Effects of bazedoxifene and low-intensity aerobic exercise on bone and fat parameters in ovariectomized rats
ConclusionCombination therapy with BZA and exercise appears effective to improve bone and fat parameters in OVX rats. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 5, 2019 Category: Orthopaedics Source Type: research

Efficacy of non-steroidal anti-inflammatory drugs on zoledronic acid-induced acute-phase reactions: randomized, open-label, Japanese OZ study
ConclusionsZoledronic acid-induced APRs appeared to be suppressed by loxoprofen. Known risk/protective factors, including prior osteoporosis treatment, were applicable to Japanese patients. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 4, 2019 Category: Orthopaedics Source Type: research

Ten years change in post-fracture care for hip fracture patients
ConclusionsThe approval of new osteoporosis drugs and the establishment of osteoporosis liaison services have had a positive effect on the use of postoperative drug therapy in the orthopedic field. Our finding that the rate of secondary fracture within 1  year of the initial fracture remained around 2% every year, despite improvements in postoperative drug therapy, suggests that both rehabilitation for preventing falls and early postoperative drug therapy are essential to prevent secondary fractures. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 3, 2019 Category: Orthopaedics Source Type: research

Factors affecting continuation of weekly teriparatide administration in rural areas
ConclusionAn older age, starting administration while hospitalized, and side effects were identified as risk factors negatively influencing teriparatide continuation. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 3, 2019 Category: Orthopaedics Source Type: research

Novel algorithm generating strategy to identify high fracture risk population using a hybrid intervention threshold
AbstractIntroductionThe aim of this study was to develop an algorithm to identify high-risk populations of fragility fractures in Taiwan.Materials and methodsA total of 16,539 postmenopausal women and men (age  ≥ 50 years) were identified from the Taiwan Osteoporosis Survey database. Using the Taiwan FRAX® tool, the 10-year probability of major osteoporotic fracture (MOF) and hip fracture (HF) and the individual intervention threshold (IIT) of each participant were calculated. Subjects with either a probability above the IIT or those with MOF  ≥ 20% or HF ≥ 9% wer...
Source: Journal of Bone and Mineral Metabolism - October 3, 2019 Category: Orthopaedics Source Type: research

Updated concept of sarcopenia based on muscle –bone relationship
AbstractSarcopenia is an age-related loss of skeletal muscle mass and strength. It has been widely recognized that low muscle mass was essential in the diagnosis of sarcopenia, whereas recent studies have emphasized the importance of muscle strength. In practice, muscle quality as well as muscle mass might determine the strength and physical performance. A new diagnostic algorithm of sarcopenia has recently been established, in which low muscle strength is a key characteristic factor for the diagnosis of sarcopenia. Although many factors are supposed to be involved in the pathology and development of sarcopenia, precise me...
Source: Journal of Bone and Mineral Metabolism - October 3, 2019 Category: Orthopaedics Source Type: research

Skeletal changes during lactation and after weaning in osteocyte-specific sclerostin overexpressed mice
Conclusions Sclerostin, secreted by osteocytes, played a role in bone loss during lactation and also in the recovery of trabecular bone compartment by activating bone formation after weaning. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 9, 2019 Category: Orthopaedics Source Type: research

Role of irisin in androgen-deficient muscle wasting and osteopenia in mice
In conclusion, the present results demonstrated that androgen deficiency decreases the expression of irisin in the skeletal muscle of mice. Irisin may be involved in muscle/bone relationships negatively affected by androgen deficiency. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 7, 2019 Category: Orthopaedics Source Type: research

MnTBAP inhibits bone loss in ovariectomized rats by reducing mitochondrial oxidative stress in osteoblasts
AbstractThe development of postmenopausal osteoporosis is thought to be closely related to oxidative stress. Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a novel superoxide dismutase (SOD) mimetic, could protect osteoblasts from cytotoxicity and dysfunction caused by oxidative stress. However, it is still unclear whether MnTBAP has effect on the development of postmenopausal osteoporosis. Here, we demonstrated that MnTBAP can inhibit bone mass loss and bone microarchitecture alteration, and increase the number of osteoblasts while reducing osteoclasts number, as well as improve the BMP-2 expression level in ovariec...
Source: Journal of Bone and Mineral Metabolism - September 6, 2019 Category: Orthopaedics Source Type: research

