Outbreak of Marburg virus in Tanzania: The need for a major public health response
Trop Doct. 2023 Apr 20:494755231169311. doi: 10.1177/00494755231169311. Online ahead of print.NO ABSTRACTPMID:37078140 | DOI:10.1177/00494755231169311 (Source: Tropical Doctor)
Source: Tropical Doctor - April 20, 2023 Category: Tropical Medicine Authors: Ibahim Idris Source Type: research
Modified coptisine derivatives as an inhibitor against pathogenic Rhizomucor miehei, Mycolicibacterium smegmatis (Black Fungus), Monkeypox, and Marburg virus by molecular docking and molecular dynamics simulation-based drug design approach
During the second phase of SARS-CoV-2, an unknown fungal infection, identified as black fungus, was transmitted to numerous people among the hospitalized COVID-19 patients and increased the death rate. The black fungus is associated with the Mycolicibacterium smegmatis, Mucor lusitanicus, and Rhizomucor miehei microorganisms. At the same time, other pathogenic diseases, such as the Monkeypox virus and Marburg virus, impacted global health. Policymakers are concerned about these pathogens due to their severe pathogenic capabilities and rapid spread. However, no standard therapies are available to manage and treat those cond...
Source: Frontiers in Pharmacology - April 19, 2023 Category: Drugs & Pharmacology Source Type: research
Fully Tin-Coated Coinage Metal Ions: A Pincer-Type Bis-stannylene Ligand for Exclusive Tetrahedral Complexation
Chemistry. 2023 Apr 11:e202300734. doi: 10.1002/chem.202300734. Online ahead of print.ABSTRACTInvited for the cover of this issue are the groups of P. W. Roesky (Karlsruhe) and F. Weigend (Marburg). The image depicts coinage metal cores with tetrahedrally coordinating tin atoms. Read the full text of the article at 10.1002/chem.202203583.PMID:37039272 | DOI:10.1002/chem.202300734 (Source: Chemistry)
Source: Chemistry - April 11, 2023 Category: Chemistry Authors: Frederic Kr ätschmer Xiaofei Sun Sebastian Gillhuber Hannes Kucher Yannick J Franzke Florian Weigend Peter W Roesky Source Type: research
Infectious Diseases in Obstetrics and Gynecology: Moving Forward in the Twenty-First Century
Infectious diseases are more important than ever in the twenty-first century. Not only did the COVID-19 pandemic catapult scrutiny of infectious disease epidemiology and prevention measures into the mainstream media and dinner table discussion, but also, thanks to social media, there are countless official and unofficial sources of information for public consumption. Emerging diseases continue to grab headlines, from COVID-19 to Mpox (or Monkeypox), Ebola virus and Marburg virus outbreaks and the “triple-demic” of COVID-19, influenza, and resp iratory syncytial virus surges in 2022. (Source: Obstetrics and Gynecology Clinics)
Source: Obstetrics and Gynecology Clinics - April 4, 2023 Category: OBGYN Authors: Kevin Ault, Alisa Kachikis Tags: Preface Source Type: research
The pathogenesis of zoonotic viral infections: Lessons learned by studying reservoir hosts
Zoonotic viral infections that cause severe disease or even death in some people may be asymptomatic or mild in reservoir hosts. Comparison of the pathogenesis of these two host categories may potentially explain the difference in disease. However, infections in reservoir hosts are often neglected. Therefore, we compared the pathogenesis of rabies virus, macacine alphaherpesvirus, West Nile virus, Puumala orthohantavirus, monkeypox virus, Lassa mammarenavirus, H5N1 highly pathogenic avian influenza, Marburg virus, Nipah virus, Middle East respiratory syndrome, and simian/human immunodeficiency viruses in both humans and re...
