Characterizing perfusion defects in metastatic lymph nodes at an early stage using high-frequency ultrasound and micro-CT imaging
AbstractA perfusion defect in a metastatic lymph node (LN) can be visualized as a localized area of low contrast on contrast-enhanced CT, MRI or ultrasound images. Hypotheses for perfusion defects include abnormal hemodynamics in neovascular vessels or a decrease in blood flow in pre-existing blood vessels in the parenchyma due to compression by LN tumor growth. However, the mechanisms underlying perfusion defects in LNs during the early stage of LN metastasis have not been investigated. We show that tumor mass formation with very few microvessels was associated with a perfusion defect in a non-enlarged LN at the early sta...
Source: Clinical and Experimental Metastasis - October 15, 2021 Category: Cancer & Oncology Source Type: research

Stereotactic body radiation therapy for adrenal gland metastases: outcome and predictive factors from a multicenter analysis
AbstractAdrenal metastases occur in 15 –35% of oncological patients. Surgery is the first treatment option. Stereotactic body radiotherapy (SBRT) has been largely explored in oligometastatic patients unfit for surgery, representing an effective and non-invasive local treatment. The results of a multi-institutional experience of SBRT on adrenal metastases in the oligorecurrent or oligoprogressive setting are herein reported. We collected data of adrenal gland metastases treated with SBRT in three Italian centers from 2010 to 2020. End-points of the present study were: Overall survival (OS), Local control of treated me...
Source: Clinical and Experimental Metastasis - October 15, 2021 Category: Cancer & Oncology Source Type: research

Stereotactic body radiotherapy to lymph nodes in oligoprogressive castration-resistant prostate cancer patients: a post hoc analysis from two phase I clinical trials
In conclusion, the efficacy in terms of LC of SBRT/SRS in patients with nodal metastases from PC was confirmed. Moreover, this analysis suggests the efficacy in terms of PFS and NEST-FS also in the setting of oligoprogressive PC. In fact, about one-third of patients were free from progressive disease and two-third of subjects did not require hormonal therapy switch or discontinuation three years after treatment. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - October 15, 2021 Category: Cancer & Oncology Source Type: research

The lymphatic system and sentinel lymph nodes: conduit for cancer metastasis
AbstractThe lymphatic system is a complicated system consisting of the lymphatic vessels and lymph nodes draining the extracellular fluid containing cellular debris, excess water and toxins to the circulatory system. The lymph nodes serve as a filter, thus, when the lymph fluid returns to the heart, it is completely sterile. In addition, the lymphatic system includes the mucosa-associated lymphoid tissue, such as tonsils, adenoids, Peyers patches in the small bowel and even the appendix. Taking advantage of the drainage system of the lymphatics, cancer cells enter the lymphatic vessels and then the lymph nodes. In general,...
Source: Clinical and Experimental Metastasis - October 15, 2021 Category: Cancer & Oncology Source Type: research

Distinguishing pure histopathological growth patterns of colorectal liver metastases on CT using deep learning and radiomics: a pilot study
In this study, we evaluated radiomics for preoperative prediction of HGPs on computed tomography (CT), and its robustness to segmentation and acquisition variations. Patients with pure HGPs [i.e. 100% desmoplastic (dHGP) or 100% replacement (rHGP)] and a CT-scan who were surgically treated at the Erasmus MC between 2003 –2015 were included retrospectively. Each lesion was segmented by three clinicians and a convolutional neural network (CNN). A prediction model was created using 564 radiomics features and a combination of machine learning approaches by training on the clinician’s and testing on the unseen CNN s...
Source: Clinical and Experimental Metastasis - September 17, 2021 Category: Cancer & Oncology Source Type: research

