Deep-learning model for background parenchymal enhancement classification in contrast-enhanced mammography
Conclusion: The proposed BPE classification tool for CEM achieves similar results than
what is published in the literature for CE-MRI.PMID:38657641 | DOI:10.1088/1361-6560/ad42ff (Source: Physics in Medicine and Biology)
Source: Physics in Medicine and Biology - April 24, 2024 Category: Physics Authors: Elodie Ripaud Cl ément Jailin Gonzalo Inaki Quintana Pablo Milioni Ruben Sanchez de la Rosa Laurence Vancamberg Source Type: research
Deep-learning model for background parenchymal enhancement classification in contrast-enhanced mammography
Conclusion: The proposed BPE classification tool for CEM achieves similar results than
what is published in the literature for CE-MRI.PMID:38657641 | DOI:10.1088/1361-6560/ad42ff (Source: Health Physics)
Source: Health Physics - April 24, 2024 Category: Physics Authors: Elodie Ripaud Cl ément Jailin Gonzalo Inaki Quintana Pablo Milioni Ruben Sanchez de la Rosa Laurence Vancamberg Source Type: research
Mitochondrial alternative oxidase pathway accelerates non-motile cell germination by enhancing respiratory carbon metabolism and maintaining redox poise in haematococcus pluvialis
Bioresour Technol. 2024 Apr 22:130729. doi: 10.1016/j.biortech.2024.130729. Online ahead of print.ABSTRACTLow efficiency of the cultivation process is a major obstacle in the commercial production of Haematococcus pluvialis. Germination of red, non-motile cells is an efficient strategy for rapid acquisition of zoospores. However, the regulatory mechanisms associated with germination remain unexplored. In the present study, it was confirmed that the mitochondrial alternative oxidase (AOX) pathway accelerates H. pluvialis cell germination, and the regulatory mechanisms were clarified. When the AOX pathway was inhibited, the ...
Source: Bioresource Technology - April 24, 2024 Category: Biotechnology Authors: Jing Li Litao Zhang Wenjie Yu Mengjie Zhang Feng Chen Jianguo Liu Source Type: research
TOPAS simulation of photoneutrons in radiotherapy: accuracy and speed with variance reduction
Phys Med Biol. 2024 Apr 24. doi: 10.1088/1361-6560/ad4303. Online ahead of print.ABSTRACTWe provide optimal particle split numbers for speeding up TOPAS Monte Carlo simulations of linear accelerator (linac) treatment heads while maintaining accuracy. In addition, we provide a new TOPAS physics module for simulating photoneutron production and transport. 
TOPAS simulation of a Siemens Oncor linac was used to determine the optimal number of splits for directional bremsstrahlung splitting as a function of the field size for 6MV and 18MV x-ray beams. The linac simulation was validated against published data of lateral ...
Source: Physics in Medicine and Biology - April 24, 2024 Category: Physics Authors: Jose Asuncion Ramos-Mendez Ramon Ortiz Jan Schuemann Harald Paganetti Bruce A Faddegon Source Type: research
Association between multimorbidity and utilization of medical and long-term care among older adults in a rural mountainous area in Japan
CONCLUSION: Multimorbidity was dominant among late-stage older adults living in depopulated mountainous areas of Japan, and the number of morbidities was associated with higher economic costs of medical and long-term care services. Mitigating the impact of multimorbidity among older adults in depopulated regions of Japan is an urgent challenge. Future research should investigate the degree and effectiveness of social protections for vulnerable older adults living in remote areas.PMID:38655230 | PMC:PMC11033674 | DOI:10.2185/jrm.2023-049 (Source: Rural Remote Health)
Source: Rural Remote Health - April 24, 2024 Category: Rural Health Authors: Yuki Kuwabara Toshihiro Hamada Tsubasa Nakai Maya Fujii Aya Kinjo Yoneatsu Osaki Source Type: research
Nicotine and Alcohol Use as Predictors of Recreational Cannabis Use in Adolescence: A Systematic Review and Narrative Synthesis
Conclusion: Current evidence suggests an association between nicotine-product use and subsequent recreational cannabis use among adolescents. However, further research is needed to establish causality between exposure to nicotine substances and the use of recreational cannabis within this age demographic. Additionally, there is a need for the development of prevention programs and targeted policies that continuously inform and update this vulnerable sub-population about the risks associated with cannabis use for leisure.PMID:38658323 | DOI:10.1080/10826084.2024.2342008 (Source: Substance Use and Misuse)
Source: Substance Use and Misuse - April 24, 2024 Category: Addiction Authors: T S Fingesi L J Kimaru B O Okusanya J E Ehiri C Rosales Source Type: research
MTH1 inhibition synergizes with ROS-inducing agents to trigger cervical cancer cells undergoing parthanatos
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 22:167190. doi: 10.1016/j.bbadis.2024.167190. Online ahead of print.ABSTRACTCervical cancer cells possess high levels of reactive oxygen species (ROS); thus, increasing oxidative stress above the toxicity threshold to induce cell death is a promising chemotherapeutic strategy. However, the underlying mechanisms of cell death are elusive, and efficacy and toxicity issues remain. Within DNA, 8-oxo-7,8-dihydroguanine (8-oxoG) is the most frequent base lesion repaired by 8-oxoguanine glycosylase 1 (OGG1)-initiated base excision repair. Cancer cells also express high levels of MutT h...
