Sero-prevalence of Nipah antibodies among close contacts of the index case: Correspondence
J Family Med Prim Care. 2023 Apr;12(4):804. doi: 10.4103/jfmpc.jfmpc_1885_22. Epub 2023 Apr 17.NO ABSTRACTPMID:37312774 | PMC:PMC10259571 | DOI:10.4103/jfmpc.jfmpc_1885_22 (Source: Primary Care)
Source: Primary Care - June 14, 2023 Category: Primary Care Authors: Pathum Sookaromdee Viroj Wiwanitkit Source Type: research
Sero-prevalence of Nipah antibodies among close contacts of the index case: Correspondence
J Family Med Prim Care. 2023 Apr;12(4):804. doi: 10.4103/jfmpc.jfmpc_1885_22. Epub 2023 Apr 17.NO ABSTRACTPMID:37312774 | PMC:PMC10259571 | DOI:10.4103/jfmpc.jfmpc_1885_22 (Source: Primary Care)
Source: Primary Care - June 14, 2023 Category: Primary Care Authors: Pathum Sookaromdee Viroj Wiwanitkit Source Type: research
GSE234213 The Sequence Basis for Selectivity of Ephrin-B2 for Eph Receptors and Pathogenic Henipavirus G Glycoproteins [EFNB2 DEEP MUTAGENESIS]
Contributor : Erik ProckoSeries Type : OtherOrganism : Homo sapiensEphrin-B2 (EFNB2) is a ligand for six Eph receptors in humans and also functions as a cell entry receptor for several henipaviruses, which are zoonotic viruses with pandemic potential. Two such viruses, Nipah (NiV) and Hendra (HeV), are highly pathogenic in humans yet do not have any widely approved virus-specific therapeutics or vaccines. Soluble Fc-fusions of EFNB2 (sEFNB2-Fc) are known to bind the attachment glycoprotein G of both viruses and inhibit viral infection of cells. However, the potential of sEFNB2-Fc as a neutralizing agent in vivo is hindere...
Source: GEO: Gene Expression Omnibus - June 12, 2023 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE234214 The Sequence Basis for Selectivity of Ephrin-B2 for Eph Receptors and Pathogenic Henipavirus G Glycoproteins [EFNB2-D62Q DEEP MUTAGENESIS]
Contributor : Erik ProckoSeries Type : OtherOrganism : Homo sapiensEphrin-B2 (EFNB2) is a ligand for six Eph receptors in humans and also functions as a cell entry receptor for several henipaviruses, which are zoonotic viruses with pandemic potential. Two such viruses, Nipah (NiV) and Hendra (HeV), are highly pathogenic in humans yet do not have any widely approved virus-specific therapeutics or vaccines. Soluble Fc-fusions of EFNB2 (sEFNB2-Fc) are known to bind the attachment glycoprotein G of both viruses and inhibit viral infection of cells. However, the potential of sEFNB2-Fc as a neutralizing agent in vivo is hindere...
Source: GEO: Gene Expression Omnibus - June 12, 2023 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Infectious Causes of Acute Encephalitis Syndrome in India: Decadal Change and the Way Forward
Indian Pediatr. 2023 May 30:S097475591600546. Online ahead of print.ABSTRACTThe diagnosis and management of encephalitis were largely based on clinical grounds and minimal laboratory investigations. Japanese encephalitis (JE) was considered as the probable diagnosis in most encephalitis cases. However, reports of JE in adults and the elderly are increasing after the JE vaccine introduction among children in 2006. The Nipah virus (NiV) emerged in 2002 and continues to afflict humans in new geographic areas. Many other infections cause encephalitis, including Chandipura, chikungunya, dengue, and West Nile. Significant advanc...
