Toshitsugu Sugimoto, MD, PhD
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 24, 2021 Category: Orthopaedics Source Type: research

Family caregiver burden of patients with osteoporotic fracture in Japan
ConclusionThe substantial humanistic and financial burden of caregiving by family members to osteoporotic fracture patients should be considered when evaluating the impact of fragility fractures, disease management and support systems for osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 17, 2021 Category: Orthopaedics Source Type: research

LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF- β/SMAD4 signaling
ConclusionsOur results demonstrate LncRNA PVT1 is involved in cartilage degradation in diabetic OA and correlated with disease severity. Efficiency of ad-siRNA-PVT1 in controlling joint inflammation in diabetic OA mice is associated with the suppression of the expression of miR-146a, pro-inflammatory cytokines and activation of TGF- β/SMAD4 pathway. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

Plasma periostin as a biomarker of osteoporosis in postmenopausal women with type 2 diabetes
This study aimed to investigate the correlation between periostin levels and bone mineral density as well as bone turnover markers in postmenopausal women with type 2 diabetes (T2DM).Materials and methodsThis study was a cross-sectional study that included 164 postmenopausal women with T2DM as study subjects and 32 age-matched nondiabetic postmenopausal women with normal bone mineral density (BMD) as healthy control subjects. A total of 164 subjects with T2DM were then divided into three groups according to BMD: the normal BMD group (n = 29), the osteopenia group (n = 70), and the osteoporosis g...
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

The potential role of lncRNAs in osteoporosis
AbstractOsteoporosis is a common bone disease characterized by low bone mass and deterioration of bone microstructure, which predisposes to higher risks of bone fragility and bone fracture. Long non-coding RNAs (lncRNAs) are a class of RNAs with a length of  >  200 nucleotides without protein-coding function, which control the expression of genes and affect multiple biological processes. Accumulating evidence suggests that lncRNAs are widely involved in the molecular mechanisms of osteoporosis. This review aims to summarize the function and underlying m echanism of lncRNAs involved in the development of os...
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

Role of irisin in effects of chronic exercise on muscle and bone in ovariectomized mice
ConclusionsWe demonstrated that chronic exercise elevated irisin expression in the gastrocnemius and soleus muscles of estrogen-deficient mice. Irisin might be related to increases in trabecular BMD in mice; however, further studies are needed to clarify the involvement of irisin in the effects of chronic exercise on muscle/bone interactions. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

Effects of iguratimod on glucocorticoid-induced disorder of bone metabolism in vitro
ConclusionThese results suggest that IGU may improve glucocorticoid-induced disorder of bone metabolism and may exhibit positive effects against GIOP associated with RA. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 9, 2021 Category: Orthopaedics Source Type: research

Retraction Note to: Effect of alendronate on bone mineral density and bone turnovermarkers in post-gastrectomy osteoporotic patients
This article has been retracted. Please see the Retraction Notice for more detail:https://doi.org/10.1007/s00774-021-1209-0 (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - February 6, 2021 Category: Orthopaedics Source Type: research

Correction to: Discovery of the RANKL/RANK/OPG system
In the original publication of the article, reference 12 was published incorrectly as follows. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 13, 2021 Category: Orthopaedics Source Type: research

Physiologic and Pathologic role of RANKL : beyond the skeletal system
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 13, 2021 Category: Orthopaedics Source Type: research

Regulation of T cell-associated tissues and T cell activation by RANKL-RANK-OPG
Abstract The receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK-osteoprotegerin (OPG) system is critical to bone homeostasis, but genetically deficient mouse models have revealed important roles in the immune system as well. RANKL-RANK-OPG is particularly important to T cell biology because of its organogenic control of thymic development and secondary lymphoid tissues influence central T cell tolerance and peripheral T cell function. RANKL-RANK-OPG cytokine-receptor interactions are often controlled by regulation of expression of RANKL on developing T cells, which interacts with RANK expressed on some lymp...
Source: Journal of Bone and Mineral Metabolism - January 12, 2021 Category: Orthopaedics Source Type: research

On challenges in clinical assessment of hip fracture risk using image-based biomechanical modelling: a critical review
ConclusionsA number of critical issues and gaps were identified. Strategies for effectively addressing the issues were discussed. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 9, 2021 Category: Orthopaedics Source Type: research

