Primary melanoma of the nipple: Report of 10 cases including coexistence with Paget's disease

Pathol Res Pract. 2023 Dec 22;253:155058. doi: 10.1016/j.prp.2023.155058. Online ahead of print.ABSTRACTPrimary melanoma of the nipple (PMN) is exceedingly rare, with only single cases reported to date. We identified 10 patients with PMN: 5 females, 5 males, median age 55.5 years (range 29-66) at diagnosis of melanoma in situ (4 cases) or invasive melanoma (6 cases, Breslow depth 0.2 mm to 3.5 mm). Follow-up was available for all 10 patients (median 19 months, range 1-183). Nine patients had no evidence of disease; one patient died of disease (13.5 months) after presenting with a nodal metastasis. One case was exceptional, because the patient presented with a pigmented lesion that histopathologically exhibited co-existence of melanoma in situ and Paget disease, a challenging differential diagnosis due to immunohistochemical pitfalls in distinction between melanoma in situ and the pigmented variant of mammary Paget disease. Here we report the second largest series of PMN including a case of PMN colliding with mammary Paget disease, to raise awareness of these rare malignancies.PMID:38181578 | DOI:10.1016/j.prp.2023.155058
Source: Pathology, Research and Practice - Category: Pathology Authors: Source Type: research