Viruses, Vol. 14, Pages 1052: Inactivation Methods for Experimental Nipah Virus Infection
ederich
Beatriz Escudero-Pérez
Nipah virus (NiV) is an emerging zoonotic paramyxovirus that causes severe disease in humans and livestock. Due to its high pathogenicity in humans and the lack of available vaccines and therapeutics, NiV needs to be handled in biosafety level 4 (BSL-4) laboratories. Safe inactivation of samples containing NiV is thus necessary to allow further processing in lower containment areas. To date, there is only limited information available on NiV inactivation methods validated by BSL-4 facilities that can be used as a reference. Here, we compare some of the most common inactivation methods ...
Source: Viruses - May 15, 2022 Category: Virology Authors: Lina Widerspick Cecilia Alejandra V ázquez Linda Niemetz Michelle Heung Catherine Olal Andr ás Bencsik Christoph Henkel Anneke Pfister Jes ús Emanuel Brunetti Indre Kucinskaite-Kodze Philip Lawrence C ésar Muñoz Fontela Sandra Diederich Beatriz Escud Tags: Article Source Type: research
Viruses, Vol. 14, Pages 936: Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models
ez
Nipah henipavirus (NiV) and Hendra henipavirus (HeV) are zoonotic emerging paramyxoviruses causing severe disease outbreaks in humans and livestock, mostly in Australia, India, Malaysia, Singapore and Bangladesh. Both are bat-borne viruses and in humans, their mortality rates can reach 60% in the case of HeV and 92% for NiV, thus being two of the deadliest viruses known for humans. Several factors, including a large cellular tropism and a wide zoonotic potential, con-tribute to their high pathogenicity. This review provides an overview of HeV and NiV pathogenicity mechanisms and provides a summary of their interacti...
Source: Viruses - April 29, 2022 Category: Virology Authors: Philip Lawrence Beatriz Escudero-P érez Tags: Review Source Type: research
Serosurvey for Nipah virus in bat population of southern part of India
Comp Immunol Microbiol Infect Dis. 2022 Mar 26;85:101800. doi: 10.1016/j.cimid.2022.101800. Online ahead of print.ABSTRACTNipah virus (NiV) is one of the priority pathogens with pandemic potential. Though the spread is far slower than SARS-CoV-2, case fatality is the biggest concern. Fruit bats belonging to genus Pteropus are identified to be the main reservoir of the virus causing sporadic cases and outbreaks in Malaysia, Bangladesh and India. The sudden emergence of Nipah in Kerala, India during 2018-2019 has been astonishing with respect to its introduction in the unaffected areas. With this, active Nipah virus surveill...
Source: Comparative immunology, microbiology and infectious diseases. - April 7, 2022 Category: Allergy & Immunology Authors: Mangesh Gokhale A B Sudeep Basavaraj Mathapati R Balasubramanian P T Ullas Sreelekshmy Mohandas Dilip R Patil Anita M Shete Sanjay Gopale Pradeep Sawant Rajlaxmi Jain Manjunath Holeppanavar Annasaheb T Suryawanshi Ganesh Chopade Sachin Dhaigude Deepak Y P Source Type: research
Serosurvey for Nipah virus in bat population of southern part of India
Comp Immunol Microbiol Infect Dis. 2022 Mar 26;85:101800. doi: 10.1016/j.cimid.2022.101800. Online ahead of print.ABSTRACTNipah virus (NiV) is one of the priority pathogens with pandemic potential. Though the spread is far slower than SARS-CoV-2, case fatality is the biggest concern. Fruit bats belonging to genus Pteropus are identified to be the main reservoir of the virus causing sporadic cases and outbreaks in Malaysia, Bangladesh and India. The sudden emergence of Nipah in Kerala, India during 2018-2019 has been astonishing with respect to its introduction in the unaffected areas. With this, active Nipah virus surveill...
