Identification of infant victims of abusive head trauma hospitalised in France from 2015 to 2017 - Paget LM, Gilard ‐Pioc S, Cottenet J, Beltzer N, Quantin C.
The objective of this study was to quantify cases of AHT as a result of child abuse admitted to French hospitals, based on the French hospital di... (Source: SafetyLit)
Source: SafetyLit - August 19, 2020 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Boston Swan Boats Will Not Operate This Year Due To Coronavirus Concerns
BOSTON (CBS) – Swan Boats will not operate this year in Boston Public Garden due to coronavirus concerns. In an announcement on its website, the family that runs Swan Boats said it “thoroughly reviewed” its options when safety guidelines were announced in Phase 3 of the state’s reopening plan. “Taking these rules into account, along with a thoughtful assessment of our operation with medical and public health professionals, we have reached the decision that it is best for us to wait until 2021 to open the Swan Boats,” the Paget family, which runs Swan Boats, posted. Opening day had been s...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - July 15, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Business Closures Covid-19 Boston, MA Featured Health Syndicated CBSN Boston Syndicated Local Coronavirus Source Type: news

Key signaling pathway in the pathogenesis of Paget's disease identified
(University of California - Irvine) Researchers from the University of California, Irvine, in collaboration with their colleagues from Beijing, China, have gained new insights into the development of malignant skin cancers collectively known as Paget's disease. The team identified new genes that highly correlate with Paget's disease. The group then used an FDA approved drug to target one of the newly identified molecular features of Paget's disease, leading to improved clinical symptoms in a small cohort of Chinese patients. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 25, 2020 Category: Cancer & Oncology Source Type: news

Health-related sustainable development goals: countdown on alcohol use, smoking prevalence, child overweight and suicide mortality - Droogers M, Jansen D, Lindert J, Saboga-Nunes L, Rud én M, Guichardon M, Zeegers Paget D.
The Sustainable Development Goals (SDGs) are a set of goals that aspire to 'leave no one behind', adopted by all members of the United Nations and to be achieved by 2030. Now, four years after the SDGs entered into force, we examine the progress towards th... (Source: SafetyLit)
Source: SafetyLit - May 16, 2020 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

A Primer on Extramammary Paget's Disease for the Urologist A Primer on Extramammary Paget's Disease for the Urologist
Find out what urologists need to know about the diagnosis and management of extramammary Paget's disease.Translational Andrology and Urology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 10, 2020 Category: Consumer Health News Tags: Urology Journal Article Source Type: news

Prescription opioid dispensing in Australian children and adolescents: a national population-based study - Bell J, Paget SP, Nielsen TC, Buckley NA, Collins J, Pearson SA, Nassar N.
SummaryBackgroundThere are few population-based studies of paediatric opioid use. We aimed to investigate the prevalence of opioid dispensing in Australian children and adolescents.MethodsIn this population-based study,... (Source: SafetyLit)
Source: SafetyLit - March 12, 2020 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

What Are Some Risk Factors for Cerebral Palsy?
Discussion The term, cerebral palsy, or CP has gone through many iterations with the first description in 1861 by W.J. Little who described it as “The condition of spastic rigidity of the limbs of newborn children.” The most recent definition is from Rosenbaun et al. in 2007 which states it is “a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cog...
Source: PediatricEducation.org - March 9, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Unexpected Cause of Myopathy in Sjogren's: Crack the Case Unexpected Cause of Myopathy in Sjogren's: Crack the Case
Dr Paget reminds us to keep non-autoimmune-related causes of muscle enzyme level elevation in mind when diagnosing a patient.Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 11, 2019 Category: Consumer Health News Tags: Rheumatology Expert Column Source Type: news

Paget Disease: Osmosis Video Paget Disease: Osmosis Video
Paget disease involves an excessive amount of bone resorption and haphazard bone growth. Refresh your knowledge with this illustrated overview of the condition.Osmosis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 30, 2019 Category: Consumer Health News Tags: Med Students Commentary Source Type: news

