Knowledge and Attitude of Iranian Youth Toward AIDS: A Systematic Review and Meta-Analysis in Iran.
This study aims to assess the knowledge and attitude toward the human immunodeficiency virus and acquired immune deficiency syndrome among youths in Iran. We conducted a systematic review, searching online databases until July 2018, focusing on knowledge and attitudes about the human immunodeficiency virus and acquired immune deficiency syndrome in Iranian youths. We included the studies that aimed to determine the knowledge and attitudes of people from Iran and were conducted in the last 18 years. In total, 14 eligible papers (out of 300) were entered into the analysis, and the overall knowledge of Iranian youth toward th...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Clinical Characteristics and Outcomes of Patients with Intracerebral Hemorrhage - A Feasibility Study on Romanian Patients.
Authors: Radu RA, Terecoasa EO, Tiu C, Ghita C, Purcaru LI, Marinescu AN, Bajenaru OA Abstract Intracerebral hemorrhage is a significant public health problem, as it is a disease associated with overwhelming mortality and disability. We performed a retrospective feasibility study of patients admitted with acute intracerebral hemorrhage in our department for four months. Our aims were to identify peculiarities of the risk factors, demographic and clinical characteristics of intracerebral hemorrhage patients from our population, to estimate a feasible recruitment rate for a larger prospective study of patients with i...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Higher Perceived Stress and Poor Glycemic Changes in Prediabetics and Diabetics Among Indian Population.
Authors: Mishra A, Podder V, Modgil S, Khosla R, Anand A, Nagarathna R, Malhotra R, Nagendra HR Abstract Diabetes mellitus (DM) is a chronic metabolic disorder with significant co-morbidities and healthcare burdens. Many large studies have investigated the association between perceived stress and DM; however, none investigated this in a larger Indian population. We hypothesized stress as one of the reasons for the progression of people with prediabetes into DM. The present study was, therefore, planned to report on associations between perceived stress and blood glucose markers stratified by diabetic status. The cu...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Protective Effect of Vitamin C and Zinc as an Antioxidant Against Chemotherapy-Induced Male Reproductive Toxicity.
Authors: Hajjar T, Soleymani F, Vatanchian M Abstract Treatment with anticancer drugs such as cyclophosphamide can harm the male reproductive system. Vitamin C and zinc are micronutrients with antioxidant activity and are the essential components of semen. Therefore, this study aimed to evaluate whether cyclophosphamide-exposed mice can recover from fertility with vitamin C and zinc therapy. In this experimental study, fifty male mice were divided into five groups. Groups 1-4 received cyclophosphamide (100 mg/kg, once a week for eight weeks). Also, group 2 received zinc (200 mg/kg), group 3 received vitamin C (300 ...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Correlations of Clinical and Biochemical Indices of Vitamin D with Erectile Dysfunction.
Authors: Dumbraveanu I, Banov P, Arian I, Ceban E Abstract Erectile dysfunction is a multifactorial disease; it has been demonstrated that endothelial dysfunction plays an essential role in the pathogenesis of this disease, and Vitamin D deficiency is considered to favor endothelial lesions. Our study, based on a group of 58 patients who have erectile dysfunction and a control group of 26 healthy subjects, tends to confirm that low levels of vitamin D could potentiate the severity of erectile dysfunction, promoting endothelial dysfunction. Statistical analysis using the Pearson's correlation criteria showed a robus...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

A Study on the Efficacy of Empirical Antibiotic Therapy for Splenectomized Children with Fever.
This study aimed to investigate the effect of the antibiotic type on the outcome of acute post-splenectomy infection in patients with thalassemia. This investigation is a retrospective cohort study. One hundred fifty medical records of hemoglobinopathy patients who underwent splenectomy were collected from the Ali-Asghar Hospital, Tehran, Iran. SPSS v. 20 and SAS v. 1.9 were used to analyze the data. A total of 150 patients that were vaccinated against post-splenectomy infections and were under antibiotic prophylaxis underwent splenectomy. The most commonly prescribed drugs were ceftriaxone or cefotaxime (132 cases, 88%), ...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Remote Ischemic Conditioning in Acute Ischemic Stroke - A Clinical Trial Design.
This study aims to explore the efficiency and safety of remote ischemic conditioning during the first five days following in patients who are ineligible for reperfusion treatment (intravenous thrombolysis or/and mechanical thrombectomy). We hypothesized that this intervention would reduce the infarct size (neuroprotection in the reperfusion window) and improve functional recovery. We aim to conduct a double-blind controlled trial, multicenter in two hospitals in Romania. Two hundred patients with acute ischemic stroke randomly divided into an experimental group and a control group will be included. The subjects in the expe...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Patients' Beliefs Regarding the Role of Food, Mucosal Trauma, Menstruation, and Psychological Stress in the Recurrence of Beh ├žet's Disease Symptoms.