Source: Comparative immunology, microbiology and infectious diseases. - April 7, 2022 Category: Allergy & Immunology Authors: Mangesh Gokhale A B Sudeep Basavaraj Mathapati R Balasubramanian P T Ullas Sreelekshmy Mohandas Dilip R Patil Anita M Shete Sanjay Gopale Pradeep Sawant Rajlaxmi Jain Manjunath Holeppanavar Annasaheb T Suryawanshi Ganesh Chopade Sachin Dhaigude Deepak Y P Source Type: research
Viruses, Vol. 14, Pages 489: The Analogs of Furanyl Methylidene Rhodanine Exhibit Broad-Spectrum Inhibitory and Inactivating Activities against Enveloped Viruses, including SARS-CoV-2 and Its Variants
Lu
Shibo Jiang
In recent years, infectious diseases caused by viral infections have seriously endangered human health, especially COVID-19, caused by SARS-CoV-2, which continues to spread worldwide. The development of broad-spectrum antiviral inhibitors is urgently needed. Here, we report a series of small-molecule compounds that proved effective against human coronaviruses (HCoV), such as SARS-CoV-2 and its variants of concern (VOCs), including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Delta (B.1.617.2), and Omicron (B.1.1.529), SARS-CoV, MERS-CoV, HCoV-OC43, and other viruses with class I viral fusion proteins...
Source: Viruses - February 27, 2022 Category: Virology Authors: Jing Pu Xiaoyang He Wei Xu Cong Wang Qiaoshuai Lan Chen Hua Kai Wang Lu Lu Shibo Jiang Tags: Article Source Type: research
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
Cell Host Microbe. 2022 Feb 16:S1931-3128(22)00050-6. doi: 10.1016/j.chom.2022.01.014. Online ahead of print.ABSTRACTThe induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 with an activated IFN receptor. Despite encoding other inhibitors of IFN-induced signaling, a poxvirus mutant lacking 018 was attenuated in mice. The 2.0 Å crystal structure of the 018:STAT1 complex reveals a phos...
Source: Cell Host and Microbe - February 19, 2022 Category: Microbiology Authors: Callum Talbot-Cooper Teodors Pantelejevs John P Shannon Christian R Cherry Marcus T Au Marko Hyv önen Heather D Hickman Geoffrey L Smith Source Type: research
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
Cell Host Microbe. 2022 Feb 16:S1931-3128(22)00050-6. doi: 10.1016/j.chom.2022.01.014. Online ahead of print.ABSTRACTThe induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 with an activated IFN receptor. Despite encoding other inhibitors of IFN-induced signaling, a poxvirus mutant lacking 018 was attenuated in mice. The 2.0 Å crystal structure of the 018:STAT1 complex reveals a phos...
Source: Cell Host and Microbe - February 19, 2022 Category: Microbiology Authors: Callum Talbot-Cooper Teodors Pantelejevs John P Shannon Christian R Cherry Marcus T Au Marko Hyv önen Heather D Hickman Geoffrey L Smith Source Type: research
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
Cell Host Microbe. 2022 Feb 16:S1931-3128(22)00050-6. doi: 10.1016/j.chom.2022.01.014. Online ahead of print.ABSTRACTThe induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 with an activated IFN receptor. Despite encoding other inhibitors of IFN-induced signaling, a poxvirus mutant lacking 018 was attenuated in mice. The 2.0 Å crystal structure of the 018:STAT1 complex reveals a phos...
Source: Cell Host and Microbe - February 19, 2022 Category: Microbiology Authors: Callum Talbot-Cooper Teodors Pantelejevs John P Shannon Christian R Cherry Marcus T Au Marko Hyv önen Heather D Hickman Geoffrey L Smith Source Type: research
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
Cell Host Microbe. 2022 Feb 16:S1931-3128(22)00050-6. doi: 10.1016/j.chom.2022.01.014. Online ahead of print.ABSTRACTThe induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 with an activated IFN receptor. Despite encoding other inhibitors of IFN-induced signaling, a poxvirus mutant lacking 018 was attenuated in mice. The 2.0 Å crystal structure of the 018:STAT1 complex reveals a phos...
Source: Cell Host and Microbe - February 19, 2022 Category: Microbiology Authors: Callum Talbot-Cooper Teodors Pantelejevs John P Shannon Christian R Cherry Marcus T Au Marko Hyv önen Heather D Hickman Geoffrey L Smith Source Type: research
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
Cell Host Microbe. 2022 Feb 16:S1931-3128(22)00050-6. doi: 10.1016/j.chom.2022.01.014. Online ahead of print.ABSTRACTThe induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 with an activated IFN receptor. Despite encoding other inhibitors of IFN-induced signaling, a poxvirus mutant lacking 018 was attenuated in mice. The 2.0 Å crystal structure of the 018:STAT1 complex reveals a phos...