SBRT for elderly oligometastatic patients as a feasible, safe and effective treatment opportunity
This study presents the outcomes of a cohort of 61 oligometastatic patients over the age of 80  years who received SBRT, that was proposed to all patients with a minimum Karnofsky Performance Status ≥ 70 and a life expectancy of at least 6 months, with up to five oligometastatic lesions. Radiotherapy was delivered in 3–10 fractions with VMAT-IGRT technique. Toxicity was retrospectiv ely collected according to CTCAE v4.0. Data were retrospectively collected and analyzed. Univariate and multivariate analysis were performed for assessing any potential predictive factor for clinical outcomes. A...
Source: Clinical and Experimental Metastasis - September 6, 2021 Category: Cancer & Oncology Source Type: research

Prospective assessment of AR splice variant and PSMA detection on circulating tumor cells of mCRPC patients: preliminary analysis of patients enrolled in PRIMERA trial (NCT04188275)
In this report, we explored the predictive value of Circulating Tumor Cell (CTC) detection in mCRPC patients undergoing 1st line therapy. Moreover, ARV7, ARFL, PSMA and PSA expression on CTC was reported to explore potential correlation with patient prognosis and response to therapy. PRIMERA is a prospective observational trial enrolling mCRPC patients undergoing standard treatment (ARTA  + ADT) after I line ADT failure. Clinical and pathological features were collected. Outcomes selected for this preliminary analysis were time to castration resistance (TTCR), PSA at 8 weeks after ARTA therapy start, PSA...
Source: Clinical and Experimental Metastasis - August 19, 2021 Category: Cancer & Oncology Source Type: research

Risk factors for surgical site infection and association of surgical site infection with survival of lower rectal cancer patients without clinical lateral pelvic lymph node metastasis (clinical Stage II/III): Analysis of data from JCOG0212
This study aimed to examine the risk factors for surgical site infection (SSI) and the association of that with recurrence in JCOG0212. The results for secondary endpoints showed that compared with the mesorectal excision (ME) alone group, ME with lateral lymph node dissection (LLND) group showed significantly longer operative time and significantly higher blood loss. These results suggested that LLND was a risk factor for SSI. All 701 patients registered in JCOG0212 were analyzed in this study. Wound infection was defined as incisional/deep SSI, and pelvic abscess and anastomotic leakage were defined as organ/space SSI. T...
Source: Clinical and Experimental Metastasis - August 18, 2021 Category: Cancer & Oncology Source Type: research

The smac mimetic LCL161 targets established pulmonary osteosarcoma metastases in mice
AbstractOsteosarcoma is the most common form of primary bone cancer and frequently metastasizes to the lungs. Current therapies fail to successfully treat over two thirds of patients with metastatic osteosarcoma, so there is an urgent imperative to develop therapies that effectively target established metastases. Smac mimetics are drugs that work by inhibiting the pro-survival activity of IAP proteins such as cIAP1 and cIAP2, which can be overexpressed in osteosarcomas. In vitro, osteosarcoma cells are sensitive to a range of Smac mimetics in combination with TNF α. This sensitivity has also been demonstrated in vivo...
Source: Clinical and Experimental Metastasis - August 16, 2021 Category: Cancer & Oncology Source Type: research

Serum conversion pattern of SCC-Ag levels between pre- and post-chemoradiotherapy predicts recurrence and metastasis in cervical cancer: a multi-institutional analysis
AbstractThe value of squamous-cell carcinoma antigen (SCC-Ag) as a tumor marker for cervical cancer is controversial because it is not elevated (>  2 ng/mL) in a quarter of patients at diagnosis. Two hundred ninety one IB-IVA cervical squamous cell-carcinoma patients who underwent definitive chemoradiotherapy (CRT) were included in four tertiary institutions. Serum conversion pattern between pre- and post-treatment SCC-Ag levels was categor ized into the following three arms: (1) Consistent Seronegative arm (both ≤ 2 ng/mL); (2) Negative Conversion arm (from >  2 ng/...
Source: Clinical and Experimental Metastasis - August 14, 2021 Category: Cancer & Oncology Source Type: research

