Prognostic influence of the treatment approach for pulmonary metastasis in patients with soft tissue sarcoma
AbstractSoft tissue sarcomas (STSs) are rare heterogeneous malignancies of mesenchymal origin. Pulmonary metastases develop in approximately 50% of the patients with high-grade STS, being the major cause of mortality in patients with metastatic STS. Pulmonary metastasectomy has been reported to contribute to long-term survival; however, an appropriate treatment has not been established. We aimed to identify factors associated with post-metastasis survival in STS patients with pulmonary metastasis and determine the appropriate treatment for each patient. We retrospectively reviewed the records of metastatic STS patients tre...
Source: Clinical and Experimental Metastasis - May 20, 2020 Category: Cancer & Oncology Source Type: research

Cumulative intracranial tumour volume prognostic assessment: a new predicting score index for patients with brain metastases treated by stereotactic radiosurgery
AbstractBrain metastases (BM) represent the most common intracranial malignancy in adults. Limitations of existing prognostic models reduce their predictivity and clinical applicability. The aim of this study is to validate the cumulative intracranial tumour volume prognostic assessment (CITVPA) as a new prognostic score system for patients with BM treated by Stereotactic Radiosurgery (SRS). Between January 2001 and December 2015, 1894 patients underwent Gamma Knife SRS treatment. The CITVPA model was implemented and validated as follows: the CITV cut-offs were identified thanks to a receiver-operating characteristic (ROC)...
Source: Clinical and Experimental Metastasis - May 19, 2020 Category: Cancer & Oncology Source Type: research

Development of 131 I-ixolaris as a theranostic agent: metastatic melanoma preclinical studies
AbstractTissue factor (TF), a blood coagulation protein, plays an important role in tumor growth, invasion, and metastasis. Ixolaris, a tick-derived non-immunogenic molecule that binds to TF, has demonstrated in vivo inhibitory effect on murine models of melanoma, including primary growth and metastasis. This work aimed to: I) develop an efficient and stable labeling technique of ixolaris with Iodine-131(131I); II) compare the biodistribution of131I and131I-ixolaris in tumor-free and melanoma-bearing mice; III) evaluate whether131I-ixolaris could serve as an antimetastatic agent. Ixolaris radioiodination was performed usin...
Source: Clinical and Experimental Metastasis - May 11, 2020 Category: Cancer & Oncology Source Type: research

Laser interstitial thermal therapy for in-field recurrence of brain metastasis after stereotactic radiosurgery: does treatment with LITT prevent a neurologic death?
In this study, we investigate the causes of death among patients with BM who undergo LITT for IFR after SRS. We conducted a  single institution retrospective case series of patients with BM who underwent LITT for IFR after SRS. Clinical and demographic data were collected via chart review. The primary endpoint was cause of death. Between 2010 and 2018, 70 patients with BM underwent LITT for IFR after SRS. Median follow- up after LITT was 12.0 months. At analysis, 49 patients died; a cause was determined in 44. Death was neurologic in 20 patients and non-neurologic in 24. The 24-month cumulative incidence of neuro...
Source: Clinical and Experimental Metastasis - May 6, 2020 Category: Cancer & Oncology Source Type: research

Tako-tsubo syndrome after intraperitoneal hyperthermic chemotherapy (HIPEC) with cisplatin: an unusual complication of cytoreductive surgery plus HIPEC
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - May 5, 2020 Category: Cancer & Oncology Source Type: research

A study on different therapies and prognosis-related factors for brain metastases in lung adenocarcinoma patients with driver mutation
AbstractBrain metastases (BMs) are frequently occurred in lung adenocarcinoma with driver mutation. There is a need to explore multi-discipline treatments and prognostic factors in those patients with most frequent driver mutations:EGFR mutation andALK fusion. In the retrospective study, different therapies and prognostic factors were compared betweenEGFR andALK-driven lung adenocarcinoma with BMs. 516 patients withEGFR mutation and 76 withALK fusion were screened for this study, 303 (58.7%) and 34 (44.7%) had BM respectively. In multivariate analyses, the pretreatment factors including delayed BMs and asymptomatic BMs, tr...
Source: Clinical and Experimental Metastasis - April 30, 2020 Category: Cancer & Oncology Source Type: research

