Exploring regional healthcare utilisation and quality of care for endometriosis in rural areas in Hesse, Germany: a mixed methods study protocol
Introduction
The need of a regional healthcare monitoring in order to evaluate quality and utilisation of health services in smaller scale is internationally and in Germany well established. Little is known about variation in healthcare in rural German areas, especially for women’s health. In particular, endometriosis is highly prevalent and known to be unsatisfactorily treated. Thus, this study aims to investigate utilisation and quality of care, the influence of structural determinants on quality and the patient’s experiences on endometriosis healthcare in rural Hesse.
Methods and analysis
We will use a mixe...
Source: BMJ Open - August 24, 2023 Category: General Medicine Authors: Brauer, L., Geraedts, M. Tags: Open access, Epidemiology Source Type: research
Viruses, Vol. 15, Pages 1739: Cheminformatics Strategies Unlock Marburg Virus VP35 Inhibitors from Natural Compound Library
In this study, the compounds Myricetin, Isosilybin, and Estradiol benzoate were subjected to a molecular dynamics (MD) simulation and free binding energy calculation using MM/GBSA analysis. The reference component Myricetin served as a control. Estradiol benzoate exhibited the most stable and consistent root-mean-square deviation (RMSD) values, whereas Isosilybin showed significant fluctuations in RMSD. The compound Estradiol benzoate exhibited the lowest ΔG binding free energy (−22.89 kcal/mol), surpassing the control compound’s binding energy (−9.29 kcal/mol). Overa...
Source: Viruses - August 15, 2023 Category: Virology Authors: Isra M. Alsaady Leena H. Bajrai Thamir A. Alandijany Hattan S. Gattan Mai M. El-Daly Sarah A. Altwaim Rahaf T. Alqawas Vivek Dhar Dwivedi Esam I. Azhar Tags: Article Source Type: research
Viruses, Vol. 15, Pages 1721: Update on the Phylodynamic and Genetic Variability of Marburg Virus
This study, which presents an update on the phylodynamics and the genetic variability of MARV, further confirmed the existence of at least two distinct patterns of viral spread. One pattern demonstrates a slower but continuous and recurring virus circulation, while the other exhibits a faster yet limited and episodic spread. These results highlight the critical need to strengthen genomic surveillance in the region to effectively curb the pathogen’s dissemination. Moreover, the study emphasizes the importance of prompt alert management, comprehensive case investigation and analysis, contact tracing, and active...
Source: Viruses - August 11, 2023 Category: Virology Authors: Fabio Scarpa Liliana Bazzani Marta Giovanetti Alessandra Ciccozzi Francesca Benedetti Davide Zella Daria Sanna Marco Casu Alessandra Borsetti Eleonora Cella Stefano Pascarella Antonello Maruotti Massimo Ciccozzi Tags: Article Source Type: research
Marburg virus disease outbreak in Tanzania: current efforts and recommendations - a short communication
Ann Med Surg (Lond). 2023 Jul 8;85(8):4190-4193. doi: 10.1097/MS9.0000000000001063. eCollection 2023 Aug.ABSTRACTOn 21 March 2023 the Tanzania's Ministry of Health reported the first Marburg virus disease (MVD) outbreak in Bukoba District reporting a total of eight cases and five fatalities including one health care worker with a case fatality ratio of 62.5%. MVD is a filoviral infection with an estimated incubation of 3-21 days and causes severe hemorrhagic fever in humans. Fruit bats are significant reservoir host leading to animal-to-human transmission and human-to-human transmission by direct contact of body fluids fro...
