Comparison of novel DXA system, Shimazu SONIALVISION G4, with GE-Lunar PRODIGY
ConclusionsAlthough BMD values by SONIALVISION G4 were close to those by PRODIGY, follow-up studies should be performed using the same device because of the small difference between devices. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 11, 2021 Category: Orthopaedics Source Type: research

Vitamin D level and fractures in children and adolescents: a systematic review and meta-analysis
AbstractIntroductionThe aim of the study was to determine the relationship between vitamin D levels and the risk of bone fractures in children and adolescents.Materials and methodsPubMed, Embase, and Cochrane library databases were searched using subject and free words. The Newcastle –Ottawa scale form was used to assess literature quality. ReVman 5.2 and Stata 13.0 were used for statistical analyses. The results were expressed as the mean difference (MD)/odds ratio (OR) and 95% confidence interval (95% CI). The heterogeneity test was conducted according toI2 andQ tests. Egger ’s test was used to evaluate publi...
Source: Journal of Bone and Mineral Metabolism - June 11, 2021 Category: Orthopaedics Source Type: research

Bone parameters of elite athletes with oligomenorrhea and prevalence seeking medical attention: a cross-sectional study
AbstractIntroductionSince the definition of secondary amenorrhea is cessation of regular menses for more than 3 months, it is likely that athletes with irregular menstrual cycles, including oligomenorrhea, do not consider the condition as serious. However, the consequences of untreated oligomenorrhea have not been investigated in elite track and field athletes.Materials and methodsThe cohort consisted of 91 elite-level track and field athletes. Body compositions, including bone parameters and bone turnover markers (BTMs), were measured.ResultsAmong the 91 participants, 52 were eumenorrheic and 33 were oligomenorrheic. The ...
Source: Journal of Bone and Mineral Metabolism - June 8, 2021 Category: Orthopaedics Source Type: research

Long-term pretreatment with alendronate inhibits calvarial defect healing in an osteoporotic rat model
ConclusionThe present study shows that long-term pretreatment with alendronate inhibited calvarial defect healing in osteoporotic rats, and this effect could not be reversed by stopping alendronate, switching to parathyroid hormone, or combining with once-weekly parathyroid hormone. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 6, 2021 Category: Orthopaedics Source Type: research

Modifiable lifestyle factors associated with fragility hip fracture: a systematic review and meta-analysis
ConclusionModifiable factors may be utilized clinically to provide more effective lifestyle interventions for at risk populations. We found that low weight and underweight BMI carried the highest risk, followed by high coffee consumption, inactivity, weight loss, and high daily alcohol consumption. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 15, 2021 Category: Orthopaedics Source Type: research

Early adverse events after the first administration of zoledronic acid in Japanese patients with osteoporosis
ConclusionOccurrence of APRs might be lesser in clinical practice than in phase 3 clinical trials. Although serum calcium levels decreased in many cases, the decrease could be suppressed by the co-administration of active vitamin D3. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 14, 2021 Category: Orthopaedics Source Type: research

Stand-up test predicts occurrence of non-traumatic vertebral fracture in outpatient women with osteoporosis
ConclusionThe stand-up test may be useful as a simple screening tool for non-traumatic vertebral fracture in patients with osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 14, 2021 Category: Orthopaedics Source Type: research

FSH modulated cartilage ECM metabolism by targeting the PKA/CREB/SOX9 pathway
ConclusionsOur results collectively indicated that FSH plays an essential role in the pathogenesis of OA and acts as a crucial mediator. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 14, 2021 Category: Orthopaedics Source Type: research

Mkx regulates the orthodontic tooth movement via osteoclast induction
ConclusionOrthodontic tooth movement experiments inMkx-deficient rats suggested thatMkx is involved in osteoclast induction at the alveolar bone surface on the compression side. This study reveals the possibility that Mkx plays a mechanosensory role in orthodontic tooth movement by inducing RANKL expression and osteoclastogenesis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 14, 2021 Category: Orthopaedics Source Type: research