Tumor shedding and metastatic progression after tumor excision in patient-derived orthotopic xenograft models of triple-negative breast cancer
This study assembles a timeline of PDOX tumor shedding and metastatic tumor progression before and after tumor excision surgery. We report the ability to use tumorectomies to increase the lifespan of TNBC PDOX models with the potential to obtain larger metastases. CTC clusters and CTCs expressing a mesenchymal marker (vimentin) were associated with metastatic burden in lung and liver. The data collected through these experiments will guide the further use of PDOX models in studying metastatic TNBC. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - April 25, 2020 Category: Cancer & Oncology Source Type: research

Astrocytic IGFBP2 and CHI3L1 in cerebrospinal fluid drive cortical metastasis of HER2+breast cancer
AbstractThe brain is often reported as the first site of recurrence among breast cancer patients overexpressing human epidermal growth factor receptor 2 (HER2). Although most HER2+tumors metastasize to the subcortical region of the brain, a subset develops in the cortical region. We hypothesize that factors in cerebrospinal fluid (CSF) play a critical role in the adaptation, proliferation, and establishment of cortical metastases. We established novel cell lines using patient biopsies to model breast cancer cortical and subcortical metastases. We assessed the localization and growth of these cells in vivo and proliferation...
Source: Clinical and Experimental Metastasis - April 11, 2020 Category: Cancer & Oncology Source Type: research

Single-fraction radiosurgery versus fractionated stereotactic radiotherapy in patients with brain metastases: a comparative study
AbstractTo compare the local control and brain radionecrosis in patients with brain metastasis primarily treated by single-fraction radiosurgery (SRS) or hypofractionated stereotactic radiotherapy (HFSRT). Between January 2012 and December 2017, 179 patients with only 1 –3 brain metastases (total: 287) primarily treated by SRS (14 Gy) or HFSRT (23.1 Gy in 3 fractions of 7.7 Gy, every other day) were retrospectively analyzed in a single center. Follow-up imaging data were available in 152 patients with 246 lesions. The corresponding Biological Effective Dose (B ED) were 33.6 Gy and 40.9 Gy res...
Source: Clinical and Experimental Metastasis - March 17, 2020 Category: Cancer & Oncology Source Type: research

Curative-intent pancreas resection for pancreatic metastases: surgical and oncological results
ConclusionDespite malignant disease, overall survival of patients after metastasectomy for pancreatic metastasis is acceptable. Better survival appears to be associated with the primary tumor entity. Further research should focus on molecular markers to elucidate the mechanisms of pancreatic metastasis to choose the suitable therapeutic approach for the individual patient. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - February 24, 2020 Category: Cancer & Oncology Source Type: research

Role of the tumor microenvironment in regulating the anti-metastatic effect of KISS1
AbstractKISS1, a metastasis suppressor gene, has been shown to block metastasis without affecting primary tumor formation. Loss ofKISS1 leads to invasion and metastasis in multiple cancers, which is the leading cause of cancer morbidity and mortality. The discovery ofKISS1 has provided a ray of hope for early clinical diagnosis and for designing effective treatments targeting metastatic cancer. However, this goal requires greater holistic understanding of its mechanism of action. In this review, we go back into history and highlight some key developments, from the discovery ofKISS1 to its role in regulating multiple physio...
Source: Clinical and Experimental Metastasis - February 22, 2020 Category: Cancer & Oncology Source Type: research

Sentinel node tumor burden in prediction of prognosis in melanoma patients
AbstractRecent data have demonstrated no survival benefit to immediate completion lymph node dissection (CLND) for positive sentinel node (SN) disease in melanoma. It is important to identify parameters in positive SNs, which predict prognosis in melanoma patients. These might provide prognostic value in staging systems and risk models by guiding high-risk patients ’ adjuvant therapy in clinical practice. In this retrospective study of university hospital melanoma database we analyzed tumor burden and prognosis in patients with positive SNs. Patients were stratified by the diameter of tumor deposit, distribution of m...
Source: Clinical and Experimental Metastasis - February 19, 2020 Category: Cancer & Oncology Source Type: research

