Genetic disorders associated with the RANKL/OPG/RANK pathway
AbstractThe RANKL/OPG/RANK signalling pathway is a major regulatory system for osteoclast formation and activity. Mutations inTNFSF11,TNFRSF11B andTNFRSF11A cause defects in bone metabolism and development, thereby leading to skeletal disorders with changes in bone density and/or morphology. To date, nine kinds of monogenic skeletal diseases have been found to be causally associated withTNFSF11,TNFRSF11B andTNFRSF11A mutations. These diseases can be divided into two types according to the mutation effects and the resultant pathogenesis. One is caused by the mutations inducing constitutional RANK activation or OPG deficienc...
Source: Journal of Bone and Mineral Metabolism - September 17, 2020 Category: Orthopaedics Source Type: research

Relationship between parathyroid hormone and renin –angiotensin–aldosterone system in hemodialysis patients with secondary hyperparathyroidism
AbstractIntroductionHyperparathyroidism (HPT) is associated with mortality and cardiovascular disease (CVD) in dialysis patients. However, its mechanism is still unclear. It is suspected that parathyroid hormone (PTH) is associated with the renin –angiotensin–aldosterone system (RAAS) as a possible mechanism. Thus, we examined their hormonal interaction in hemodialysis patients with secondary HPT.Materials and methodsSeventeen hemodialysis patients with HPT were included. All patients underwent total parathyroidectomy (PTx). Serum intact PTH (iPTH), calcium and phosphate levels, plasma renin activity (PRA), and...
Source: Journal of Bone and Mineral Metabolism - September 12, 2020 Category: Orthopaedics Source Type: research

Progressive rise in the prevalence of asymptomatic primary hyperparathyroidism in India: Data from PHPT registry
AbstractIntroductionPrimary hyperparathyroidism (PHPT), a third common endocrine disorder,  varies from asymptomatic disease, mostly seen in the West where routine biochemical screening is practiced, to the classical symptomatic disease mostly seen in the Eastern countries. We aimed to compare the demographic, clinical, biochemical measurements in patients with asymptomatic and symptomat ic PHPT from the Indian PHPT registry.Material and methodsData of PHPT patients from the last 25  years (1995–2019) were analyzed for demographic, clinical presentation and biochemical measurements, and compared these chara...
Source: Journal of Bone and Mineral Metabolism - September 7, 2020 Category: Orthopaedics Source Type: research

Executive summary of clinical practice guide on fracture risk in lifestyle diseases
AbstractAccumulating evidence has shown that patients with lifestyle diseases such as type 2 diabetes mellitus, chronic kidney disease, and chronic obstructive pulmonary disease are at increased risk of osteoporotic fracture. Fractures deteriorate quality of life, activities of daily living, and mortality as well as a lifestyle disease. Therefore, preventing fracture is an important issue for those patients. Although the mechanism of the lifestyle diseases-induced bone fragility is still unclear, not only bone mineral density (BMD) reduction but also bone quality deterioration are involved in it. Because fracture predictiv...
Source: Journal of Bone and Mineral Metabolism - September 5, 2020 Category: Orthopaedics Source Type: research

Hand grip strength in predicting the risk of osteoporosis in Asian adults
ConclusionThe measurement of hand grip strength is a simple, cost-effective and an easy assessment method for identifying individuals at a  high risk of osteoporosis. The cutoff strength for evaluating osteoporosis in adults is age and sex specific. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 5, 2020 Category: Orthopaedics Source Type: research

Jabuticaba peel extract modulates adipocyte and osteoblast differentiation of MSCs from healthy and osteoporotic rats
ConclusionOur results demonstrated that JPE drives MSCs to inhibit adipocyte differentiation and toward osteoblast differentiation under healthy and osteoporotic conditions. These findings pave the way for further translational studies to investigate the therapeutic possibilities of JPE in both prevention and treatment of osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 5, 2020 Category: Orthopaedics Source Type: research

The regulation of RANKL by mechanical force
AbstractReceptor activator of nuclear factor- κB ligand (RANKL) is a key mediator of osteoclast differentiation and bone resorption. Osteoblast-lineage cells including osteoblasts and osteocytes express RANKL, which is regulated by several different factors, including hormones, cytokines, and mechanical forces. In vivo and in vitro analyses ha ve demonstrated that various types of mechanosensing proteins on the cell membrane (i.e. mechanosensors) and intracellular mechanosignaling proteins play essential roles in the differentiation and functions of osteoblasts, osteoclasts, and osteocytes via soluble factors, such a...
Source: Journal of Bone and Mineral Metabolism - September 5, 2020 Category: Orthopaedics Source Type: research

