Long-term safety of eldecalcitol in Japanese patients with osteoporosis: a retrospective, large-scale database study
ConclusionThe risk of hypercalcemia and AKI associated with ELD use observed in this retrospective analysis is similar to that reported previously in the Japanese post-marketing surveillance of ELD. Furthermore, ELD, similar to AVD, may not increase the risk of ONJ and AFF. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 18, 2022 Category: Orthopaedics Source Type: research

Association between obesity and ossification of spinal ligaments in 622 asymptomatic subjects: a cross-sectional study
AbstractIntroductionPrevious studies on patients with symptoms of spinal ligament ossification, including ossification of the posterior longitudinal ligament (OPLL) and ligamentum flavum (OLF), have not clarified whether obesity is a cause or consequence of these diseases and were limited by selection bias. Thus, we investigated the association between obesity and the prevalence of spinal ligament ossification in randomly selected asymptomatic subjects.Materials and methodsBetween April 2020 and March 2021, 622 asymptomatic Japanese subjects who underwent computed tomography of neck to pelvis for medical check-up purposes ...
Source: Journal of Bone and Mineral Metabolism - January 16, 2022 Category: Orthopaedics Source Type: research

Disease-specific complications and multidisciplinary interventions in achondroplasia
AbstractAchondroplasia (ACH) is the most common skeletal dysplasia and characterized by a disproportionate short stature, macrocephaly with frontal bossing, exaggerated lumbar lordosis, and trident hands. It is induced by activated mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. In addition to short stature, patients with ACH have a high prevalence of medical complications, including upper airway obstructive apnea, increased mortality, foramen magnum stenosis, hydrocephalus, developmental delay, recurrent ear infections, genu varum, obesity, and spinal canal stenosis, throughout their whole life. Several...
Source: Journal of Bone and Mineral Metabolism - January 14, 2022 Category: Orthopaedics Source Type: research

Inhibitor of protein kinase N3 suppresses excessive bone resorption in ovariectomized mice
ConclusionsOur results showed that Pkn3 has potential as a therapeutic target for bone loss due to increased bone resorption. SB202190 is promising as a lead compound for the development of novel anti-bone-resorbing agents. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 14, 2022 Category: Orthopaedics Source Type: research

Impacts of low molecular weight heparin on bone healing and osseointegration
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 14, 2022 Category: Orthopaedics Source Type: research

Correction to: Osteoprotegerin/bone morphogenetic protein 2 combining with collagen sponges on tendon-bone healing in rabbits
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 17, 2021 Category: Orthopaedics Source Type: research

Maximum number of bone cross-linked vertebrae: an index for BMD in diffuse idiopathic skeletal hyperostosis
ConclusionFemur proximal BMD and mean max TB showed different trends after max VB  = 9, which suggests that max VB is an index of BMD, and that DISH has at least two possible populations in terms of BMD and bone cross-link thickness. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 29, 2021 Category: Orthopaedics Source Type: research

LINC02381, a sponge of miR-21, weakens osteogenic differentiation of hUC-MSCs through KLF12-mediated Wnt4 transcriptional repression
ConclusionIn summary, LINC02381 repressed osteogenic differentiation of hUS-MSCs through sponging miR-21 to enhance KLF12-mediated inactivation of Wnt/ β-catenin pathway, indicating that LINC02381 might be a therapeutic target for osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 15, 2021 Category: Orthopaedics Source Type: research

Risk factors affecting vertebral collapse and kyphotic progression in postmenopausal osteoporotic vertebral fractures
AbstractIntroductionWe aimed to investigate the risk factors that affect vertebral deformity 6  months after osteoporotic vertebral fractures (OVFs) at the time of injury.Materials and methodsFrom May 2017 to May 2020, 70 postmenopausal women with OVFs were evaluated for age; body mass index; number of previous OVFs; total 25-hydroxy vitamin D [25(OH)D] levels; posterior wall injury on computed tomography; cross-sectional area (CSA) of the psoas major, erector spinae, and multifidus; fat infiltration; vertebral instability (VI) upon admission; collapse rate (CR); and kyphotic angle (KA) at 6  months after injury....
Source: Journal of Bone and Mineral Metabolism - November 13, 2021 Category: Orthopaedics Source Type: research

