Tackling a global epidemic threat: Nipah surveillance in Bangladesh, 2006 –2021
This article emphasizes that the overall epidemiology of Nipah virus infection in Bangladesh has remained consistent throughout the years. This is the only systematic surveillance to detect human NiV infection globally. The findings from this surveillance have contributed to early detection of NiV cases in hospital settings, understanding of Nipah disease epidemiology, and have enabled timely public health interventions for prevention and containment of NiV infection. Although we still have much to learn regarding the transmission dynamics and risk factors of human NiV infection, surveillance has played a significant role ...
Source: PLoS Neglected Tropical Diseases - September 27, 2023 Category: Tropical Medicine Authors: Syed Moinuddin Satter Source Type: research
Viruses, Vol. 15, Pages 1980: Animal Models for Henipavirus Research
olsey
Hendra virus (HeV) and Nipah virus (NiV) are zoonotic paramyxoviruses in the genus Henipavirus (HNV) that emerged nearly thirty years ago. Outbreaks of HeV and NiV have led to severe respiratory disease and encephalitis in humans and animals characterized by a high mortality rate. Despite the grave threat HNVs pose to public health and global biosecurity, no approved medical countermeasures for human use currently exist against HeV or NiV. To develop candidate vaccines and therapeutics and advance the field’s understanding of HNV pathogenesis, animal models of HeV and NiV have been instrumental and ...
Source: Viruses - September 22, 2023 Category: Virology Authors: Declan D. Pigeaud Thomas W. Geisbert Courtney Woolsey Tags: Review Source Type: research
Nipah virus outbreak: what scientists know so far
Nature, Published online: 20 September 2023; doi:10.1038/d41586-023-02967-xIndia is taking urgent steps to halt the transmission of a rare but deadly virus that spreads from bats to humans. (Source: Nature AOP)
Source: Nature AOP - September 20, 2023 Category: Research Authors: Gemma Conroy Source Type: research
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6721. Online ahead of print.ABSTRACTThe zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug helps in overcoming the number of casualties and reducing the mortality rate, but no long-lasting solution has been proposed yet putting global health security in jeopardy. Given the cognizance of mRNA-based vaccines as safe and efficacious preventative strategies against pathogens, the current study has utilized the reverse-vaccinology approach coupled...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Muhammad Naveed Sarmad Mehmood Tariq Aziz Muhammad Hammad Arif Urooj Ali Faisal Nouroz Christos Zacharis Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
An mRNA-based reverse-vaccinology strategy to stimulate the immune response against Nipah virus in humans using fusion glycoproteins
Acta Biochim Pol. 2023 Sep 17. doi: 10.18388/abp.2020_6721. Online ahead of print.ABSTRACTThe zoonotic pathogen, Nipah virus, is considered a potential healthcare threat due to its high mortality rates and detrimental symptoms like encephalitis. Ribavirin, an antiviral drug helps in overcoming the number of casualties and reducing the mortality rate, but no long-lasting solution has been proposed yet putting global health security in jeopardy. Given the cognizance of mRNA-based vaccines as safe and efficacious preventative strategies against pathogens, the current study has utilized the reverse-vaccinology approach coupled...
Source: Acta Biochim Pol - September 17, 2023 Category: Biochemistry Authors: Muhammad Naveed Sarmad Mehmood Tariq Aziz Muhammad Hammad Arif Urooj Ali Faisal Nouroz Christos Zacharis Metab Alharbi Abdulrahman Alshammari Abdullah F Alasmari Source Type: research
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics
Immunology. 2023 Sep 15. doi: 10.1111/imm.13695. Online ahead of print.ABSTRACTNipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV-Malaysia (NiVM ), NiV Bangladesh (NiVB ), and NiV India (NiVI reported in 2019) have been circulating in South-Asian nations. Sporadic outbreak observed in South-East Asian countries but human to human transmission raises the concern about its pandemic potential. The presence of the viral genome in reservoir bats has further confirmed that NiV has spread to the African and Australian continents. NiV research activities have gained momentum to achieve specific preparedn...
Source: Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Gayatree Mishra Vishal Prajapat Debasis Nayak Source Type: research
Advancements in Nipah virus treatment: Analysis of current progress in vaccines, antivirals, and therapeutics
Immunology. 2023 Sep 15. doi: 10.1111/imm.13695. Online ahead of print.ABSTRACTNipah virus (NiV) causes severe encephalitis in humans. Three NiV strains NiV-Malaysia (NiVM ), NiV Bangladesh (NiVB ), and NiV India (NiVI reported in 2019) have been circulating in South-Asian nations. Sporadic outbreak observed in South-East Asian countries but human to human transmission raises the concern about its pandemic potential. The presence of the viral genome in reservoir bats has further confirmed that NiV has spread to the African and Australian continents. NiV research activities have gained momentum to achieve specific preparedn...