Oral risk factors associated with medication-related osteonecrosis of the jaw in patients with cancer
AbstractIntroductionBone-modifying agents (BMAs) are indispensable to cancer therapy. However, the number of patients with medication-related osteonecrosis of the jaw (MRONJ) is increasing according to the BMA administration. Oral factors predisposing to development of MRONJ are receiving attention, and oral management is recommended for prevention of MRONJ; however, the strategy and criteria have not yet been established. Therefore, we investigated the oral risk factors associated with MRONJ development in this study.Materials and MethodsA  retrospective study was carried out on 398 cancer patients who had recei...
Source: Journal of Bone and Mineral Metabolism - January 8, 2021 Category: Orthopaedics Source Type: research

Aging and direct medical costs of osteoporotic fractures
This study estimated the direct medical costs of osteoporotic fractures from a large claims database in Korea.Materials and methodsWe compared the medical costs of hip, vertebral, and wrist fractures between two age groups (50 –64 years vs 65 years and older). We used a generalized linear model to investigate the drivers of osteoporotic fracture medical costs.ResultsHip fractures had the highest costs, regardless of age, followed by vertebral and wrist. The cost of hip fracture was USD 7285 for those aged 65  years and over and USD 6589 for those aged 50–64 years. The length of hospital days...
Source: Journal of Bone and Mineral Metabolism - January 8, 2021 Category: Orthopaedics Source Type: research

Blood lipid levels in patients with osteopenia and osteoporosis:a systematic review and meta-analysis
ConclusionHDL-C was elevated in patients with OP. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 8, 2021 Category: Orthopaedics Source Type: research

Hypophosphatasia: is it an underdiagnosed disease even by expert physicians?
DiscussionConsidering the wide spectrum of clinical signs and symptoms, HPP should be among the differential lists of bone, muscle, and tooth abnormalities at any age. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 6, 2021 Category: Orthopaedics Source Type: research

Reduction in parathyroid adenomas by cinacalcet therapy in patients with primary hyperparathyroidism
ConclusionThe present study revealed that cinacalcet treatment reduces the size of parathyroid adenomas in patients with PHPT. The accumulation of more PHPT cases with cinacalcet therapy is required to confirm this finding. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 6, 2021 Category: Orthopaedics Source Type: research

Bone microarchitectural alterations in boys with Duchenne muscular dystrophy on long-term glucocorticoid treatment
ConclusionLower microarchitectural measurement of trabecular bones, but higher cortical vBMD, was observed in DMD boys on long-term oral glucocorticoid. The results from this study provide preliminary, yet important insights into the bone microarchitecture of this group of patients. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 5, 2021 Category: Orthopaedics Source Type: research

Insufficient persistence of and adherence to osteoporosis pharmacotherapy in Japan
AbstractIntroductionOnly a few large-scale studies have examined the care gap in Japan. The aim of this study was to investigate the persistence of and adherence to osteoporosis pharmacotherapy in Japan.Materials and MethodsThe rates of continuation (persistence) of and adherence to osteoporosis pharmacotherapy were investigated using medical insurance data, issued from July 2013 to December 2018, from the medical care system for elderly individuals in Hokkaido, Japan.ResultsThe study included 7918 male and 52,585 female patients. Persistence rates were 62.1% in the first year and 45.3% in the second year. There were 33,09...
Source: Journal of Bone and Mineral Metabolism - January 5, 2021 Category: Orthopaedics Source Type: research

Teriparatide and exercise improve bone, skeletal muscle, and fat parameters in ovariectomized and tail-suspended rats
ConclusionTPTD or treadmill exercise improved bone, skeletal muscle, and fat mass. Combination therapy with TPTD and exercise had synergistic effects on BMD, structure, and bone strength in ovariectomized, tail-suspended rats. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 3, 2021 Category: Orthopaedics Source Type: research

Twice-weekly teriparatide improves lumbar spine BMD independent of pre-treatment BMD and bone turnover marker levels
Conclusion2/W-TPTD, just like 1/W-TPTD, improved LS-BMD significantly, regardless of baseline LS-BMD and bone turnover marker levels. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 3, 2021 Category: Orthopaedics Source Type: research

Discovery of the RANKL/RANK/OPG system
AbstractAlmost a quarter century has passed since discovery of receptor activator of NF- κB ligand (RANKL). This discovery had a major impact on identification of mechanisms regulating osteoclast differentiation and function, establishment of a research field bridging bone and the immune system (osteoimmunology), and development of a fully human anti-RANKL neutralizing antibody (denosu mab). Denosumab is now clinically available for treatment of osteoporosis and cancer-induced bone diseases in the US, Europe and many other countries, including Japan. Denosumab is a so-called blockbuster drug, with sales of 5.0 billio...
Source: Journal of Bone and Mineral Metabolism - January 3, 2021 Category: Orthopaedics Source Type: research