Diffuse microdamage in bone activates anabolic response by osteoblasts via involvement of voltage-gated calcium channels
AbstractIntroductionMatrix damage sustained by bone tissue is repaired by the concerted action of bone cells. Previous studies have reported extracellular calcium ([Ca2+]E) efflux to originate from regions of bone undergoing diffuse microdamage termed as “diffuse microdamage-induced calcium efflux” (DMICE). DMICE has also been shown to activate and increase intracellular calcium ([Ca2+]I) signaling in osteoblasts via the involvement of voltage-gated calcium channels (VGCC). Past studies have assessed early stage (
Source: Journal of Bone and Mineral Metabolism - September 6, 2019 Category: Orthopaedics Source Type: research

Bone fracture risk factors in prevalent hemodialysis patients
AbstractBone fractures are an important cause of morbidity and mortality in hemodialysis (HD) patients. The aim of this study was to quantify the incidence of fractures in a cohort of prevalent HD patients and evaluate its relationship with possible risk factors. We performed a retrospective analysis of 341 patients, since they started HD (median of 51  months). Demographic, clinical, and biochemical parameters as well as vascular calcifications (VC) were evaluated. Fifty-seven episodes of fracture were identified with a median HD vintage of 47 months (incidence rate of 31 per 1000 person-years). Age (p 
Source: Journal of Bone and Mineral Metabolism - September 5, 2019 Category: Orthopaedics Source Type: research

25-Hydroxyvitamin D profiles and maternal bone mass during pregnancy and lactation in Japanese women
AbstractVitamin D deficiency is observed worldwide and represents a health hazard for mothers, infants and elderly persons. We know that many young Japanese women experience vitamin D insufficiency; however, there is a lack of knowledge regarding the serum 25-hydroxyvitamin D [25(OH)D] profile of pregnant Japanese women and of the association between maternal 25(OH)D level and maternal bone mass during pregnancy and lactation. In this longitudinal study, 160 pregnant Japanese women were enrolled; of them, 68 have been followed-up from the first trimester through at least 1  year of breast-feeding. We estimated serum 2...
Source: Journal of Bone and Mineral Metabolism - August 20, 2019 Category: Orthopaedics Source Type: research

Low serum 25-hydroxyvitamin D is associated with low grip strength in an older Japanese population
This study used a cross-sectional design. Participants were 492 community-dwelling individuals aged  ≥ 40 years living in Yuzawa Town, Japan. The health check examination was conducted in 2015, and serum 25-hydroxyvitamin D [25(OH)D, an index of vitamin D levels], and hand grip strength were measured. Covariates were serum albumin concentration, body mass index, and physical activity level. The associations of serum 25(OH)D concentrations with hand grip strength and low grip strength (
Source: Journal of Bone and Mineral Metabolism - August 16, 2019 Category: Orthopaedics Source Type: research

Circulating FGF23 is not associated with cardiac dysfunction, atherosclerosis, infection or inflammation in hemodialysis patients
AbstractFibroblast growth factor (FGF) 23 is a bone-derived hormone regulating serum inorganic phosphate (Pi) concentration. FGF23 is also involved in the development of chronic kidney disease (CKD)-mineral and bone disorder. Serum FGF23 concentration begins to increase early in the progression of CKD and can be remarkably high in hemodialysis patients with end-stage renal disease. It has been reported that high FGF23 concentration is a risk factor for cardiac dysfunction, atherosclerosis, infection or systemic inflammation in CKD patients. FGF23 was also shown to induce cardiac hypertrophy directly acting on cardiomyocyte...
Source: Journal of Bone and Mineral Metabolism - August 16, 2019 Category: Orthopaedics Source Type: research

Phase II/III, randomized, double-blind, parallel-group study of monthly delayed-release versus daily immediate-release risedronate tablets in Japanese patients with involutional osteoporosis
In this study, non-inferiority could n ot be declared for 37.5 or 25 mg DR following breakfast QM (p = 0.1346 orp = 0.6711, respectively) versus 2.5 mg IR on awakening QD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 16, 2019 Category: Orthopaedics Source Type: research