Exploratory cost-effectiveness analysis of 68 Gallium-PSMA PET/MRI-based imaging in patients with biochemical recurrence of prostate cancer
AbstractMen treated for prostate cancer with curative intent face a recurrence rate of up to 53% at 10  years.68Ga-PSMA imaging is a new technique that can more accurately stage cancer recurrences and facilitate personalised treatment. We evaluated the cost-effectiveness of68Ga-PSMA PET/MRI for staging men with prostate cancer biochemical recurrence. A cost-effectiveness analysis using a decision-analytic model with Markov chains was constructed.68Ga-PSMA PET/MRI was compared with usual care in staging of men with suspected prostate cancer recurrence. Men with biochemical recurrence from a study in Brisbane, Australia...
Source: Clinical and Experimental Metastasis - February 17, 2020 Category: Cancer & Oncology Source Type: research

Development of a novel murine model of lymphatic metastasis
AbstractCurrent laboratory models of lymphatic metastasis generally require either genetically modified animals or are technically challenging. Herein, we have developed a robust protocol for the induction of intralymphatic metastasis in wild-type mice with reproducible outcomes. To determine an optimal injection quantity and timeline for tumorigenesis, C57Bl/6 mice were injected directly into the mesenteric lymph duct (MLD) with varying numbers of syngeneic murine colon cancer cells (MC38) or gastric cancer cells (YTN16) expressing GFP/luciferase and monitored over 2 –4 weeks. Tumor growth was tracked via whole-anim...
Source: Clinical and Experimental Metastasis - February 12, 2020 Category: Cancer & Oncology Source Type: research

Suppression of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma through IKK β inhibition
AbstractWe explored the role of the transcription factor, NF- κB, and its upstream kinase IKKβ in regulation of migration, invasion, and metastasis of cisplatin-resistant head and neck squamous cell carcinoma (HNSCC). We showed that cisplatin-resistant HNSCC cells have a stronger ability to migrate and invade, as well as display higher IKKβ/NF-κB activity compared to their parental partners. Importantly, we found that knockdown of IKKβ, but not NF-κB, dramatically impaired cell migration and invasion in these cells. Consistent with this, the IKKβ inhibitor, CmpdA, also inhibited cell m...
Source: Clinical and Experimental Metastasis - February 4, 2020 Category: Cancer & Oncology Source Type: research

Poor perfusion of the microvasculature in peritoneal metastases of ovarian cancer
AbstractMost women with epithelial ovarian cancer (EOC) suffer from peritoneal carcinomatosis upon first clinical presentation. Extensive peritoneal carcinomatosis has a poor prognosis and its pathophysiology is not well understood. Although treatment with systemic intravenous chemotherapy is often initially successful, peritoneal recurrences occur regularly. We hypothesized that insufficient or poorly-perfused microvasculature may impair the therapeutic efficacy of systemic intravenous chemotherapy but may also limit expansive and invasive growth characteristic of peritoneal EOC metastases. In 23 patients with advanced EO...
Source: Clinical and Experimental Metastasis - February 1, 2020 Category: Cancer & Oncology Source Type: research

Upfront radiosurgery plus targeted agents followed by active brain control using radiosurgery delays neurological death in non-small cell lung cancer with brain metastasis
AbstractThe role of radiosurgery has become further accentuated in the era of targeted agents (TA). Thus, the neurologic outcome of radiosurgery in brain metastasis (BM) of non-small cell lung cancer (NSCLC) was reviewed. We analyzed 135 patients with BM of NSCLC who were administered Cyberknife radiosurgery (CKRS) as either initial or salvage therapy. We evaluated local failure (LF), intracranial failure (IF), and neurological death (ND) due to BM. Primary outcome was neurological death-free survival (NDFS). Median follow-up was 16.2  months. Median CKRS dose of 22 Gy was administered to median 2 targets per pat...
Source: Clinical and Experimental Metastasis - February 1, 2020 Category: Cancer & Oncology Source Type: research

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) of peritoneal metastasis from gastric cancer: a descriptive cohort study
We report our experience with PIPAC in patients with peritoneal metastasis (PM) from gastric cancer (GC). Data from GC patients (n  = 20) included in the prospective PIPAC-OPC1 and PIPAC-OPC2 studies are reported. All patients had received prior systemic chemotherapy. The mean peritoneal cancer index (PCI) was 10.5 (range 0–39) and nine patients had diffuse GC. PIPAC with cisplatin 7.5 mg/m2 and doxorubicin 1.5  mg/m2 were administered at 4 –6-week intervals. Outcome criteria were objective tumour response, survival and adverse events. Twenty patients had 52 PIPAC procedures with a media...
Source: Clinical and Experimental Metastasis - January 30, 2020 Category: Cancer & Oncology Source Type: research