Association between movement control during one-leg standing and femoral BMD in patients with hip fractures
ConclusionOur results suggest that improving movement control during one-leg standing may be important for maintaining and improving femoral BMD on the non-fractured side. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 2, 2021 Category: Orthopaedics Source Type: research

Long-term safety and effectiveness of denosumab in Japanese patients with osteoporosis: 3-year post-marketing surveillance study
This study aimed to investigate the long-term safety and effectiveness of denosumab in Japanese patients with osteoporosis in daily clinical practice.Materials and methodsThis 3-year, prospective, observational, post-marketing study included patients who initiated treatment with denosumab (60  mg/6 months) for osteoporosis. Data were assessed at baseline, 3, 6, 12, 24 and 36 months. Key endpoints were adverse events (AEs), adverse drug reactions (ADRs), occurrence of osteoporotic fractures, bone mineral density (BMD), and bone turnover markers. Multivariate analyses were conducted to identify predictors of h...
Source: Journal of Bone and Mineral Metabolism - January 2, 2021 Category: Orthopaedics Source Type: research

Two-year changes of bone mineral density in steroid-treated myasthenia gravis
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 2, 2021 Category: Orthopaedics Source Type: research

Performance of the Nottingham Hip Fracture Score and Clinical Frailty Scale as predictors of short and long-term outcomes: a dual-centre 3-year observational study of hip fracture patients
ConclusionBoth CFS and NHFS predict 1-year survival with similar, moderate discrimination. Future research could explore whether other factors could be combined to allow better risk stratification following a hip fracture to inform patients and clinicians. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 2, 2021 Category: Orthopaedics Source Type: research

Role of RANKL in cancer development and metastasis
AbstractBone metastasis involves tumor-induced osteoclast activation, resulting in skeletal tumor progression as well as skeletal disorders. Aberrant expression of receptor activator of NF- κB ligand (RANKL), an essential cytokine for osteoclast differentiation, induced by the metastatic tumor cells is responsible for the pathological bone resorption in bone metastasis. A fully human anti-RANKL neutralizing antibody has been developed to block osteoclast activation and is now used for the treatment of patients with bone metastasis and multiple myeloma. On the other hand, numerous studies have revealed that the RANKL/...
Source: Journal of Bone and Mineral Metabolism - January 2, 2021 Category: Orthopaedics Source Type: research

RANKL as the master regulator of osteoclast differentiation
AbstractRANKL, the essential cue for osteoclast differentiation, is the membrane-bound factor expressed by osteoclastogenesis-supporting cells such as osteoblasts and osteocytes. In vivo evidence indicates that RANKL functions as the indispensable and irreplaceable in the program of osteoclast differentiation. The reason why RANKL plays a critical role in osteoclastogenesis is discussed from the viewpoint of the distinct signaling pathways mediated by co-stimulatory receptors and the key transcription factor NFATc1. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - January 1, 2021 Category: Orthopaedics Source Type: research

Correction to: RANKL as a therapeutic target of rheumatoid arthritis
In the original publication of the article, the title of Table was published incorrectly. The correct title should read as “Baseline patient demographics and characteristics in DESIRABLE trial. Adopted from Reference with permission”. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - December 17, 2020 Category: Orthopaedics Source Type: research

Efficacy of once-weekly teriparatide in patients with glucocorticoid-induced osteoporosis: the TOWER-GO study
AbstractIntroductionBisphosphonates are the standard treatment for glucocorticoid-induced osteoporosis (GIOP) with teriparatide being another option. While daily teriparatide has been shown to be effective in increasing bone mineral density (BMD), the efficacy of once-weekly teriparatide (56.5  µg) has not yet been evaluated. The TOWER-GO study, a 72-week, multicenter, open-label, randomized controlled trial, was conducted in patients with GIOP to compare the effects of once-weekly teriparatide and once-weekly alendronate 35 mg on BMD.Materials and methodsPatients (N = 180) with GIOP for whom ...
Source: Journal of Bone and Mineral Metabolism - November 19, 2020 Category: Orthopaedics Source Type: research

Sclerostin: from bench to bedside
AbstractSkeletal integrity is maintained by a meticulous balance between bone resorption and bone formation, and recent studies have revealed the essential role of canonical Wnt signaling pathways in maintaining skeletal homeostasis. TheSOST gene, which encodes sclerostin, a member of Dan family glycoproteins, was originally identified as the gene responsible for two sclerosing bone dysplasias, sclerosteosis and van Buchem disease. Sclerostin is highly expressed by osteocytes, negatively regulates canonical Wnt signaling pathways by binding to low-density lipoprotein receptor-related protein (LRP) 5/6, and suppresses osteo...
Source: Journal of Bone and Mineral Metabolism - November 18, 2020 Category: Orthopaedics Source Type: research