Introduction to novel developments in radio-imaging and radiotherapy
AbstractRadiation therapy has long been known to be a very effective form of therapy in relieving symptoms and prolonging the life of patients with brain metastases. Novel developments in this field have allowed oncologists to improve on older forms of radiation therapy; these recent advances in radiotherapeutic techniques (stereotactic radiosurgery and hippocampal-avoidant whole brain radiation therapy) allow sparing of the healthy brain from receiving unnecessary radiation while delivering effective treatment to the metastases, thus improving the quality of life for surviving patients. Furthermore, multiple clinical tria...
Source: Clinical and Experimental Metastasis - August 13, 2021 Category: Cancer & Oncology Source Type: research

The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo
AbstractTyrosyl-DNA phosphodiesterase 1 (Tdp1) is a repair enzyme for 3 ′-end DNA lesions, predominantly stalled DNA–topoisomerase 1 (Top1) cleavage complexes. Tdp1 is a promising target for anticancer therapy based on DNA damage caused by Top1 poisoning. Earlier, we have reported about usnic acid enamine derivatives that are Tdp1 inhibitors sensitizing tumor cells to the action of Top1 poison (Zakharenko in J Nat Prod 79:2961−2967, 2016). In the present work, we showed a sensitizing effect of an enamine derivative of usnic acid (when administered intragastrically) on Lewis lung carcinoma in mice in combi...
Source: Clinical and Experimental Metastasis - August 9, 2021 Category: Cancer & Oncology Source Type: research

JUNB suppresses distant metastasis by influencing the initial metastatic stage
AbstractThe complex interactions between cells of the tumor microenvironment and cancer cells are considered a major determinant of cancer progression and metastasis. Yet, our understanding of the mechanisms of metastatic disease is not sufficient to successfully treat patients with advanced-stage cancer. JUNB is a member of the AP-1 transcription factor family shown to be frequently deregulated in human cancer and associated with invasion and metastasis. A strikingly high stromal JUNB expression in human breast cancer samples prompted us to functionally investigate the consequences of JUNB loss in cells of the tumor micro...
Source: Clinical and Experimental Metastasis - July 19, 2021 Category: Cancer & Oncology Source Type: research

Donald L. Morton Memorial Lecture: the legacy of Donald Morton: past, present and future
AbstractDonald L. Morton, MD persevered against great odds throughout his life and career. Beginning in the humblest of circumstances, he worked his way to the highest echelon of academic surgery, revolutionized surgical treatment of melanoma with innovations that rippled through the rest of oncology. His research led to dramatically improved disease staging while also decreasing morbidity. He stood as a champion of immunotherapy for many years when few others believed it would ever work. His greatest professional legacy, and the achievement of which he was most proud, is in the accomplishments of those he trained over his...
Source: Clinical and Experimental Metastasis - July 18, 2021 Category: Cancer & Oncology Source Type: research

Collective metastasis: coordinating the multicellular voyage
AbstractThe metastatic process is arduous. Cancer cells must escape the confines of the primary tumor, make their way into and travel through the circulation, then survive and proliferate in unfavorable microenvironments. A key question is how cancer cells overcome these multiple barriers to orchestrate distant organ colonization. Accumulating evidence in human patients and animal models supports the hypothesis that clusters of tumor cells can complete the entire metastatic journey in a process referred to as collective metastasis. Here we highlight recent studies unraveling how multicellular coordination, via both physica...
Source: Clinical and Experimental Metastasis - July 12, 2021 Category: Cancer & Oncology Source Type: research

Arresting metastasis within the microcirculation
AbstractThe behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metastasis. Revisiting how these mediators impact the ability of circulating tumour cells to survive and metastasise, will be vital to understand the role of microcirculation and advance our knowledge on metastasis. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - July 9, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Assessment of incentivizing effects for cancer care frameworks
The article “Assessment of incentivizing effects for cancer care frameworks”, written by Jörg Haier, Jonathan Sleeman and Jürgen Schäfers, was originally published Online First without Open Access. After publication in volume 37, issue 4, page 447–450 the author decided to opt for Open Choice and to ma ke the article an Open Access publication. Therefore, the copyright of the article has been changed to © The Author(s) 2020 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, dist...
Source: Clinical and Experimental Metastasis - June 28, 2021 Category: Cancer & Oncology Source Type: research