Skeletal effects of combined bisphosphonates treatment and parathyroidectomy in osteoporotic patients with primary hyperparathyroidism
AbstractIntroductionBone loss caused by primary hyperparathyroidism (PHPT) is an indication for parathyroidectomy (PTX). However, whether adding bisphosphonates would be superior to PTX alone to increase bone mass remains unclear. We thus aimed to compare the skeletal effects of the combination treatment of bisphosphonates and PTX with PTX alone.Materials and methodsIn this retrospective analysis, bone mineral density (BMD) changes after 1  year of combination treatment and PTX alone were compared. We also analyzed the correlation between changes in serum biochemical parameters and BMD after 1 year of treatment i...
Source: Journal of Bone and Mineral Metabolism - November 10, 2021 Category: Orthopaedics Source Type: research

Local bone metabolism during the consolidation process of spinal interbody fusion
ConclusionFollowing LIF surgery, there is a rapid increase in bone metabolism at the vertebral endplates that develops towards the center of the interbody region. Knowing the local bone metabolism during uncompromised consolidation of spinal interbody fusion might enable identification of impaired bone formation early after LIF surgery using18F-NaF PET/CT scanning. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 10, 2021 Category: Orthopaedics Source Type: research

Expression of concern to: Effects of growth hormone on bone modeling and remodeling in hypophysectomized young female rats: a bone histomorphometric study
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 10, 2021 Category: Orthopaedics Source Type: research

Regulation of osteoarthritis development by ADAM17/Tace in articular cartilage
ConclusionsThis study demonstrates regulation of OA development by Adam17, involvement of EGFR and TNF pathways, and the possibility of Adam17 as a therapeutic target for OA. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 9, 2021 Category: Orthopaedics Source Type: research

Upregulated miR-9-5p inhibits osteogenic differentiation of bone marrow mesenchymal stem cells under high glucose treatment
ConclusionMiR-9-5p knockdown promotes HG-induced osteogenic differentiation BMSCs in vitro and mitigates the DOP condition of rats in vivo by targeting DDX17. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 9, 2021 Category: Orthopaedics Source Type: research

List of reviewers 2020 –2021
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 8, 2021 Category: Orthopaedics Source Type: research

Polypharmacy, chronic kidney disease, and incident fragility fracture: a prospective cohort study
ConclusionHyperpolypharmacy is associated with an increased risk of fragility fracture regardless of CKD status, and has a strong impact on incident fragility fractures in dialysis-dependent CKD patients. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 3, 2021 Category: Orthopaedics Source Type: research

Journal of Bone and Mineral Metabolism Best Paper Award 2021
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 29, 2021 Category: Orthopaedics Source Type: research

Disruption of the mouse Bmal1 locus promotes heterotopic ossification with aging via TGF-beta/BMP signaling
ConclusionsThese findings demonstrated thatBmal1 negatively regulates endochondral ossification in heterotopic ossification of tendons and ligaments with aging via TGF β/BMP signaling, thereby identifying a new regulatory mechanism in age-related heterotopic ossification of tendons and ligaments. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 9, 2021 Category: Orthopaedics Source Type: research

Association between alcohol and bone mineral density in a Mendelian randomization study: the Dong-gu study
ConclusionIn our MR study, genetically predicted alcohol consumption was positively associated with BMD in men. This result suggests that the association between alcohol consumption and BMD is causal. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 9, 2021 Category: Orthopaedics Source Type: research

Kefir alters craniomandibular bone development in rats fed excess dose of high fructose corn syrup
ConclusionIn conclusion, dietary the excess dose of HFCS at an early age has been observed to pose a risk for cranial and mandible bone development. The healing effects of kefir may be a new approach to the treatment via kefir consumption in young's. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 6, 2021 Category: Orthopaedics Source Type: research

Correction to: Equivalent values between anterior vertebral height, wedge ratio, and wedge angle in osteoporotic vertebral fractures
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 30, 2021 Category: Orthopaedics Source Type: research

Wnt3a and ASCs are capable of restoring mineralization in staph aureus-infected primary murine osteoblasts
ConclusionsIn summary, we gained further osteoblast-related insights into pathomechanisms of reduced bone healing capacity upon infections. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 25, 2021 Category: Orthopaedics Source Type: research