Incidence rate of vitamin D deficiency and FGF23 levels in 12- to 13-year-old adolescents in Japan
AbstractIntroductionThe incidence rate of vitamin D deficiency is increasing throughout the world. We measured the incidence rate of vitamin D deficiency and fibroblast growth factor 23 (FGF23) levels in 12- to 13-year-old adolescents in Japan.Materials and methodsA total of 492 adolescents (247 boys and 245 girls) from Japanese community enrolled in this study. 25 hydroxyvitamin D (25(OH)D) was measured with radioimmunoassay. In the subjects with low 25(OH)D levels ( ≦ 20 ng/ml), intact parathyroid hormone (iPTH), calcium (Ca), phosphorus (P), albumin (Alb), alkaline phosphatase (ALP) and FGF23 were measured...
Source: Journal of Bone and Mineral Metabolism - November 18, 2020 Category: Orthopaedics Source Type: research

Tooth extraction in mice administered zoledronate increases inflammatory cytokine levels and promotes osteonecrosis of the jaw
Conclusions Taken together, the cytokine storm induced by invasive dental treatment under bisphosphonate treatment promotes ONJ development due to elevated levels of inflammatory cytokine-producing cells. Our work identifies novel targets potentially useful to prevent ONJ. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 17, 2020 Category: Orthopaedics Source Type: research

Trends in the prevalence of underweight in women across generations in Japan
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 17, 2020 Category: Orthopaedics Source Type: research

Etelcalcetide decreases the PTH –calcium setpoint without changing maximum and minimum PTH secretion in mice with primary hyperparathyroidism
ConclusionEtelcalcetide decreased the PTH –calcium setpoint without changing maximum and minimum PTH secretion in PC mice, suggesting that like cinacalcet, etelcalcetide has calcimimetic potency. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 16, 2020 Category: Orthopaedics Source Type: research

Anti-VEGFR therapy is one of the healing inhibitors of antiresorptive-related osteonecrosis of the jaw
ConclusionIn the conservative treatment of ARONJ, the administration of several BMAs and anti-VEGFR drugs was the factor contributing to the inhibition of healing. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 16, 2020 Category: Orthopaedics Source Type: research

Bone fracture healing: perspectives according to molecular basis
AbstractFractures have a great impact on health all around the world and with fracture healing optimization; this problem could be resolved partially. To make a practical contribution to this issue, the knowledge of bone tissue, cellularity, and metabolism is essential, especially cytoskeletal architecture and its transformations according to external pressures. Special physical and chemical characteristics of the extracellular matrix (ECM) allow the transmission of mechanical stimuli from outside the cell to the plasmatic membrane. The osteocyte cytoskeleton is conformed by a complex network of actin and microtubules comb...
Source: Journal of Bone and Mineral Metabolism - November 5, 2020 Category: Orthopaedics Source Type: research

Evaluation of aortic calcification using a three-dimensional volume-rendering method in patients with end-stage kidney disease
ConclusionThis study using a 3D visualization and quantification method demonstrated that AC was more severe and occurred more frequently in the abdominal aorta in ESKD patients with DM compared to those without DM. This method would enable us to precisely evaluate the volume and distribution of AC. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - November 3, 2020 Category: Orthopaedics Source Type: research

List of reviewers 2019 –2020
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 31, 2020 Category: Orthopaedics Source Type: research

Journal of Bone and Mineral Metabolism Best Paper Award 2020
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 30, 2020 Category: Orthopaedics Source Type: research

Novel method for gain-of-function analyses in primary osteoclasts using a non-viral gene delivery system
ConclusionRNA-mediated gene delivery is quick and easy method for performing gain-of-function analyses in primary osteoclast precursors and mature osteoclasts. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 27, 2020 Category: Orthopaedics Source Type: research

Osteoclast differentiation by RANKL and OPG signaling pathways
ConclusionsBone mass loss depends on the RANK –RANKL–OPG system, which is a major regulatory system of osteoclast differentiation induction, activation, and survival. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 20, 2020 Category: Orthopaedics Source Type: research

SDF-1 mediates mesenchymal stem cell recruitment and migration via the SDF-1/CXCR4 axis in bone defect
ConclusionsCollectively, our study speculated that up-regulation of SDF-1 promotes the mobilization and migration of MSCs through the activation of the SDF-1/CXCR4 signal pathway. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 20, 2020 Category: Orthopaedics Source Type: research