Source: Biochimica et Biophysica Acta - April 24, 2024 Category: Biochemistry Authors: Chunshuang Li Yaoyao Xue Jiaxin Wu Lihong Zhang Tianming Yang Mengtao Ai Jinling Han Xu Zheng Ruoxi Wang Istvan Boldogh Xueqing Ba Source Type: research
Macrocycle-Based Charge Transfer Cocrystals with Dynamically Reversible Chiral Self-Sorting Display Chain Length-Selective Vapochromism to Alkyl Ketones
Angew Chem Int Ed Engl. 2024 Apr 24:e202407095. doi: 10.1002/anie.202407095. Online ahead of print.ABSTRACTChirality-driven self-sorting plays an essential role in controlling the biofunction of biosystems, such as the chiral double-helix structure of DNA from self-recognition by hydrogen bonding. However, achieving precise control over the chiral self-sorted structures and their functional properties for the bioinspired supramolecular systems still remains a challenge, not to mention realizing dynamically reversible regulation. Herein, we report an unprecedented saucer[4]arene-based charge transfer (CT) cocrystal system w...
Source: Angewandte Chemie - April 24, 2024 Category: Chemistry Authors: Meng-Jie Gu Wei-Chen Guo Xiao-Ni Han Ying Han Chuan-Feng Chen Source Type: research
Bithiophene-Functionalized Infrared Two-Photon Absorption Metal Complexes as Single-Molecule Platforms for Synergistic Photodynamic, Photothermal, and Chemotherapy
Angew Chem Int Ed Engl. 2024 Apr 24:e202402028. doi: 10.1002/anie.202402028. Online ahead of print.ABSTRACTA planar conjugated ligand functionalized with bithiophene and its Ru(II), Os(II), and Ir(III) complexes have been constructed as single-molecule platform for synergistic photodynamic, photothermal, and chemotherapy. The complexes have significant two-photon absorption at 808 nm and remarkable singlet oxygen and superoxide anion production in aqueous solution and cells when exposed to 808 nm infrared irradiation. The most potent Ru(II) complex Ru7 enters tumor cells via the rare macropinocytosis, locates in both nucle...
Source: Angewandte Chemie - April 24, 2024 Category: Chemistry Authors: Xue-Lian Li Meng-Fan Wang Li-Zhen Zeng Guo-Kui Li Run-Yu Zhao Fu-Dan Liu Yun Li Yu-Fei Yan Qishuai Liu Zhao Li Hongbin Zhang Xiaoxia Ren Feng Gao Source Type: research
Crown Ether Electrolyte Induced Li2O2 Amorphization for Low Polarization and Long Lifespan Li-O2 batteries
Angew Chem Int Ed Engl. 2024 Apr 24:e202403521. doi: 10.1002/anie.202403521. Online ahead of print.ABSTRACTLithium-oxygen batteries possess an extremely high theoretical energy density, rendering them a prime candidate for next-generation secondary batteries. However, they still face multiple problems such as huge charge polarization and poor cycle life, which lay a significant gap between laboratory research and commercial applications. In this work, we adapt 15-crown-5 ether (C15) as solvent to regulate the generation of discharge products in lithium-oxygen batteries. The coronal structure endows C15 with strong affinity...
Source: Angewandte Chemie - April 24, 2024 Category: Chemistry Authors: Meng Li Jiaxin Wu Zichang You Zhongqin Dai Yuanfan Gu Lei Shi Meifen Wu Zhaoyin Wen Source Type: research
Space-confined manganese oxides nanosheets for efficient catalytic decomposition of ozone
Chemosphere. 2024 Apr 22:142113. doi: 10.1016/j.chemosphere.2024.142113. Online ahead of print.ABSTRACTGround-level ozone has long posed a substantial menace to human well-being and the ecological milieu. The widely reported manganese-based catalysts for ozone decomposition still facing the persisting issues encompass inefficiency and instability. To surmount these challenges, we developed a mesoporous silica thin films with perpendicular nanochannels (SBA(⊥)) confined Mn3O4 catalyst (Mn3O4@SBA(⊥)). Under a weight hourly space velocity (WHSV) of 500,000 mL g-1 h-1, the Mn3O4@SBA(⊥) catalyst exhibited 100% ozone decom...