Innovations in radiotherapy and advances in immunotherapy for the treatment of brain metastases
AbstractRadiotherapy for brain metastases has evolved tremendously over the past four decades, allowing for improved intracranial control of disease with reduced neurotoxicity. The main technological advance was provided by volumetric modulated arc therapy (VMAT), a computer-controlled delivery method that has opened the door for single-isocenter multi-metastases stereotactic radiosurgery (SRS) and hippocampal avoidance whole brain radiation therapy (HA-WBRT). Other notable advances have occurred in the combination of immune checkpoint inhibitors (ICI) and radiosurgery. When these two modalities are combined in the proper ...
Source: Clinical and Experimental Metastasis - June 17, 2021 Category: Cancer & Oncology Source Type: research

Cardiooncology —dealing with modern drug treatment, long-term complications, and cancer survivorship
AbstractModern treatment strategies have improved prognosis and survival of patients with malignant diseases. The key components of tumor treatment are conventional chemotherapy, radiotherapy, targeted therapies, and immunotherapy. Cardiovascular side-effects may occur in the early phase of tumor therapy or even decades later. Therefore, knowledge and awareness of acute and long-lasting cardiac side effects of anti-cancer therapies are essential. Cardiotoxicity impairs quality of life and overall survival. The new cardiologic subspecialty ‘cardio-oncology’ deals with the different cardiovascular problems arisin...
Source: Clinical and Experimental Metastasis - June 12, 2021 Category: Cancer & Oncology Source Type: research

CXCL2-CXCR2 axis mediates αV integrin-dependent peritoneal metastasis of colon cancer cells
AbstractPeritoneal metastasis is an insidious aspect of colorectal cancer. The aim of the present study was to define mechanisms regulating colon cancer cell adhesion and spread to peritoneal wounds after abdominal surgery. Mice was laparotomized and injected intraperitoneally with CT-26 colon carcinoma cells and metastatic noduli in the peritoneal cavity was quantified after treatment with a CXCR2 antagonist or integrin- αV-antibody. CT-26 cells expressed cell surface chemokine receptors CXCR2, CXCR3, CXCR4 and CXCR5. Stimulation with the CXCR2 ligand, CXCL2, dose-dependently increased proliferation and migration of...
Source: Clinical and Experimental Metastasis - June 11, 2021 Category: Cancer & Oncology Source Type: research

Sentinel lymph node biopsy in melanoma: beyond histologic factors
AbstractSentinel lymph node (SLN) biopsy should be performed with the technical expertise required to correctly identify the sentinel node, in the context of understanding both the likelihood of positivity in a given patient and the prognostic significance of a positive or negative result. National Comprehensive Cancer Network guidelines recommend SLN biopsy for all cutaneous melanoma patients with primary tumor thickness greater than 1  mm and in select patients with thickness between 0.8 and 1 mm, yet admit a lack of consistent clarity in its utility for prognosis and therapeutic value in tumors 
Source: Clinical and Experimental Metastasis - June 8, 2021 Category: Cancer & Oncology Source Type: research

Cancer cell metabolic plasticity in migration and metastasis
AbstractMetabolic reprogramming is a hallmark of cancer metastasis in which cancer cells manipulate their metabolic profile to meet the dynamic energetic requirements of the tumor microenvironment. Though cancer cell proliferation and migration through the extracellular matrix are key steps of cancer progression, they are not necessarily fueled by the same metabolites and energy production pathways. The two main metabolic pathways cancer cells use to derive energy from glucose, glycolysis and oxidative phosphorylation, are preferentially and plastically utilized by cancer cells depending on both their intrinsic metabolic p...
Source: Clinical and Experimental Metastasis - June 2, 2021 Category: Cancer & Oncology Source Type: research

Novel approach involving stereotactic body radiotherapy followed by intramedullary nail placement for long bone metastases: a case report
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - May 30, 2021 Category: Cancer & Oncology Source Type: research