Source: Frontiers in Microbiology - March 28, 2023 Category: Microbiology Source Type: research
Expectation focused and frequency enhanced cognitive behavioural therapy for patients with major depression (EFFECT): a study protocol of a randomised active-control trial
Introduction
The effectiveness of psychotherapy in depression is subject of an ongoing debate. The mechanisms of change are still underexplored. Research tries to find influencing factors fostering the effect of psychotherapy. In that context, the dose–response relationship should receive more attention. Increasing the frequency from one to two sessions per week seems to be a promising start. Moreover, the concept of expectations and its influence in depression can be another auspicious approach. Dysfunctional expectations and the lack of their modification are central in symptom maintenance. Expectation focused psyc...
Source: BMJ Open - March 22, 2023 Category: General Medicine Authors: Ewen, A.-C. I., Bleichhardt, G., Rief, W., Von Blanckenburg, P., Wambach, K., Wilhelm, M. Tags: Open access, Mental health Source Type: research
Viruses, Vol. 15, Pages 790: One Health Surveillance Highlights Circulation of Viruses with Zoonotic Potential in Bats, Pigs, and Humans in Viet Nam
c
Nguyen Duc Thinh
Randal Schoepp
Keersten Ricks
Ken Inui
Pawin Padungtod
Christine K. Johnson
Jonna A. K. Mazet
Chris Walzer
Sarah H. Olson
Amanda E. Fine
A One Health cross-sectoral surveillance approach was implemented to screen biological samples from bats, pigs, and humans at high-risk interfaces for zoonotic viral spillover for five viral families with zoonotic potential in Viet Nam. Over 1600 animal and human samples from bat guano harvesting sites, natural bat roosts, and pig farming operations were tested for coronaviruses (CoVs), paramyxoviruses, influenza viruses, filoviruses and flavivir...
Source: Viruses - March 20, 2023 Category: Virology Authors: Alice Latinne Nguyen Thi Thanh Nga Nguyen Van Long Pham Thi Bich Ngoc Hoang Bich Thuy PREDICT Consortium PREDICT Consortium Nguyen Van Long Pham Thanh Long Nguyen Thanh Phuong Le Tin Vinh Quang Nguyen Tung Vu Sinh Nam Vu Trong Duoc Nguyen Duc Thinh Randal Tags: Article Source Type: research
2- and 3-Fluoro-3-deaza-1',6'-isoneplanocin: synthesis and antiviral properties (including Ebola and Marburg)
Bioorg Med Chem Lett. 2023 Mar 8:129219. doi: 10.1016/j.bmcl.2023.129219. Online ahead of print.ABSTRACTTo extend the antiviral properties of 2- and 3-fluoro-3-deazaneplanocins into the evolving 3-deaza-1',6'-isoneplanocin library, 2- (11) and 3-fluoro-1',6'-iso-3-deazaneplanocin A (12) have been explored. The requisite synthesis began with an Ullmann reaction by coupling of a protected cyclopentenyl iodide with either 2-fluoro- or 3-fluoro-3-deazaadenine. Target 12 displayed significant activity towards 5 viruses (μM): H1N1 (EC50 <0.36, CC50 >357, SI >1000), hepatitis B virus (EC50 1.28, CC50 >357, SI >279...
Source: Bioorganic and Medicinal Chemistry Letters - March 10, 2023 Category: Chemistry Authors: Chong Liu Qi Chen Stewart W Schneller Source Type: research
WHO: Marburg Virus Outbreak Confirmed in Equatorial Guinea
The Institute Pasteur in Dakar, Senegal, confirmed Equatorial Guinea ’s first case of Marburg virus disease, which carries a case-fatality rate of up to 88%, on February 8. The person with the confirmed infection died, as did 8 of their contacts who had probable or suspected cases. Their symptoms included fever, vomiting, and bloody diarrhea. Two people also experi enced skin lesions and bleeding from the ear. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - March 8, 2023 Category: General Medicine Source Type: research
The re-emergence of Marburg virus Disease in West Africa: how prepared is the sub-region for preventing recurrent zoonotic outbreaks?
