Marburg Virus Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Evaluation of the Marburg Heart Score and INTERCHEST score compared to current telephone triage for chest pain in out-of-hours primary care
CONCLUSION: Diagnostic risk stratification scores for chest pain may also improve telephone triage for major events in out-of-hours primary care, by reducing the number of unnecessary referrals without compromising triage safety. Further validation is warranted.PMID:36580267 | DOI:10.1007/s12471-022-01745-0 (Source: Netherlands Heart Journal)
Source: Netherlands Heart Journal - December 29, 2022 Category: Cardiology Authors: A Manten L De Clercq R P Rietveld W A M Lucassen E P Moll van Charante R E Harskamp Source Type: research

Molecules, Vol. 28, Pages 51: Sulfonamides with Heterocyclic Periphery as Antiviral Agents
k Sulfonamides are the basic motifs for a whole generation of drugs from a large group of antibiotics. Currently, research in the field of the new sulfonamide synthesis has received a &ldquo;second wind&rdquo;, due to the increase in the synthetic capabilities of organic chemistry and the study of their medical and biological properties of a wide spectrum of biological activity. New reagents and new reactions make it possible to significantly increase the number of compounds with a sulfonamide fragment in combination with other important pharmacophore groups, such as, for example, a wide class of N-cont...
Source: Molecules - December 21, 2022 Category: Chemistry Authors: Mikhail Yu. Moskalik Tags: Review Source Type: research

A1-antitrypsin deficiency in greeks: focus on rare variants
Conclusion: Almost half of the A1ATD in Greece are non-Z ultra-rare pathogenic A1AT variants, confirming an established North-South European geographical trend in Z variant A1ATD. Thus, in addition to early diagnosis of A1ATD, the detection of this rare genotypes is mandatory to personalize preventive and therapeutic measures. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Papiris, S., Veith, M., Papaioannou, A. I., Apollonatou, V., Ferrarotti, I., Ottaviani, S., Tzouvelekis, A., Tzilas, V., Rovina, N., Stratakos, G., Gerogianni, I., Daniil, Z., Kolilekas, L., Tsaroucha, A., Dimakou, K., Pitsidianakis, G., Tzanakis, N., Try Tags: 05.02 - Monitoring airway disease Source Type: research

Influence of public health and infection control interventions during the severe acute respiratory syndrome coronavirus 2 pandemic on the in-hospital epidemiology of pathogens: in hospital versus community circulating pathogens
ConclusionsThe COVID-19 pandemic and associated public health measures had a significant impact on infectious diseases and the detection of pathogens at the Marburg University Hospital. Significant changes were observed for community transmissible infections, while no such effects on pathogens primarily associated with nosocomial transmission could be detected. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - November 11, 2022 Category: Infectious Diseases Source Type: research

Ultrathin organic solar cells could turn buildings into power generators
In November 2021, while the municipal utility in Marburg, Germany, was performing scheduled maintenance on a hot water storage facility, engineers glued 18 solar panels to the outside of the main 10-meter-high cylindrical tank. It’s not the typical home for solar panels, most of which are flat, rigid silicon and glass rectangles arrayed on rooftops or in solar parks. The Marburg facility’s panels, by contrast, are ultrathin organic films made by Heliatek, a German solar company. In the past few years, Heliatek has mounted its flexible panels on the sides of office towers, the curved roofs of bus stops, and even the cyl...
Source: Science of Aging Knowledge Environment - November 10, 2022 Category: Geriatrics Source Type: research

Viruses, Vol. 14, Pages 2291: Natural History of Marburg Virus Infection to Support Medical Countermeasure Development
This study will be instrumental in the design and development of medical countermeasures to Marburg virus disease. (Source: Viruses)
Source: Viruses - October 18, 2022 Category: Virology Authors: Comer Brasel Massey Beasley Cirimotich Sanford Chou Niemuth Novak Sabourin Merchlinsky Long Stavale Wolfe Tags: Article Source Type: research

Development of a Factor VII Activating Protease (FSAP) generation assay and its application in studying FSAP in venous thrombosis
Human genetic studies based on the Marburg I polymorphism in the factor VII activating protease (FSAP) encoding gene, analysis of FSAP activity in plasma and biochemical characterization of FSAP substrates indicate a possible causal link between FSAP activity and venous thrombosis. We hypothesized that a direct standardized assay to measure FSAP activity in plasma could provide convincing arguments for or against such a potential link. Using Ac-Pro-DTyr-Lys-Arg-AMC as a highly specific and sensitive substrate, histones as a trigger to activate pro-FSAP and plasma-purified active FSAP as a calibrator, we have developed a fl...
Source: Thrombosis Research - October 4, 2022 Category: Hematology Authors: Michael Etscheid, Kay-Martin Hanschmann, Per Morten Sandset, Sandip M. Kanse Tags: Full Length Article Source Type: research

Development and optimization of biologically contained Marburg virus for high-throughput antiviral screening
Antiviral Res. 2022 Sep 29:105426. doi: 10.1016/j.antiviral.2022.105426. Online ahead of print.ABSTRACTComparable to the related Ebola virus, Marburg virus is an emerging zoonotic pathogen that causes hemorrhagic fever with a high mortality rate. Therefore, handling of Ebola virus and Marburg virus is limited to biosafety level 4 facilities, of which only a limited number exists worldwide. However, researchers have developed several virus alternatives that are safe to handle in lower biosafety settings. One particularly interesting approach is the engineering of biologically contained Ebola virus by removing an essential g...
Source: Antiviral Research - October 2, 2022 Category: Virology Authors: Bert Vanmechelen Joren Stroobants Winston Chiu Lieve Naesens Joost Schepers Kurt Vermeire Piet Maes Source Type: research

Is the world ready for another viral outbreak? - The deadly Marburg virus
Trop Doct. 2022 Sep 26:494755221122566. doi: 10.1177/00494755221122566. Online ahead of print.NO ABSTRACTPMID:36164685 | DOI:10.1177/00494755221122566 (Source: Tropical Doctor)
Source: Tropical Doctor - September 27, 2022 Category: Tropical Medicine Authors: Sai Kiran Kuchana G Anthony Reddy L V Simhachalam Kutikuppala Sri Harsha Boppana Sai Venkata Kalyani Ponnaganti Kode Rohith Source Type: research

Expression of nectin-4 in papillary renal cell carcinoma
ConclusionNectin-4 could not be confirmed as a prognostic marker in pRCC in general. Due to its high abundance on pRCC specimens Nectin-4 is an interesting target for therapeutical approaches e.g. with EV. Clinical trials are warranted to elucidate its role in the pRCC treatment landscape. (Source: Hormones and Cancer)
Source: Hormones and Cancer - September 22, 2022 Category: Cancer & Oncology Source Type: research

Effect of prolonged storage on quality characteristics of recovered plasma: Is there an expiration date?
DISCUSSION: Our study is in agreement with all the previous studies and concludes that there is a putative usability of recovered plasma and some of its coagulation factors after many years of storage at the recommended temperature.PMID:36120965 | DOI:10.1111/trf.17115 (Source: Transfusion)
Source: Transfusion - September 19, 2022 Category: Hematology Authors: Marianna Politou Ifigeneia Vasiliki Kontoteza Abraham Pouliakis Georgios Dryllis Panagiota Fortsa Serena Valsami Konstantinos Stamoulis Source Type: research