Epidemiological survey and risk factor analysis of dialysis-related amyloidosis including destructive spondyloarthropathy, dialysis amyloid arthropathy, and carpal tunnel syndrome
In conclusion, long dialysis period was a risk factor for DRA. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 14, 2019 Category: Orthopaedics Source Type: research

Mutation spectrum of COL1A1/COL1A2 screening by high-resolution melting analysis of Chinese patients with osteogenesis imperfecta
AbstractHigh-resolution melting (HRM) analysis has been shown to be a time-saving method for the screening of genetic variants. To increase the precision of the diagnosis of osteogenesis imperfecta (OI), we used HRM to exploreCOL1A1/COL1A2 mutations in 87 Chinese OI patients and to perform population-based studies of the relationships between their genotypes and phenotypes. Peripheral blood samples were collected from the 87 non-consanguineous probands. The coding regions and exon boundaries ofCOL1A1/COL1A2 were detected by HRM and confirmed by Sanger sequencing. The functional effects of mutations were predicted through b...
Source: Journal of Bone and Mineral Metabolism - August 14, 2019 Category: Orthopaedics Source Type: research

Inhibition of MSTN signal pathway may participate in LIPUS preventing bone loss in ovariectomized rats
ConclusionsThe present study shows that LIPUS improved osteoporosis and promoted bone defect healing in the ovariectomized rats may through the inhibition of the MSTN signal pathway. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 14, 2019 Category: Orthopaedics Source Type: research

Response to “Is grip strength an actual/significant predictor of areal bone mineral density by itself? Potential confounders and/or effect modifiers”
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 14, 2019 Category: Orthopaedics Source Type: research

Drug holiday clinical relevance verification for antiresorptive agents in medication-related osteonecrosis cases of the jaw
This study aimed to evaluate the efficacy of drug holidays and treatment strategies in MRONJ cases. Four-hundred and twenty-seven patients with MRONJ treated at nine hospitals from 2009 to 2017 were included in this multicenter retrospective study. Multivariate Cox regression analysis showed that the primary disease (osteoporosis or malignant tumor), diabetes, serum albumin, and treatment method (surgical or nonsurgical) were significantly correlated with the cure rate. The cumulative 1-year cure rates in the surgical and nonsurgical treatment groups were 64.7% and 18.2%, respectively. However, discontinuing antiresorptive...
Source: Journal of Bone and Mineral Metabolism - August 13, 2019 Category: Orthopaedics Source Type: research

Retraction Note To: The relationship between subclinical thyroid dysfunction and the risk of fracture or low bone mineral density: a systematic review and meta-analysis of cohort studies
The editors have retracted this article [1] because it shows significant overlap with a publication by Blum et al. [2] Limin Tian does not agree to this retraction. All the other authors have not responded to any correspondence from the editor about this retraction. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 2, 2019 Category: Orthopaedics Source Type: research

Correction to: Effectiveness of monthly intravenous ibandronate on the low responders to oral bisphosphonate: the MOVEMENT study
In the original publication of the article, the Figures  2 and 3 were published incorrectly. The corrected figures are given below, (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 27, 2019 Category: Orthopaedics Source Type: research

Correction to: Effects of growth hormone on bone modeling and remodeling in hypophysectomised young female rats: a bone histomorphometric study
The following corrections are found in the original publication of the article and corrected as below: (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 27, 2019 Category: Orthopaedics Source Type: research

Comparison of once-weekly teriparatide and alendronate against new osteoporotic vertebral fractures at week 12
The objective of the present multicenter randomized study was to compare weekly teriparatide with alendronate in their inhibition of vertebral collapse, effects on delayed union, pain relief, and improvement of quality of life (QOL) in women with new osteoporotic vertebral fractures within 1 week after onset of the fracture. Patients were randomly allocated to the teriparatide and alendronate groups. Vertebral collapse, low back pain assessed by a visual analog scale, and QOL assessed by EuroQol 5 dimension at weeks 1, 2, 4, 8, and 12 after the start of the treatment were compared between the groups. Lumbar bone mineral de...
Source: Journal of Bone and Mineral Metabolism - July 11, 2019 Category: Orthopaedics Source Type: research