Hospital appoints new chief executive
James Paget University Hospitals Foundation Trust has promoted deputy chief Anna Hills to the chief executive role on a permanent basis. (Source: HSJ)
Source: HSJ - August 5, 2019 Category: UK Health Source Type: news

Bone and Mineral Disorders | Medscape Bone and Mineral Disorders | Medscape
Review in-depth clinical information, latest medical news, and guidelines about bone and mineral disorders, including the most common etiologies, such as osteoporosis, renal osteodystrophy, Paget's disease, metabolic bone disease, and primary hyperparathyroidism. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 5, 2019 Category: Consumer Health News Tags: Resource Center Source Type: news

Reviews highlight new advances in our understanding of focal and sclerotic bone diseases
(International Osteoporosis Foundation) A new special edition of 'Calcified Tissue International' provides expert commentary and insight into the advances in the knowledge of several rare focal and sclerotic bone diseases including Paget's disease of bone and related syndromes, fibrous dysplasia of bone and McCune-Albright syndrome, Melorheostosis and Osteopoikilosis, chronic non-bacterial osteomyelitis, as well as Camurati-Engelmann disease. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 13, 2019 Category: Biology Source Type: news

Medical News Today: Dry nipples: Causes and treatment
The nipples are a sensitive area of the body. Many factors can cause nipple dryness, including chafing, eczema, and Paget ’s disease of the breast. In this article, we look at the causes, symptoms, and treatments for dry nipples, as well as when to see a doctor. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 11, 2019 Category: Consumer Health News Tags: Dermatology Source Type: news

Fluorouracil Plus Calcipotriene May Help Refractory Extramammary Paget Disease Fluorouracil Plus Calcipotriene May Help Refractory Extramammary Paget Disease
In patients who fail other therapies for extramammary Paget disease (EMPD), palliative therapy with topical fluorouracil and calcipotriene may be an option, a small case series suggests.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 5, 2019 Category: Consumer Health News Tags: Dermatology News Source Type: news

Regulated proteolysis of p62/SQSTM1 enables differential control of autophagy and nutrient sensing
The multidomain scaffold protein p62 (also called sequestosome-1) is involved in autophagy, antimicrobial immunity, and oncogenesis. Mutations in SQSTM1, which encodes p62, are linked to hereditary inflammatory conditions such as Paget’s disease of the bone, frontotemporal dementia (FTD), amyotrophic lateral sclerosis, and distal myopathy with rimmed vacuoles. Here, we report that p62 was proteolytically trimmed by the protease caspase-8 into a stable protein, which we called p62TRM. We found that p62TRM, but not full-length p62, was involved in nutrient sensing and homeostasis through the mechanistic target of rapam...
Source: Signal Transduction Knowledge Environment - December 4, 2018 Category: Science Authors: Sanchez-Garrido, J., Sancho-Shimizu, V., Shenoy, A. R. Tags: STKE Research Articles Source Type: news

What Causes Post-Inflammatory Hypopigmentation?
Discussion Hypopigmentation can be worrisome for many families because of cosmesis and the worry that “something is wrong.” The normal natural changes in skin-tone over the year due to different light exposure and wide variations within individuals is not something that many people are aware of. Post-inflammatory hypopigmentation is a common cause of hypopigmentation. Vitiligo is the most common cause of depigmentation. Vitiligo is an acquired, depigmenting disorder with typical lesions appearing as milky white macules with distinct margins that are not scaly. Hair (including eyebrows and eyelashes) can be dep...
Source: PediatricEducation.org - November 12, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Medical News Today: Are red spots on the breast a sign of cancer?
There are many possible causes of red spots or a rash on the breast, including allergic reactions, infections, problems with the milk ducts, and several other skin conditions. However, red spots can sometimes be an early sign of inflammatory breast cancer or Paget ’s disease of the breast. Learn more here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 30, 2018 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Paget Disease of the Breast (Paget's Disease of the Nipple)
Title: Paget Disease of the Breast (Paget's Disease of the Nipple)Category: Diseases and ConditionsCreated: 2/22/2006 12:00:00 AMLast Editorial Review: 4/11/2018 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - April 11, 2018 Category: Cancer & Oncology Source Type: news