Toll-like receptors: exploring their potential connection with post-operative infectious complications and cancer recurrence
AbstractCancer is the leading cause of death in North America. Despite modern advances in cancer therapy, many patients will ultimately develop cancer metastasis resulting in mortality. Surgery to resect early stage solid malignancies remains the cornerstone of cancer treatment. However, surgery places patients at risk of developing post-operative infectious complications that are linked to earlier cancer metastatic recurrence and cancer mortality. Toll-like receptors (TLRs) are evolutionarily-conserved sentinel receptors of the innate immune system that are activated by microbial products present during infection, leading...
Source: Clinical and Experimental Metastasis - January 23, 2020 Category: Cancer & Oncology Source Type: research

Impact of decompressive laminectomy on the functional outcome of patients with metastatic spinal cord compression and neurological impairment
AbstractMetastatic spinal cord compression (MSCC) is a frequent phenomenon in advanced tumor diseases with often severe neurological impairments. Affected patients are often treated by decompressive laminectomy. To assess the impact of this procedure on Karnofsky Performance Index (KPI) and Frankel Grade (FG) at discharge, a single center retrospective cohort study of neurologically impaired MSCC-patients treated with decompressive laminectomy between 2004 and 2014 was performed. 101 patients (27 female/74 male; age 66.1  ± 11.5 years) were identified. Prostate was the most common primary tumor si...
Source: Clinical and Experimental Metastasis - January 20, 2020 Category: Cancer & Oncology Source Type: research

Breast brain metastases are associated with increased risk of leptomeningeal disease after stereotactic radiosurgery: a systematic review and meta-analysis
AbstractBrain metastases are the most common malignant tumors of the brain. Leptomeningeal dissemination is a late-stage complication of intracranial metastasis and portends an extremely poor prognosis. An increased risk of leptomeningeal disease (LMD) from metastatic breast cancer compared to other cancer types after stereotactic radiosurgery (SRS) has been reported. Validation of this observation has significant public health ramifications. The aim of this study was to determine the consistency of this association in the available literature via formal meta-analysis and systematic review of the literature. Searches of se...
Source: Clinical and Experimental Metastasis - January 16, 2020 Category: Cancer & Oncology Source Type: research

The utility of the “Glowing Head” mouse for breast cancer metastasis research
AbstractThe expression of cellular reporters to label cancer cells, such as green fluorescent protein (GFP) and luciferase, can stimulate immune responses and effect tumor growth. Recently, a mouse model that expresses GFP and luciferase in the anterior pituitary gland was generated to tolerize mice to these proteins; the “Glowing Head” mouse. Mice were obtained from a commercial vendor, bred, and then used for tumor growth and metastasis studies. The transgene expression of luciferase was assessed within tumor-naïve mice as well as mice with mammary tumors or metastases. Tumor-free mice with white fur, co...
Source: Clinical and Experimental Metastasis - January 14, 2020 Category: Cancer & Oncology Source Type: research

Tissue inhibitor of matrix metalloproteinase-3 has both anti-metastatic and anti-tumourigenic properties
AbstractTIMP-3 is one of four tissue inhibitors of matrix metalloproteinases, the endogenous inhibitors of the matrix metalloproteinase enzymes. These enzymes have an important role in metastasis, in the invasion of cancer cells through the basement membrane and extracellular matrix. TIMP-1, -2 and -4 both promote and inhibit tumour development, in a context-dependent manner, however TIMP-3 is consistently anti-tumourigenic. TIMP-3 is also the only insoluble member of the family, being either bound to the extracellular matrix or the low density lipoprotein-related protein-1, through which it can be endocytosed. Levels of T...
Source: Clinical and Experimental Metastasis - January 1, 2020 Category: Cancer & Oncology Source Type: research

Hepatic artery infusion pump for nasopharyngeal carcinoma with liver metastasis
AbstractTo evaluate the benefits and risks of hepatic artery infusion (HAI) gemcitabine and floxuridine (FUDR) in patients with nasopharyngeal carcinoma liver metastases. HAI catheter systems were implanted under the guide of digital subtract angiography (DSA) in 16 patients with unresectable nasopharyngeal carcinoma liver metastases. HAI gemcitabine and FUDR in combination with radiotherapy and systemic chemotherapy were delivered. Disease control rate (DCR) of intrahepatic lesions is 100%, objective response rate (ORR) of intrahepatic lesions is 87.5%, including 4 patients (25%) with complete response (CR), 10 patients (...
Source: Clinical and Experimental Metastasis - December 20, 2019 Category: Cancer & Oncology Source Type: research

