An Immunoinformatics Prediction of Novel Multi-Epitope Vaccines Candidate Against Surface Antigens of Nipah Virus
This study aimed at predicting a dual-antigen multi-epitope subunit chimeric vaccine against surface-glycoproteins G and F of NiV. Targeted proteins were subjected to immunoinformatics analyses to predict antigenic B-cell and T-cell epitopes. The proposed vaccine designs were implemented based on the conservancy, population coverage, molecular docking, immune simulations, codon adaptation, secondary mRNA structure, and in-silico cloning. Total 40 T and B-cell epitopes were found to be conserved, antigenic (vaxijen-value > 0.4), non-toxic, non-allergenic, and human non-homologous. Of 12 hypothetical vaccines, two (NiV_BG...
Source: Cell Research - June 28, 2022 Category: Cytology Authors: Md Mahfuzur Rahman Joynob Akter Puspo Ahmed Ahsan Adib Mohammad Enayet Hossain Mohammad Mamun Alam Sharmin Sultana Ariful Islam John D Klena Joel M Montgomery Syed M Satter Tahmina Shirin Mohammed Ziaur Rahman Source Type: research
Zika, Nipah and Kala-azar: Emerging lethal infectious diseases amid COVID-19 as an escalating public health threat in South India
Ann Med Surg (Lond). 2022 Jul;79:103972. doi: 10.1016/j.amsu.2022.103972. Epub 2022 Jun 15.ABSTRACTAs of 6 June 2022, a sum 25,782 of active cases and 524,701 deaths due to Coronavirus disease-19 (COVID-19) have been recorded in India. Stewing in the flares of the pandemic, Kerala is entwined in the wrath of multiple emerging infectious diseases. India, a home to 1.3 billion people, recently faced a devastating second wave of COVID-19 during May of 2021, with a ruckus of chronic shortage of medicine, oxygen supplies, ventilators, besides, being challenged by secondary infections and chronic health ailments. The state of Ke...
Source: Annals of Medicine - June 27, 2022 Category: Internal Medicine Authors: Utkarsha Uday Lakshmi Jyothi Tadi Zarmina Islam Parvathy Mohanan Shamas Ghazanfar Maryam Salma Babar Sumayya Ismail Source Type: research
Nipah Virus Detection at Bat Roosts after Spillover Events, Bangladesh, 2012-2019
We report a series of investigations at Pteropus medius bat roosts identified near the locations of human Nipah cases in Bangladesh during 2012-2019. Pooled bat urine was collected from 23 roosts; 7 roosts (30%) had >1 sample in which Nipah RNA was detected from the first visit. In subsequent visits to these 7 roosts, RNA was detected in bat urine up to 52 days after the presumed exposure of the human case-patient, although the probability of detection declined rapidly with time. These results suggest that rapidly deployed investigations of Nipah virus shedding from bat roosts near human cases could increase the success...
Source: Emerging Infectious Diseases - June 22, 2022 Category: Infectious Diseases Authors: Clifton D McKee Ausraful Islam Mohammed Ziaur Rahman Salah Uddin Khan Mahmudur Rahman Syed M Satter Ariful Islam Claude Kwe Yinda Jonathan H Epstein Peter Daszak Vincent J Munster Peter J Hudson Raina K Plowright Stephen P Luby Emily S Gurley Source Type: research
Nipah Virus Detection at Bat Roosts after Spillover Events, Bangladesh, 2012-2019
We report a series of investigations at Pteropus medius bat roosts identified near the locations of human Nipah cases in Bangladesh during 2012-2019. Pooled bat urine was collected from 23 roosts; 7 roosts (30%) had >1 sample in which Nipah RNA was detected from the first visit. In subsequent visits to these 7 roosts, RNA was detected in bat urine up to 52 days after the presumed exposure of the human case-patient, although the probability of detection declined rapidly with time. These results suggest that rapidly deployed investigations of Nipah virus shedding from bat roosts near human cases could increase the success...
