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Mechanistic inhibition of Monkeypox and Marburg virus infection by O-rhamnosides and Kaempferol-o-rhamnosides derivatives: a new-fangled computational approach
This study investigates the potential of several O-rhamnosides and Kaempferol-O-rhamnosides as Mpox and MARV inhibitors using molecular modeling methods, including ADMET, molecular docking, and molecular dynamics/MD simulation. The effectiveness of these compounds against the viruses was assessed using the Prediction of Activity Spectra for Substances (PASS) prediction. The study's primary focus is molecular docking prediction, which demonstrated that ligands (L07, L08, and L09) bind to Mpox (PDB ID: 4QWO) and MARV (PDB ID: 4OR8) with binding affinities ranging from -8.00 kcal/mol to -9.5 kcal/mol. HOMO-LUMO based quantum ...
Source: Molecular Medicine - June 9, 2023 Category: Molecular Biology Authors: Md Abdullah Al Mashud Ajoy Kumer Nobendu Mukerjee Akhel Chandro Swastika Maitra Unesco Chakma Abhijit Dey Shopnil Akash Athanasiosis Alexiou Azmat Ali Khan Amer M Alanazi Arabinda Ghosh Kow-Tong Chen Rohit Sharma Source Type: research

Ruling out acute coronary syndrome in primary care with a clinical decision rule and a capillary, high-sensitive troponin I point of care test: study protocol of a diagnostic RCT in the Netherlands (POB HELP)
Introduction Chest pain is a common reason for consultation in primary care. To rule out acute coronary syndrome (ACS), general practitioners (GP) refer 40%–70% of patients with chest pain to the emergency department (ED). Only 10%–20% of those referred, are diagnosed with ACS. A clinical decision rule, including a high-sensitive cardiac troponin-I point-of-care test (hs-cTnI-POCT), may safely rule out ACS in primary care. Being able to safely rule out ACS at the GP level reduces referrals and thereby alleviates the burden on the ED. Moreover, prompt feedback to the patients may reduce anxiety and stress. Meth...
Source: BMJ Open - June 8, 2023 Category: General Medicine Authors: van den Bulk, S., Petrus, A. H. J., Willemsen, R. T. A., Boogers, M. J., Meeder, J. G., Rahel, B. M., van den Akker-van Marle, M. E., Numans, M. E., Dinant, G.-J., Bonten, T. N. Tags: Open access, General practice / Family practice Source Type: research

Disinfection of Phi6, MS2, and Escherichia coli by Natural Sunlight on Healthcare Critical Surfaces
Am J Trop Med Hyg. 2023 Jun 5:tpmd220464. doi: 10.4269/ajtmh.22-0464. Online ahead of print.ABSTRACTUltraviolet (UV) radiation systems, commonly used to disinfect surfaces, drinking water, and air, stem from historical practice to use sunlight to disinfect household items after contagious illness. Currently, it is still recommended in viral outbreak contexts such as COVID-19, Ebola, and Marburg to expose soft surfaces to sunlight after washing with detergent or disinfecting with chlorine. However, sunlight that reaches the Earth's surface is in the UVA/UVB wavelengths, whereas UV disinfection systems typically rely on bioc...
Source: The American Journal of Tropical Medicine and Hygiene - June 5, 2023 Category: Tropical Medicine Authors: Gabrielle M String Yarmina Kamal Christine Kelly David M Gute Daniele S Lantagne Source Type: research

Disinfection of Phi6, MS2, and Escherichia coli by Natural Sunlight on Healthcare Critical Surfaces
Am J Trop Med Hyg. 2023 Jun 5:tpmd220464. doi: 10.4269/ajtmh.22-0464. Online ahead of print.ABSTRACTUltraviolet (UV) radiation systems, commonly used to disinfect surfaces, drinking water, and air, stem from historical practice to use sunlight to disinfect household items after contagious illness. Currently, it is still recommended in viral outbreak contexts such as COVID-19, Ebola, and Marburg to expose soft surfaces to sunlight after washing with detergent or disinfecting with chlorine. However, sunlight that reaches the Earth's surface is in the UVA/UVB wavelengths, whereas UV disinfection systems typically rely on bioc...
Source: Am J Trop Med Hyg - June 5, 2023 Category: Infectious Diseases Authors: Gabrielle M String Yarmina Kamal Christine Kelly David M Gute Daniele S Lantagne Source Type: research