Skeletal impact of 17 β-estradiol in T cell-deficient mice: age-dependent bone effects and osteosarcoma formation
AbstractEstrogen (E2)-dependent ER+  breast cancer, the most common breast cancer subtype, is also the most likely to metastasize to bone and form osteolytic lesions. However, ER+ breast cancer bone metastasis human xenograft models in nude mice are rarely studied due to complexities associated with distinguishing possible tumoral vs. bone microenvironmental effects of E2. To address this knowledge gap, we systematically examined bone effects of E2 in developing young (4-week-old) vs. skeletally mature (15-week-old) femaleFoxn1nu nude mice supplemented with commercial 60-day slow-release E2 pellets and doses ...
Source: Clinical and Experimental Metastasis - December 20, 2019 Category: Cancer & Oncology Source Type: research

Guidance of healthcare development for metastatic cancer patients as an example for setting incentives
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - December 16, 2019 Category: Cancer & Oncology Source Type: research

Prognostic role of 14q32.31 miRNA cluster in various carcinomas: a systematic review and meta-analysis
AbstractDeregulated miR-379/miR-656 cluster expression is considered as important for carcinogenesis and can be used as a potential prognostic marker. Hence, the meta-analysis was conducted to test the utility of miR-379/miR-656 cluster as a prognostic marker in various cancers. A literature search was performed using Web of Science, PubMed and Cochrane Library to obtain relevant studies and were subjected to various subgroup and bioinformatics analyses. Selected twenty-three studies contained 13 cancer types comprising of 3294 patients from 7 nations. Univariate and multivariate data showed an association of high expressi...
Source: Clinical and Experimental Metastasis - December 7, 2019 Category: Cancer & Oncology Source Type: research

Upfront citorreduction and hyperthermic intraperitoneal chemotherapy with paclitaxel in patients with stage III-C serous epithelial ovarian cancer
AbstractThe main objective of this retrospective multicenter study, conducted by the Spanish Peritoneal Surgical Oncology Group (GECOP) was to analyze the survival outcomes of patients with stage IIIC serous epithelial ovarian cancer, after cytoreduction and intraoperative administration of hyperthermic intraperitoneal chemotherapy (HIPEC) with paclitaxel. Patients with stage IIIC serous epithelial ovarian cancer were recruited between May 2005 and October 2015, and treated by radical surgery using peritonectomy procedures, and HIPEC with paclitaxel. This multi-institutional retrospective study was carried out using a data...
Source: Clinical and Experimental Metastasis - December 6, 2019 Category: Cancer & Oncology Source Type: research

A novel RNA sequencing-based risk score model to predict papillary thyroid carcinoma recurrence
AbstractThe papillary thyroid carcinoma (PTC) usually shows an excellent prognosis. But some patients suffer recurrence after treatment. Recent progress in RNA sequencing (RNA-Seq) allows us to explore whole-transcriptomic gene expression profiles to develop RNA-seq based predictive model for stratifying the risk of recurrence of PTC. RNA-seq and clinical data from The Cancer Genome Atlas thyroid carcinoma cohort were divided chronologically into a training cohort (before 2011, n  = 240) and a validation cohort (after 2011, n = 239). A risk score model was developed in training cohort using univ...
Source: Clinical and Experimental Metastasis - December 2, 2019 Category: Cancer & Oncology Source Type: research

Bevacizumab suppresses the growth of established non-small-cell lung cancer brain metastases in a hematogenous brain metastasis model
AbstractBrain metastases are common in patients with non-small-cell lung cancer (NSCLC). The efficacy of bevacizumab, an anti-vascular endothelial growth factor (VEGF) humanized antibody, has been demonstrated in patients with nonsquamous NSCLC. We established a transplantable NSCLC cell line (Nluc-H1915) that stably expresses NanoLuc ® reporter and confirmed the correlation between total Nluc activity in tumor and tumor volume in vivo. SCID mice inoculated with these cells through the internal carotid artery formed reproducible brain metastases, in which human VEGF was detected. Next, after metastases were established...
Source: Clinical and Experimental Metastasis - November 25, 2019 Category: Cancer & Oncology Source Type: research