Source: Annals of Medicine - August 9, 2023 Category: Internal Medicine Authors: Deusdedith B Bulimbe Daniel S Masunga Innocent K Paul Ghalib H Kassim Paschal B Bahati Jonaviva A Thomas Christina Mwakisole Abubakar Nazir Olivier Uwishema Source Type: research
Idiopathic hypersomnia: the long journey from classification to an efficacious drug
Journal of Clinical Sleep Medicine, Ahead of Print. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - August 9, 2023 Category: Sleep Medicine Authors: Geert Mayer
Andrea Rodenbeck
1Department of Neurology Philipps-Universit ät Marburg, Marburg, Germany
2Evangelisches Krankenhaus Göttingen-Weende, Göttingen, Germany Source Type: research
SARS-CoV-2 variants, its recombinants and epigenomic exploitation of host defenses
Biochim Biophys Acta Mol Basis Dis. 2023 Aug 5:166836. doi: 10.1016/j.bbadis.2023.166836. Online ahead of print.ABSTRACTSince 2003, we have seen the emergence of novel viruses, such as SARS-CoV-1, MERS, ZIKA, swine flu virus H1N1, Marburg, Monkeypox, Ebola, and SARS-CoV-2, but none of them gained pandemic proportions similar to SARS-CoV-2. This could be attributed to unique viral traits, allowing its rapid global dissemination following its emergence in October 2019 in Wuhan, China, which appears to be primarily driven by the emergence of highly transmissible and virulent variants that also associate, in some cases, with s...
Source: Biochimica et Biophysica Acta - August 7, 2023 Category: Biochemistry Authors: Nitin K Saksena Srinivas Bonam Reddy Monica Miranda-Saksena Thyago H S Cardoso Edson M A Silva Juliana C Fereira Wael M Rabeh Source Type: research
Variations in small-scale movements of, Rousettus aegyptiacus, a Marburg virus reservoir across a seasonal gradient
Bats are increasingly being recognized as important hosts for viruses, some of which are zoonotic and carry the potential for spillover within human and livestock populations. Biosurveillance studies focused o... (Source: Frontiers in Zoology)
Source: Frontiers in Zoology - July 18, 2023 Category: Zoology Authors: Matthew R. Wood, J. Low de Vries, Jonathan H. Epstein and Wanda Markotter Tags: Research Source Type: research
Choosing the best apple: counselling leaflets and technologies of communication in the history of reproduction
Historians have shown how the establishment of human genetic counselling in West Germany was characterised by several sociohistorical factors, in particular the impact of the legacies of Nazi biopolitics. These accounts have reconstructed continuities on an intellectual level which delayed a turn towards non-directive approaches, emphasising individual (emotional) well-being and voluntariness, and instead have prolonged a discourse that defined disability as an economic and social burden. However, while the distinct legacies of eugenics and racial hygienics are well researched, other factors that constituted counselling en...
Source: Medical Humanities - July 11, 2023 Category: International Medicine & Public Health Authors: Nemec, B. Tags: Open access Original research Source Type: research
News at a glance: Long Covid treatment, global earthquake model, and deep-sea mining
MARINE SCIENCE
Ocean mining ban sought
Europe’s top science advisory panel last week called for a moratorium on commercial deep-sea mining, arguing that its environmental impacts are poorly understood and that critical clean energy minerals can be harvested from mines on land. According to some forecasts, only the highest demand scenarios for minerals used in renewable power and electric vehicles require supplies from the deep sea, says the report from the European Academies’ Science Advisory Council. Next month, the United Nations’s International Seabed Authority (ISA) will consider a moratori...
Source: Science of Aging Knowledge Environment - June 15, 2023 Category: Geriatrics Source Type: research
The histological assessment of new bone formation with zolendronic acid loaded bone allograft in rabbit femoral bone defect
In conclusion, local co-administration of ZOL on heat-treated allograft inhibits allograft resorption and new bone formation in the bone defect.PMID:37305828 | PMC:PMC10251371 | DOI:10.25122/jml-2022-0314 (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - June 12, 2023 Category: General Medicine Authors: Dina Saginova Elyarbek Tashmetov Yevgeniy Kamyshanskiy Amina Koshanova Marietta Arutyunyan Ibrahim Rustambek Source Type: research
