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Dietary restriction plus exercise change gene expression of Cxcl12 abundant reticular cells in female mice
ConclusionDietary restriction combined with exercise promotes CAR cell differentiation into bone marrow adipocyte and suppresses osteoblast differentiation. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 1, 2024 Category: Orthopaedics Source Type: research

The 2023 Guidelines for the management and treatment of glucocorticoid-induced osteoporosis
ConclusionThe 2023 guidelines for the management and treatment of GIOP was developed through systematic reviews and consensus conferences using the Delphi method. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 28, 2024 Category: Orthopaedics Source Type: research

Prevalence of osteosarcopenia and its association with mortality and fractures among patients undergoing hemodialysis
ConclusionsPatients undergoing hemodialysis showed a high prevalence of osteosarcopenia, and osteosarcopenia was associated with a poor prognosis in this patient population. Assessing osteosarcopenia may be useful for accurate prognostic stratification of patients undergoing hemodialysis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 28, 2024 Category: Orthopaedics Source Type: research

Effectiveness of calcimimetics on fractures in dialysis patients with secondary hyperparathyroidism: meta-analysis of randomized trials
ConclusionThe use of calcimimetics offers a significant benefit in reducing the risk of fractures in patients undergoing dialysis with SHPT. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 27, 2024 Category: Orthopaedics Source Type: research

Long-term effects of denosumab on bone mineral density and turnover markers in patients undergoing hemodialysis
ConclusionThe study showed long-term suppression of TRACP-5b and BAP levels and sustaining BMD after denosumab administration over an extended period in patients undergoing hemodialysis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 21, 2024 Category: Orthopaedics Source Type: research

History of fragility fracture is associated with cardiovascular mortality in hemodialysis patients: the Q-Cohort study
ConclusionIn a large cohort of patients undergoing hemodialysis, a history of fragility fracture was an independent predictor of CV death. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 20, 2024 Category: Orthopaedics Source Type: research

Associations of pyrethroid exposure with bone mineral density and osteopenia in adults
ConclusionIn conclusion, pyrethroids exposure was negatively correlated with BMD levels, and the associations of pyrethroids with BMD and low BMD varied by specific pyrethroids, pyrethroid concentrations, and bone sites. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 18, 2024 Category: Orthopaedics Source Type: research

Androgen deprivation therapy-related fracture risk in prostate cancer: an insurance claims database study in Japan
ConclusionADT is associated with a 1.6-fold increase in the risk of osteoporotic fracture in men with prostate cancer. Densitometry in this population is infrequent and monitoring urgently needs to be improved in order to implement effective fracture prevention. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 17, 2024 Category: Orthopaedics Source Type: research

Seasonal variation of surgically treated distal radius fracture in Japan using inpatient database: cross-sectional study
ConclusionSurgically treated distal radius fractures occur frequently during the winter months among female individuals in eastern Japan or those aged  ≥ 50 years and increase from school age to adolescence, especially in male individuals from spring to autumn. We should be aware of the high incidence of distal radius fractures in winter, especially in regions with snowfall and cold temperatures. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 28, 2024 Category: Orthopaedics Source Type: research

Inhibition of cysteine protease disturbs the topological relationship between bone resorption and formation in vitro
ConclusionThese new findings help clarify coupling mechanisms and will contribute to the development of new drugs for osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 20, 2024 Category: Orthopaedics Source Type: research

Effects of acute- and long-term aerobic exercises at different intensities on bone in mice
ConclusionThese results showed that moderate-intensity exercise can inhibit bone resorption earlier, and long-term exercise can increase bone mass and strength through promoted bone formation via the Wnt/ β-catenin activation. High-intensity exercise, traditionally considered better for bone, may fail to stimulate bone remodeling, leading to no change in bone mass and strength. Our findings suggest that moderate-intensity exercise, neither too low nor high, can maintain bone health. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 13, 2024 Category: Orthopaedics Source Type: research

Histomorphometric analysis of patients with femoral neck fracture and 25-hydroxyvitamin D deficiency: a cross-sectional study
ConclusionThis is the first study in the twenty-first century to examine serum 25OHD concentrations and bone mineralization disorders in Japanese patients with osteoporosis. The results indicate that vitamin D deficiency does not necessarily cause bone mineralization disorders and rarely leads to osteomalacia. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 8, 2024 Category: Orthopaedics Source Type: research

The impact of chronic obstructive pulmonary disease on bone strength
AbstractChronic obstructive pulmonary disease (COPD) is a lifestyle-related disease that develops in middle-aged and older adults, often due to smoking habits, and has been noted to cause bone fragility. COPD is a risk factor for osteoporosis and fragility fracture, and a high prevalence of osteoporosis and incidence of vertebral fractures have been shown in patients with COPD. Findings of lung tissue analysis in patients with COPD are primarily emphysema with a loss of alveolar septal walls, and the severity of pulmonary emphysema is negatively correlated with thoracic spine bone mineral density (BMD). On the other hand, ...
Source: Journal of Bone and Mineral Metabolism - February 7, 2024 Category: Orthopaedics Source Type: research

Bone –fat linkage via interleukin-11 in response to mechanical loading
AbstractPositive regulators of bone formation, such as mechanical loading and PTH, stimulate and negative regulators, such as aging and glucocorticoid excess, suppressIL-11 gene transcription in osteoblastic cells. Signal transduction from mechanical loading and PTH stimulation involves two pathways: one is Ca2+–ERK–CREB pathway which facilitates binding of ∆FosB/JunD to the AP-1 site to enhanceIL-11 gene transcription, and the other is Smad1/5 phosphorylation that promotesIL-11 gene transcription via SBE binding and complex formation with ∆FosB/JunD. The increased IL-11 suppressesSost expression via IL-11Rα–STA...
Source: Journal of Bone and Mineral Metabolism - February 7, 2024 Category: Orthopaedics Source Type: research

Zinc improves Denosumab and eldecalcitol efficacy for bone mineral density in patients with hypozincemia
ConclusionHypozincemia may reduce the efficacy of DMAb and eldecalcitol in increasing BMD and fracture prevention. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 7, 2024 Category: Orthopaedics Source Type: research