Articular cartilage degeneration and bone adaptation due to lack of dystrophin in mice
This study aimed to investigate femoral morphological characteristics of lack of dystrophin in MDX mice, considering that this model, different from DMD patient, is not influenced by corticosteroids administration and limited ambulation.Materials and methodsProximal femur of male 16-week-old Control and MDX mice were submitted to histological, morphometric (volume density of articular cartilage, compact bone, trabecular bone and bone marrow; articular cartilage layers area; articular cartilage cell area), and immunohistochemistry analysis for RUNX-2, RANK-L, MMP-2, MMP-9, Caspase-3 and KI-67.ResultsMDX showed loss of linea...
Source: Journal of Bone and Mineral Metabolism - September 22, 2021 Category: Orthopaedics Source Type: research

The relat ıonshıp between serum hydroxyvıtamın D levels and postural stabılıty ın young adults
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 22, 2021 Category: Orthopaedics Source Type: research

The prevalence of vertebral fractures among Indian perimenopausal women and its association with ovarian biomarkers
The objective was to study the prevalence of vertebral fractures (VF) and to assess the utility of FSH, estradiol and AMH in predicting them in Indian perimenopausal womenMaterials and methodsIt was a cross-sectional study. Perimenopausal women aged 40 –49 years underwent assessment for prevalent vertebral fractures, bone mineral density (BMD) and trabecular bone score (TBS). Utility of serum FSH, estradiol and AMH in predicting prevalent vertebral fractures was also assessed.ResultsA total of 300 perimenopausal women with mean (SD) age of 43.2 (2.8) years was recruited and 18% had moderate –severe VF. Mea...
Source: Journal of Bone and Mineral Metabolism - September 17, 2021 Category: Orthopaedics Source Type: research

Impaired bone healing by enoxaparin via inhibiting the differentiation of bone marrow mesenchymal stem cells towards osteoblasts
Conclusion It was suggested that enoxaparin impaired bone healing through suppressing the differentiation of BMSCs towards osteoblasts. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 15, 2021 Category: Orthopaedics Source Type: research

Imaging findings and treatment outcomes of a rare subtype of medication-related osteonecrosis of the jaw
ConclusionAmong the MRONJ types, the PRd type has a poor prognosis. Therefore, accumulating and analyzing more PRd cases in the future is warranted. This is the first report to describe the presence of this specific subtype of MRONJ. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 12, 2021 Category: Orthopaedics Source Type: research

Association of serum 25OHD levels with risk of paediatric fractures
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 26, 2021 Category: Orthopaedics Source Type: research

Incidence of and risk factors for spondylolisthesis, scoliosis, and vertebral fracture in rheumatoid arthritis
ConclusionThe incidence of scoliosis was related in patients with poor control of RA, while new vertebral fracture was more common in patients with use of glucocorticoid. Control of disease activity might be important in preventing radiological lumbar disorders in RA. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 23, 2021 Category: Orthopaedics Source Type: research

Treatment pattern in postmenopausal women with osteoporosis: a population-based cohort study in South Korea
ConclusionGiven the frequent treatment interruptions across all OP medications, our findings on the factors associated with treatment interruption will serve to implement targeted interventions in reinforcing persistence to OP treatment. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 23, 2021 Category: Orthopaedics Source Type: research

PGC-1: a key regulator in bone homeostasis
AbstractPeroxisome proliferator-activated receptor- γ coactivator-1 (PGC-1) is an inducible co-regulator of nuclear receptors and is involved in a wide variety of biological responses. As the master regulators of mitochondrial biogenesis and function, PGC-1α and PGC-1β have been reported to play key roles in bone metabolism. They can be rapidly in duced under conditions of increased metabolic activities, such as osteoblastogenesis and osteoclastogenesis, to fulfill greater energy demand or facilitate other biochemical reactions. PGC-1α and PGC-1β have both overlapping and distinct functions with...
Source: Journal of Bone and Mineral Metabolism - August 23, 2021 Category: Orthopaedics Source Type: research

Impacts of hydroxyvitamin D deficiency on impaired balance function and muscle weakness in young adults
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 23, 2021 Category: Orthopaedics Source Type: research

Equivalent values between anterior vertebral height, wedge ratio, and wedge angle in osteoporotic vertebral fractures
ConclusionThe equivalent values for V-mobility presented as Ha, WR, and WA were obtained. The mean WR and WA values equivalent to Ha of 1.0  mm in grade 1–3 vertebrae were 3.5% and 1.5°, respectively. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 22, 2021 Category: Orthopaedics Source Type: research