The effect of denosumab in breast cancer patients receiving adjuvant aromatase inhibitors: 36-month results
ConclusionTwice-yearly administration of denosumab to the breast cancer patients treated with adjuvant AI, regardless of the skeletal site, resulted in consistent increases in BMD without severe adverse events at 36  months. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 5, 2020 Category: Orthopaedics Source Type: research

The role of the RANKL/RANK/OPG system in the central nervous systems (CNS)
AbstractThe receptor-activator of NF- κB ligand (RANKL) and its specific receptor RANK have essential roles in regulating bone metabolism and the immune system. Besides, the RANKL/RANK system plays important roles in multiple physiological and pathophysiological processes such as mammary gland development during pregnancy, cancer devel opment, and bone metastasis. While it has long been known that RANKL and RANK are expressed in the central nervous system (CNS), the physiological roles of RANKL/RANK system in the CNS and the underlying molecular mechanisms have been elucidated recently. Over the last decade, several ...
Source: Journal of Bone and Mineral Metabolism - September 4, 2020 Category: Orthopaedics Source Type: research

Sparing effect of peritoneal dialysis vs hemodialysis on BMD changes and its impact on mortality
ConclusionsPD had beneficial effect compared with HD on BMD changes during first year of dialysis therapy. Better preservation of BMD, especially in bone sites rich in cortical bone, associated with lower subsequent mortality. BMD in cortical bone may have stronger association with clinical outcome than BMD in trabecular bone. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 4, 2020 Category: Orthopaedics Source Type: research

Evaluations of daily teriparatide using finite-element analysis over 12  months in rheumatoid arthritis patients
ConclusionsIncreased LS PBS at 12  months was predicted by increased PINP at 1 month from baseline. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 4, 2020 Category: Orthopaedics Source Type: research

Antiresorptive agent-related osteonecrosis of the jaw in prostate cancer patients with bone metastasis treated with bone-modifying agents
AbstractIntroductionThe incidence rate and risk factors of antiresorptive agent-related osteonecrosis of the jaw (ARONJ) in prostate cancer patients with bone metastasis are not clear.Materials and MethodsWe retrospectively reviewed patients ’ records of prostate cancer patients with bone metastasis who were treated with zoledronic acid or denosumab between 1/Dec/2008 and 31/Mar/2019. ARONJ-free survival rate was analyzed with Kaplan–Meier analysis, and risk factors for ARONJ were analyzed with Cox proportional hazard model.ResultsWe identified 124 and 67 patients treated with zoledronic acid and denosumab, res...
Source: Journal of Bone and Mineral Metabolism - September 4, 2020 Category: Orthopaedics Source Type: research

Sclerostin, preadipocyte factor-1 and bone mineral values in eumenorrheic adolescent athletes with different training patterns
This study included 62 eumenorrheic adolescents (RG  = 22; SW = 20; UC = 20). Bone mineral and body composition characteristics were measured by dual-energy X-ray absorptiometry, and sclerostin, Pref-1, osteocalcin and C-terminal telopeptide of type I collagen (CTx) were measured.ResultsSclerostin was higher (P = 0.001) in RG (129.35 ± 51.01 pg/ml; by 74%) and SW (118.05 ± 40.05 pg/ml; by 59%) in comparison with UC (74.32 ± 45.41 pg/ml), while no differences (P = 0.896) were se...
Source: Journal of Bone and Mineral Metabolism - September 2, 2020 Category: Orthopaedics Source Type: research

Changes of bone turnover markers after elderly hip fracture surgery
ConclusionsBTMs reached the peak level in 30 –60 days after surgery, P1NP showed less than 4 times elevation, and CTX and OC had less than 2 times rise. It was not necessary to take gender into account when observing P1NP, and it was not necessary to take fracture and operation type into account when observing CTX and OC. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - September 2, 2020 Category: Orthopaedics Source Type: research

Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading
ConclusionsOur results showed that even short-term mechanical unloading is enough to decrease bone density, and mechanical unloading not only regulated the Scl expression but also changed the Scl distribution in both the osteocyte network and subcellular structures. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 25, 2020 Category: Orthopaedics Source Type: research