Ovarian, uterine, and cervical cancer patients with distant metastases at diagnosis: most common locations and outcomes
AbstractTo determine the location patterns of distant metastases at initial staging and outcomes of ovarian, uterine, and cervical cancer patients. Data were obtained from the SEER database from 2010 to 2015. Analyses were performed using Kaplan –Meier and multivariate Cox proportional hazard methods. Of 3035 patients (median age: 63, range: 17–95) with stage IV gynecologic cancer, ovarian, uterine, and cervical cancers were present in 42%, 40%, and 18% of the cohort. The proportion of lung, liver, bone and brain metastases were identif ied in 38%, 57%, 4%, and 1% of ovarian cancer patients, 62%, 22%, 13%, and ...
Source: Clinical and Experimental Metastasis - November 22, 2019 Category: Cancer & Oncology Source Type: research

The contribution of platelets to intravascular arrest, extravasation, and outgrowth of disseminated tumor cells
AbstractPlatelets are primarily known for their contribution to hemostasis and subsequent wound healing. In addition to these functions, platelets play a role in the process of metastasis. Since the first study that suggested a metastasis-promoting function for platelets was published in 1968, various mechanisms have been proposed to explain how platelets contribute to the metastatic process. These include roles in the intravascular arrest of tumor cells, in tumor cell transendothelial migration, in the degradation of basement membrane barriers, in migration and invasion at the metastatic site, and in the proliferation of ...
Source: Clinical and Experimental Metastasis - November 22, 2019 Category: Cancer & Oncology Source Type: research

Quality of life in patients with liver tumors treated with holmium-166 radioembolization
AbstractHolmium-166 radioembolization is a palliative treatment option for patients with unresectable hepatic malignancies. Its influence on quality of life has not been evaluated yet. Since quality of life is very important in the final stages of disease, the aim of this study was to evaluate the effect of holmium-166 radioembolization on quality of life. Patients with hepatic malignancies were treated with holmium-166 radioembolization in the HEPAR I and II studies. The European Organization for Research and Treatment of Cancer QLQ-C30 and LMC21 questionnaires were used to evaluate quality of life at baseline, 1  we...
Source: Clinical and Experimental Metastasis - November 15, 2019 Category: Cancer & Oncology Source Type: research

Disparities in the use of stereotactic radiosurgery for the treatment of lung cancer brain metastases: a SEER-Medicare study
This study investigates potential disparities in the use of SRS to treat Medicare patients. Surveillance, Epidemiology, and End-Results cancer registry data for patients diagnosed between the years 2010 and 2012 were examined to identify lung cancer patients diagnosed with BM at the same time as their primary cancer (SBM). Medicare claims for SRS were identified; the odds of having SRS claims and hazards of mortality associated with those odds were examined with respect to various clinical and demographic characteristics. Of 74,142 Medicare-enrolled patients diagnosed with lung cancer, 9192 were diagnosed with SBM and 3259...
Source: Clinical and Experimental Metastasis - November 8, 2019 Category: Cancer & Oncology Source Type: research

Repeated stereotactic radiosurgery (SRS) using a non-coplanar mono-isocenter (HyperArc ™) technique versus upfront whole-brain radiotherapy (WBRT): a matched-pair analysis
AbstractStereotactic radiosurgery (SRS) is an effective treatment option for multiple brain metastases (BMs). Modern mono-isocentric techniques allow the delivery of multiple stereotactic courses, in the event of intracranial failure. Nevertheless, limited data on effectiveness and toxicity have been reported in comparison to WBRT. Aim of this retrospective matched-pair analysis was to compare patients affected by limited BMs treated with multiple SRS courses using a mono-isocentric, non-coplanar technique (HyperArc ™, Varian Medical System) to upfront WBRT. One hundred and two patients accounting for 677 BMs were tr...
Source: Clinical and Experimental Metastasis - November 6, 2019 Category: Cancer & Oncology Source Type: research

Companion canines: an under-utilised model to aid in translating anti-metastatics to the clinic
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - November 5, 2019 Category: Cancer & Oncology Source Type: research

Editorial series: cancer care in low- and middle-income countries
(Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - October 31, 2019 Category: Cancer & Oncology Source Type: research

