Antiviral Effects of Micafungin against Pteropine Orthoreovirus, an Emerging Zoonotic Virus Carried by Bats
Virus Res. 2023 Oct 17:199248. doi: 10.1016/j.virusres.2023.199248. Online ahead of print.ABSTRACTBat-borne emerging zoonotic viruses cause major outbreaks, such as the Ebola virus, Nipah virus, and/or beta coronavirus. Pteropine orthoreovirus (PRV), whose spillover event occurred from fruits bats to humans, causes respiratory syndrome in humans widely in South East Asia. Repurposing approved drugs against PRV is an effective tool to confront future PRV pandemics. We screened 2,943 compounds in an FDA-approved drug library and identified eight hit compounds that reduce viral cytopathic effects on cultured Vero cells. Real-...
Source: Virus Research - October 20, 2023 Category: Virology Authors: Eiichi Hondo Tetsufumi Katta Ayato Sato Naoya Kadofusa Tomoki Ishibashi Hiroshi Shimoda Atsuo Iida Source Type: research
Daily briefing: Fossilized footprints show people’s first steps into the Americas
Nature, Published online: 11 October 2023; doi:10.1038/d41586-023-03213-0Human footprints might be the oldest direct evidence that people lived in the Americas thousands of years earlier than thought. Plus, gene editing makes chickens flu-resistant and how to lower the risk of a Nipah virus pandemic. (Source: Nature AOP)
Source: Nature AOP - October 11, 2023 Category: Research Authors: Flora Graham Source Type: research
Nipah virus is deadly — but smart policy changes can help quell pandemic risk
Nature, Published online: 10 October 2023; doi:10.1038/d41586-023-03162-8Repeated outbreaks increase the risk of a Nipah strain emerging that is better at spreading. (Source: Nature AOP)
Source: Nature AOP - October 10, 2023 Category: Research Authors: Thekkumkara Surendran Anish Source Type: research
Viruses, Vol. 15, Pages 2062: Nipah Virus: An Overview of the Current Status of Diagnostics and Their Role in Preparedness in Endemic Countries
annetier
Nipah virus (NiV) is a paramyxovirus responsible for a high mortality rate zoonosis. As a result, it has been included in the list of Blueprint priority pathogens. Bats are the main reservoirs of the virus, and different clinical courses have been described in humans. The Bangladesh strain (NiV-B) is often associated with severe respiratory disease, whereas the Malaysian strain (NiV-M) is often associated with severe encephalitis. An early diagnosis of NiV infection is crucial to limit the outbreak and to provide appropriate care to the patient. Due to high specificity and sensitivity, qRT-PCR is currently con...
Source: Viruses - October 7, 2023 Category: Virology Authors: Anna Rosa Garbuglia Daniele Lapa Silvia Pauciullo Herv é Raoul Delphine Pannetier Tags: Review Source Type: research
Viruses, Vol. 15, Pages 2048: A Survey of Henipavirus Tropism & mdash;Our Current Understanding from a Species/Organ and Cellular Level
Viruses, Vol. 15, Pages 2048: A Survey of Henipavirus Tropism—Our Current Understanding from a Species/Organ and Cellular Level
Viruses doi: 10.3390/v15102048
Authors:
Sandra Diederich
Shawn Babiuk
Hani Boshra
Henipaviruses are single-stranded RNA viruses that have been shown to be virulent in several species, including humans, pigs, horses, and rodents. Isolated nearly 30 years ago, these viruses have been shown to be of particular concern to public health, as at least two members (Nipah and Hendra viruses) are highly virulent, as well as zoonotic, and are thus classified as BSL4 pathogens. Although ...
Source: Viruses - October 4, 2023 Category: Virology Authors: Sandra Diederich Shawn Babiuk Hani Boshra Tags: Review Source Type: research
Tackling a global epidemic threat: Nipah surveillance in Bangladesh, 2006 –2021
This article emphasizes that the overall epidemiology of Nipah virus infection in Bangladesh has remained consistent throughout the years. This is the only systematic surveillance to detect human NiV infection globally. The findings from this surveillance have contributed to early detection of NiV cases in hospital settings, understanding of Nipah disease epidemiology, and have enabled timely public health interventions for prevention and containment of NiV infection. Although we still have much to learn regarding the transmission dynamics and risk factors of human NiV infection, surveillance has played a significant role ...
Source: PLoS Neglected Tropical Diseases - September 27, 2023 Category: Tropical Medicine Authors: Syed Moinuddin Satter Source Type: research
Viruses, Vol. 15, Pages 1980: Animal Models for Henipavirus Research
olsey
Hendra virus (HeV) and Nipah virus (NiV) are zoonotic paramyxoviruses in the genus Henipavirus (HNV) that emerged nearly thirty years ago. Outbreaks of HeV and NiV have led to severe respiratory disease and encephalitis in humans and animals characterized by a high mortality rate. Despite the grave threat HNVs pose to public health and global biosecurity, no approved medical countermeasures for human use currently exist against HeV or NiV. To develop candidate vaccines and therapeutics and advance the field’s understanding of HNV pathogenesis, animal models of HeV and NiV have been instrumental and ...