Adult Paget's Disease of Bone: A Review Adult Paget's Disease of Bone: A Review
A better understanding of the pathogenesis of Paget's disease of bone in adults will lead to improved diagnostic and treatment strategies for this metabolic bone disorder.Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 8, 2018 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Fast-tracked rehabilitation and return to sport of an elite rugby player with a complicated posterolateral corner injury and associated peroneal paralysis - Paget LDA, Kuijer PPFM, Maas M, Kerkhoffs GMMJ.
Acute posterolateral corner injuries of the knee with associated hamstring avulsions and peroneal paralysis are rare in rugby. Regain of motor function following a complete paralysis is documented to be 38%. To our knowledge, only one case describes return... (Source: SafetyLit)
Source: SafetyLit - October 30, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Which children and young people are excluded from school? Findings from a large British birth cohort study, the Avon Longitudinal Study of Parents and Children (ALSPAC) - Paget A, Parker C, Heron J, Logan S, Henley W, Emond A, Ford T.
BACKGROUND: Exclusion from school is increasingly recognized as pertinent to child health. National educational data reveal that boys, children who are looked-after, living in poverty, have special educational needs, or from certain ethnic minorities, are ... (Source: SafetyLit)
Source: SafetyLit - September 19, 2017 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Pregnant With a Rare Vasculitis: How to Treat Pregnant With a Rare Vasculitis: How to Treat
Dr Stephen Paget reviews the case of a 40-year-old woman with Takayasu arteritis being treated with prednisone.Hospital for Special Surgery (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 13, 2017 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

The psychiatric hospital discharge database (RIM-P): an essential tool for the surveillance of hospitalization after a suicide attempt - Chan Chee C, Paget LM.
BACKGROUND: Epidemiological surveillance of suicide attempts is essential for monitoring indicator trends in the evaluation of prevention actions. As part of this surveillance, analysis of data from hospitalization for suicide attempts is particularly usef... (Source: SafetyLit)
Source: SafetyLit - September 13, 2017 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

Nurses hoping to encourage staff flu jabs with new game
Nurse innovators at James Paget Hospitals NHS Foundation Trust are hoping to create a “buzz” about flu vaccination this winter with a new online game featuring a flu-fighting bee. (Source: Nursing Times)
Source: Nursing Times - August 15, 2017 Category: Nursing Source Type: news

Under fire: the Falklands War and the revival of naval gunfire support - Paget S.
The provision of naval gunfire support was an important aspect of the Falklands War. By the end of the 1970s, naval gunfire support appeared to be doomed, but its vital role during the Falklands War led to a timely reappraisal. Indeed, the use of naval gun... (Source: SafetyLit)
Source: SafetyLit - August 15, 2017 Category: International Medicine & Public Health Tags: Commentary Source Type: news

Mylan Launches Generic Reclast(R) Injection
HERTFORDSHIRE, England and PITTSBURGH, June 2, 2017 -- (Healthcare Sales & Marketing Network) -- Mylan N.V. (NASDAQ, TASE: MYL) today announced the U.S. launch of Zoledronic Acid Injection, 5 mg/100 mL Single Dose Vial, a generic version of Novartis' Recl... Biopharmaceuticals, Generics, FDA, Product Launch Mylan, Zoledronic Acid, Reclast, Paget's disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 2, 2017 Category: Pharmaceuticals Source Type: news

Handheld Microscopy May Help Detect Recurrent Extramammary Paget Disease Handheld Microscopy May Help Detect Recurrent Extramammary Paget Disease
Handheld reflectance confocal microscopy (HRCM) may help diagnose recurrent extramammary Paget disease (EMPD) and guide biopsy decision making, researchers say.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - May 18, 2017 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Tingling, Pain, Rash, and Fatigue: Crack the Case Tingling, Pain, Rash, and Fatigue: Crack the Case
Rheumatologist Dr Stephen Paget presents a complicated case of a 35-year-old patient with an array of multisystem symptoms.Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 15, 2017 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