Source: Chemosphere - April 24, 2024 Category: Chemistry Authors: Yunjun Yang Jialin Li Zhijian Xiao Yang Yun Mingshan Zhu Jingling Yang Source Type: research
Identification and characterization of emGalaseE, a β-1,4 galactosidase from Elizabethkingia meningoseptica, and its application on living cell surface
In this study, a unique beta 1,4 galactosidase was isolated from Elizabethkingia meningoseptica (Em). It exhibited favorable stability at various temperatures (4-37 °C) and pH (5-8) levels and can remove β-1, 4 linked galactoses directly from glycoproteins. Using Alanine scanning, we found that two acidic residues (Glu-468, and Glu-531) in the predicted active pocket are critical for galactosidase activity. In addition, we also demonstrated that it could cleave galactose residues present on living cell surface. As this enzyme has a potential application for living cell glycan editing, we named it emGalaseE or glycan-edit...
Source: International Journal of Biological Macromolecules - April 24, 2024 Category: Biochemistry Authors: Yongliang Tong Xinrong Lu Danfeng Shen Lin Rao Lin Zou Shaoxian Lyu Linlin Hou Guiqin Sun Li Chen Source Type: research
Analysis of unsaturated alginate oligosaccharides using high-performance anion exchange chromatography coupled with mass spectrometry
Anal Bioanal Chem. 2024 Apr 24. doi: 10.1007/s00216-024-05299-5. Online ahead of print.ABSTRACTAlginate is a commercially important polysaccharide composed of mannuronic acid and its C5 differential isomer guluronic acid. Comprehensive research on alginate and alginate lyases requires efficient and precise analytical methods for alginate oligosaccharides. In this research, high-performance anion exchange chromatography (HPAEC) in parallel with pulsed amperometric detection (PAD) and mass spectrometry (MS) was applied to the analysis of oligosaccharides obtained by alginate lyase. By optimizing the chromatographic condition...
Source: Analytical and Bioanalytical Chemistry - April 24, 2024 Category: Chemistry Authors: Jiajing Li Menghui Sun Xiao Song Guangning Chen Jinhang Zhou Yaoguang Chang Changhu Xue Source Type: research
Acute myocardial infarction due to spontaneous coronary artery dissection in a young male with systemic lupus erythematosus: A case report
Exp Ther Med. 2024 Apr 9;27(6):246. doi: 10.3892/etm.2024.12534. eCollection 2024 Jun.ABSTRACTSystemic lupus erythematosus (SLE) is an autoimmune disease which typically presents in young women. Patients with SLE exhibit features of accelerated atherosclerosis. Here, the present study reported a rare case of acute myocardial infarction (AMI) in a male patient diagnosed with SLE. A 29-year-old male with no cardiovascular history was diagnosed with AMI and underwent coronary angiography, which showed a long-extended spiral-shaped dissection of the right coronary artery (RCA). The patient's autoimmune panel tested positive fo...
Source: Experimental and Therapeutic Medicine - April 24, 2024 Category: General Medicine Authors: Yunyi Li Quan Zhou Xiao Meng Source Type: research
Biological and chemical characterization in relation to the yield of radish (Raphanus sativus L.) nourished with humus from plant residues
The objective was to determine the appropriate dose of humus to obtain greater yield and its relationship with the chemical and biological characteristics of the radish. It is based on applied methodology with an experimental approach; Therefore, the Completely Random Block Design model was used, which consisted of 3 blocks and 5 treatments that were T1 with 0, T2 with 4, T3 with 6, T4 with 8 and T5 with 10 t/ha of humus and They applied 15 days after sowing. The physical characteristics of the radish were evaluated and processed using analysis of variance and Duncan. Concentration of elements in leaves and stomatal densit...
Source: Braz J Biol - April 24, 2024 Category: Biology Authors: D D Cruz Nieto N E Muguruza Crispin C M Caira Mamani H J Castro Bartolom é M A Inga Sotelo M N M Alberto A S Valderrama Romero V C Vargas Godoy J M More L ópez H E Chanducas Tantale án N E Menacho Javier M A Lara Castillo W Flores Casanova E R Benavent Source Type: research