Impact of high-load resistance training on bone mineral density in osteoporosis and osteopenia: a meta-analysis
This study aimed to examine the effect of high-load resistance training (HLRT) on bone mineral density (BMD) in patients with osteoporosis and osteopenia using a meta-analysis.Materials and methodsWe searched for randomized controlled trials (RCTs) on HLRT in patients with osteoporosis and osteopenia from medical databases. Our meta-analysis was performed with the primary endpoints being the standardized mean difference (SMD) of the change in BMD of the lumbar spine (LS), femoral neck (FN), and total hip (TH). The robustness of the results was assessed by subgroup analysis. Heterogeneity factors were examined by meta-regre...
Source: Journal of Bone and Mineral Metabolism - April 13, 2021 Category: Orthopaedics Source Type: research

Effects after starting or switching from bisphosphonate to romosozumab or denosumab in Japanese postmenopausal patients
ConclusionsROMO continuously increased BMD for 12  months and performed better than DENO. On the other hand, effects of ROMO switched from BP on BMD of femoral neck and total hip were almost same with DENO. Bone metabolic markers at baseline and changes in TRACP-5b from baseline to 3 months may predict the efficacy of ROMO after 12 months of adm inistration. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 13, 2021 Category: Orthopaedics Source Type: research

Osteoporotic patients treated with bisphosphonates do not show the increased mortality observed in those untreated
AbstractIntroductionOsteoporosis has been said to be associated with increased mortality. On the other hand, it is debated whether treatment with bisphosphonates may reduce mortality in osteoporotic patients. To contribute to the clarification of these issues, we have studied in a prospective cohort the mortality in people without osteoporosis and in patients with osteoporosis, untreated or treated with bisphosphonatesMaterial and MethodsAt their inclusion in the cohort, four groups of participants were identified: (a) people without osteoporosis (group 1); (b) osteoporotic patients treated with bisphosphonates (group 2); ...
Source: Journal of Bone and Mineral Metabolism - April 13, 2021 Category: Orthopaedics Source Type: research

The effect of aging on the nanostructure of murine alveolar bone and dentin
ConclusionsThese results indicated that mineral particle characteristics were found to evolve differently between molar and alveolar bone as a function of age. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 11, 2021 Category: Orthopaedics Source Type: research

Jumping rope and whole-body vibration program effects on bone values in Olympic artistic swimmers
In conclusions, combined jump rope and vibration should be considered to reduce the risk of bone damage in artistic swimmers. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 11, 2021 Category: Orthopaedics Source Type: research

Association of hemoglobin level with fracture: a nationwide cohort study
AbstractIntroductionThe association between hemoglobin (Hb) level including anemia and fracture has not been studied thoroughly.Materials and methods197, 187 adults  ≥ 50 years from the National Health Insurance Service of Korea were studied. Hb was determined during health screening examinations in 2004 or 2005. From 1 January 2006, participants were followed up for fracture until 31 December 2013. Hb levels (g/dL) were categorized into five groups, wit h normal hemoglobin levels subdivided into three groups (low normal, normal, and high normal Hb): 
Source: Journal of Bone and Mineral Metabolism - April 8, 2021 Category: Orthopaedics Source Type: research

Persistent bone resorption lacunae on necrotic bone distinguish bisphosphonate-related osteonecrosis of jaw from denosumab-related osteonecrosis
ConclusionsPersistent bone resorption lacunae on the necrotic bone surface are unique to BRONJ, providing a basis for distinguishing BRONJ from DRONJ and OM in histopathological diagnosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 8, 2021 Category: Orthopaedics Source Type: research

Altered immunolocalization of FGF23 in murine femora metastasized with human breast carcinoma MDA-MB-231 cells
AbstractIntroductionAfter the onset of bone metastasis, tumor cells appear to modify surrounding microenvironments for their benefit, and particularly, the levels of circulating fibroblast growth factor (FGF) 23 in patients with tumors have been highlighted.Materials and methodsWe have attempted to verify if human breast carcinoma MDA-MB-231 cells metastasized in the long bone of nu/nu mice would synthesize FGF23. Serum concentrations of calcium, phosphate (Pi) and FGF23 were measured in control nu/nu mice, bone-metastasized mice, and mice with mammary gland injected with MDA-MB-231 cells mimicking primary mammary tumors.R...
Source: Journal of Bone and Mineral Metabolism - April 8, 2021 Category: Orthopaedics Source Type: research

Protective effects of berberine on senile osteoporosis in mice
ConclusionThe present results suggest that berberine exerts potent bone protective effects by promoting bone formation, inhibiting marrow fat accumulation and bone resorption. This effect may be achieved through cAMP/PKA/CREB signaling pathway. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 8, 2021 Category: Orthopaedics Source Type: research