Source: Emerging Infectious Diseases - June 22, 2022 Category: Infectious Diseases Authors: Clifton D McKee Ausraful Islam Mohammed Ziaur Rahman Salah Uddin Khan Mahmudur Rahman Syed M Satter Ariful Islam Claude Kwe Yinda Jonathan H Epstein Peter Daszak Vincent J Munster Peter J Hudson Raina K Plowright Stephen P Luby Emily S Gurley Source Type: research
Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessment
Vaccine. 2022 Jun 14:S0264-410X(22)00755-1. doi: 10.1016/j.vaccine.2022.06.008. Online ahead of print.ABSTRACTReplication-deficient adenoviral vectors have been under investigation as a platform technology for vaccine development for several years and have recently been successfully deployed as an effective COVID-19 counter measure. A replication-deficient adenoviral vector based on the simian adenovirus type Y25 and named ChAdOx1 has been evaluated in several clinical trials since 2012. The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) was formed to evaluate the safety and other key fe...
Source: Vaccine - June 17, 2022 Category: Allergy & Immunology Authors: Pedro M Folegatti Daniel Jenkin Susan Morris Sarah Gilbert Denny Kim James S Robertson Emily R Smith Emalee Martin Marc Gurwith Robert T Chen Benefit-Risk Assessment of VAccines by TechnolOgy Working Group BRAVATO, ex-V3SWG) Source Type: research
Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessment
Vaccine. 2022 Jun 14:S0264-410X(22)00755-1. doi: 10.1016/j.vaccine.2022.06.008. Online ahead of print.ABSTRACTReplication-deficient adenoviral vectors have been under investigation as a platform technology for vaccine development for several years and have recently been successfully deployed as an effective COVID-19 counter measure. A replication-deficient adenoviral vector based on the simian adenovirus type Y25 and named ChAdOx1 has been evaluated in several clinical trials since 2012. The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) was formed to evaluate the safety and other key fe...
Source: Vaccine - June 17, 2022 Category: Allergy & Immunology Authors: Pedro M Folegatti Daniel Jenkin Susan Morris Sarah Gilbert Denny Kim James S Robertson Emily R Smith Emalee Martin Marc Gurwith Robert T Chen Benefit-Risk Assessment of VAccines by TechnolOgy Working Group BRAVATO, ex-V3SWG) Source Type: research
Nipah Virus Detection at Bat Roosts after Spillover Events, Bangladesh, 2012 –2019
C. D. McKee et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - June 6, 2022 Category: Infectious Diseases Source Type: research
Mapping Risk of Nipah Virus Transmission from Bats to Humans in Thailand
AbstractNipah virus (NiV) is a zoonotic virus that can pose a serious threat to human and livestock health. Old-world fruit bats (Pteropus spp.) are the natural reservoir hosts for NiV, andPteropus lylei, Lyle ’s flying fox, is an important host of NiV in mainland Southeast Asia. NiV can be transmitted from bats to humans directly via bat-contaminated foods (i.e., date palm sap or fruit) or indirectly via livestock or other intermediate animal hosts. Here we construct risk maps for NiV spillover and tra nsmission by combining ecological niche models for theP. lylei bat reservoir with other spatial data related to direct ...
Source: EcoHealth - June 3, 2022 Category: Environmental Health Source Type: research
Designing potential siRNA molecules for silencing the gene of the nucleocapsid protein of Nipah virus: A computational investigation
Infect Genet Evol. 2022 May 27:105310. doi: 10.1016/j.meegid.2022.105310. Online ahead of print.ABSTRACTNipah virus (NiV), a zoonotic virus, engenders severe infections with noticeable complications and deaths in humans and animals. Since its emergence, it is frightening that this virus has been causing regular outbreaks in various countries, particularly Bangladesh, India, and Malaysia. Unfortunately, no efficient vaccine or drug is available to combat this baneful virus. It employs the nucleocapsid protein in its genetic material encapsidation, which is a crucial for viral replication. The small interfering RNAs (siRNAs)...