On 13 February 2023, Equatorial Guinea confirmed its first-ever outbreak of Marburg virus disease (MVD).[1] This latest outbreak in Ki é-Ntem province, north of Equatorial Guinea, was linked to 9 deaths among 25 suspected cases. This is the third country in West Africa, in 18 months, to report MVD outbreak since it was first detected in Guinea in August 2021 [2] and Ghana in June 2022.[3] (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 2, 2023 Category: Infectious Diseases Authors: Moses John Bockarie, Jarod Hanson, Rashid Ansumana, Dorothy Yeboah-Manu, Alimuddin Zumla, Shui Shan Lee Tags: Editorial Source Type: research
Marburg Virus- A threat during SARS-CoV-2 era: A Review
Infect Disord Drug Targets. 2023 Feb 28. doi: 10.2174/1871526523666230228103845. Online ahead of print.ABSTRACTIn the German towns of Marburg, Frankfurt, and Belgrade in 1967, this single negative-stranded RNA virus was initially discovered. The importation of infected grivet monkeys from Uganda is what caused this virus-related sickness. As a result of the early link between viruses and non-human primates, this virus is frequently referred to as vervet monkey sickness. This virus causes Marburg hemorrhagic fever in humans and non-human primates. Human endothelial cells serve as the primary vehicle for replication. Accordi...
Source: Infectious Disorders Drug Targets - February 28, 2023 Category: Infectious Diseases Authors: Sumel Ashique Vatan Chaudhary Soumen Pal Jonee Panwar Mukesh Kumar Soumi Pramanik Abhipsa Sinha Anagh Mukherjee Source Type: research
Marburg Virus- A threat during SARS-CoV-2 era: A Review
Infect Disord Drug Targets. 2023 Feb 28. doi: 10.2174/1871526523666230228103845. Online ahead of print.ABSTRACTIn the German towns of Marburg, Frankfurt, and Belgrade in 1967, this single negative-stranded RNA virus was initially discovered. The importation of infected grivet monkeys from Uganda is what caused this virus-related sickness. As a result of the early link between viruses and non-human primates, this virus is frequently referred to as vervet monkey sickness. This virus causes Marburg hemorrhagic fever in humans and non-human primates. Human endothelial cells serve as the primary vehicle for replication. Accordi...
Source: Infectious Disorders Drug Targets - February 28, 2023 Category: Infectious Diseases Authors: Sumel Ashique Vatan Chaudhary Soumen Pal Jonee Panwar Mukesh Kumar Soumi Pramanik Abhipsa Sinha Anagh Mukherjee Source Type: research
A Review on Zoonotic Pathogens Associated with Non-Human Primates: Understanding the Potential Threats to Humans
This article reviews the research evidence, diagnostic methods, prevention, and treatment measures that may be useful in limiting the spread of several common viral pathogens via NHP and providing ideas for preventing zoonotic diseases with epidemic potential.PMID:36838210 | DOI:10.3390/microorganisms11020246 (Source: Herpes)
Source: Herpes - February 25, 2023 Category: Infectious Diseases Authors: Xinjie Jiang Zhenyu Fan Shijia Li Haichang Yin Source Type: research
A Review on Zoonotic Pathogens Associated with Non-Human Primates: Understanding the Potential Threats to Humans
This article reviews the research evidence, diagnostic methods, prevention, and treatment measures that may be useful in limiting the spread of several common viral pathogens via NHP and providing ideas for preventing zoonotic diseases with epidemic potential.PMID:36838210 | PMC:PMC9964884 | DOI:10.3390/microorganisms11020246 (Source: Herpes)
Source: Herpes - February 25, 2023 Category: Infectious Diseases Authors: Xinjie Jiang Zhenyu Fan Shijia Li Haichang Yin Source Type: research
Marburg virus: What you need to know about the disease outbreak
The deadly Marburg virus has been detected in Equatorial Guinea and neighbouring Cameroon, and the World Health Organization is deploying teams to trace the spread of the disease (Source: New Scientist - Health)
Source: New Scientist - Health - February 15, 2023 Category: Consumer Health News Source Type: research