CircRNA TGFBR2/MiR-25-3p/TWIST1 axis regulates osteoblast differentiation of human aortic valve interstitial cells
ConclusionThe findings indicated that TGFBR2/miR-25-3p/TWIST1 axis regulates osteoblast differentiation in VICs, supporting the fact that TGFBR2 is a miRNA sponge in CAVD. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 18, 2020 Category: Orthopaedics Source Type: research

RANKL as a therapeutic target of rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is an inflammatory disorder characterized by progressive joint destruction. Recent studies have demonstrated that osteoclasts are responsible for bone destruction in RA. Receptor activator of nuclear factor kappa B ligand (RANKL), an osteoclast differentiation factor, belongs to the tumor necrosis factor superfamily and plays a critical role in osteoclast differentiation. RANKL is highly expressed in the synovial tissues in patients with RA and is involved in osteoclast development and thus bone destruction in RA. Denosumab, a specific antibody to human RANKL, efficiently suppressed the pr...
Source: Journal of Bone and Mineral Metabolism - October 18, 2020 Category: Orthopaedics Source Type: research

RANKL and osteoimmunology in periodontitis
AbstractPeriodontitis, one of the most common infectious diseases in humans, is characterized by inflammation of the periodontal tissue and subsequent destruction of the alveolar bone, which ultimately leads to tooth loss. Recently, it was revealed that the osteoclastic bone damage that occurs during periodontitis is dependent on the receptor activator of NF-kB ligand (RANKL) produced by osteoblastic cells and periodontal ligament cells. Immune cells provide essential cues for the RANKL induction that takes place during periodontal inflammation. The knowledge accumulated and experimental tools established in the field of &...
Source: Journal of Bone and Mineral Metabolism - October 17, 2020 Category: Orthopaedics Source Type: research

Clinical and genetic analysis in 185 Chinese probands of osteogenesis imperfecta
AbstractIntroductionOsteogenesis imperfecta (OI) is a well-known heritable disorder of connective tissue characterized by skeletal fragility and low bone mass. Nearly 90% of patients with OI have disease variants inCOL1A1 andCOL1A2 that encode for the α1 and α2 chains of type I collagen.Materials and methodsA retrospective analysis of 185 probands who were diagnosed with OI in Shanghai Jiao Tong University Affiliated Sixth People ’s Hospital from March 2005 to December 2019 was performed.ResultsA total of 140 mutations inCOL1A1 and 45 mutations inCOL1A2 were identified, of which 18 variations were novel. ...
Source: Journal of Bone and Mineral Metabolism - October 17, 2020 Category: Orthopaedics Source Type: research

RANKL as a target for the treatment of osteoporosis
AbstractOsteoporosis is characterized by compromised bone strength, predisposing to an increased risk of fracture. Because bone is constantly remodeled, and bone mass and structure are determined by the balance between bone resorption and bone formation, it is important to maintain normal bone turnover. Therefore, therapies that reduce bone resorption have been the mainstream of osteoporosis treatment. Receptor activator of nuclear factor-kappa B ligand (RANKL)-RANK signaling was found to play a pivotal role in the regulation of osteoclastic bone resorption, and inhibition of RANKL-RANK system has become an important thera...
Source: Journal of Bone and Mineral Metabolism - October 15, 2020 Category: Orthopaedics Source Type: research

Romosozumab followed by denosumab in Japanese women with high fracture risk in the FRAME trial
AbstractIntroductionThis post-hoc analysis of the FRAME study investigated the long-term efficacy and safety of romosozumab followed by denosumab in postmenopausal Japanese women with osteoporosis at high fracture risk.Materials and methodsData from Japanese women with a high fracture risk participating in the international, randomised, double-blind, placebo-controlled, phase 3 FRAME study were analysed. High risk of fracture was defined as  ≥ 1 fragility fracture with bone mineral density (BMD) ≤ − 2.5 standard deviations [SD], >  2 prevalent vertebral fractu...
Source: Journal of Bone and Mineral Metabolism - October 15, 2020 Category: Orthopaedics Source Type: research

Repercussions of osteoporosis on the maxillofacial complex: a critical overview
ConclusionEven though orofacial bones are not compromised by osteoporosis as much as the axial/appendicular skeleton, a regular dental follow-up of osteoporotic patients is advised, especially in the case of periodontal disease and maxillofacial surgery. Further controlled longitudinal studies considering the site-specificity of osteogenesis would be helpful regarding this issue. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - October 13, 2020 Category: Orthopaedics Source Type: research