopigmented Area in Extramammary Paget Disease
We report a case of a 62-year-old male with EMPD that invaded the subcutaneous fat layer. He presented with a several-year history of a slowly expanding erythematous plaque with the hypopigmented area on the left penoscrotum. One month before presentation, the patient had undergone punch biopsy at another hospital and diagnosed with EMPD. He had no personal history of urogenital cancers. The patient was treated with Mohs micrographic surgery, and negative margins were achieved after four stages. The histopathologic findings revealed Paget cells scattered throughout the epidermis. At the hypopigmented area, Paget cells exte...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Gyoo Huh Ga-Young Lee Yumin Chung Seung-Wan Chae Young-Jun Choi Source Type: research
Extramammary Paget's Disease of the Glans Penis Secondary to a Recurrent Urothelial Carcinoma of the Bladder
Ann Dermatol. 2023 Nov;35(Suppl 2):S369-S370. doi: 10.5021/ad.21.133.NO ABSTRACTPMID:38061748 | DOI:10.5021/ad.21.133 (Source: Annals of Dermatology)
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Gyoo Huh Bo-Bin Cha Heun Joo Lee Young-Jun Choi Won-Serk Kim Ga-Young Lee Source Type: research
Pathologically Confirmed Subcutaneous Fat and Lymphovascular Invasion of a Hypopigmented Area in Extramammary Paget Disease
We report a case of a 62-year-old male with EMPD that invaded the subcutaneous fat layer. He presented with a several-year history of a slowly expanding erythematous plaque with the hypopigmented area on the left penoscrotum. One month before presentation, the patient had undergone punch biopsy at another hospital and diagnosed with EMPD. He had no personal history of urogenital cancers. The patient was treated with Mohs micrographic surgery, and negative margins were achieved after four stages. The histopathologic findings revealed Paget cells scattered throughout the epidermis. At the hypopigmented area, Paget cells exte...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Gyoo Huh Ga-Young Lee Yumin Chung Seung-Wan Chae Young-Jun Choi Source Type: research
Extramammary Paget's Disease of the Glans Penis Secondary to a Recurrent Urothelial Carcinoma of the Bladder
Ann Dermatol. 2023 Nov;35(Suppl 2):S369-S370. doi: 10.5021/ad.21.133.NO ABSTRACTPMID:38061748 | DOI:10.5021/ad.21.133 (Source: Annals of Dermatology)
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Gyoo Huh Bo-Bin Cha Heun Joo Lee Young-Jun Choi Won-Serk Kim Ga-Young Lee Source Type: research
Pathologically Confirmed Subcutaneous Fat and Lymphovascular Invasion of a Hypopigmented Area in Extramammary Paget Disease
We report a case of a 62-year-old male with EMPD that invaded the subcutaneous fat layer. He presented with a several-year history of a slowly expanding erythematous plaque with the hypopigmented area on the left penoscrotum. One month before presentation, the patient had undergone punch biopsy at another hospital and diagnosed with EMPD. He had no personal history of urogenital cancers. The patient was treated with Mohs micrographic surgery, and negative margins were achieved after four stages. The histopathologic findings revealed Paget cells scattered throughout the epidermis. At the hypopigmented area, Paget cells exte...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Gyoo Huh Ga-Young Lee Yumin Chung Seung-Wan Chae Young-Jun Choi Source Type: research
Extramammary Paget's Disease of the Glans Penis Secondary to a Recurrent Urothelial Carcinoma of the Bladder
Ann Dermatol. 2023 Nov;35(Suppl 2):S369-S370. doi: 10.5021/ad.21.133.NO ABSTRACTPMID:38061748 | DOI:10.5021/ad.21.133 (Source: Annals of Dermatology)
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Gyoo Huh Bo-Bin Cha Heun Joo Lee Young-Jun Choi Won-Serk Kim Ga-Young Lee Source Type: research
Remote Respiratory Resistance Exercise Training Improves Respiratory Function in Individuals with VCP Multisystem Proteinopathy
Mutations in the valosin-containing protein (VCP) gene cause an autosomal dominant multisystem proteinopathy, associated with inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD), also known as VCP disease. VCP, one of the most abundant cytosolic proteins, is involved in cellular processes such as endoplasmic reticulum-associated degradation pathway, nuclear envelope reconstruction, post-mitotic Golgi reassembly, and apoptosis [4]. In affected individuals, heterozygous variants in the VCP gene result in progressive muscle atrophy and weakness in approximately 90%, Paget's disease of bon...
Source: Neuromuscular Disorders - December 7, 2023 Category: Neurology Authors: Madeline Halseth, Ryan Mahoney, Joyce Hsiou, Harrison N. Jones, Virginia Kimonis Source Type: research
Paget's disease of bone in the patient presented with a bowed leg
Key Clinical MessageIn dealing with bowed limbs along with increased alkaline phosphatase (ALP), even if the typical changes to the face are not very noticeable at first glance, Paget's disease of the bone (PDB) should be suspected, and the necessary investigations should be carried out to confirm the diagnosis.AbstractPaget's disease of the bone (PDB) is the second most prevalent metabolic bone disorder worldwide with disorganized bone remodeling. Here, a patient is presented with pain and bending of the right leg, whose skull and forehead changes are not noticeable at first glance, but with clinical suspicion and additio...