A meta-analysis of bone morphogenetic protein-2 versus iliac crest bone graft for the posterolateral fusion of the lumbar spine
AbstractThe impact of autologous iliac crest bone graft versus BMP-2 to improve fusion rates for posterolateral fusion (PLF) of the lumbar spine remains unanswered. Single-institution-centered data dominate the literature, providing results that may be contradictory or inconclusive. The aim of this paper is to analyze data pooled from multiple well-controlled studies that examined both ICBG and BMP-2 for use in PLF. This meta-analysis also provides details of success in different subsets of patients with variable risk factors for delayed and non-unions. Six high-quality randomized clinical trials were selected. Efficacy, m...
Source: Journal of Bone and Mineral Metabolism - July 10, 2019 Category: Orthopaedics Source Type: research

Functional disuse initiates medullary endosteal micro-architectural impairment in cortical bone characterized by nanoindentation
In this study, we evaluated the effect of functional disuse-induced bone remodeling on its mechanical properties, individually at periosteum and medullary endosteum regions of the cortical bone. Left middle tibiae were obtained from 5-month-old female Sprague –Dawley rats for the baseline control as well as hindlimb suspended (disuse) groups. Micro-nano-mechanical elastic moduli (at lateral region) was evaluated along axial (Z), circumferential (C) and radial (R) orientations using nanoindentation. Results indicated an anisotropic microstructure with a xial orientation having the highest and radial orientation with t...
Source: Journal of Bone and Mineral Metabolism - July 10, 2019 Category: Orthopaedics Source Type: research

Clinical characteristics of patients with thoracic myelopathy caused by ossification of the posterior longitudinal ligament
AbstractAlthough ossification of the posterior longitudinal ligament (OPLL) commonly develops in the cervical spine, it also occurs, albeit less commonly, in the thoracic spine. However, data are scarce regarding the characteristics of patients with thoracic OPLL. In the current study, we performed a cross-sectional study on a total of 133 patients with OPLL to clarify the clinical characteristics of patients with thoracic OPLL compared with those of patients with cervical OPLL. The subjects were divided into four groups according to the main region of OPLL and treatment type: C-OPLL-C, cervical OPLL treated conservatively...
Source: Journal of Bone and Mineral Metabolism - July 9, 2019 Category: Orthopaedics Source Type: research

Maternal 25-hydroxycholecalciferol during lactation improves intestinal calcium absorption and bone properties in sow-suckling piglet pairs
In conclusion, improved milk fatty acids and higher mRNA expressions of calcitropic genes triggered by maternal 25-OH-D3 supplementation would be the potential mechanism underlying the positive effects of 25-OH-D3 on maternal and neonatal bone health. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 9, 2019 Category: Orthopaedics Source Type: research

Urolithiasis increases the risk of subsequent onset of osteoporosis
AbstractUrolithiasis and osteoporosis are two different pathological entities, but are both important public health issues in older patients. Moreover, the two diseases may share some similar pathogenesis pathway. Currently, few studies focus on the relationship between urolithiasis and osteoporosis. Furthermore, whether the common mobilities influence the long-term osteoporosis rate in urolithiasis patients has never been studied. In the present study, we used the Taiwan National Health Insurance Database (LHID 2000) compiled by the NHI from 1996 to 2013 to determine whether urolithiasis influenced long-term osteoporosis;...
Source: Journal of Bone and Mineral Metabolism - July 9, 2019 Category: Orthopaedics Source Type: research

Prevalence and co-existence of locomotive syndrome, sarcopenia, and frailty: the third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study
This study aimed to estimate the prevalence of locomotive syndrome, sarcopenia, and frailty and clarify their co-existence in a population-based cohort. The third survey of Research on Osteoarthritis/Osteoporosis Against Disability (ROAD) study was conducted between 2012 and 2013, examining 963 subjects (aged  ≥ 60 years; 321 men, 642 women). Locomotive syndrome, sarcopenia, and frailty were defined using three tests proposed by Japanese Orthopaedic Association, Asian Working Group for Sarcopenia criteria, and Fried’s definition, respectively. Prevalence of locomotive syndrome stages 1 and 2 wer...
Source: Journal of Bone and Mineral Metabolism - June 20, 2019 Category: Orthopaedics Source Type: research