Intrafamilial phenotypic distinction of hypophosphatasia with identical tissue nonspecific alkaline phosphatase gene mutation: a family report
In this report, we present a family with HPP mother (case 1) and HPP child (case 2) who have identical TNSALP gene mutation (c.1015G>A p.Gly339Arg heterozygous mutation) but distinct clinical phenotypes. Whereas case 1 appeared to be asymptomatic despite extremely low levels of serum ALP, case 2 had several HPP-related symptoms, such as tooth loss, fractures, short stature, with slightly decreased ALP levels. Upon the diagnosis of HPP, case 1 discontinued denosumab, which was used to treat her rheumatoid arthritis, concerning the risk of atypical femoral fractures. The clinical course of this family was suggestive in a ...
Source: Journal of Bone and Mineral Metabolism - August 8, 2020 Category: Orthopaedics Source Type: research

Pulp chamber features, prevalence of abscesses, disease severity, and PHEX mutation in X-linked hypophosphatemic rickets
ConclusionEnlarged pulp chambers with altered shape and morphology affected the majority of XLH patients predisposing to recurrent periapical abscesses with fistulae. Dental phenotype was associated with severity of rickets, high serum PTH, and low serum 1,25(OH)2D levels. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 8, 2020 Category: Orthopaedics Source Type: research

Long non-coding RNA PCAT-1 regulates apoptosis of chondrocytes in osteoarthritis by sponging miR-27b-3p
ConclusionsBased on the comparisons and analysis, we could conclude that lncRNA PCAT-1 regulated the apoptosis of chondrocytes through sponging miR-27b-3p in OA. PCAT-1 has potential values to act as a new therapeutic target for OA patients. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 8, 2020 Category: Orthopaedics Source Type: research

Post-surgery cholecystectomy, hepatectomy, and pancreatectomy patients increase the risk of osteoporotic vertebral fracture
ConclusionsPatients post cholecystectomy, hepatectomy, or pancreatectomy significantly increased risk of developing osteoporotic fracture, suggesting closer attention in post-operative care is needed. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - August 5, 2020 Category: Orthopaedics Source Type: research

Role of matrix vesicles and crystal ghosts in bio-mineralization
AbstractMatrix vesicles (MVs) are extracellular membrane-bound vesicles of about  ~ 50–200 nm in diameter that play a role in the bio-mineralization process of hard tissue formation. The present review is based on the empirical phenomenon of primary mineralization process via matrix vesicle-mediated mechanism with special reference to crystal ghosts as well as the mechani sm on the organic–inorganic relationship between matrix vesicles and crystal ghosts, and the transformation that these structures undergo during bio-mineralization. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 31, 2020 Category: Orthopaedics Source Type: research

Role of the renin –angiotensin–aldosterone system in bone metabolism
This article reviews the effects of RAAS and RAAS inhibitors on bone metabolism and provides new ideas for the prevention of osteoporosis. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 30, 2020 Category: Orthopaedics Source Type: research

Osteoporosis and the risk of temporomandibular disorder in chronic obstructive pulmonary disease
AbstractIntroductionChronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality worldwide. The coexistence of COPD and temporomandibular disorder (TMD) has been noted, and dysfunctional mastication resulting from TMD can worsen individuals ’ nutritional status. This association between COPD and TMD has been rarely discussed in previous studies. Therefore, this study aimed to determine whether osteoporosis increases the risk of TMD in COPD and whether anti-osteoporosis medications can prevent TMD.Materials and methodsThis retrospective nationwide population-based study utilized the...
Source: Journal of Bone and Mineral Metabolism - July 28, 2020 Category: Orthopaedics Source Type: research

Protective role of osteocalcin in diabetes pathogenesis
AbstractIn diabetes, metabolic, inflammatory, and stress-associated alterations conduce to ß-cell failure and tissue damage. Osteocalcin is a bone protein with several endocrine functions in different tissues. In this review, we gathered scientific evidence of how osteocalcin could modulate functional disorders that are altered in diabetes in an integrative way. We include adipose tissue , pancreatic function, and oxidative stress aspects. In the first section, we focus on the role of inflammatory mediators and adiponectin in energy homeostasis and insulin sensitivity. In the following section, we discuss the effect ...
Source: Journal of Bone and Mineral Metabolism - July 28, 2020 Category: Orthopaedics Source Type: research