Source: Infection, Genetics and Evolution - May 31, 2022 Category: Genetics & Stem Cells Authors: A M U B Mahfuz Md Arif Khan Emran Hossain Sajib Anamika Deb Shafi Mahmud Mahmudul Hasan Otun Saha Ariful Islam M Mizanur Rahaman Source Type: research
Designing potential siRNA molecules for silencing the gene of the nucleocapsid protein of Nipah virus: A computational investigation
Infect Genet Evol. 2022 May 27:105310. doi: 10.1016/j.meegid.2022.105310. Online ahead of print.ABSTRACTNipah virus (NiV), a zoonotic virus, engenders severe infections with noticeable complications and deaths in humans and animals. Since its emergence, it is frightening that this virus has been causing regular outbreaks in various countries, particularly Bangladesh, India, and Malaysia. Unfortunately, no efficient vaccine or drug is available to combat this baneful virus. It employs the nucleocapsid protein in its genetic material encapsidation, which is a crucial for viral replication. The small interfering RNAs (siRNAs)...
Source: Infection, Genetics and Evolution - May 31, 2022 Category: Genetics & Stem Cells Authors: A M U B Mahfuz Md Arif Khan Emran Hossain Sajib Anamika Deb Shafi Mahmud Mahmudul Hasan Otun Saha Ariful Islam M Mizanur Rahaman Source Type: research
The nanoscale organization of Nipah virus matrix protein revealed by super-resolution microscopy
Biophys J. 2022 May 24:S0006-3495(22)00419-2. doi: 10.1016/j.bpj.2022.05.026. Online ahead of print.ABSTRACTThe matrix proteins (M) of many enveloped RNA viruses mediate virus assembly and budding. However, it remains poorly understood how M is involved in virus budding and how they interact with envelope proteins. Here, we show that the expression level of Nipah (NiV) M in particles produced by the host cells deviates from a Gamma distribution and does not reflect that of the host cells, indicating assembly of the NiV-M in the process. Our data reveal that NiV-M affects the circularity of the particles while the NiV envel...
Source: Biophysical Journal - May 26, 2022 Category: Physics Authors: Qian T Liu Qian Wang Youchang Zhang Vicky Kliemke Qian Liu Keng C Chou Source Type: research
The nanoscale organization of Nipah virus matrix protein revealed by super-resolution microscopy
Biophys J. 2022 May 24:S0006-3495(22)00419-2. doi: 10.1016/j.bpj.2022.05.026. Online ahead of print.ABSTRACTThe matrix proteins (M) of many enveloped RNA viruses mediate virus assembly and budding. However, it remains poorly understood how M is involved in virus budding and how they interact with envelope proteins. Here, we show that the expression level of Nipah (NiV) M in particles produced by the host cells deviates from a Gamma distribution and does not reflect that of the host cells, indicating assembly of the NiV-M in the process. Our data reveal that NiV-M affects the circularity of the particles while the NiV envel...
Source: Biophysical Journal - May 26, 2022 Category: Physics Authors: Qian T Liu Qian Wang Youchang Zhang Vicky Kliemke Qian Liu Keng C Chou Source Type: research
Viruses, Vol. 14, Pages 1100: Climate Anomalies and Spillover of Bat-Borne Viral Diseases in the Asia & ndash;Pacific Region and the Arabian Peninsula
In this study, we investigated the potential association between climate factors and anomalies, including El Niño Southern Oscillation (ENSO) and land surface temperature anomalies, as well as the emergence and spillover events of bat-borne viral diseases in humans and livestock in the Asia–Pacific region and the Arabian Peninsula. Our findings from time series analyses, logistic regression models, and structural equation modelling revealed that the spillover patterns of the Nipah virus in Bangladesh and the Hendra virus in Australia were differently impacted by climate variability and with dif...
Source: Viruses - May 20, 2022 Category: Virology Authors: Alice Latinne Serge Morand Tags: Article Source Type: research