The Shisa3 knockout mouse exhibits normal bone phenotype
This study found that Shisa3 was strongly expressed in the calvarial bones of mice, especially in osteoblasts. In addition, adenovirus-mediated gene transfer of murine Shisa3 significantly inhibited Wnt3a-induced nuclear translocation ofβ-catenin and mRNA expression of the Wnt target geneAxin2. In bone phenotype assessments ofShisa3 knockout (Shisa3 KO) mice, micro-computed tomography, mRNA expressions of osteoblast markers, and skeletal preparations all displayed no significant differences compared withShisa3 wild-type mice. mRNA expression analysis of canonical Wnt signaling target genes (Axin2,Lef1,Dkk1, andTnfrsf1...
Source: Journal of Bone and Mineral Metabolism - June 20, 2019 Category: Orthopaedics Source Type: research

Association of objectively measured physical activity and sedentary behavior with bone stiffness in peripubertal children
ConclusionThis study suggests that MVPA is positively associated with bone stiffness in Japanese schoolchildren in boys and SB is negatively associated with that in girls. Reducing SB might be a brief modifiable factor for preventing lower peak bone mass in girls, in addition to increasing MVPA. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 18, 2019 Category: Orthopaedics Source Type: research

Angiopoietin-like 2 upregulation promotes human chondrocyte injury via NF- κB and p38/MAPK signaling pathway
This study, for the first time, highlights that ANGPTL2 secreted by human chondrocytes plays a negative role in the pathogenesis of osteoarthritis, and it may be a potential therapeutic target in OA. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 18, 2019 Category: Orthopaedics Source Type: research

Effects of lanthanum carbonate on bone markers and bone mineral density in incident hemodialysis patients
ConclusionsThe results of the present study suggest that LC has potential in preventing low bone turnover, in comparison to CC, in patients new to HD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 18, 2019 Category: Orthopaedics Source Type: research

The association of urinary pentosidine levels with the prevalence of osteoporotic fractures in postmenopausal women
This study employed a cross-sectional design to analyze a subset of postmenopausal women in the Nagano Cohort Study. A total of 517 urine samples were analyzed using an ELISA system, which can measure urinary pentosidine without hydrolysis. Patients were asked about their history of non-vertebral osteoporotic fracture and the prevalence of vertebral fracture was semi-quantitatively assessed on X-ray films. A 10-year increase in age was related to a 1.09-fold increase in the urinary pentosidine level (95% CI 1.05 –1.13,P 
Source: Journal of Bone and Mineral Metabolism - June 18, 2019 Category: Orthopaedics Source Type: research

Is grip strength an actual/significant predictor of areal bone mineral density by itself? Potential confounders and/or effect modifiers
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 18, 2019 Category: Orthopaedics Source Type: research

Systematic and meta-analytic analysis of cross-sectional and longitudinal explorations of bone health in youth with obesity: from methodological considerations to clinical relevance
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 18, 2019 Category: Orthopaedics Source Type: research

Therapeutic potential of exosomes in rotator cuff tendon healing
AbstractRotator cuff tears are common musculoskeletal injuries that can cause significant pain and disability. While the clinical results of rotator cuff repair can be good, failure of tendon healing remains a significant problem. Molecular mechanisms underlying structural failure following surgical repair remain unclear. Histologically, enhanced inflammation, disorganization of the collagen fibers, calcification, apoptosis and tissue necrosis affect the normal healing process. Mesenchymal stem cells (MSCs) have the ability to provide improved healing following rotator cuff repair via the release of mediators from secreted...
Source: Journal of Bone and Mineral Metabolism - June 1, 2019 Category: Orthopaedics Source Type: research