Myeloid derived suppressor cells and the release of micro-metastases from dormancy
AbstractMetastasis is the primary cause of cancer mortality and an improved understanding of its pathology is critical to the development of novel therapeutic approaches. Mechanism-based therapeutic strategies require insight into the timing of tumor cell dissemination, seeding of distant organs, formation of occult lesions and critically, their release from dormancy. Due to imaging limitations, primary tumors can only be detected when they reach a relatively large size (e.g.  >  1 cm3), which, based on our understanding of tumor evolution, occurs approximately 10  years and about 30 doubling t...
Source: Clinical and Experimental Metastasis - May 20, 2021 Category: Cancer & Oncology Source Type: research

In-transit metastatic cutaneous melanoma: current management and future directions
AbstractManagement of in-transit melanoma encompasses a variety of possible treatment pathways and modalities. Depending on the location of disease, number of lesions, burden of disease and patient preference and characteristics, some treatments may be more beneficial than others. After full body radiographic staging is performed to rule out metastatic disease, curative therapy may be performed through surgical excision, intraarterial regional perfusion and infusion therapies, intralesional injections, systemic therapies or various combinations of any of these. While wide excision is limited in indication to superficial le...
Source: Clinical and Experimental Metastasis - May 17, 2021 Category: Cancer & Oncology Source Type: research

Cancer heterogeneity and metastasis: life at the edge
AbstractThere is abundant evidence that the phenotype of cells the tumor at the stromal interface is distinct from the tumor cells that are within the core. Molecular phenotyping of cells at the edge show that they express higher levels of proteins associated with elevated glycolytic metabolism, including GLUT-1, HIF-1, and CA-IX. An end product of glycolysis is the production of acid, and acidosis of tumors is strongly associated with increased metastatic potential across a wide variety of tumor types. The molecular machinery promoting this export of acid is being defined, with close collaboration between carbonic anhydra...
Source: Clinical and Experimental Metastasis - May 17, 2021 Category: Cancer & Oncology Source Type: research

Cancer microenvironment and genomics: evolution in process
AbstractCancer heterogeneity is a result of genetic mutations within the cancer cells. Their proliferation is not only driven by autocrine functions but also under the influence of cancer microenvironment, which consists of normal stromal cells such as infiltrating immune cells, cancer-associated fibroblasts, endothelial cells, pericytes, vascular and lymphatic channels. The relationship between cancer cells and cancer microenvironment is a critical one and we are just on the verge to understand it on a molecular level. Cancer microenvironment may serve as a selective force to modulate cancer cells to allow them to evolve ...
Source: Clinical and Experimental Metastasis - May 10, 2021 Category: Cancer & Oncology Source Type: research

Detection of cancer metastasis: past, present and future
This article attempts to address some of the resultant questions that were the subject of the session “Novel Frontiers in the Diagnosis of Cancer” at the 8th International Congress on Cancer Metastases, held in San Francisco, CA in October 2019. Some of these questions addressed include the significance of sentinel node metastasis in melanoma, and the optimal method for their pathologic analysis. The finding of circulating tumor cells in the blood may potentially supplant surgical techniques for detection of metastatic disease, and we are beginning to perfect techniques for their detection, understand how to ap...
Source: Clinical and Experimental Metastasis - May 7, 2021 Category: Cancer & Oncology Source Type: research

Current management of melanoma patients with nodal metastases
AbstractThe management of melanoma patients with nodal metastases has undergone dramatic changes over the last decade. In the past, the standard of care for patients with a positive sentinel lymph node biopsy (SLNB) was a completion lymph node dissection (CLND), while patients with palpable macroscopic nodal disease underwent a therapeutic lymphadenectomy in cases with no evidence of systemic spread. However, studies have shown that SLN metastases present as a spectrum of disease, with certain SLN-based factors being prognostic of and correlated with outcomes. Furthermore, the results of key clinical trials demonstrate tha...
Source: Clinical and Experimental Metastasis - May 7, 2021 Category: Cancer & Oncology Source Type: research

