Drivers of African Filovirus (Ebola and Marburg) Outbreaks
Vector-Borne and Zoonotic Diseases,Volume 22, Issue 9, Page 478-490, September 2022. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - September 9, 2022 Category: Infectious Diseases Authors: Patrick R. Stephens Mekala Sundaram Susana Ferreira Nicole Gottdenker Kaniz Fatema Nipa Annakate M. Schatz John Paul Schmidt John M. Drake Source Type: research
Marburg virus outbreak in Ghana: An impending crisis
Ann Med Surg (Lond). 2022 Aug 18;81:104377. doi: 10.1016/j.amsu.2022.104377. eCollection 2022 Sep.ABSTRACTSince the initial identification of the Marburg virus in 1967, it has sporadically emerged in several countries throughout Africa, including Zimbabwe, Kenya, South Africa, the Democratic Republic of the Congo (DRC), Uganda, and Zimbabwe. Due to the concurrent occurrence of other epidemics like the coronavirus disease 2019 (COVID-19), this outbreak could endanger the healthcare systems in these many African nations. Recently, two cases of the Marburg virus were detected in Ghana for the first time. However, there has be...
Source: Annals of Medicine - September 2, 2022 Category: Internal Medicine Authors: Jack Wellington Ay ça Nur Aderinto Nicholas Olivier Uwishema Hassan Chaito Olutola Awosiku Yusuf Jaafer Al Tarawneh Jana Abdul Nasser Sharafeddine Chinyere Vivian Patrick Onyeaka Helen Onyeaka Source Type: research
Evaluating effects of the structural reform of outpatient psychotherapy for patients with mental disorders in Germany: comparing patients with and without comorbid chronic physical condition - rationale and study protocol of the ES-RiP project
Introduction
In 2017, in Germany, a structural reform of the outpatient psychotherapy guideline took place, aiming to reduce waiting times, to facilitate flexible low-threshold access (eg, general reachability by phone) and to lower access barriers for specific patient groups. The reform included new service elements, such as the implementation of additional psychotherapeutic consultations, acute short-term psychotherapeutic interventions and relapse prophylaxis as well as the promotion of group therapies, the facilitation of psychotherapists’ availability, and the installation of appointment service centres. The ES-...
Source: BMJ Open - September 2, 2022 Category: General Medicine Authors: Kampling, H., Kruse, J., Friederich, H.-C., Heuft, G., Christoffer, A., Grobe, T. G., Marschall, U., Szecsenyi, J., Wild, B., Hartmann, M., The ES-RiP-Consortium Study Group, Borchers, Christoffer, Soufiane, Friederich, Thomas G, Hartmann, Hegelow, Heuft, Tags: Open access, Health services research Source Type: research
Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep
Gene Therapy, Published online: 01 September 2022; doi:10.1038/s41434-022-00361-2Adeno-associated virus mediated expression of monoclonal antibody MR191 protects mice against Marburg virus and provides long-term expression in sheep (Source: Gene Therapy)
Source: Gene Therapy - September 1, 2022 Category: Genetics & Stem Cells Authors: Amira D. Rghei Laura P. van Lieshout Wenguang Cao Shihua He Kevin Tierney Jordyn A. Lopes Nicole Zielinska Enzo M. Baracuhy Elena S. B. Campbell Jessica A. Minott Matthew M. Guilleman Pamela C. Hasson Brad Thompson Khalil Karimi Byram W. Bridle Leonardo S Source Type: research
Baseline of Physiological Body Temperature and Hematological Parameters in Captive Rousettus aegyptiacus and Eidolon helvum Fruit Bats
The discovery of bats as reservoir hosts for a number of highly pathogenic zoonotic agents has led to an increasing interest of infectious disease research in experimental studies with bats. Therefore, we established breeding colonies of Rousettus aegyptiacus and Eidolon helvum fruit bats, which both have been identified as reservoir hosts for relevant zoonotic disease agents, such as Marburg virus and Lagos bat virus. Since 2013, individuals of both species have been recruited to the Friedrich-Loeffler-Institut (FLI) from zoological gardens in Europe, to where these species had been introduced from the wild several decade...
Source: Frontiers in Physiology - August 29, 2022 Category: Physiology Source Type: research
The Evolution of Medical Countermeasures for Ebola Virus Disease: Lessons Learned and Next Steps
Vaccines (Basel). 2022 Jul 29;10(8):1213. doi: 10.3390/vaccines10081213.ABSTRACTThe Ebola virus disease outbreak that occurred in Western Africa from 2013-2016, and subsequent smaller but increasingly frequent outbreaks of Ebola virus disease in recent years, spurred an unprecedented effort to develop and deploy effective vaccines, therapeutics, and diagnostics. This effort led to the U.S. regulatory approval of a diagnostic test, two vaccines, and two therapeutics for Ebola virus disease indications. Moreover, the establishment of fieldable diagnostic tests improved the speed with which patients can be diagnosed and publi...