Selective loss of phosphoserine aminotransferase 1 (PSAT1) suppresses migration, invasion, and experimental metastasis in triple negative breast cancer
In this report, we investigate the role of PSAT1 in migration and invasion potential in a subset of TNBC cell types. We found that the expression of PSAT1 increases with TNBC clinical grade. We also demonstrate that suppression of PSAT1 or phosphoglycerate dehydrogenase (PHGDH) does not negatively impact cell proliferation in TNBC cells that are not dependent on de novo serine synthesis. However, we observed that suppression of PSAT1 specifically alters the F-actin cytoskeletal arrangement and morphology in these TNBC cell lines. In addition, suppression of PSAT1 inhibits motility and migration in these TNBC cell lines, wh...
Source: Clinical and Experimental Metastasis - October 19, 2019 Category: Cancer & Oncology Source Type: research

NHE5 regulates growth factor signaling, integrin trafficking, and degradation in glioma cells
AbstractNa+/H+ exchanger 5 (NHE5) is enriched in neurons and cycles between recycling endosomes and plasma membranes and transports protons to the endosomal lumen as well as to the extracellular space. Although NHE5 expression is undetectable in normal astrocytes, C6 glioma cells express NHE5 at an elevated level. Using C6 cells as a model, here we demonstrate that NHE5 has an important role in tumor growth and tumor cell proliferation and invasion. Glioma xenografts originating fromNHE5-knockdown cells exhibited significantly slower growth than those fromNHE1-knockdown cells and control cells. Histological characterizatio...
Source: Clinical and Experimental Metastasis - October 8, 2019 Category: Cancer & Oncology Source Type: research

Breast cancer cells expressing cancer-associated sialyl-Tn antigen have less capacity to develop osteolytic lesions in a mouse model of skeletal colonization
In conclusion, breast cancer cells expressing STn antigen had less capacity for skeletal colonization, possibly due to impaired adhesive capability. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - October 8, 2019 Category: Cancer & Oncology Source Type: research

Harnessing the versatile role of OPG in bone oncology: counterbalancing RANKL and TRAIL signaling and beyond
AbstractMore than 2 decades ago, the discovery of osteoprotegerin (OPG) as inhibitor of the receptor of activator of nuclear factor Kb (RANK) ligand (RANKL) revolutionized our understanding of bone biology and oncology. Besides acting as decoy receptor for RANKL, OPG acts as decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). OPG, RANKL, and TRAIL are ubiquitously expressed, stimulating per se pivotal signaling cascades implicated in cancer. In the context of cancer cell –bone cell interactions, cancer cells skew the OPG/RANKL/RANK (RANKL cognate receptor) balance towards bone destruct...
Source: Clinical and Experimental Metastasis - October 1, 2019 Category: Cancer & Oncology Source Type: research

Retrospective analysis by site of primary tumor of patients with unresectable locally-advanced or metastatic pancreatic adenocarcinoma receiving chemotherapy
AbstractThe primary tumor site of pancreatic cancer has been suggested as a recommended variable in future studies of treatments of patients with unresectable or metastatic pancreatic adenocarcinoma (mPDAC). The aim of the current study is to analyze the differences between mPDAC of the head and mPDAC of the body-tail, both in prognostic and predictive terms in patients with mPDAC receiving palliative chemotherapy. Data of patients with a diagnosis of mPDAC and receiving chemotherapy (CHT), registered in the database of the division of Medical Oncology of the Ospedale Civile di Sanremo, were analyzed. Thirty-two variables ...
Source: Clinical and Experimental Metastasis - October 1, 2019 Category: Cancer & Oncology Source Type: research

PTEN loss activates a functional AKT/CXCR4 signaling axis to potentiate tumor growth and lung metastasis in human osteosarcoma cells
AbstractOsteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Loss of the tumor suppressor PTEN or activation of chemokine receptor CXCR4 has been demonstrated to associate with OS respectively. However, the signaling mechanism underlying PTEN-mediated antitumor effect remains largely unknown, and the crosstalk between PTEN and CXCR4 in OS has not been investigated. Here, we uncover a PTEN/AKT/CXCR4 pathway nexus in highly tumorigenic and metastatic human 143B OS cells. Loss of PTEN activates AKT/CXCR4 signaling axis and regulates a series of tumor cell behaviors. Notably, ERK is in...
Source: Clinical and Experimental Metastasis - September 30, 2019 Category: Cancer & Oncology Source Type: research