Source: Cell Host and Microbe - February 19, 2022 Category: Microbiology Authors: Callum Talbot-Cooper Teodors Pantelejevs John P Shannon Christian R Cherry Marcus T Au Marko Hyv önen Heather D Hickman Geoffrey L Smith Source Type: research
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
Cell Host Microbe. 2022 Feb 16:S1931-3128(22)00050-6. doi: 10.1016/j.chom.2022.01.014. Online ahead of print.ABSTRACTThe induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 with an activated IFN receptor. Despite encoding other inhibitors of IFN-induced signaling, a poxvirus mutant lacking 018 was attenuated in mice. The 2.0 Å crystal structure of the 018:STAT1 complex reveals a phos...
Source: Cell Host and Microbe - February 19, 2022 Category: Microbiology Authors: Callum Talbot-Cooper Teodors Pantelejevs John P Shannon Christian R Cherry Marcus T Au Marko Hyv önen Heather D Hickman Geoffrey L Smith Source Type: research
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
Cell Host Microbe. 2022 Feb 16:S1931-3128(22)00050-6. doi: 10.1016/j.chom.2022.01.014. Online ahead of print.ABSTRACTThe induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 with an activated IFN receptor. Despite encoding other inhibitors of IFN-induced signaling, a poxvirus mutant lacking 018 was attenuated in mice. The 2.0 Å crystal structure of the 018:STAT1 complex reveals a phos...
Source: Cell Host and Microbe - February 19, 2022 Category: Microbiology Authors: Callum Talbot-Cooper Teodors Pantelejevs John P Shannon Christian R Cherry Marcus T Au Marko Hyv önen Heather D Hickman Geoffrey L Smith Source Type: research
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
Cell Host Microbe. 2022 Feb 16:S1931-3128(22)00050-6. doi: 10.1016/j.chom.2022.01.014. Online ahead of print.ABSTRACTThe induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 with an activated IFN receptor. Despite encoding other inhibitors of IFN-induced signaling, a poxvirus mutant lacking 018 was attenuated in mice. The 2.0 Å crystal structure of the 018:STAT1 complex reveals a phos...
Source: Cell Host and Microbe - February 19, 2022 Category: Microbiology Authors: Callum Talbot-Cooper Teodors Pantelejevs John P Shannon Christian R Cherry Marcus T Au Marko Hyv önen Heather D Hickman Geoffrey L Smith Source Type: research
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
Cell Host Microbe. 2022 Feb 16:S1931-3128(22)00050-6. doi: 10.1016/j.chom.2022.01.014. Online ahead of print.ABSTRACTThe induction of interferon (IFN)-stimulated genes by STATs is a critical host defense mechanism against virus infection. Here, we report that a highly expressed poxvirus protein, 018, inhibits IFN-induced signaling by binding to the SH2 domain of STAT1, thereby preventing the association of STAT1 with an activated IFN receptor. Despite encoding other inhibitors of IFN-induced signaling, a poxvirus mutant lacking 018 was attenuated in mice. The 2.0 Å crystal structure of the 018:STAT1 complex reveals a phos...
Source: Cell Host and Microbe - February 19, 2022 Category: Microbiology Authors: Callum Talbot-Cooper Teodors Pantelejevs John P Shannon Christian R Cherry Marcus T Au Marko Hyv önen Heather D Hickman Geoffrey L Smith Source Type: research
< i > Henipaviruses < /i > —A constant threat to livestock and humans
by Susann Kummer, Denise-Carina Kranz
In this review, we highlight the risk to livestock and humans from infections withhenipaviruses, which belong to the virus family Paramyxoviridae. We provide a comprehensive overview of documented outbreaks of Nipah and Hendra virus infections affecting livestock and humans and assess the burden on the economy and health systems. In an increasingly globalized and interconnected world, attention must be paid to emerging viruses and infectious diseases, as transmission routes can be rapid and worldwide. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - February 18, 2022 Category: Tropical Medicine Authors: Susann Kummer Source Type: research