A quality improvement project to address the challenges surrounding zoledronic acid use in children
ConclusionsThe implementation of a standardized protocol for ZA use in children was successful in confirming patient eligibility with pre-infusion bloodwork but failed to ensure that patients obtained post-first-infusion bloodwork and received all prescribed infusions. Further efforts to systematize the management of children on ZA are needed. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 7, 2021 Category: Orthopaedics Source Type: research

Mapping cortical bone stiffness and mineralization from endosteal to periosteal surfaces of bovine mid-diaphyseal femur
ConclusionStarting from endosteal to periosteal surfaces of mid-diaphyseal bovine femur, it was found that stiffness, mineralization, and HU values all exhibit increasing and correlating trends. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 6, 2021 Category: Orthopaedics Source Type: research

Differences in subtrochanteric and diaphyseal atypical femoral fractures in a super-aging prefectural area: YamaCAFe Study
AbstractIntroductionAtypical femoral fractures (AFFs) have been correlated with long-term use of bisphosphonates (BPs), glucocorticoids (GCs), and femoral geometry. We investigated the incidence and characteristics of subtrochanteric (ST) and diaphyseal (DP) AFFs in all institutes in a super-aging prefectural area.Materials and methodsWe performed a blinded analysis of radiographic data in 87 patients with 98 AFFs in all institutes in Yamagata prefectural area from 2009 to 2014. Among the 98 AFFs, 57 AFFs comprising 11 ST fractures in 9 patients and 46 DP fractures in 41 patients with adequate medical records and X-rays we...
Source: Journal of Bone and Mineral Metabolism - April 5, 2021 Category: Orthopaedics Source Type: research

PTH1-34 promotes osteoblast formation through Beclin1-dependent autophagic activation
ConclusionPTH1-34 can enhance the autophagic activity of osteoblast precursors, which is involved in PTH1-34-regulated osteoblast formation. Furthermore, Beclin1, as a key autophagic regulator, plays a pivotal role in PTH1-34-regulated osteoblast precursor autophagy and osteoblastogenesis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 5, 2021 Category: Orthopaedics Source Type: research

Short-term efficacy and safety of zoledronate acid or denosumab in Japanese patients with postmenopausal osteoporosis
ConclusionsThe combination therapy of Zol or DMAb and ELD may increase BMD at 12  months after the first administration in Japanese patients with postmenopausal osteoporosis, regardless of BPs pretreatment. Bone metabolic markers at baseline may be useful predictors for reaction to the therapy and side effects caused by these combination therapies in postmenopausal osteoporosis . (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 5, 2021 Category: Orthopaedics Source Type: research

Novel mutation in the ALPL gene with a dominant negative effect in a Japanese family
ConclusionOur approach would help to avoid the inappropriate use of bone resorption inhibitors for currently mis- or under-diagnosed HPP, given that the presence of further, yet undetected mutations of theALPL gene are plausible. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 5, 2021 Category: Orthopaedics Source Type: research

Prior adherence to statins is a predictor of subsequent adherence and persistence to oral, but not parenteral, osteoporosis medications
ConclusionsPrior adherence to statins is a predictor of subsequent short-term and long-term adherence and persistence with oral bisphosphonates but not parenteral osteoporosis therapies. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 5, 2021 Category: Orthopaedics Source Type: research

The relationship between osteoporosis and sarcopenia, according to EWGSOP-2 criteria, in outpatient elderly
This study aimed to investigate the relationship between sarcopenia and osteoporosis.Materials and methodsThe study included 444 participants who had undergone a dual-energy X-ray absorptiometry scan, handgrip test, 4-m walking speed test, and bioimpedance analysis within the past year. Participants were classified into control, osteopenia, or osteoporosis groups according to the World Health Organization classification. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People-2 criteria.ResultsThe mean age of the participants was 75.88  ± 7.20 years, and 80.9...
Source: Journal of Bone and Mineral Metabolism - April 5, 2021 Category: Orthopaedics Source Type: research

Risk factors for incident vertebral fractures in osteoporosis pharmacotherapy: a 2-year, prospective, observational study
ConclusionEvaluating fracture risk for patients with osteoporosis considering these potential risk factors for fracture in addition to the established risk factors may be useful when starting pharmaceutical treatment. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 18, 2021 Category: Orthopaedics Source Type: research