Secondary lymphedema from cancer therapy
AbstractThis manuscript is a summary of findings focusing on various aspects of secondary lymphedema specifically as a sequelae of treatment for cancer. The topic was addressed at a session held during the 8th International Congress on Cancer Metastasis that was unique a for the inclusion of patients with lymphedema and therapists joining physicians, healthcare professionals, and researchers in an effort to give an overview of secondary lymphedema following cancer therapy as well as highlighting the unknowns in the field. Lymphedema is defined and both diagnosis and incidence of cancer-related lymphedema are explored. Furt...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Cancer neoantigens as potential targets for immunotherapy
AbstractImmune checkpoint inhibitors (ICIs) targeting the cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) and programed cell death protein 1 (PD-1) or its ligand PD-L1 have increased the survival and cure rates for patients with many cancer types in various disease settings. However, only 10 –40% of cancer patients benefited from these ICIs, of whom ~ 20% have treatment interruption or discontinuation due to immune-related adverse events that can be severe and even fatal. Current efforts in precision immunotherapy are focused on improving biomarker-based patient selection for curr ently available I...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Emerging photoacoustic and thermoacoustic imaging technologies for detecting primary and metastatic cancer and guiding therapy
AbstractIn recent years, there has been a progressive trend towards less invasive technologies for detecting metastatic cancer and guiding therapy with the goal of lower morbidity, better outcomes, and superior cosmetic appearance than traditional methods. This mini-review examines three emerging noninvasive hybrid technologies for detecting primary cancer, metastasis and guiding thermal therapy. Real-time thermoacoustic imaging and thermometry potentially provides valuable and critical feedback for guiding focused microwave ablation therapy. Label-free photoacoustic monitoring of cancer cells is a promising clinical diagn...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Mechanisms of breast cancer metastasis
AbstractInvasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth of the disease in the breast/chest wall, and at metastatic sites, initially by surgery alone, then by a combination of surgery with radiation, and later by adding systemic treatments in the form of chemotherapy, hormone manipulation, targeted therapy, immunotherapy and other treatments aimed at inhibiting the proliferation of cancer cells. It would be valuable for us to know how breast cancer metastasizes; such knowledge would likely encourage the development ...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Precision oncology for breast cancer through clinical trials
AbstractPrecision treatment for breast cancers has made several notable advances in recent decades, but challenges of tumor heterogeneity, drug resistance, and aggressive recurrence and metastases remain. To meet and overcome these challenges, we must refine our understanding of breast subtypes and treatment biomarkers according to the knowledge afforded across the spectrum of ‘omics assays. A critical aspect of harnessing this knowledge into actionable biomarkers for treatment decision relies on our ability to integrate knowledge across data types and leverage our insight in evidence-based clinical trials. We review...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Current status of gastrointestinal tract cancer brain metastasis and the use of blood-based cancer biomarker biopsy
AbstractBrain metastasis (BM) frequently occurs in patients with cutaneous melanoma, lung, and breast cancer; although, BM rarely arises from cancers of the gastrointestinal tract (GIT). The reported incidence of GIT cancer BM is less than 4%. In the last few years, effective systemic therapy has prolonged the survival of GIT patients and consequently, the incidence of developing BM is rising. Therefore, the epidemiology and biology of BM arising from GIT cancer requires a more comprehensive understanding. In spite of the development of new therapeutic agents for patients with metastatic GIT cancers, survival for patients ...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Breast cancer disparities in outcomes; unmasking biological determinants associated with racial and genetic diversity
AbstractBreast cancer (BC) remains a leading cause of death among women today, and mortality among African American women in the US remains 40% higher than that of their White counterparts, despite reporting a similar incidence of disease over recent years. Previous meta-analyses and studies of BC mortality highlight that tumor characteristics, rather than socio-economic factors, drive excess mortality among African American women with BC. This is further complicated by the heterogeneity of BC, where BC can more appropriately be defined as a collection of diseases rather than a single disease. Molecular phenotyping and gen...
Source: Clinical and Experimental Metastasis - May 5, 2021 Category: Cancer & Oncology Source Type: research