Association of plasma neutrophil gelatinase-associated lipocalin with parameters of CKD –MBD in maintenance hemodialysis patients
AbstractIntroductionNeutrophil gelatinase-associated lipocalin (NGAL) is not only a biomarker of kidney injury but also a bone-derived factor involved in metabolism. We aimed to explore relationships between plasma NGAL and chronic kidney disease-mineral bone disorder (CKD-MBD) parameters in maintenance hemodialysis (MHD) patients.Materials and methodsFirst, a cross sectional observational study, including 105 MHD patients, was conducted to explore relationships between plasma NGAL levels and CKD –MBD parameters. Second, impact of parathyroidectomy and auto-transplantation (PTX + AT) on plasma NGAL was ...
Source: Journal of Bone and Mineral Metabolism - August 15, 2021 Category: Orthopaedics Source Type: research

Baseline renal dysfunction determines mortality following parathyroidectomy in primary hyperparathyroidism: analysis of Indian PHPT registry
ConclusionsNonsurvivors in PHPT had greater prevalence and more severe baseline renal dysfunction than survivors. Survival after parathyroidectomy was significantly associated with estimated glomerular filtration rate at baseline. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 15, 2021 Category: Orthopaedics Source Type: research

Performance evaluation of the new chemiluminescent intact FGF23 assay relative to the existing assay system
This study assessed the performance of a new fully automated immunoassay for fibroblast growth factor (FGF) 23 (Determinar CL FGF23 CL) among healthy individuals and those with chronic hypophosphatemia compared with the previous assay (Kainos FGF23 KI).Materials and methodsA total of 380 serum samples from healthy participants were collected to determine the reference range of FGF23 levels with CL. A total of 200 serum samples from 22 hypophosphatemic patients were collected simultaneously to compare the difference in FGF23 levels between CL and KI. The Mann –WhitneyU test and linear regression analysis were adopted ...
Source: Journal of Bone and Mineral Metabolism - August 5, 2021 Category: Orthopaedics Source Type: research

USF2 reduces BMP3 expression via transcriptional activation of miR-34a, thus promoting osteogenic differentiation of BMSCs
ConclusionTaken together, USF2 enhanced osteogenic differentiation of BMSCs via downregulating BMP3 by interacting with miR-34a promoter. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 4, 2021 Category: Orthopaedics Source Type: research

Novel microbiota-related gene set enrichment analysis identified osteoporosis associated gut microbiota from autoimmune diseases
AbstractIntroductionGut microbiota is now considered to be a hidden organ that interacts bidirectionally with cellular responses in numerous organs belonged to the immune, bone, and nervous systems. Here, we aimed to investigate the relationships between gut microbiota and complex diseases by utilizing multiple publicly available genome-wide association.Materials and methodsWe applied a novel microbiota-related gene set enrichment analysis approach to detect the associations between gut microbiota and complex diseases by processing genome-wide association studies (GWASs) data sets of six autoimmune diseases (including celi...
Source: Journal of Bone and Mineral Metabolism - August 2, 2021 Category: Orthopaedics Source Type: research

The relationship between serum hydroxyvitamin D levels and fall risks in young adults
AbstractIntroductionSerum hydroxyvitamin D [25(OH)D] has a role in several aspects of physical performance. Our aim was to determine the possible association between serum 25(OH)D deficiency on the fall risk in young adults by using an objective computerized technique.Materials and methodsThis cross-sectional study included 80 adults aged 18 –40 years with 25(OH)D deficiency and 40 age-matched controls. The participants were devided into three groups according to serum 25(OH)D levels: Group 1; deficient, Group 2; insufficient and Group 3; sufficient (serum 25(OH)D level
Source: Journal of Bone and Mineral Metabolism - July 29, 2021 Category: Orthopaedics Source Type: research

Efficacy of romosozumab in patients with osteoporosis on maintenance hemodialysis in Japan; an observational study
ConclusionsBMD was increased significantly during romosozumab treatment at the lumbar spine, and the femoral neck, respectively, at 1  year in HD patients. Hypocalcemia occurred but without any intolerable event. There was no apparent increase in CVD events during 1 year of study, suggesting romosozumab as a promising agent for HD patients with severe osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 29, 2021 Category: Orthopaedics Source Type: research