Chemokine ligand 28 (CCL28) negatively regulates trabecular bone mass by suppressing osteoblast and osteoclast activities
ConclusionIn summary, this study indicated that CCL28 is one of the negative regulators of bone mass by suppressing osteoblast and osteoclast activities. These results provide important insights into bone immunology and the selection of new osteoporosis treatments. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 15, 2021 Category: Orthopaedics Source Type: research

An examination of histomorphometric relationships in the anterior and posterior human femoral cortex
ConclusionOur findings support an increased rate of remodelling associated with decreases in osteon geometry in the anterior and posterior femur. Future studies should examine static osteon histomorphometry using anterior and posterior measurements in larger samples of documented age and sex. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 13, 2021 Category: Orthopaedics Source Type: research

Predictors of bone mineral density in adolescents with atypical anorexia nervosa
ConclusionIn the adolescent period similar to AN, AAN cases are also at risk for disordered bone health. In adolescents with AAN, BMI prior to the illness was estimated to be the significant parameter for the risk of low BMD. Special attention should be paid to the bone health of adolescents with AAN, especially for those who do not have a previous overweight history. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 12, 2021 Category: Orthopaedics Source Type: research

Response to the letter from Otsuka et al. Trends in the prevalence of underweight in women across generations in Japan
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 11, 2021 Category: Orthopaedics Source Type: research

Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) in urological malignancies: a multi-center retrospective study
ConclusionARONJ is not a rare adverse event in urological malignancies. Especially, kidney cancer, high BMI patients and who needed tooth extraction before BMA were high risk for developing ARONJ. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - March 11, 2021 Category: Orthopaedics Source Type: research

Toshitsugu Sugimoto, MD, PhD
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 24, 2021 Category: Orthopaedics Source Type: research

Family caregiver burden of patients with osteoporotic fracture in Japan
ConclusionThe substantial humanistic and financial burden of caregiving by family members to osteoporotic fracture patients should be considered when evaluating the impact of fragility fractures, disease management and support systems for osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 17, 2021 Category: Orthopaedics Source Type: research

LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF- β/SMAD4 signaling
ConclusionsOur results demonstrate LncRNA PVT1 is involved in cartilage degradation in diabetic OA and correlated with disease severity. Efficiency of ad-siRNA-PVT1 in controlling joint inflammation in diabetic OA mice is associated with the suppression of the expression of miR-146a, pro-inflammatory cytokines and activation of TGF- β/SMAD4 pathway. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

Plasma periostin as a biomarker of osteoporosis in postmenopausal women with type 2 diabetes
This study aimed to investigate the correlation between periostin levels and bone mineral density as well as bone turnover markers in postmenopausal women with type 2 diabetes (T2DM).Materials and methodsThis study was a cross-sectional study that included 164 postmenopausal women with T2DM as study subjects and 32 age-matched nondiabetic postmenopausal women with normal bone mineral density (BMD) as healthy control subjects. A total of 164 subjects with T2DM were then divided into three groups according to BMD: the normal BMD group (n = 29), the osteopenia group (n = 70), and the osteoporosis g...
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

The potential role of lncRNAs in osteoporosis
AbstractOsteoporosis is a common bone disease characterized by low bone mass and deterioration of bone microstructure, which predisposes to higher risks of bone fragility and bone fracture. Long non-coding RNAs (lncRNAs) are a class of RNAs with a length of  >  200 nucleotides without protein-coding function, which control the expression of genes and affect multiple biological processes. Accumulating evidence suggests that lncRNAs are widely involved in the molecular mechanisms of osteoporosis. This review aims to summarize the function and underlying m echanism of lncRNAs involved in the development of os...
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

Role of irisin in effects of chronic exercise on muscle and bone in ovariectomized mice
ConclusionsWe demonstrated that chronic exercise elevated irisin expression in the gastrocnemius and soleus muscles of estrogen-deficient mice. Irisin might be related to increases in trabecular BMD in mice; however, further studies are needed to clarify the involvement of irisin in the effects of chronic exercise on muscle/bone interactions. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

Effects of iguratimod on glucocorticoid-induced disorder of bone metabolism in vitro
ConclusionThese results suggest that IGU may improve glucocorticoid-induced disorder of bone metabolism and may exhibit positive effects against GIOP associated with RA. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 9, 2021 Category: Orthopaedics Source Type: research

