Construction of a recombinant vaccine expressing Nipah virus glycoprotein using the replicative and highly attenuated vaccinia virus strain LC16m8
In this study, we generated recombinant vaccinia viruses expressing the NiV glycoprotein (G) or fusion (F) protein using the LC16m8 strain, and examined their antigenicity and ability to induce immunity. Neutralizing antibodies against NiV were successfully induced in hamsters inoculated with LC16m8 expressing NiV G or F, and the antibody titers were higher than those induced by other vaccinia virus vectors previously reported to prevent lethal NiV infection. These findings indicate that the LC16m8-based vaccine format has superior features as a proliferative vaccine compared with other poxvirus-based vaccines. Moreover, t...
Source: PLoS Neglected Tropical Diseases - December 15, 2023 Category: Tropical Medicine Authors: Shumpei Watanabe Source Type: research
Viruses, Vol. 15, Pages 2407: Recently Emerged Novel Henipa-like Viruses: Shining a Spotlight on the Shrew
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Henipaviruses are zoonotic viruses, including some highly pathogenic and capable of serious disease and high fatality rates in both animals and humans. Hendra virus and Nipah virus are the most notable henipaviruses, resulting in significant outbreaks across South Asia, South-East Asia, and Australia. Pteropid fruit bats have been identified as key zoonotic reservoirs; however, the increased discovery of henipaviruses outside the geographic distribution of Pteropid fruit bats and the detection of novel henipa-like viruses in other species such as the shrew, rat, and opossum suggest that Pteropid bats are not the so...
Source: Viruses - December 11, 2023 Category: Virology Authors: Sarah Caruso Sarah J. Edwards Tags: Review Source Type: research
Rebuilding for Tomorrow ’s Outbreak: The State of Special Pathogen Preparedness in the USA in the Wake of COVID-19
AbstractPurpose of ReviewSpecial pathogens require unique planning care capabilities within healthcare facilities and can pose significant public health threats. Outbreaks have continued to emerge through the COVID-19 pandemic and serve as reminders of the need to have tiered levels of readiness and resources supporting all healthcare settings.Recent FindingsRecent outbreaks of Marburg virus, Sudan virus, Lassa virus, and Nipah virus are examples of low-incidence pathogens that carry disproportionally high potential consequences for healthcare worker safety and public health. While the COVID-19 pandemic has increased aware...
Source: Current Infectious Disease Reports - December 1, 2023 Category: Infectious Diseases Source Type: research
EPH101 Assessing the Relative Benefits Associated With Developing Vaccines for Nipah Virus Infection and Rift Valley Fever From Local, National, and Global Perspectives
Vaccination is a vital component of public health policy though there are many diseases for which vaccines are not available. Global health-care organizations with limited resources must make difficult choices over which vaccines to develop and where to deploy them. Here we provide a comparison between Nipah Virus Infection (NPI) and Rift Valley Fever (RVF), two diseases that have been prioritized by the WHO for R&D in public health emergency contexts. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: R. Gani, A. Pinsent, R. Chapman Source Type: research
Pangenomic and immunoinformatics based analysis of Nipah virus revealed CD4+ and CD8+ T-Cell epitopes as potential vaccine candidates
Conclusion: Our vaccinomics and system-level investigation could help to trigger the host immune system to prevent NiV infection. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - November 14, 2023 Category: Drugs & Pharmacology Source Type: research
In silico designing of an epitope-based peptide vaccine cocktail against Nipah virus: an Indian population-based epidemiological study
This study may serve as a new avenue for development of more efficient peptide cocktail vaccines in recent future based on the population genetics and ethnicity.PMID:37955744 | DOI:10.1007/s00203-023-03717-3 (Source: Archives of Microbiology)
Source: Archives of Microbiology - November 13, 2023 Category: Microbiology Authors: Dwaipayan Chaudhuri Satyabrata Majumder Joyeeta Datta Kalyan Giri Source Type: research