Source: Cancer Control - August 26, 2022 Category: Cancer & Oncology Authors: Ian Crozier Kyla A Britson Daniel N Wolfe John D Klena Lisa E Hensley John S Lee Larry A Wolfraim Kimberly L Taylor Elizabeth S Higgs Joel M Montgomery Karen A Martins Source Type: research
Developing capacity for implementation and evaluation of vaccine trials in Uganda: Perspective of the Makerere University Walter Reed Project
Conclusion: Academia, through establishment of appropriate partnerships can contribute to the identification of solutions to complex public health challenges.Keywords: Vaccines; community participation; developing countries. (Source: African Health Sciences)
Source: African Health Sciences - August 26, 2022 Category: African Health Authors: Prossy Naluyima, Betty Mwesigwa, Allan Tindikahwa, Stephen Mugamba, Jude Thaddeus Ssensamba, Ezra Musingye, Grace Mirembe, Hannah Kibuuka, Fred Wabwire-Mangen Source Type: research
They come in threes: Marburg virus, emerging infectious diseases, and the blood supply
On July 17, in the midst of the ongoing SARS-CoV-2 pandemic and several months into the monkeypox outbreak currently expanding worldwide, the World Health Organization announced that Ghana had declared its first ever outbreak of Marburg virus [1]. As of July 18, 2 persons have died and almost 100 have been quarantined, raising fears of an impending mass outbreak [1]. This marks only the second time in history this infectious disease has been identified in western Africa, though previous outbreaks and sporadic cases have been reported in various geographic regions of Africa, particularly the Democratic Republic of the Congo...
Source: Transfusion and Apheresis Science - August 26, 2022 Category: Hematology Authors: Jeremy W. Jacobs, Laura Filkins, Garrett S. Booth, Brian D. Adkins Tags: Letter to the Editor Source Type: research
Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses
Antiviral Res. 2022 Aug 22:105399. doi: 10.1016/j.antiviral.2022.105399. Online ahead of print.ABSTRACTFiloviruses enter cells through micropinocytosis and trafficking into the endosomes in which they bind to the receptor Niemann-Pick C1 protein (NPC1) for membrane fusion and entry into the cytoplasm. The endosomal receptor-binding is critical step for filovirus entry. Designing inhibitors to block receptor binding will prevent viral entry. Using available binding structural information from the co-crystal structures of the viral GP with the receptor NPC1 or with monoclonal antibodies, we have conducted structure-based des...
Source: Antiviral Research - August 25, 2022 Category: Virology Authors: Leah Liu Wang Leslie Estrada Joshua Wiggins Manu Anantpadma J J Patten Robert A Davey Shi-Hua Xiang Source Type: research
Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses
Antiviral Res. 2022 Aug 22:105399. doi: 10.1016/j.antiviral.2022.105399. Online ahead of print.ABSTRACTFiloviruses enter cells through micropinocytosis and trafficking into the endosomes in which they bind to the receptor Niemann-Pick C1 protein (NPC1) for membrane fusion and entry into the cytoplasm. The endosomal receptor-binding is critical step for filovirus entry. Designing inhibitors to block receptor binding will prevent viral entry. Using available binding structural information from the co-crystal structures of the viral GP with the receptor NPC1 or with monoclonal antibodies, we have conducted structure-based des...
Source: Antiviral Research - August 25, 2022 Category: Virology Authors: Leah Liu Wang Leslie Estrada Joshua Wiggins Manu Anantpadma J J Patten Robert A Davey Shi-Hua Xiang Source Type: research
Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses
Antiviral Res. 2022 Aug 22:105399. doi: 10.1016/j.antiviral.2022.105399. Online ahead of print.ABSTRACTFiloviruses enter cells through micropinocytosis and trafficking into the endosomes in which they bind to the receptor Niemann-Pick C1 protein (NPC1) for membrane fusion and entry into the cytoplasm. The endosomal receptor-binding is critical step for filovirus entry. Designing inhibitors to block receptor binding will prevent viral entry. Using available binding structural information from the co-crystal structures of the viral GP with the receptor NPC1 or with monoclonal antibodies, we have conducted structure-based des...
Source: Antiviral Research - August 25, 2022 Category: Virology Authors: Leah Liu Wang Leslie Estrada Joshua Wiggins Manu Anantpadma J J Patten Robert A Davey Shi-Hua Xiang Source Type: research
Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses
Antiviral Res. 2022 Aug 22:105399. doi: 10.1016/j.antiviral.2022.105399. Online ahead of print.ABSTRACTFiloviruses enter cells through micropinocytosis and trafficking into the endosomes in which they bind to the receptor Niemann-Pick C1 protein (NPC1) for membrane fusion and entry into the cytoplasm. The endosomal receptor-binding is critical step for filovirus entry. Designing inhibitors to block receptor binding will prevent viral entry. Using available binding structural information from the co-crystal structures of the viral GP with the receptor NPC1 or with monoclonal antibodies, we have conducted structure-based des...
Source: Antiviral Research - August 25, 2022 Category: Virology Authors: Leah Liu Wang Leslie Estrada Joshua Wiggins Manu Anantpadma J J Patten Robert A Davey Shi-Hua Xiang Source Type: research
Ligand-based design of peptide entry inhibitors targeting the endosomal receptor binding site of filoviruses
Antiviral Res. 2022 Aug 22:105399. doi: 10.1016/j.antiviral.2022.105399. Online ahead of print.ABSTRACTFiloviruses enter cells through micropinocytosis and trafficking into the endosomes in which they bind to the receptor Niemann-Pick C1 protein (NPC1) for membrane fusion and entry into the cytoplasm. The endosomal receptor-binding is critical step for filovirus entry. Designing inhibitors to block receptor binding will prevent viral entry. Using available binding structural information from the co-crystal structures of the viral GP with the receptor NPC1 or with monoclonal antibodies, we have conducted structure-based des...
Source: Antiviral Research - August 25, 2022 Category: Virology Authors: Leah Liu Wang Leslie Estrada Joshua Wiggins Manu Anantpadma J J Patten Robert A Davey Shi-Hua Xiang Source Type: research
