Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Late remdesivir treatment initiation partially protects African green monkeys from lethal Nipah virus infection
Antiviral Res. 2023 Jun 23:105658. doi: 10.1016/j.antiviral.2023.105658. Online ahead of print.ABSTRACTRemdesivir is a nucleotide prodrug with preclinical efficacy against lethal Nipah virus infection in African green monkeys when administered 1 day post inoculation (dpi) (Lo et al., 2019). Here, we determined whether remdesivir treatment was still effective when treatment administration initiation was delayed until 3 dpi. Three groups of six African green monkeys were inoculated with a lethal dose of Nipah virus, genotype Bangladesh. On 3 dpi, one group received a loading dose of 10 mg/kg remdesivir followed by daily dosi...
Source: Antiviral Research - June 25, 2023 Category: Virology Authors: Emmie de Wit Brandi N Williamson Friederike Feldmann Kerry Goldin Michael K Lo Atsushi Okumura Jamie Lovaglio Elaine Bunyan Danielle P Porter Tomas Cihlar Greg Saturday Christina F Spiropoulou Heinz Feldmann Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
Experimental infection of tick cells with Nipah virus
Trop Biomed. 2023 Mar 1;40(1):29-36. doi: 10.47665/tb.40.1.009.ABSTRACTNipah virus (NiV), a highly pathogenic henipavirus of the family Paramyxoviridae, which causes fatal encephalitis in 40-70% of affected patients, was first reported in Malaysia over 20 years ago. Pteropid bats are the natural hosts of henipaviruses, and ticks have been proposed as a possible link between bats and mammalian hosts. To investigate this hypothesis, infection of the tick cell line IDE8 with NiV was examined. Presence of viral RNA and antigen in the NiV-infected tick cells was confirmed. Infectious virions were recovered from NiV-infected tic...
Source: Tropical Biomedicine - June 25, 2023 Category: Tropical Medicine Authors: W H Phoon L Bell-Sakyi S AbuBakar L Y Chang Source Type: research