Assessment of eldecalcitol and alendronate effect on postural balance control in aged women with osteoporosis
ConclusionsThese results suggest that ELD and ALN treatments may each be beneficial to improve postural balance control in older patients with osteoporosis via different mechanisms of action. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 27, 2020 Category: Orthopaedics Source Type: research

Fracture risk assessment in an Italian group of transgender women after gender-confirming surgery
AbstractIntroductionBone health is a critical issue in transgender women (TW) health care. Conflicting results have been reported on bone status after gender-confirming surgery (GCS). No recent data in Italian TW are available.Materials and methodsThe aim of this cross-sectional study was to evaluate fracture risk, lumbar spine BMD and 25OH vitamin D (25OHD) levels in a population of TW on estrogen replacement therapy (ERT) after GCS. We retrospectively analyzed a group of 57 TW, aged 45.3  ± 11.3 years, referred to our Gender Dysphoria Clinic, at least 2 years after GCS. Anthropometric param...
Source: Journal of Bone and Mineral Metabolism - July 20, 2020 Category: Orthopaedics Source Type: research

Association between handgrip strength and subsequent vertebral-fracture risk following percutaneous vertebral augmentation
AbstractIntroductionThe aim of this study was to investigate the association between handgrip strength (HGS) and the risk of subsequent vertebral fracture (SVF) after percutaneous vertebral augmentation (PVA).Materials and methodsA total of 340 patients aged over 50  years with osteoporotic vertebral fracture were enrolled in this 3-year follow-up investigation. HGS was measured with a hand-held dynamometer before PVA. Female patients and male patients were grouped using the HGS threshold recommended by the Asian Working Group for Sarcopenia (AWGS). Kaplan–M eier analysis was used to evaluate SVF-free survival. ...
Source: Journal of Bone and Mineral Metabolism - July 20, 2020 Category: Orthopaedics Source Type: research

Risk factors for subsequent vertebral fractures following a previous hip fracture
AbstractIntroductionThe purpose of our study was to evaluate the incidence and to identify risk factors of subsequent vertebral fractures after hip fractures, and to determine whether the subsequent vertebral fracture increases the mortality rate of elderly hip fracture patients.Materials and methodsFrom January 2009 to July 2016, 1,554 patients were diagnosed as having a hip fracture and were treated surgically at our institution. Among them, 1121 patients age  >  50 years at the time of injury and were followed up for 1 year or longer after the hip fracture surgery. In these patients, radiograp...
Source: Journal of Bone and Mineral Metabolism - July 18, 2020 Category: Orthopaedics Source Type: research

Efficacy of denosumab co-administered with vitamin D and Ca by baseline vitamin D status
AbstractIntroductionIn anti-osteoporosis drug trials, vitamin D and calcium (Ca) are common supplements; however, the optimal dose of each is unclear. Using data from the randomized, double-blind, placebo-controlled DIRECT trial, we assessed whether baseline serum 25-hydroxy vitamin D (25[OH]D) level influences the efficacy of denosumab co-administered with vitamin D and Ca.Materials and methodsIn this prespecified sub-analysis, subjects with primary osteoporosis who received denosumab or placebo, plus vitamin D ( ≥ 400 IU/day) and Ca (≥ 600 mg/day), were classified as 25(OH)D deficient (
Source: Journal of Bone and Mineral Metabolism - July 15, 2020 Category: Orthopaedics Source Type: research

Maternal pre-pregnancy underweight is associated with underweight and low bone mass in school-aged children
ConclusionsWe determined that pre-pregnancy underweight status was more likely to lead to an underweight status and low TBLH BMC in school-aged offspring. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 13, 2020 Category: Orthopaedics Source Type: research

High bone turnover state under osteoporotic changes induces pain-like behaviors in mild osteoarthritis model mice
ConclusionThese results indicated that a high bone turnover state under osteoporotic changes could affect the induction of pain-like behaviors in mild OA model mice. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 12, 2020 Category: Orthopaedics Source Type: research

Zoledronic acid sequential therapy could avoid disadvantages due to the discontinuation of less than 3-year denosumab treatment
ConclusionIt was suggested that sequential therapy using ZOL could suppress the decrease of BMD, and increase of BTM, if the period of Dmab administration was less than 3  years. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 12, 2020 Category: Orthopaedics Source Type: research