Replacing sedentary time for physical activity on bone density in patients with chronic kidney disease
ConclusionThese results suggest that a small increase in MVPA time (e.g., 10  min/day) may attenuate the decline in bone density in patients with CKD. Our findings may provide insight for the development of novel strategies for improving bone health in patients with CKD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 28, 2021 Category: Orthopaedics Source Type: research

Quantitative investigation of the effect of surgically induced hypoparathyroidism on cataract development
ConclusionThe clarity of the crystalline lens may decrease in surgically induced hypoparathyroidism patients depending on the disease duration and PTH levels. Additionally, this study detected an increased frequency of blue-dot-like cataract in the patient group, which may be due to the effect of hypoparathyroidism. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 27, 2021 Category: Orthopaedics Source Type: research

Assessment of bone repair in animal models with suppressed osteoclast function by pretreatment of bisphosphonates
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 21, 2021 Category: Orthopaedics Source Type: research

Lower trabecular bone score is associated with an increased incidence of localized femoral periosteal thickening
ConclusionsThe TBS was lower in glucocorticoid-treated Japanese women with autoimmune diseases with LPT than in those without LPT, and deteriorated trabecular microarchitecture influenced by longer use of BP and glucocorticoid might be associated with the development of LPT. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 20, 2021 Category: Orthopaedics Source Type: research

Clinical performance of a novel chemiluminescent enzyme immunoassay for FGF23
ConclusionThe novel FGF23 assay tested in this study is useful for the differential diagnosis of hypophosphatemic rickets/osteomalacia in a clinical setting. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 13, 2021 Category: Orthopaedics Source Type: research

Recent advances in the epigenetics of bone metabolism
AbstractOsteoporosis is a common form of metabolic bone disease that is costly to treat and is primarily diagnosed on the basis of bone mineral density. As the influences of genetic lesions and environmental factors are increasingly studied in the pathological development of osteoporosis, regulated epigenetics are emerging as the important pathogenesis mechanisms in osteoporosis. Recently, osteoporosis genome-wide association studies and multi-omics technologies have revealed that susceptibility loci and the misregulation of epigenetic modifiers are key factors in osteoporosis. Over the past decade, extensive studies have ...
Source: Journal of Bone and Mineral Metabolism - July 11, 2021 Category: Orthopaedics Source Type: research

Anti-RANKL monoclonal antibody and bortezomib prevent mechanical unloading-induced bone loss
ConclusionsWe demonstrated for the first time that anti-RANKL antibody and Bzb had a positive effect on preventing mechanical unloading-induced bone loss. This finding puts forward the potential use of anti-RANKL and Bzb on bone loss therapies or prophylaxis of astronauts in spaceflight. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 1, 2021 Category: Orthopaedics Source Type: research

Elevated red blood cell distribution width is associated with poor outcome in osteoporotic vertebral fracture
ConclusionElevated RDW was associated with the poor clinical outcomes of conservative treatment of an OVF, independent of osteoporosis or severity of the OVF. RDW provides prognostic information for risk stratification as a senescence biomarker. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 1, 2021 Category: Orthopaedics Source Type: research

Adjuvant endocrine therapy effects on bone mineral density and microstructure in women with breast cancer
In this study, we evaluated changes in the bone mineral density (BMD) and bone microstructure associated with AI treatment using high-resolution peripheral quantitative computed tomography (HR-pQCT) in patients with early breast cancer.Materials and methodsThis prospective, single-arm, observational study included non-osteoporotic, postmenopausal women with hormone receptor-positive breast cancer. Patients underwent dual-energy X-ray absorptiometry (DXA), HR-pQCT, and tartrate-resistant acid phosphatase-5b (TRACP-5b) or procollagen type-I N-terminal propeptide measurements at baseline and 6 and 12  months after AI the...
Source: Journal of Bone and Mineral Metabolism - June 30, 2021 Category: Orthopaedics Source Type: research

6-Shogaol promotes bone resorption and accelerates orthodontic tooth movement through the JNK-NFATc1 signaling axis
In conclusion, our results suggest that 6-shogoal accelerates tooth movement by inducing osteopenia by a mechanism similar to surgically induced bone injury. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 30, 2021 Category: Orthopaedics Source Type: research