Identification of inflammatory mediators associated with metastasis of oral squamous cell carcinoma in experimental and clinical studies: systematic review
AbstractMetastasis, whether regional or distant, remains the main cause of morbidity and recurrence in oral cancer. The accumulating evidence suggests that inflammatory mediators are strong drivers for cancer progression and spread. However, the precise role of these inflammatory mediators in mediating specific metastatic stage is poorly understood  due to lack of integration/validation of experimental research data and the clinical trials, i.e., the data produced from research is not translated to clinical therapeutic targets. This, in turn, results in the lack of developing reliable biomarker that can be used for ac...
Source: Clinical and Experimental Metastasis - September 26, 2019 Category: Cancer & Oncology Source Type: research

Gene expression signatures of site-specificity in cancer metastases
AbstractWe have previously shown that metastases are generally characterized by a core program of gene expression that induces the oxidative energy metabolism, activates vascularization/tissue remodeling, silences extracellular matrix interactions, and alters ion homeostasis. This core program distinguishes metastases from their originating primary tumors as well as from their target host tissues. We hypothesized that organ preference is reflected in additional, site-selective components within the metastatic gene expression programs. Expanding our prior analysis of 653 human gene expression profiles plus data from a murin...
Source: Clinical and Experimental Metastasis - September 25, 2019 Category: Cancer & Oncology Source Type: research

The prognostic value of PET/CT evaluation with Deauville score on the recurrence and survival in diffuse large B-cell lymphoma: a multi-institutional study of KROG 17-02
This study showed and validated that Deauville score of 4–5 of PET-CT imaging taken after full-course of R-CHOP chemotherapy with or without RT could predict recurrence-free survival and overall survival in DLBCL patients. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - September 25, 2019 Category: Cancer & Oncology Source Type: research

CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway
In conclusion, these data indicate CCL2 in CAMCs-CM promoted the malignant potential of EOC. CCL2 plays a crucial role in the tumor microenvironment of EOC. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - September 21, 2019 Category: Cancer & Oncology Source Type: research

Intraperitoneal mitomycin C improves survival compared to cytoreductive surgery alone in an experimental model of high-grade pseudomyxoma peritonei
In conclusion, the addition of IPEC with MMC after CRS doubled the survival time and reduced tumor growth compared to CRS alone. Adding regional hyperthermia resulted in a modest improvement of treatment outcome. (Source: Clinical and Experimental Metastasis)
Source: Clinical and Experimental Metastasis - September 20, 2019 Category: Cancer & Oncology Source Type: research

Adaptation to chronic acidic extracellular pH elicits a sustained increase in lung cancer cell invasion and metastasis
This study assessed whether adaptation to acidic pHe enhances the metastatic phenotype of tumor cells. The low metastatic variant of Lewis lung carcinoma (LLCm1) cells were subjected to stepwise acidification, establishing acidic pHe-adapted (LLCm1A) cells growing exponentially at pH 6.2. These LLCm1A cells showed increased production of matrix metalloproteinases (MMPs), including MMP-2, -3, -9, and -13, and pulmonary metastasis following injection into mouse tail veins. Although LLCm1A cells exhibited a fibroblastic shape, keratin-5 expression was increased and α-smooth muscle actin expression was reduced. Despite s...
Source: Clinical and Experimental Metastasis - September 5, 2019 Category: Cancer & Oncology Source Type: research

Cullin 3 overexpression inhibits lung cancer metastasis and is associated with survival of lung adenocarcinoma
This study investigated the CUL3-modulating potential of non-small cell lung cancer cell lines, H1299, H358, H2170 and H520, by using immunoblotting, MTT, migration, invasion, colony formation and in vivo tumorigenicity assays. The prognostic significance of CUL3 was measured by public KM plotter database (http://kmplot.com/analysis/index.php?p=service&cancer=breast) and tissue immunohistochemistry analysis. The public online database analysis revealed that elevated mRNA expression of CUL3 was associated with better prognosis for non-small cell lung cancer and lung adenocarcinoma. In vitro experiments showed that ectop...
Source: Clinical and Experimental Metastasis - August 28, 2019 Category: Cancer & Oncology Source Type: research