Breakdown of effective information flow in disorders of consciousness: Insights from TMS-EEG
The complexity of the neurophysiological mechanisms underlying human consciousness is widely acknowledged, with information processing and flow originating in cortex conceived as a core mechanism of consciousness emergence. Combination of transcranial magnetic stimulation and electroencephalography (TMS-EEG) is considered as a promising technique to understand the effective information flow associated with consciousness. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - April 17, 2024 Category: Neurology Authors: Yang Bai, Li Yang, Xiangqiang Meng, Ying Huang, Qijun Wang, Anjuan Gong, Zhen Feng, Ulf Ziemann Source Type: research
Additional suture augmentation to anterior cruciate ligament reconstruction with hamstring autografts bring no benefits to clinical results, graft maturation and graft-bone interface healing
From the perspective of graft protection and early rehabilitation during the maturation and remodeling phases of graft healing, suture augmentation (SA) for anterior cruciate ligament reconstruction (ACLR) has... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - April 17, 2024 Category: Orthopaedics Authors: Qingyang Meng, Ruilan Dai, Cheng Wang, Weili Shi, Yanfang Jiang, Ningjing Liu, Rui Li, Yingfang Ao, Xi Gong and Yong Ma Tags: Research Source Type: research
Promiscuous G-protein activation by the calcium-sensing receptor
Nature, Published online: 17 April 2024; doi:10.1038/s41586-024-07331-1Structures of the human calcium-sensing receptor can be bound into complex with G proteins from three different Gα subtypes while maintaining G-protein-binding specificity. (Source: Nature AOP)
Source: Nature AOP - April 17, 2024 Category: Research Authors: Hao Zuo Jinseo Park Aurel Frangaj Jianxiang Ye Guanqi Lu Jamie J. Manning Wesley B. Asher Zhengyuan Lu Guo-bin Hu Liguo Wang Joshua Mendez Edward Eng Zhening Zhang Xin Lin Robert Grassucci Wayne A. Hendrickson Oliver B. Clarke Jonathan A. Javitch Arthur D Source Type: research
Hybrid speciation driven by multilocus introgression of ecological traits
Nature, Published online: 17 April 2024; doi:10.1038/s41586-024-07263-wGenomic studies of Heliconius butterflies provide evidence that Heliconius elevatus is a hybrid species, and that its speciation was driven by introgression of traits from Heliconius melpomene into the other parent, an ancestor of Heliconius pardalinus. (Source: Nature AOP)
Source: Nature AOP - April 17, 2024 Category: Research Authors: Neil Rosser Fernando Seixas Lucie M. Queste Bruna Cama Ronald Mori-Pezo Dmytro Kryvokhyzha Michaela Nelson Rachel Waite-Hudson Matt Goringe Mauro Costa Marianne Elias Clarisse Mendes Eleres de Figueiredo Andr é Victor Lucci Freitas Mathieu Joron Krzyszto Source Type: research
Cancers, Vol. 16, Pages 1534: A Prospective Study on Deep Inspiration Breath Hold Thoracic Radiation Therapy Guided by Bronchoscopically Implanted Electromagnetic Transponders
Conclusions: Bronchoscopically implanted electromagnetic transponder–guided DIBH lung RT is feasible and safe, allowing for precise tumor targeting and reduced normal tissue exposure. Transponder–antenna distance was the most common challenge due to a limited antenna range, which could sometimes be circumvented by prone positioning. (Source: Cancers)
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Yuzhong Jeff Meng Nikhil P. Mankuzhy Mohit Chawla Robert P. Lee Ellen D. Yorke Zhigang Zhang Emily Gelb Seng Boh Lim John J. Cuaron Abraham J. Wu Charles B. Simone Simone II Daphna Y. Gelblum Dale Michael Lovelock Wendy Harris Andreas Rimner Tags: Article Source Type: research
Human Brain Organoid Transplantation: Testing the Foundations of Animal Research Ethics
AbstractAlongside in vitro studies, researchers are increasingly exploring the transplantation of human brain organoids (HBOs) into non-human animals to study brain development, disease, and repair. This paper focuses on ethical issues raised by such transplantation studies. In particular, it investigates the possibility that they might yield enhanced brain function in recipient animals (especially non-human primates), thereby fundamentally altering their moral status. I assess the critique, raised by major voices in the bioethics and science communities, according to which such concerns are premature and misleading. I ide...
Source: Neuroethics - April 17, 2024 Category: Medical Ethics Source Type: research
Sensors, Vol. 24, Pages 2562: Non-Intrusive Load Identification Based on Retrainable Siamese Network
Miao Yu
Non-intrusive load monitoring (NILM) can identify each electrical load and its operating state in a household by using the voltage and current data measured at a single point on the bus, thereby behaving as a key technology for smart grid construction and effective energy consumption. The existing NILM methods mainly focus on the identification of pre-trained loads, which can achieve high identification accuracy and satisfying outcomes. However, unknown load identification is rarely involved among those methods and the scalability of NILM is still a crucial problem at the current stage. In light of this, we hav...