Source: Clinical Case Reports - December 1, 2023 Category: General Medicine Authors: Mehrzad Hajialiloo,
Sepideh Tahsini Tekantapeh Tags: CASE IMAGE Source Type: research
Cancers, Vol. 15, Pages 5665: Topical Imiquimod in Primary Cutaneous Extramammary Paget & rsquo;s Disease: A Systematic Review
Cancers, Vol. 15, Pages 5665: Topical Imiquimod in Primary Cutaneous Extramammary Paget’s Disease: A Systematic Review
Cancers doi: 10.3390/cancers15235665
Authors:
Fátima Mayo-Martínez
Ruggero Moro
David Millán-Esteban
Elisa Ríos-Viñuela
Iker Javier Bautista
Eduardo Nagore
Onofre Sanmartín
Beatriz Llombart
Extramammary Paget’s disease (EMPD) is subclinical in extent and multifocal in nature. There is no global consensus for treatment, so its management represents a challenge in clinical practice. Therefore, we conducted a systematic review through the main electronic dat...
Source: Cancers - November 30, 2023 Category: Cancer & Oncology Authors: F átima Mayo-Martínez Ruggero Moro David Mill án-Esteban Elisa R íos-Viñuela Iker Javier Bautista Eduardo Nagore Onofre Sanmart ín Beatriz Llombart Tags: Systematic Review Source Type: research
Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study
CONCLUSION: The clinico-epidemio and histological profile of breast cancer in Chhattisgarh is similar to other parts of India. Scarff Bloom Richardson Grade was predominantly grade 2 in 46.25% (37/80) contrary to Grade III (70%) in other series from India.PMID:38024932 | PMC:PMC10657078 | DOI:10.4103/jfmpc.jfmpc_2315_22 (Source: Primary Care)
Source: Primary Care - November 29, 2023 Category: Primary Care Authors: Niraj Kumar Srivastava Sunita Singh Debajyoti Mohanty Nughat Hussain Source Type: research
Clinicopathological profile of breast cancer from Chhattisgarh India: A single-center hospital-based study
CONCLUSION: The clinico-epidemio and histological profile of breast cancer in Chhattisgarh is similar to other parts of India. Scarff Bloom Richardson Grade was predominantly grade 2 in 46.25% (37/80) contrary to Grade III (70%) in other series from India.PMID:38024932 | PMC:PMC10657078 | DOI:10.4103/jfmpc.jfmpc_2315_22 (Source: Primary Care)
Source: Primary Care - November 29, 2023 Category: Primary Care Authors: Niraj Kumar Srivastava Sunita Singh Debajyoti Mohanty Nughat Hussain Source Type: research
Are there clinical and subclinical/pathological forms of Paget ’s disease of the breast?
ConclusionPDB is a rare condition associated with multifocality/multicentricity and HER2 overexpression. Cases of clinical disease and those of subclinical/pathological disease differ significantly. Further studies are required to evaluate the clinical/areolar disease and the impact of advances in breast disease management on PDB. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 28, 2023 Category: Cancer & Oncology Source Type: research
A case of male Paget's disease of the breast
Asian J Surg. 2023 Nov 24:S1015-9584(23)01671-8. doi: 10.1016/j.asjsur.2023.10.059. Online ahead of print.NO ABSTRACTPMID:38007346 | DOI:10.1016/j.asjsur.2023.10.059 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - November 25, 2023 Category: Surgery Authors: Xiangdong Zhao Xiaoru Qin Shuaichong Ji Kewen Lu Pei Yang Yuexin Wang Source Type: research
A case of male Paget's disease of the breast
Asian J Surg. 2023 Nov 24:S1015-9584(23)01671-8. doi: 10.1016/j.asjsur.2023.10.059. Online ahead of print.NO ABSTRACTPMID:38007346 | DOI:10.1016/j.asjsur.2023.10.059 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - November 25, 2023 Category: Surgery Authors: Xiangdong Zhao Xiaoru Qin Shuaichong Ji Kewen Lu Pei Yang Yuexin Wang Source Type: research
Longitudinal qualitative study of paired mentor-mentee perspectives on the abstract submission process
Submitting research abstracts to scientific societies is expected in academic medicine and requires dedicated time and effort. The authors queried mentors and mentees to ascertain what topics and proposed stra... (Source: BMC Medical Education)
Source: BMC Medical Education - November 23, 2023 Category: Universities & Medical Training Authors: Carol A. Mancuso, Laura Robbins and Stephen A. Paget Tags: Research Source Type: research