In silico designing of an epitope-based peptide vaccine cocktail against Nipah virus: an Indian population-based epidemiological study
This study may serve as a new avenue for development of more efficient peptide cocktail vaccines in recent future based on the population genetics and ethnicity.PMID:37955744 | DOI:10.1007/s00203-023-03717-3 (Source: Archives of Microbiology)
Source: Archives of Microbiology - November 13, 2023 Category: Microbiology Authors: Dwaipayan Chaudhuri Satyabrata Majumder Joyeeta Datta Kalyan Giri Source Type: research
In silico designing of an epitope-based peptide vaccine cocktail against Nipah virus: an Indian population-based epidemiological study
This study may serve as a new avenue for development of more efficient peptide cocktail vaccines in recent future based on the population genetics and ethnicity.PMID:37955744 | DOI:10.1007/s00203-023-03717-3 (Source: Archives of Microbiology)
Source: Archives of Microbiology - November 13, 2023 Category: Microbiology Authors: Dwaipayan Chaudhuri Satyabrata Majumder Joyeeta Datta Kalyan Giri Source Type: research
In silico prediction of interaction between Nipah virus attachment glycoprotein and host cell receptors Ephrin-B2 and Ephrin-B3 in domestic and peridomestic mammals
In this study, we assessed the degree of NiV host tropism in domestic and peridomestic mammals commonly found in Bangladesh that may be crucial in the transmission of NiV by serving as intermediate hosts. We carried out a protein-protein docking analysis of NiV G complexes (n = 52) with Ephrin-B2 and B3 of 13 domestic and peridomestic species using bioinformatics tools. Protein models were generated by homology modelling and the structures were validated for model quality. The different protein-protein complexes in this study were stable, and their binding affinity (ΔG) scores ranged between -8.0 to -19.1 kcal/mol. NiV Ba...
Source: Infection, Genetics and Evolution - November 4, 2023 Category: Genetics & Stem Cells Authors: Ananya Ferdous Hoque M D Mahfuzur Rahman Ayeasha Siddika Lamia Ariful Islam John D Klena Syed Moinuddin Satter Jonathan H Epstein Joel M Montgomery Mohammad Enayet Hossain Tahmina Shirin Iqbal Kabir Jahid Mohammed Ziaur Rahman Source Type: research
In silico prediction of interaction between Nipah virus attachment glycoprotein and host cell receptors Ephrin-B2 and Ephrin-B3 in domestic and peridomestic mammals
In this study, we assessed the degree of NiV host tropism in domestic and peridomestic mammals commonly found in Bangladesh that may be crucial in the transmission of NiV by serving as intermediate hosts. We carried out a protein-protein docking analysis of NiV G complexes (n = 52) with Ephrin-B2 and B3 of 13 domestic and peridomestic species using bioinformatics tools. Protein models were generated by homology modelling and the structures were validated for model quality. The different protein-protein complexes in this study were stable, and their binding affinity (ΔG) scores ranged between -8.0 to -19.1 kcal/mol. NiV Ba...
Source: Infection, Genetics and Evolution - November 4, 2023 Category: Genetics & Stem Cells Authors: Ananya Ferdous Hoque M D Mahfuzur Rahman Ayeasha Siddika Lamia Ariful Islam John D Klena Syed Moinuddin Satter Jonathan H Epstein Joel M Montgomery Mohammad Enayet Hossain Tahmina Shirin Iqbal Kabir Jahid Mohammed Ziaur Rahman Source Type: research
In silico prediction of interaction between Nipah virus attachment glycoprotein and host cell receptors Ephrin-B2 and Ephrin-B3 in domestic and peridomestic mammals
In this study, we assessed the degree of NiV host tropism in domestic and peridomestic mammals commonly found in Bangladesh that may be crucial in the transmission of NiV by serving as intermediate hosts. We carried out a protein-protein docking analysis of NiV G complexes (n = 52) with Ephrin-B2 and B3 of 13 domestic and peridomestic species using bioinformatics tools. Protein models were generated by homology modelling and the structures were validated for model quality. The different protein-protein complexes in this study were stable, and their binding affinity (ΔG) scores ranged between -8.0 to -19.1 kcal/mol. NiV Ba...