Association between non-Caucasian-specific ASCC1 gene polymorphism and osteoporosis and obesity in Korean postmenopausal women
AbstractIntroductionOsteoporosis is a common disorder characterized by decreased bone mineral density (BMD). Interestingly, osteoporosis and obesity have several similar features, including a genetic predisposition and a common bone marrow stem cell. With aging, the composition of bone marrow shifts to adipocytes, osteoclast activity increases, and osteoblast function declines, resulting in osteoporosis.Materials and methodsWe performed a genome-wide association study (GWAS) analysis with osteoporosis and body mass index (BMI) and did identify an association in 349 and 384 SNPs by filtering with the significantp values (p 
Source: Journal of Bone and Mineral Metabolism - July 11, 2020 Category: Orthopaedics Source Type: research

LncRNA LOXL1-AS1 controls osteogenic and adipocytic differentiation of bone marrow mesenchymal stem cells in postmenopausal osteoporosis through regulating the miR-196a-5p/Hmga2 axis
ConclusionThese findings facilitate understanding the molecular mechanism of hBMMSCs differentiation and bring up a novel sight for postmenopausal osteoporosis therapy. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - July 10, 2020 Category: Orthopaedics Source Type: research

Antiresorptive agents-related osteonecrosis of the jaw (ARONJ) in rheumatoid arthritis
(Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 26, 2020 Category: Orthopaedics Source Type: research

Effects of hypoxia environment on osteonecrosis of the femoral head in Sprague-Dawley rats
ConclusionsHypoxic environments can aggravate ONFH in SD rats; this aggravation may be related to the hypercoagulable state of the blood. We suggest that long-term hypoxia should be regarded as one of the risk factors of ONFH and we need to conduct a more extensive epidemiological investigation on the occurrence of ONFH in hypoxic populations. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 12, 2020 Category: Orthopaedics Source Type: research

Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT
ConclusionsTrabecular and cortical bone microstructure were deteriorated markedly with age. Cortical thickness decreased after menopause and was most related to bone strength. Non-metric parameters give additional information about osteoporotic changes of trabecular bone. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 9, 2020 Category: Orthopaedics Source Type: research

Correction to: Effect of RAB31 silencing on osteosarcoma cell proliferation and migration through the Hedgehog signaling pathway
In the original publication of the article, some of the pictures were misplaced in the Fig.  6 and published incorrectly. The correct Fig. 6 is provided in this version (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - June 8, 2020 Category: Orthopaedics Source Type: research

Changing face of medication-related osteonecrosis of the jaw: Sheba Medical Center experience-fifteen years
AbstractIntroductionOur aim is to track the development of the epidemiological characteristics in patient populations diagnosed with MRONJ at the Sheba Medical Center.Materials and methodsThe files of patients diagnosed with MRONJ from 2003 until December 2017 were retrieved. Data on demographics, medical background, type and duration of drug use and triggering events at presentation was collected.ResultsThe study included 448 patients, 336 females and 112 males. A decrease in the proportion of multiple myeloma patients (p 
Source: Journal of Bone and Mineral Metabolism - June 7, 2020 Category: Orthopaedics Source Type: research

Association of air pollution with osteoporotic fracture risk among women over 50  years of age
We examined the association of 2  year averaged concentrations of PM and osteoporotic fracture over 4 years. Exposure to 2-year averaged air pollution [PM2.5 (
Source: Journal of Bone and Mineral Metabolism - June 7, 2020 Category: Orthopaedics Source Type: research

Impact of diabetes mellitus simulations on bone cell behavior through in vitro models
AbstractDiabetes mellitus (DM) is related to impaired bone healing and an increased risk of bone fractures. While it is recognized that osteogenic differentiation and the function of osteoblasts are suppressed in DM, the influence of DM on osteoclasts is still unclear. Hyperglycemia and inflammatory environment are the hallmark of DM that causes dysregulation of various pro-inflammatory cytokines and alternated gene expression in periodontal ligament cells, osteoblasts, osteocytes, osteoclasts, and osteoclast precursors. A methodological review on conceptual and practical implications of in vitro study models is used for D...
Source: Journal of Bone and Mineral Metabolism - May 16, 2020 Category: Orthopaedics Source Type: research