Inhibition of the Axl pathway impairs breast and prostate cancer metastasis to the bones and bone remodeling
AbstractApproximately 90% of cancer-related deaths result from cancer metastasis. In prostate and breast cancers, bone is the most common site of cancer cell dissemination. Key steps in the metastatic cascade are promoted through upregulation of critical cell signaling pathways in neoplastic cells. The present study assessed the role of the receptor tyrosine kinase Axl in prostate and breast cancer cell metastasis to bones using (i) Axl knockdown neoplastic cells and osteoclast progenitor cellsin vitro, (ii) intracardiac injection of Axl knockdown tumor cellsin vivo, and (iii) selective Axl inhibitor BGB324. Axl inhibition...
Source: Clinical and Experimental Metastasis - March 31, 2021 Category: Cancer & Oncology Source Type: research

RETRACTED ARTICLE: Upfront citorreduction and hyperthermic intraperitoneal chemotherapy with paclitaxel in patients with stage III-C serous epithelial ovarian cancer
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 23, 2021 Category: Cancer & Oncology Source Type: research

Protective measures for patients with advanced cancer during the Sars-CoV-2 pandemic: Quo vadis?
AbstractCancer patients represent a vulnerable cohort during the Sars-CoV-2 pandemic. Oncological societies have generated a plethora of recommendations, but precise instructions about routine oncological procedures remain scarce. Here, we report on local COVID-19 protection measures established in an interdisciplinary approach at a tertiary care center during the first wave of the pandemia in Germany. Following these measures, no additional morbidity or mortality during oncological procedures was observed, and no nosocomial infections were registered. However, Validation of our measures is outstanding and regional SARS-Co...
Source: Clinical and Experimental Metastasis - March 23, 2021 Category: Cancer & Oncology Source Type: research

Synchronous peritoneal metastases from lung cancer: incidence, associated factors, treatment and survival: a Dutch population-based study
AbstractPeritoneal metastases (PM) from lung cancer are rare and it is unknown how they affect the prognosis of patients with lung cancer. This population-based study aimed to assess the incidence, associated factors, treatment and prognosis of PM from lung cancer. Data from the Netherlands Cancer Registry were used. All patients diagnosed with lung cancer between 2008 and 2018 were included. Logistic regression analysis was performed to identify factors associated with the presence of PM. Cox regression analysis was performed to identify factors associated with the overall survival (OS) of patients with PM. Between 2008 a...
Source: Clinical and Experimental Metastasis - March 18, 2021 Category: Cancer & Oncology Source Type: research

Single ‐fraction versus hypofractionated gamma knife radiosurgery for small metastatic brain tumors
AbstractStereotactic radiosurgery (SRS) has become a standard of care for the treatment of metastatic brain tumors (METs). Although a better balance of tumor control and toxicity of hypofractionated SRS (hfSRS) compared with single-fraction SRS (sfSRS) was demonstrated in large METs, there is no data comparing two approaches for small METs (
Source: Clinical and Experimental Metastasis - March 17, 2021 Category: Cancer & Oncology Source Type: research

Breast cancer liver metastasis: current and future treatment approaches
AbstractNearly all fatalities arising from breast tumors are attributable to distant metastases. Breast cancer liver metastasis (BCLM) is associated with poor prognoses, with the median survival time being 2 to 3  years. Tumor intrinsic subtype directs preferential metastasis to specific organs, with HER2-enriched tumors demonstrating the highest rates of metastasis to the liver, though all subtypes can grow in the liver. There is no singular established standard-of-care for BCLM; therapeutic selection is d riven by histologic and molecular hallmarks of the primary tumor or biopsied metastasis samples. Given the poor ...
Source: Clinical and Experimental Metastasis - March 6, 2021 Category: Cancer & Oncology Source Type: research

Type IV collagen as a potential biomarker of metastatic breast cancer
AbstractNo reliable, non-invasive biomarker of metastatic breast cancer (mBC) exists: circulating CA15-3 (cCA15-3) is the marker mostly used to monitor mBC. Circulating collagen IV (cCOLIV) has been evaluated in other metastatic cancers and has been found to be a promising biomarker. The overarching aim of this study was to evaluate cCOLIV as a potential biomarker in patients with mBC. The first aim was to determine the levels of cCOL IV and cCA15-3 in patients with healthy controls, primary breast cancer (pBC) and mBC. The second aim was to compare levels of cCOLIV and cCA15-3 in patients with different metastatic sites o...
Source: Clinical and Experimental Metastasis - March 3, 2021 Category: Cancer & Oncology Source Type: research