Source: Infection, Genetics and Evolution - November 4, 2023 Category: Genetics & Stem Cells Authors: Ananya Ferdous Hoque M D Mahfuzur Rahman Ayeasha Siddika Lamia Ariful Islam John D Klena Syed Moinuddin Satter Jonathan H Epstein Joel M Montgomery Mohammad Enayet Hossain Tahmina Shirin Iqbal Kabir Jahid Mohammed Ziaur Rahman Source Type: research
In silico prediction of interaction between Nipah virus attachment glycoprotein and host cell receptors Ephrin-B2 and Ephrin-B3 in domestic and peridomestic mammals
In this study, we assessed the degree of NiV host tropism in domestic and peridomestic mammals commonly found in Bangladesh that may be crucial in the transmission of NiV by serving as intermediate hosts. We carried out a protein-protein docking analysis of NiV G complexes (n = 52) with Ephrin-B2 and B3 of 13 domestic and peridomestic species using bioinformatics tools. Protein models were generated by homology modelling and the structures were validated for model quality. The different protein-protein complexes in this study were stable, and their binding affinity (ΔG) scores ranged between -8.0 to -19.1 kcal/mol. NiV Ba...
Source: Infection, Genetics and Evolution - November 4, 2023 Category: Genetics & Stem Cells Authors: Ananya Ferdous Hoque M D Mahfuzur Rahman Ayeasha Siddika Lamia Ariful Islam John D Klena Syed Moinuddin Satter Jonathan H Epstein Joel M Montgomery Mohammad Enayet Hossain Tahmina Shirin Iqbal Kabir Jahid Mohammed Ziaur Rahman Source Type: research
Rebuilding for Tomorrow ’s Outbreak: The State of Special Pathogen Preparedness in the USA in the Wake of COVID-19
AbstractPurpose of ReviewSpecial pathogens require unique planning care capabilities within healthcare facilities and can pose significant public health threats. Outbreaks have continued to emerge through the COVID-19 pandemic and serve as reminders of the need to have tiered levels of readiness and resources supporting all healthcare settings.Recent FindingsRecent outbreaks of Marburg virus, Sudan virus, Lassa virus, and Nipah virus are examples of low-incidence pathogens that carry disproportionally high potential consequences for healthcare worker safety and public health. While the COVID-19 pandemic has increased aware...
Source: Current Infectious Disease Reports - November 1, 2023 Category: Infectious Diseases Source Type: research
An Overview of Conventional and Black Cumin Seeds (Nigella sativa) Therapy in the Management of Nipah Viral Infection
Infect Disord Drug Targets. 2023 Oct 25. doi: 10.2174/0118715265258029231017112421. Online ahead of print.ABSTRACTThe recent outbreaks of Nipah viral infection were associated with severe respiratory illness, lethal encephalitis, and an extremely high mortality rate. As there are no approved antiviral medications, patients with NiV infections are currently treated with repurposed or investigational antivirals and supportive care. This review examines the potential health benefits of N. sativa in the treatment of NiV infection. To identify relevant studies, the literature was searched in online databases like Medline/PubMed...
Source: Infectious Disorders Drug Targets - October 27, 2023 Category: Infectious Diseases Authors: Naina Mohamed Pakkir Maideen Rajkapoor Balasubramaniam Mohamed Harsath Jahir Hussain Rupeshkumar Mani Thirumal Margesan Vasanth Kumar Solaimalai Source Type: research
An Overview of Conventional and Black Cumin Seeds (Nigella sativa) Therapy in the Management of Nipah Viral Infection
Infect Disord Drug Targets. 2023 Oct 25. doi: 10.2174/0118715265258029231017112421. Online ahead of print.ABSTRACTThe recent outbreaks of Nipah viral infection were associated with severe respiratory illness, lethal encephalitis, and an extremely high mortality rate. As there are no approved antiviral medications, patients with NiV infections are currently treated with repurposed or investigational antivirals and supportive care. This review examines the potential health benefits of N. sativa in the treatment of NiV infection. To identify relevant studies, the literature was searched in online databases like Medline/PubMed...
Source: Infectious Disorders Drug Targets - October 27, 2023 Category: Infectious Diseases Authors: Naina Mohamed Pakkir Maideen Rajkapoor Balasubramaniam Mohamed Harsath Jahir Hussain Rupeshkumar Mani Thirumal Margesan Vasanth Kumar Solaimalai Source Type: research