DDR2, a discoidin domain receptor, is a marker of periosteal osteoblast and osteoblast progenitors
ConclusionDDR2 is a novel potential cell surface marker for identifying and isolating osteoblasts and osteoblast progenitors within the periosteum that can be used for musculoskeletal regenerative therapies. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 15, 2020 Category: Orthopaedics Source Type: research

Analysis of fracture healing process by HR-pQCT in patients with distal radius fracture
ConclusionIn the healing process of postoperative distal radius fractures, increased BMD at the inner surface of the fracture site was confirmed in all fractures. Bone formation on the endosteal side may be a necessary condition for bone union of distal radius fractures. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 14, 2020 Category: Orthopaedics Source Type: research

Aromatase inhibitors attenuate the effect of alendronate in women with breast cancer
ConclusionThe effect of alendronate on the LS and FN BMD was attenuated in postmenopausal women who were taking AI compared to those who were not on AI. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 13, 2020 Category: Orthopaedics Source Type: research

Association between LGR4 polymorphisms and peak bone mineral density and body composition
ConclusionIt is the first family-based association analysis to explore and demonstrate significant associations betweenLGR4 genotypes and variations of peak BMD and body composition in young Chinese men. The results are consistent with the findings that recent studies revealed, and confirm the critical relationship betweenLGR4 gene and both BMD and body composition. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 12, 2020 Category: Orthopaedics Source Type: research

Long-term excess mortality after hip fracture in hemodialysis patients: a nationwide cohort study in Japan
ConclusionExcess mortality persisted for many years after hip fracture in hemodialysis patients, and was still present after adjusting for several premorbid conditions and propensity score matching. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - May 12, 2020 Category: Orthopaedics Source Type: research

Reduction of visceral fat could be related to the improvement of TBS in diabetes mellitus
AbstractIntroductionDiabetes has been proposed as a risk factor for increased skeletal fragility. Visceral fat is known to yield adverse effects on bone metabolism in people with diabetes. We investigated the relationship between the change in visceral fat mass over time and TBS or BMD.Materials and methodsThis retrospective study enrolled 690 (male: 367; female: 323) subjects with type 2 diabetes mellitus. Visceral fat mass, lumbar and femoral neck BMD, and lumbar spine TBS were measured via dual-energy X-ray absorptiometry (DXA), including the follow-up data within a 3-year period.ResultsTBS significantly increased as vi...
Source: Journal of Bone and Mineral Metabolism - May 12, 2020 Category: Orthopaedics Source Type: research

Effects of mild hyperbaric oxygen on osteoporosis induced by hindlimb unloading in rats
ConclusionsWe conclude that exposure to mild hyperbaric oxygen partially protects from the osteoporosis induced by hindlimb unloading. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 29, 2020 Category: Orthopaedics Source Type: research

Oral administration of bovine lactoferrin accelerates the healing of fracture in ovariectomized rats
AbstractIntroductionLactoferrin has recently been reported for its potent bone growth effects. However, the effects of lactoferrin on the healing process of fragility fracture have not yet been studied, so the purpose of this study is to investigate whether oral administration of lactoferrin can promote the fracture healing in an OVX animal model.Materials and methodsThree months after bilateral ovariectomy, all rats underwent unilateral tibial osteotomy and were then randomly divided into control group and bovine lactoferrin (bLF) group. At 4 and 8 weeks post-fracture, animals were sacrificed, and the fractured tibiae and...
Source: Journal of Bone and Mineral Metabolism - April 29, 2020 Category: Orthopaedics Source Type: research

Association of osteosarcopenic obesity and its components: osteoporosis, sarcopenia and obesity with insulin resistance
ConclusionsCombinations of co-existent osteopenia, obesity, and/or sarcopenia had different associations with IR according to obesity classification methods and consideration of BMI adjustment. Osteosarcopenic obesity may not have a stronger association with IR compared to obesity only and obesity co-existent other conditions. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 25, 2020 Category: Orthopaedics Source Type: research

Marine collagen scaffolds and photobiomodulation on bone healing process in a model of calvaria defects
ConclusionIt can be concluded that the associated treatment can be considered as a promising therapeutical intervention. (Source: Journal of Bone and Mineral Metabolism)
Source: Journal of Bone and Mineral Metabolism - April 18, 2020 Category: Orthopaedics Source Type: research