Source: Immunology - September 15, 2023 Category: Allergy & Immunology Authors: Gayatree Mishra Vishal Prajapat Debasis Nayak Source Type: research
Immunological correlates of protection afforded by PHV02 live, attenuated recombinant vesicular stomatitis virus vector vaccine against Nipah virus disease
Discussion and conclusionIt was concluded that PHV02 vaccine elicited a rapid onset of protection and that any detectable level of neutralizing antibody was a functional immune correlate of survival. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - September 4, 2023 Category: Allergy & Immunology Source Type: research
Global dynamics of a compartmental model to assess the effect of transmission from deceased
We present a compartmental model for the spread of a disease with an imperfect vaccine available, also considering transmission from deceased infected in general. The global dynamics of the system are completely described by constructing appropriate Lyapunov functions. To support our analytical results, we perform numerical simulations to assess the importance of transmission from the deceased, considering the data collected from three infectious diseases, Ebola virus disease, COVID-19, and Nipah fever.PMID:37619887 | DOI:10.1016/j.mbs.2023.109059 (Source: Mathematical Biosciences)
Source: Mathematical Biosciences - August 24, 2023 Category: Statistics Authors: Saumen Barua Attila D énes Source Type: research
Global dynamics of a compartmental model to assess the effect of transmission from deceased
We present a compartmental model for the spread of a disease with an imperfect vaccine available, also considering transmission from deceased infected in general. The global dynamics of the system are completely described by constructing appropriate Lyapunov functions. To support our analytical results, we perform numerical simulations to assess the importance of transmission from the deceased, considering the data collected from three infectious diseases, Ebola virus disease, COVID-19, and Nipah fever.PMID:37619887 | DOI:10.1016/j.mbs.2023.109059 (Source: Mathematical Biosciences)
Source: Mathematical Biosciences - August 24, 2023 Category: Statistics Authors: Saumen Barua Attila D énes Source Type: research
Global dynamics of a compartmental model to assess the effect of transmission from deceased
We present a compartmental model for the spread of a disease with an imperfect vaccine available, also considering transmission from deceased infected in general. The global dynamics of the system are completely described by constructing appropriate Lyapunov functions. To support our analytical results, we perform numerical simulations to assess the importance of transmission from the deceased, considering the data collected from three infectious diseases, Ebola virus disease, COVID-19, and Nipah fever.PMID:37619887 | DOI:10.1016/j.mbs.2023.109059 (Source: Mathematical Biosciences)
Source: Mathematical Biosciences - August 24, 2023 Category: Statistics Authors: Saumen Barua Attila D énes Source Type: research
Isolation of Primary Porcine Bronchial Epithelial Cells for Nipah Virus Infections
Methods Mol Biol. 2023;2682:103-120. doi: 10.1007/978-1-0716-3283-3_8.ABSTRACTThe Malaysian strain of Nipah virus (NiV) first emerged in 1998/99 and caused a major disease outbreak in pigs and humans. While humans developed fatal encephalitis due to a prominent infection of brain microvessels, NiV-infected pigs mostly suffered from an acute respiratory disease and efficiently spread the infection via airway secretions. To elucidate the molecular basis of the highly productive NiV replication in porcine airways in vitro, physiologically relevant cell models that have maintained functional characteristics of airway epithelia...
Source: Mol Biol Cell - August 23, 2023 Category: Molecular Biology Authors: Mareike Elvert Lucie Sauerhering Anja Heiner Andrea Maisner Source Type: research
In Vitro Antiviral Screening for Henipaviruses at BSL4
Methods Mol Biol. 2023;2682:93-102. doi: 10.1007/978-1-0716-3283-3_7.ABSTRACTIn vitro screening for antivirals is an essential step in the development of effective treatments against new and emerging pathogens. Here, we describe a simple, cell-based screening assay for evaluating antiviral effectiveness against Hendra and Nipah live virus infection under BSL4 conditions.PMID:37610576 | DOI:10.1007/978-1-0716-3283-3_7 (Source: Mol Biol Cell)
Source: Mol Biol Cell - August 23, 2023 Category: Molecular Biology Authors: Bruce A Mungall Source Type: research
Cell-Cell Fusion Assays to Study Henipavirus Entry and Evaluate Therapeutics
Methods Mol Biol. 2023;2682:59-69. doi: 10.1007/978-1-0716-3283-3_4.ABSTRACTHenipaviruses include the deadly zoonotic Nipah (NiV) and Hendra (HeV) paramyxoviruses, which have caused recurring outbreaks in human populations. A hallmark of henipavirus infection is the induction of cell-cell fusion (syncytia), caused by the expression of the attachment (G) and fusion (F) glycoproteins on the surface of infected cells. The interactions of G and F with each other and with receptors on cellular plasma membranes drive both viral entry and syncytia formation and are thus of great interest. While F shares structural and functional ...
Source: Mol Biol Cell - August 23, 2023 Category: Molecular Biology Authors: I Abrrey Monreal Hector C Aguilar Source Type: research
& #39;The Bug Stops Here! & #39; Nipah Encephalitis; Kerala 2019
Boby V Maramattom, S Ananth Ram, Anup Warrier, Anuroop BalagopalNeurology India 2023 71(4):819-820 (Source: Neurology India)
Source: Neurology India - August 18, 2023 Category: Neurology Authors: Boby V Maramattom S Ananth Ram Anup Warrier Anuroop Balagopal Source Type: research