Source: Viruses - September 22, 2023 Category: Virology Authors: Declan D. Pigeaud Thomas W. Geisbert Courtney Woolsey Tags: Review Source Type: research
Nipah virus outbreak: what scientists know so far
Nature, Published online: 20 September 2023; doi:10.1038/d41586-023-02967-xIndia is taking urgent steps to halt the transmission of a rare but deadly virus that spreads from bats to humans. (Source: Nature AOP)
Source: Nature AOP - September 20, 2023 Category: Research Authors: Gemma Conroy Source Type: research
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6721. Online ahead of print.ABSTRACTThe zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug helps in overcoming the number of casualties and reducing the mortality rate, but no long-lasting solution has been proposed yet putting global health security in jeopardy. Given the cognizance of mRNA-based vaccines as safe and efficacious preventative strategies against pathogens, the current study has utilized the reverse-vaccinology approach coupled...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Muhammad Naveed Sarmad Mehmood Tariq Aziz Muhammad Hammad Arif Urooj Ali Faisal Nouroz Christos Zacharis Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6721. Online ahead of print.ABSTRACTThe zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug helps in overcoming the number of casualties and reducing the mortality rate, but no long-lasting solution has been proposed yet putting global health security in jeopardy. Given the cognizance of mRNA-based vaccines as safe and efficacious preventative strategies against pathogens, the current study has utilized the reverse-vaccinology approach coupled...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Muhammad Naveed Sarmad Mehmood Tariq Aziz Muhammad Hammad Arif Urooj Ali Faisal Nouroz Christos Zacharis Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics
Immunology. 2023 Sep 15. doi: 10.1111/imm.13695. Online ahead of print.ABSTRACTNipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV-Malaysia (NiVM ), NiV Bangladesh (NiVB ), and NiV India (NiVI reported in 2019) have been circulating in South-Asian nations. Sporadic outbreak observed in South-East Asian countries but human to human transmission raises the concern about its pandemic potential. The presence of the viral genome in reservoir bats has further confirmed that NiV has spread to the African and Australian continents. NiV research activities have gained momentum to achieve specific preparedn...
Source: Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Gayatree Mishra Vishal Prajapat Debasis Nayak Source Type: research
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics
Immunology. 2023 Sep 15. doi: 10.1111/imm.13695. Online ahead of print.ABSTRACTNipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV-Malaysia (NiVM ), NiV Bangladesh (NiVB ), and NiV India (NiVI reported in 2019) have been circulating in South-Asian nations. Sporadic outbreak observed in South-East Asian countries but human to human transmission raises the concern about its pandemic potential. The presence of the viral genome in reservoir bats has further confirmed that NiV has spread to the African and Australian continents. NiV research activities have gained momentum to achieve specific preparedn...
Source: Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Gayatree Mishra Vishal Prajapat Debasis Nayak Source Type: research
Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease
Discussion and conclusionIt was concluded that PHV02 vaccine elicited a rapid onset of protection and that any detectable level of neutralizing antibody was a functional immune correlate of survival. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - September 4, 2023 Category: Allergy & Immunology Source Type: research
Global dynamics of a compartmental model to assess the effect of transmission from deceased
We present a compartmental model for the spread of a disease with an imperfect vaccine available, also considering transmission from deceased infected in general. The global dynamics of the system are completely described by constructing appropriate Lyapunov functions. To support our analytical results, we perform numerical simulations to assess the importance of transmission from the deceased, considering the data collected from three infectious diseases, Ebola virus disease, COVID-19, and Nipah fever.PMID:37619887 | DOI:10.1016/j.mbs.2023.109059 (Source: Mathematical Biosciences)
Source: Mathematical Biosciences - August 24, 2023 Category: Statistics Authors: Saumen Barua Attila D énes Source Type: research
Global dynamics of a compartmental model to assess the effect of transmission from deceased
We present a compartmental model for the spread of a disease with an imperfect vaccine available, also considering transmission from deceased infected in general. The global dynamics of the system are completely described by constructing appropriate Lyapunov functions. To support our analytical results, we perform numerical simulations to assess the importance of transmission from the deceased, considering the data collected from three infectious diseases, Ebola virus disease, COVID-19, and Nipah fever.PMID:37619887 | DOI:10.1016/j.mbs.2023.109059 (Source: Mathematical Biosciences)
Source: Mathematical Biosciences - August 24, 2023 Category: Statistics Authors: Saumen Barua Attila D énes Source Type: research