Kissing Goodbye Sepsis at James Paget University Hospital
This article outlines a sepsis project at the James Paget University Hospital. The aim was to try to improve Sepsis outcomes at the Trust. They realised that that the key to succeed was to simplify and make it easy for frontline to identify Sepsis. They scrapped all paperwork and were left with just one simple tick box form that staff can complete in less than 30 seconds. They also empowered their specialist Nurses by launching a PGD for them to be able to administer first dose of antibiotics in special circumstances where the doctor is not available immediately. In 9 months the amount of patients given antibiotics inside ...
Source: Current Awareness Service for Health (CASH) - April 20, 2017 Category: Consumer Health News Source Type: news

Methods of data selection from the french medical information system program for trauma patient's analysis: burns and traumatic brain injuries - Paget LM, Dupont A, P édrono G, Lasbeur L, Thelot B.
BACKGROUND: Data from the French medical information system program in medicine, surgery, obstetrics and dentistry can be adapted in some cases and under certain conditions, to account for hospitalizations for injuries. Two areas have been explored: burn a... (Source: SafetyLit)
Source: SafetyLit - April 11, 2017 Category: Global & Universal Tags: Burns, Electricity, Explosions, Fire, Scalds Source Type: news

Sodium citrate spray could temporarily restore sense of smell
(University of East Anglia) A substance commonly used to treat bladder issues could temporarily treat people who have lost their sense of smell, according to research published in the journal Clinical Otolaryngology.A study by the University of East Anglia (UEA) with the Smell& Taste clinic at the James Paget University Hospital showed sodium citrate nasal spray could offer temporary improvement in the ability to smell for patients suffering from anosmia or hyposmia- - the loss of smell -- in cases caused by a virus or other non-obstructive causes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 5, 2017 Category: Global & Universal Source Type: news

Researchers identify potential treatment for type of muscle and brain degenerative disease
In fruit flies modeled with IBMPFD disease, mitochondria (red circles) are severely disrupted. Treatment of VCP inhibitors in these diseased flies reversed  mitochondrial damage (green circles). FINDINGSUCLA researchers have discovered the molecular basis of, and identified potential treatment for, an incurable disease known as inclusion body myopathy, Paget disease with frontotemporal dementia, or IBMPFD. Using both genetically engineered fruit flies that have the fly equivalent of the disease gene as well as cells from people with IBMPFD, the researchers discovered how mutations carried by those with IBMPFD cau...
Source: UCLA Newsroom: Health Sciences - March 21, 2017 Category: Universities & Medical Training Source Type: news

Paget's Disease
Title: Paget's DiseaseCategory: Diseases and ConditionsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 2/28/2017 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - February 28, 2017 Category: Rheumatology Source Type: news

Intensive Bisphosphonate Therapy Questioned in Paget's Disease Intensive Bisphosphonate Therapy Questioned in Paget's Disease
The clinical benefit of long-term suppression of bone turnover with bisphosphonates in Paget's disease is questioned by extension findings from PRISM.Medscape Medical News (Source: Medscape Diabetes Headlines)
Source: Medscape Diabetes Headlines - February 14, 2017 Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news

Insights on optimal treatment of Paget's disease of bone
In a study of patients with Paget's disease of bone -- a common skeletal disorder that can lead to bone deformity, fractures, osteoarthritis, and bone pain -- long-term intensive bisphosphonate therapy conferred no clinical benefit over giving bisphosphonates only when patients felt bone pain. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 8, 2017 Category: Science Source Type: news

Study provides insights on optimal treatment of Paget's disease of bone
(Wiley) In a study of patients with Paget's disease of bone--a common skeletal disorder that can lead to bone deformity, fractures, osteoarthritis, and bone pain -- long-term intensive bisphosphonate therapy conferred no clinical benefit over giving bisphosphonates only when patients felt bone pain. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 8, 2017 Category: Global & Universal Source Type: news