Effectiveness of monthly intravenous ibandronate on the low responders to oral bisphosphonate: the MOVEMENT study
This study was a multicenter, prospective, interventional study (52 sites; August 2015 to March 2018). Patients aged ≥ 50 years with primary osteoporosis, evaluated as low responders to oral bisphosphonate treatment for 1–3 years, continued on their existing oral bisphosphonate or switched to monthly intravenous ibandronate (1 mg) for 12 months. The primary endpoint was change in lumbar spine BMD from ba seline to 12 months in the intravenous ibandronate group (IV IBN). A total of 240 and 141 patients were enrolled in the IV IBN and oral bisphosphonate groups (OBP), respectively. At...
Source: Journal of Bone and Mineral Metabolism - May 16, 2019 Category: Orthopaedics Source Type: research

Rabbit as model for osteoporosis research
AbstractOsteoporosis is a major public health problem affecting more than 200 million people worldwide. The use of different animal models, for the study of its pathophysiology and treatments, is important being actually the ovariectomized rat the most widely used; although this model has several problems due its small size, lack of true closure of epiphyseal plate and bone differences with humans. This review is aimed at summarizing the most common methods published for osteoporosis induction in rabbits as model for human disease with their advantages and disadvantages. The paper shows the advantages of the use of this sp...
Source: Journal of Bone and Mineral Metabolism - May 13, 2019 Category: Orthopaedics Source Type: research

Eldecalcitol increases bone mineral density in Chinese osteoporotic patients without vitamin D or calcium supplementation
In conclusion, baseline BMD tended to be lower in patients with low calcium intake and serum 25(OH)D. Eldecalci tol increased lumbar and hip BMD more than alfacalcidol regardless of serum 25(OH)D or calcium intake without vitamin D or calcium supplementation. These results suggest that eldecalcitol is effective in increasing the BMD of osteoporotic patients regardless of vitamin D status or calcium intake.Clinical Trial Registration number JAPIC CTI 152904. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 13, 2019 Category: Orthopaedics Source Type: research

Accumulation of microdamage and low bone mass in the femoral head as a cause of subchondral insufficiency fracture in a patient with osteogenesis imperfecta
In this report, we describe a patient with osteogenesis imperfecta who developed a subchondral insufficiency fracture of the femoral head after a fall that had resulted in a subcapital femoral neck fracture. Bipolar hemiarthroplasty was performed, and bone at the femoral head and neck was sampled for pathophysiological examination. Hematoxylin and eosin staining revealed microfractures and microcallus in the subchondral bone in the femoral head, indicating healing of a subchondral insufficiency fracture before the subcapital femoral neck fracture. Moreover, decreased bone volume and accumulated microdamage were observed in...
Source: Journal of Bone and Mineral Metabolism - May 11, 2019 Category: Orthopaedics Source Type: research

Local administration of aspirin with β-tricalcium phosphate/poly-lactic-co-glycolic acid (β-TCP/PLGA) could enhance osteoporotic bone regeneration
The objective of the present study was to inc orporate PLGA into β-TCP combined with a lower single-dose local administration of ASP to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defect, PLGA -modified β-TCP (TP) was prepared by mixing sieved granules of β -TCP and PLGA (50:50, v/v) for medical use, then TP with dripped 50 µg/0.1 ml and 100 µg/0.1 ml aspirin solution was implanted into the defect of OVX rats until death at 8 weeks. The defected area in distal femurs of rats was harveste...
Source: Journal of Bone and Mineral Metabolism - May 10, 2019 Category: Orthopaedics Source Type: research

The age modification to leukocyte telomere length effect on bone mineral density and osteoporosis among Chinese elderly women
AbstractCritically short telomeres indicate cellular senescence. Leukocyte telomere length (LTL) is regarded as an aging predictor. Osteoporosis is an age-related disease. The purpose of our study is to examine the association between LTL, and BMD and osteoporosis among an elderly Chinese population. A total of 1017 participants (584 postmenopausal women) with a mean age of 66.4  years were recruited from April 2016 to August 2017. Dual-energy X-ray absorptiometry was used for BMD measurement at skeleton sites of lumbar spine (LS), femoral neck (FN), and total hip (TH). LTL was measured using quantitative real-time po...
Source: Journal of Bone and Mineral Metabolism - April 20, 2019 Category: Orthopaedics Source Type: research

