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The history of circadian rhythm research in Austria
Wien Klin Wochenschr. 2023 May 31. doi: 10.1007/s00508-023-02199-z. Online ahead of print.ABSTRACTIn view of the recent revival of interest in circadian biology and circadian epidemiology at the Medical University of Vienna, it seems appropriate to highlight the rich and pioneering history of circadian research in Austria. Among the forefathers of circadian research in Vienna are Otto Marburg (1874-1948), who discovered important elements of the pineal gland physiology, Robert Hofstätter (1883-1970), who used pineal gland extract in obstetrics/gynecology, and Paul Engel (1907-1997), who discovered that the pineal gland wa...
Source: Wiener Klinische Wochenschrift - May 31, 2023 Category: General Medicine Authors: Eva S Schernhammer Gerhard Kl ösch Isabella Ellinger Dietmar Winkler Edda Winkler-Pjrek Galateja Jordakieva Kyriaki Papantoniou Susanne Strohmaier Bertrand Lell Franz Waldhauser Source Type: research

Mechanistic inhibition of Monkeypox and Marburg virus infection by O-rhamnosides and Kaempferol-o-rhamnosides derivatives: a new-fangled computational approach
This study investigates the potential of several O-rhamnosides and Kaempferol-O-rhamnosides as Mpox and MARV inhibitors using molecular modeling methods, including ADMET, molecular docking, and molecular dynamics/MD simulation. The effectiveness of these compounds against the viruses was assessed using the Prediction of Activity Spectra for Substances (PASS) prediction. The study’s primary focus is molecular docking prediction, which demonstrated that ligands (L07, L08, and L09) bind to Mpox (PDB ID: 4QWO) and MARV (PDB ID: 4OR8) with binding affinities ranging from -8.00 kcal/mol to -9.5 kcal/mol. HOMO-LUMO based quantu...
Source: Frontiers in cellular and infection microbiology - May 24, 2023 Category: Microbiology Source Type: research

Bismuth Cations: Fluoride Ion Abstraction, Isocyanide Coordination, and Impact of Steric Bulk on Lewis Acidity
Chemistry. 2023 May 12:e202301354. doi: 10.1002/chem.202301354. Online ahead of print.ABSTRACTInvited for the cover of this issue are the groups of Carsten von Hänisch and Crispin Lichtenberg at the Philipps University of Marburg. The image depicts a bismuth kraken, eagerly grabbing Lewis basic substrates, thereby solving scientific puzzles about bismuth-based Lewis acidity. Read the full text of the article at 10.1002/chem.202204012.PMID:37170665 | DOI:10.1002/chem.202301354 (Source: Chemistry)
Source: Chemistry - May 12, 2023 Category: Chemistry Authors: Tobias Dunaj Johannes Schwarzmann Jacqueline Ramler Andreas Stoy Sascha Reith Joel Nitzsche Lena V öllinger Carsten von H änisch Crispin Lichtenberg Source Type: research

Risk factors and protective factors of acute postoperative pain: an observational study at a German university hospital with cross-sectional and longitudinal inpatient data
Conclusions The German SFQ is a valid, reliable and economical instrument with which the important psychological predictor surgical fear can be assessed. Modifiable factors that increase the risk of postoperative pain were higher pain intensity before surgery and being fearful about negative consequences of the surgery whereas positive expectations seem to buffer against postsurgical pain. Trial registration numbers DRKS00021764 and DRKS00021766. (Source: BMJ Open)
Source: BMJ Open - May 8, 2023 Category: General Medicine Authors: Riecke, J., Zerth, S. F., Schubert, A.-K., Wiesmann, T., Dinges, H.-C., Wulf, H., Volberg, C. Tags: Open access, Anaesthesia Source Type: research

Computational Modeling and Evaluation of Potential mRNA and Peptide-Based Vaccine against Marburg Virus (MARV) to Provide Immune Protection against Hemorrhagic Fever
This study provides a rationale point to begin with the development of an efficient vaccine against Marburg virus; however, the findings need further experimental validation to confirm the computational finding of this study.PMID:37101690 | PMC:PMC10125739 | DOI:10.1155/2023/5560605 (Source: Cell Research)
Source: Cell Research - April 27, 2023 Category: Cytology Authors: Faisal F Albaqami Ali Altharawi Hassan N Althurwi Khalid M Alharthy Muhammad Qasim Ziyad Tariq Muhseen Muhammad Tahir Ul Qamar Source Type: research

Computational Modeling and Evaluation of Potential mRNA and Peptide-Based Vaccine against Marburg Virus (MARV) to Provide Immune Protection against Hemorrhagic Fever
This study provides a rationale point to begin with the development of an efficient vaccine against Marburg virus; however, the findings need further experimental validation to confirm the computational finding of this study.PMID:37101690 | PMC:PMC10125739 | DOI:10.1155/2023/5560605 (Source: Biomed Res)
Source: Biomed Res - April 27, 2023 Category: Research Authors: Faisal F Albaqami Ali Altharawi Hassan N Althurwi Khalid M Alharthy Muhammad Qasim Ziyad Tariq Muhseen Muhammad Tahir Ul Qamar Source Type: research

Marburg virus in Egyptian Rousettus bats in Guinea: Investigation of Marburg virus outbreak origin in 2021
by Marat T. Makenov, Sanaba Boumbaly, Faya Raphael Tolno, Noumouny Sacko, Leno Tamba N ’Fatoma, Oumar Mansare, Bonaventure Kolie, Olga A. Stukolova, Evgeny S. Morozkin, Ivan S. Kholodilov, Olga B. Zhurenkova, Marina V. Fyodorova, Vasily G. Akimkin, Anna Yu. Popova, Namoudou Conde, Mamadou Yero Boiro, Lyudmila S. Karan In 2021, a patient died from Marburg virus (MARV) disease in Guinea and it was the first confirmed case in West Africa. The origin of the outbreak has not been identified. It was revealed that the patient didn ’t travel anywhere before the illness. Prior to outbreak, MARV had been found in bats in the ne...
Source: PLoS Neglected Tropical Diseases - April 26, 2023 Category: Tropical Medicine Authors: Marat T. Makenov Source Type: research

Outbreak of Marburg virus in Tanzania: The need for a major public health response
Trop Doct. 2023 Apr 20:494755231169311. doi: 10.1177/00494755231169311. Online ahead of print.NO ABSTRACTPMID:37078140 | DOI:10.1177/00494755231169311 (Source: Tropical Doctor)
Source: Tropical Doctor - April 20, 2023 Category: Tropical Medicine Authors: Ibahim Idris Source Type: research