Source: Sensors - April 17, 2024 Category: Biotechnology Authors: Lingxia Lu Ju-Song Kang Fanju Meng Miao Yu Tags: Article Source Type: research
Genes, Vol. 15, Pages 502: The Impact of Blood Sample Processing on Ribonucleic Acid (RNA) Sequencing
This study aims to investigate the extent and mechanism of the impact of sample selection and processing on ribonucleic acid (RNA) sequencing. RNA from PBMCs and blood samples was investigated in this study. The integrity of this RNA was measured under different storage times. All the samples underwent high-throughput sequencing for comprehensive evaluation. The differentially expressed genes and their potential functions were analyzed after the samples were placed at room temperature for 0h, 4h and 8h, and different feature changes in these samples were also revealed. The sequencing results showed that the differences in ...
Source: Genes - April 17, 2024 Category: Genetics & Stem Cells Authors: Zhiyu Liu Tinglan Ouyang Yuwei Yang Yuqi Sheng Huajuan Shi Quanjun Liu Yunfei Bai Qinyu Ge Tags: Article Source Type: research
Effects of saturated and monounsaturated fatty acids on cognitive impairment: evidence from Mendelian randomization study
European Journal of Clinical Nutrition, Published online: 17 April 2024; doi:10.1038/s41430-024-01437-5Effects of saturated and monounsaturated fatty acids on cognitive impairment: evidence from Mendelian randomization study (Source: European Journal of Clinical Nutrition)
Source: European Journal of Clinical Nutrition - April 17, 2024 Category: Nutrition Authors: Youjie Zeng Si Cao Juan Tang Guoxin Lin Source Type: research
Unmet clinical needs in women with polycystic ovary syndrome in regard to mental health: a cross-sectional study
ConclusionWomen affected by PCOS are not properly managed according to ESHRE guideline in regard to mental health issues. Overall consultation rates and corresponding satisfaction with management were poor, highlighting the need for significant improvements in healthcare provision. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - April 16, 2024 Category: OBGYN Source Type: research
The contradictive findings between ultrasound, hysteroscopy and cytokines in women with nonhormonal IUDs suffering from menorrhagia: a prospective study
ConclusionThe results suggest that ultrasonographic assessment may lead to an overdiagnosis of IUD mispositioning compared to hysteroscopy. In addition, both ultrasound and hysteroscopy have limitations in diagnosing the cause of bleeding in most cases. The role of local reactive inflammatory cytokines should be further studied. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - April 16, 2024 Category: OBGYN Source Type: research
Acute Heart Valve Emergencies
Within the cardiac intensive care unit, prompt recognition of severe acute valvular lesions is essential because hemodynamic collapse can occur rapidly, especially when cardiac chambers have not had time for compensatory remodeling. Within this context, optimal medical management, considerations for temporary mechanical circulatory support and decisive treatments strategies are addressed. Fundamental concepts include an appreciation for how sudden changes in flow and pressure gradients between cardiac chambers can impact hemodynamic and echocardiographic findings differently compared to similarly severe chronic lesions, as...
Source: Cardiology Clinics - April 16, 2024 Category: Cardiology Authors: Ryan R. Keane, Venu Menon, Paul C. Cremer Source Type: research
Morphology of Impact Polypropylene Copolymer Extruded Cast Film Revealed by Confocal Raman Imaging
Soft Matter, 2024, Accepted Manuscript DOI: 10.1039/D4SM00156G, PaperChunbo Zhang, Meng Xu, Minqiao Ren, Hongwei Shi, Guoming Liu, Juan Li, Xuanbo Liu, Longgui Zhang, Dali Gao An impact polypropylene copolymer (IPC), composed of polypropylene (PP) and ethylene-propylene copolymer (EPC), was synthesized through two-stage in-reactor polymerization. A systematic investigation of the crystalline structure, thermal behavior, morphology, and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Soft Matter latest articles)
Source: RSC - Soft Matter latest articles - April 16, 2024 Category: Chemistry Authors: Chunbo Zhang Source Type: research
Magnetic-responsive Pickering Emulsion Based on MFe2O4 (M=Mn, Fe, Co, Ni, Cu, Zn) for Green and Efficient Oxidation of Benzyl Alcohol
Green Chem., 2024, Accepted Manuscript DOI: 10.1039/D4GC00554F, PaperYan Wang, Xuan Wang, Yonghao Dong, Mingli Peng, Lina Guo, Mengyao Cui, Yuan He, Jiabao Yi, Huijun Ma, Huan Zhang, Haiming Fan The selective oxidation of alcohols has drawn significant attention in heterogeneous catalysis, with the increasing use of Pickering interfacial catalysis (PIC) for green transformations of alcohols. However, it is still... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Green Chem. latest articles)
Source: RSC - Green Chem. latest articles - April 16, 2024 Category: Chemistry Authors: Yan Wang Source Type: research
Association between enthesitis/dactylitis resolution and patient-reported outcomes in guselkumab-treated patients with psoriatic arthritis
ConclusionIn biologic-na ïve patients with active PsA treated with guselkumab, achieving ER or DR was associated with durable improvements in selected PROs, including those of high importance to patients.Trial registrationClinicalTrials.gov (https://clinicaltrials.gov) NCT03158285; Registered: May 16, 2017.Key Points•At week 100, 65% and 76% of guselkumab-treated patients achieved enthesitis and dactylitis resolution (ER/DR).•Achieving ER was associated with achieving DR and vice versa through the end of study.•Achieving ER or DR was associated with durable and meaningful improvements in selected patient-reported ou...
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