Source: Indian Pediatrics - June 1, 2023 Category: Pediatrics Authors: Babasaheb V Tandale Rahul Narang G Vijay Kumar Manish Jain Shilpa J Tomar Pravin S Deshmukh Source Type: research
Infectious Causes of Acute Encephalitis Syndrome in India: Decadal Change and the Way Forward
Indian Pediatr. 2023 May 30:S097475591600546. Online ahead of print.ABSTRACTThe diagnosis and management of encephalitis were largely based on clinical grounds and minimal laboratory investigations. Japanese encephalitis (JE) was considered as the probable diagnosis in most encephalitis cases. However, reports of JE in adults and the elderly are increasing after the JE vaccine introduction among children in 2006. The Nipah virus (NiV) emerged in 2002 and continues to afflict humans in new geographic areas. Many other infections cause encephalitis, including Chandipura, chikungunya, dengue, and West Nile. Significant advanc...
Source: Indian Pediatrics - June 1, 2023 Category: Pediatrics Authors: Babasaheb V Tandale Rahul Narang G Vijay Kumar Manish Jain Shilpa J Tomar Pravin S Deshmukh Source Type: research
Infectious Causes of Acute Encephalitis Syndrome in India: Decadal Change and the Way Forward
Indian Pediatr. 2023 May 30:S097475591600546. Online ahead of print.ABSTRACTThe diagnosis and management of encephalitis were largely based on clinical grounds and minimal laboratory investigations. Japanese encephalitis (JE) was considered as the probable diagnosis in most encephalitis cases. However, reports of JE in adults and the elderly are increasing after the JE vaccine introduction among children in 2006. The Nipah virus (NiV) emerged in 2002 and continues to afflict humans in new geographic areas. Many other infections cause encephalitis, including Chandipura, chikungunya, dengue, and West Nile. Significant advanc...
Source: Indian Pediatrics - June 1, 2023 Category: Pediatrics Authors: Babasaheb V Tandale Rahul Narang G Vijay Kumar Manish Jain Shilpa J Tomar Pravin S Deshmukh Source Type: research
Infectious Causes of Acute Encephalitis Syndrome in India: Decadal Change and the Way Forward
Indian Pediatr. 2023 May 30:S097475591600546. Online ahead of print.ABSTRACTThe diagnosis and management of encephalitis were largely based on clinical grounds and minimal laboratory investigations. Japanese encephalitis (JE) was considered as the probable diagnosis in most encephalitis cases. However, reports of JE in adults and the elderly are increasing after the JE vaccine introduction among children in 2006. The Nipah virus (NiV) emerged in 2002 and continues to afflict humans in new geographic areas. Many other infections cause encephalitis, including Chandipura, chikungunya, dengue, and West Nile. Significant advanc...
Source: Indian Pediatrics - June 1, 2023 Category: Pediatrics Authors: Babasaheb V Tandale Rahul Narang G Vijay Kumar Manish Jain Shilpa J Tomar Pravin S Deshmukh Source Type: research
Infectious Causes of Acute Encephalitis Syndrome in India: Decadal Change and the Way Forward
Indian Pediatr. 2023 May 30:S097475591600546. Online ahead of print.ABSTRACTThe diagnosis and management of encephalitis were largely based on clinical grounds and minimal laboratory investigations. Japanese encephalitis (JE) was considered as the probable diagnosis in most encephalitis cases. However, reports of JE in adults and the elderly are increasing after the JE vaccine introduction among children in 2006. The Nipah virus (NiV) emerged in 2002 and continues to afflict humans in new geographic areas. Many other infections cause encephalitis, including Chandipura, chikungunya, dengue, and West Nile. Significant advanc...
Source: Indian Pediatrics - June 1, 2023 Category: Pediatrics Authors: Babasaheb V Tandale Rahul Narang G Vijay Kumar Manish Jain Shilpa J Tomar Pravin S Deshmukh Source Type: research
Infectious Causes of Acute Encephalitis Syndrome in India: Decadal Change and the Way Forward
Indian Pediatr. 2023 May 30:S097475591600546. Online ahead of print.ABSTRACTThe diagnosis and management of encephalitis were largely based on clinical grounds and minimal laboratory investigations. Japanese encephalitis (JE) was considered as the probable diagnosis in most encephalitis cases. However, reports of JE in adults and the elderly are increasing after the JE vaccine introduction among children in 2006. The Nipah virus (NiV) emerged in 2002 and continues to afflict humans in new geographic areas. Many other infections cause encephalitis, including Chandipura, chikungunya, dengue, and West Nile. Significant advanc...