Correction to: Intraperitoneal mitomycin C improves survival compared to cytoreductive surgery alone in an experimental model of highgrade pseudomyxoma peritonei
A correction to this paper has been published: https://doi.org/10.1007/s10585-021-10084-0 (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - March 2, 2021 Category: Cancer & Oncology Source Type: research

Longitudinal CTCs gene expression analysis on metastatic castration-resistant prostate cancer patients treated with docetaxel reveals new potential prognosis markers
AbstractCTCs have extensively been used for the monitoring and characterization of metastatic prostate cancer, but their application in the clinic is still very scarce. Besides, the resistance mechanisms linked to prostate cancer treatment remain unclear. Liquid biopsies represent the most promising alternative due to the complexity of biopsying bone metastasis and the duration of the disease. We performed a prospective longitudinal study in CTCs from 20 castration-resistant prostate cancer patients treated with docetaxel. For that, we used CellSearch ® technology and a custom gene expression panel with qRT-PCR using a...
Source: Clinical and Experimental Metastasis - February 26, 2021 Category: Cancer & Oncology Source Type: research

Wnt/ β-catenin/Slug pathway contributes to tumor invasion and lymph node metastasis in head and neck squamous cell carcinoma
In conclusion, the canonical Wnt/β-catenin/Slug signaling axis significantly contributes to cancer cell invasion and LNM. Its blockade may be a treatment strategy for LNM and tumor recurrence in HNSCC. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 25, 2021 Category: Cancer & Oncology Source Type: research

Impact of the COVID-19 pandemic on quality of life and emotional wellbeing in patients with bone metastases treated with radiotherapy: a prospective cohort study
This study has shown a strong increase in the experience of isolation and a decrease of emotional functioning and general quality of life during the COVID-19 lockdown in cancer patients with bone metastases. Due to the nature of the treatment of this patient pop ulation, efforts should be made to minimize these changes during future lockdowns. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 25, 2021 Category: Cancer & Oncology Source Type: research

Electron beam intraoperative radiotherapy for metastatic epidural spinal cord compression: a prospective observational study
This study’s findings suggest that decompression surgery and IORT followed by EBRT are effective in achieving local control and maintaining ambulation in patients with MESCC. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 24, 2021 Category: Cancer & Oncology Source Type: research

Molecular insights into the interplay between adiposity, breast cancer and bone metastasis
AbstractCancer is a complex disease, with various pre-existing health ailments enhancing its pathology. In cancer, the extracellular environment contains various intrinsic physiological factors whose levels are altered with aging and pre-existing conditions. In obesity, the tumor microenvironment and metastases are enriched with factors that are both derived locally, and from other physiological compartments. Similarly, in obesity, the cancer cell environment both at the site of origin and at the secondary site i.e., metastatic niche, contains significantly more phenotypically-altered adipocytes than that of un-obese cance...
Source: Clinical and Experimental Metastasis - February 16, 2021 Category: Cancer & Oncology Source Type: research

TGF β signaling networks in ovarian cancer progression and plasticity
AbstractEpithelial ovarian cancer (EOC) is a leading cause of cancer-related death in women. Late-stage diagnosis with significant tumor burden, accompanied by recurrence and chemotherapy resistance, contributes to this poor prognosis. These morbidities are known to be tied to events associated with epithelial-mesenchymal transition (EMT) in cancer. During EMT, localized tumor cells alter their polarity, cell –cell junctions, cell–matrix interactions, acquire motility and invasiveness and an exaggerated potential for metastatic spread. Key triggers for EMT include the Transforming Growth Factor-β (TGF&beta...
Source: Clinical and Experimental Metastasis - February 15, 2021 Category: Cancer & Oncology Source Type: research