Comparative effectiveness of alendronate and zoledronic acid on bone mass improvement in transfusion-dependent thalassemia patients
AbstractThalassemia, as the most prevalent genetic blood disorder, has many associated comorbidities including low bone mass. We studied the comparative effectiveness of alendronate (AL) and zoledronic acid (ZOL) on bone mass improvement in transfusion-dependent thalassemia (TDT) patients a year after treatment. Three hundred seventy-five TDT patients with low bone mass were enrolled in this study. After a year of treatment with either AL or ZOL, a second bone mineral density (BMD) test was ordered to compare the effectiveness of the two aforementioned drugs. Body mass index (BMI), physical activity, sun exposure, and bioc...
Source: Journal of Bone and Mineral Metabolism - April 11, 2019 Category: Orthopaedics Source Type: research

Ketogenic diet compromises vertebral microstructure and biomechanical characteristics in mice
This study aimed to compare the changes in the microstructure and mechanical properties of the forth lumbar (L4) vertebra in KD and ovariectomized (OVX) mice. Forty eight-week-old female C57BL/6J mice were assigned into four groups: SD (standard diet)  + Sham, SD + OVX, KD + Sham, and KD + OVX groups. L4 vertebra was scanned by micro-CT to examine the microstructure of cancellous bone, after which simulative compression tests were performed using finite element (FE) analysis. Vertebral compressive test and histological staining of the L4 and L5 vertebrae were performe...
Source: Journal of Bone and Mineral Metabolism - April 9, 2019 Category: Orthopaedics Source Type: research

Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor
AbstractWarfarin, a vitamin K antagonist, is the most common anticoagulant used to prevent thromboembolisms associated with atrial fibrillation or following valvular surgery. Although several studies have revealed that long-term warfarin use accelerates aortic valve calcification and the development of aortic stenosis (AS), the detailed mechanism for this phenomenon remains unclear. Therefore, our aim was twofold: to establish the conditions for warfarin-induced calcification of human aortic valve interstitial cells (HAVICs) using high-inorganic phosphate (Pi) conditions and to investigate the underlying mechanism. We prep...
Source: Journal of Bone and Mineral Metabolism - April 8, 2019 Category: Orthopaedics Source Type: research

Correction to: Re ‑fracture and correlated risk factors in patients with osteoporotic vertebral fractures
In the Original publication of the article, the funding ID has been incorrectly published as (815602390) in the Acknowledgements. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 2, 2019 Category: Orthopaedics Source Type: research

Predicting radiological vertebral fractures with a combined physical function and body composition scoring system
This study included 307 subjects (113 men, 194 women) at least 40  years of age who were assessed at community health check-ups in 2008 and 2016. PF was assessed by grip strength and by single-leg stance, timed up-and-go, and 30-s chair stand tests, each scored from 0 to 3 for a possible total of 12 points (higher scores reflect lower function). BC was scored on bioelectrical impedance measurements of trunk and appendage muscle volume, with 6 possible points. We diagnosed radiological VFx semiquantitatively on lateral views of the lumbar spine, and measured bone mineral status by quantitative ultrasound (QUS) of the c...
Source: Journal of Bone and Mineral Metabolism - March 27, 2019 Category: Orthopaedics Source Type: research

The association between CD31 hi Emcn hi endothelial cells and bone mineral density in Chinese women
AbstractOsteoporosis is the most common bone disease in humans. During bone remodeling, specialized blood vessels influenced by the endothelial cells (CD31hiEmcnhi, also called type H cells) are formatted to supply nutrients. Reductions in vascular supply are associated with bone loss resulting in osteoporosis. Therefore, the objective of the present study was to explore the association between the CD31hiEmcnhi endothelial cells and bone mineral density (BMD). In this prospective study, 134 Chinese women were enrolled and examined. BMD was measured by DEXA method while the percentage of CD31hiEmcnhi endothelial cells in th...
Source: Journal of Bone and Mineral Metabolism - March 27, 2019 Category: Orthopaedics Source Type: research