Source: Indian Pediatrics - June 1, 2023 Category: Pediatrics Authors: Babasaheb V Tandale Rahul Narang G Vijay Kumar Manish Jain Shilpa J Tomar Pravin S Deshmukh Source Type: research
Viruses, Vol. 15, Pages 1302: Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism
her F. Basler
Nipah virus (NiV) and Hendra virus (HeV) are highly pathogenic species from the Henipavirus genus within the paramyxovirus family and are harbored by Pteropus Flying Fox species. Henipaviruses cause severe respiratory disease, neural symptoms, and encephalitis in various animals and humans, with human mortality rates exceeding 70% in some NiV outbreaks. The henipavirus matrix protein (M), which drives viral assembly and budding of the virion, also performs non-structural functions as a type I interferon antagonist. Interestingly, M also undergoes nuclear trafficking that mediates critical monoubiquitinati...
Source: Viruses - May 31, 2023 Category: Virology Authors: Camilla M. Donnelly Olivia A. Vogel Megan R. Edwards Paige E. Taylor Justin A. Roby Jade K. Forwood Christopher F. Basler Tags: Article Source Type: research
New U.S. lab will work with deadly animal pathogens —in the middle of farm country
Virologist Robert Cross’s lab is equipped to handle some of the world’s most dangerous viruses. At the Galveston National Laboratory he has worked with guinea pigs infected with Ebola virus and macaques carrying Lassa fever. What it can’t accommodate are pigs, which are common carriers of the deadly Nipah virus. “We’re not really geared to handle large animals,” says Cross, who wears a pressurized biosafety suit for his studies. “You can’t just pick them up when you’re wearing these space suits.”
That’s one reason why Cross is welcoming tomorrow’s
ceremonial opening
of a massive new ...
Source: Science of Aging Knowledge Environment - May 23, 2023 Category: Geriatrics Source Type: research
< em > In silico < /em > identification and validation of phenolic lipids as potential inhibitor against bacterial and viral strains
J Biomol Struct Dyn. 2023 May 22:1-14. doi: 10.1080/07391102.2023.2212811. Online ahead of print.ABSTRACTThe recurrence of coronavirus disease and bacterial resistant strains has drawn attention to naturally occurring bioactive molecules that can demonstrate broad-spectrum efficacy against bacteria as well as viral strains. The drug-like abilities of naturally available "anacardic acids" (AA) and their derivatives against different bacterial and viral protein targets through in-silico tools were explored. Three viral protein targets [P DB: 6Y2E (SARS-CoV-2), 1AT3 (Herpes) and 2VSM (Nipah)] and four bacterial protein target...
Source: Herpes - May 22, 2023 Category: Infectious Diseases Authors: Kavita Khatana Anjali Gupta Anujit Ghosal Pinki Dey Fahmina Zafar Anubha Srivastava Priya Verma Source Type: research
Rapid detection of Nipah virus using the one-pot RPA-CRISPR/Cas13a assay
In this study, we developed an optimized one-pot assay using recombinase polymerase amplification (RPA) coupled to CRISPR/Cas13a for the molecular detection of NiV. The one-pot RPA-CRISPR/Cas13a assay for NiV detection was specific and did not cross-react against other selected (re)-emerging pathogens. The sensitivity of the one-pot RPA-CRISPR/Cas13a assay for NiV detection can detect as little as 103 cp/μL of total synthetic NiV cDNA. The assay was then validated with simulated clinical samples. The results for the one-pot RPA-CRISPR/Cas13a assay could be visualized with either fluorescence or lateral flow strips for con...
Source: Virus Research - May 13, 2023 Category: Virology Authors: Jing Miao Lulu Zuo Dongmei He Zhixin Fang Nicolas Berthet Chao Yu Gary Wong Source Type: research