' Why I Went Into Rheumatology'' Why I Went Into Rheumatology '
The practice of rheumatology demands extraordinary clinical and investigative skills, but if you are up to this challenge, you will never regret it, says Dr Stephen Paget.Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 7, 2017 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

Portuguese man says staff forced him to stay in hospital
Adriano Guedes was admitted to the James Paget Hospital in Norfolk following a stroke in August 2014. But he was removed after the hospital obtained a court order on January 10 this year. (Source: the Mail online | Health)
Source: the Mail online | Health - January 24, 2017 Category: Consumer Health News Source Type: news

'I was forced to stay': Man hits back after eviction
Adriano Guedes was admitted to the James Paget Hospital in Norfolk following a stroke in August 2014. But he was removed after the hospital obtained a court order on January 10 this year. (Source: the Mail online | Health)
Source: the Mail online | Health - January 24, 2017 Category: Consumer Health News Source Type: news

James Paget Hospital patient evicted after two years
A hospital patient who occupied a bed for more than years was evicted after a hospital applied for a court order. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - January 20, 2017 Category: Consumer Health News Source Type: news

Hospital takes legal action to evict bed blocker
The patient arrived at the James Paget University Hospital in Norfolk in August 2014 and remained there until this year. But he was deemed 'fit for discharge', according to the BBC. (Source: the Mail online | Health)
Source: the Mail online | Health - January 20, 2017 Category: Consumer Health News Source Type: news

Norfolk hospital trust appoints director of nursing
Julia Hunt has been appointed as the new director of nursing at James Paget University Hospitals NHS Foundation Trust in Norfolk. (Source: Nursing Times)
Source: Nursing Times - January 5, 2017 Category: Nursing Source Type: news

Severe Testicular Pain: Crack the Case Severe Testicular Pain: Crack the Case
Dr Stephen Paget reviews the case of a 32-year-old man with severe testicular pain for 2 years.Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 3, 2017 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

A Painful, Red Wrist: Crack the Case A Painful, Red Wrist: Crack the Case
Infection? Pseudogout? Both? Dr Paget discusses the interesting case of a 76-year-old man with pain and swelling in his wrist.Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - December 23, 2016 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

Choosing a Management Strategy in RA Choosing a Management Strategy in RA
Drs Paget and Bykerk discuss the current data on treatment timing, disease modification, and comorbidities in rheumatoid arthritis.Hospital for Special Surgery eAcademy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 30, 2016 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

Comorbidities in Inflammatory Joint Disease Comorbidities in Inflammatory Joint Disease
Drs Paget and Schwartzman discuss both rare and common comorbidities, and the latest strategies to prevent their damaging effects.Hospital for Special Surgery eAcademy (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 30, 2016 Category: Consumer Health News Tags: Rheumatology Commentary Source Type: news

Bristol runner who blamed sports bra for rash is devastated to be told she has breast cancer
Sarah Lang, 32, from Bristol, was diagnosed with news she had Paget's disease of the nipple, a rare type of cancer. She has now undergone a full mastectomy and will start chemotherapy shortly. (Source: the Mail online | Health)
Source: the Mail online | Health - August 17, 2016 Category: Consumer Health News Source Type: news

A Tricky Case of Arm Pain and a Swollen Ear A Tricky Case of Arm Pain and a Swollen Ear
A 52-year-old woman's symptoms initially suggest polychondritis, but a viral infection could be to blame. Dr Stephen Paget shares the case details. Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 27, 2016 Category: Consumer Health News Tags: Rheumatology Clinical Case Source Type: news

Another Vacation, Another Bout of Back Pain: A Case Another Vacation, Another Bout of Back Pain: A Case
Dr Stephen Paget shares the details of a patient who, for the second time in as many years, was rendered almost incapacitated during international travel. Medscape Rheumatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 20, 2016 Category: Consumer Health News Tags: Rheumatology Clinical Case Source Type: news