Retraction Note to: Effect of alendronate on bone mineral density and bone turnovermarkers in post-gastrectomy osteoporotic patients
This article has been retracted. Please see the Retraction Notice for more detail:https://doi.org/10.1007/s00774-021-1209-0 (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 6, 2021 Category: Orthopaedics Source Type: research

Correction to: Discovery of the RANKL/RANK/OPG system
In the original publication of the article, reference 12 was published incorrectly as follows. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 13, 2021 Category: Orthopaedics Source Type: research

Physiologic and Pathologic role of RANKL : beyond the skeletal system
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 13, 2021 Category: Orthopaedics Source Type: research

Regulation of T cell-associated tissues and T cell activation by RANKL-RANK-OPG
Abstract The receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK-osteoprotegerin (OPG) system is critical to bone homeostasis, but genetically deficient mouse models have revealed important roles in the immune system as well. RANKL-RANK-OPG is particularly important to T cell biology because of its organogenic control of thymic development and secondary lymphoid tissues influence central T cell tolerance and peripheral T cell function. RANKL-RANK-OPG cytokine-receptor interactions are often controlled by regulation of expression of RANKL on developing T cells, which interacts with RANK expressed on some lymp...
Source: Journal of Bone and Mineral Metabolism - January 12, 2021 Category: Orthopaedics Source Type: research

On challenges in clinical assessment of hip fracture risk using image-based biomechanical modelling: a critical review
ConclusionsA number of critical issues and gaps were identified. Strategies for effectively addressing the issues were discussed. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 9, 2021 Category: Orthopaedics Source Type: research

Oral risk factors associated with medication-related osteonecrosis of the jaw in patients with cancer
AbstractIntroductionBone-modifying agents (BMAs) are indispensable to cancer therapy. However, the number of patients with medication-related osteonecrosis of the jaw (MRONJ) is increasing according to the BMA administration. Oral factors predisposing to development of MRONJ are receiving attention, and oral management is recommended for prevention of MRONJ; however, the strategy and criteria have not yet been established. Therefore, we investigated the oral risk factors associated with MRONJ development in this study.Materials and MethodsA  retrospective study was carried out on 398 cancer patients who had recei...
Source: Journal of Bone and Mineral Metabolism - January 8, 2021 Category: Orthopaedics Source Type: research

Aging and direct medical costs of osteoporotic fractures
This study estimated the direct medical costs of osteoporotic fractures from a large claims database in Korea.Materials and methodsWe compared the medical costs of hip, vertebral, and wrist fractures between two age groups (50 –64 years vs 65 years and older). We used a generalized linear model to investigate the drivers of osteoporotic fracture medical costs.ResultsHip fractures had the highest costs, regardless of age, followed by vertebral and wrist. The cost of hip fracture was USD 7285 for those aged 65  years and over and USD 6589 for those aged 50–64 years. The length of hospital days...
Source: Journal of Bone and Mineral Metabolism - January 8, 2021 Category: Orthopaedics Source Type: research

Blood lipid levels in patients with osteopenia and osteoporosis:a systematic review and meta-analysis
ConclusionHDL-C was elevated in patients with OP. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 8, 2021 Category: Orthopaedics Source Type: research

Hypophosphatasia: is it an underdiagnosed disease even by expert physicians?
DiscussionConsidering the wide spectrum of clinical signs and symptoms, HPP should be among the differential lists of bone, muscle, and tooth abnormalities at any age. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 6, 2021 Category: Orthopaedics Source Type: research

Reduction in parathyroid adenomas by cinacalcet therapy in patients with primary hyperparathyroidism
ConclusionThe present study revealed that cinacalcet treatment reduces the size of parathyroid adenomas in patients with PHPT. The accumulation of more PHPT cases with cinacalcet therapy is required to confirm this finding. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 6, 2021 Category: Orthopaedics Source Type: research

Bone microarchitectural alterations in boys with Duchenne muscular dystrophy on long-term glucocorticoid treatment
ConclusionLower microarchitectural measurement of trabecular bones, but higher cortical vBMD, was observed in DMD boys on long-term oral glucocorticoid. The results from this study provide preliminary, yet important insights into the bone microarchitecture of this group of patients. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 5, 2021 Category: Orthopaedics Source Type: research