The Patients' Beliefs Regarding the Role of Food, Mucosal Trauma, Menstruation, and Psychological Stress in the Recurrence of Behçet's Disease Symptoms. J Med Life. 2020 Apr-Jun;13(2):164-169 Authors: Shenavandeh S, Asis M, Eftekhari MH, Aflaki E, Abdollahifard GR, Abnavi MA, Ahmadi A Abstract Behçet's disease is a systemic vasculitis. Mucocutaneous involvement is the most prominent finding, but triggering factors are not well-known. We decided to assess the beliefs of patients with Behçet's disease regarding the potential role of food, mucosal injury, menstruation, and stress in t...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Non-Motor Manifestations in Idiopathic Dystonia with Focal Onset - A Pilot Study.
This study represents a component of an ongoing research project - GENDYS. From the database of this project, we selected 48 patients 56.62+/-14.16 years old who have been examined clinically and using specific scales: Patient Health Questionnaire-9 (for depression), Montreal Cognitive Assessment - MoCA (for cognitive impairment), and a 5-degree analog scale for subjective perception of the severity of the disease. We conducted a descriptive cross-sectional study on patients with depression and cognition evaluated by the above-mentioned scales. We also performed a nested case-control analysis on 20 IDFO patients with and w...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Children Food and Nutrition Literacy - a New Challenge in Daily Health and Life, the New Solution: Using Intervention Mapping Model Through a Mixed Methods Protocol.
Authors: Ahmadpour M, Omidvar N, Doustmohammadian A, Rahimiforoushani A, Shakibazadeh E Abstract Food and nutrition literacy is a fundamental and new idiom among health policymakers. Improving children's food and nutrition literacy is a fundamental task, and it requires detailed planning. The aim of this study is to design, implement, and evaluate a food and nutrition literacy promotion intervention in elementary school children based on the Intervention Mapping model. This is a sequential study to design, implement, and evaluate a food and nutrition literacy promotion intervention in elementary school children age...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Contribution of an Early Internal Medicine Rotation to the Clinical Reasoning Learning for Young Residents.
Authors: Sovaila S, Purcarea A, Froissart A, Ranque B, Kieffer P, Andres E, Goujard C, Weber JC, Bergmann JF, Gayet S, Granel B, Bourgarit A Abstract Clinical reasoning is the cornerstone of medical practice, and achieving this competence depends on a large number of factors. Internal medicine departments provide junior doctors with plentiful and varied patients, offering a comprehensive basis for learning clinical reasoning. In order to evaluate the usefulness of an early rotation at internal medicine departments, we compared, via script concordance tests, the evolution of residents' clinical reasoning after an in...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Effect of Cognitive-Behavioral Counseling on Lifestyle in Pregnant Women: A Randomized Controlled Clinical Trial.
Authors: Farhodimoghadam M, Heydarpour S, Salari N, Jaberghaderi N Abstract The lifestyle of pregnant women has a close relationship with maternal and fetal health. In pregnant women, health-promoting behaviors lead to the promotion of quality of life and improvement of pregnancy outcomes. Therefore, the present study aimed to determine the effect of cognitive-behavioral counseling on pregnant women's lifestyle. This randomized controlled clinical trial study was performed in the health centers of Sanandaj, Iran. Seventy pregnant women were randomly assigned to intervention (n = 35) and control (n = 35) groups. The...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media.
Authors: Borcan F, Mioc M, Ghiulai R, Pinzaru I, Dehelean CA, Soica CM Abstract Polyurethane nano- and micro-structures have been studied intensively in the last decade as drug delivery systems for various herbal extracts as well as pure active biological substances. Their biocompatibility, haemocompatibility, safe degradation, and low-cost production are just a few advantages of these materials that were already used in numerous medical applications (catheters, surgical drapes, wound dressing). The primary purposes of this study include obtaining empty polyurethane microstructures and the assessment of their modif...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Intestinal Dysbiosis As a Possible Predictor of Very Early Preterm Labor in Pregnant Women With Metabolic Syndrome.
Authors: Pavlovska OM, Pavlovska KM, Heryak SM, Khmil SV, Gorban NY Abstract The work assessed the state of the intestinal microbiocenosis in 52 puerperae at the in whom the pregnancy developed against the background of the metabolic syndrome. The diagnosis of metabolic syndrome was determined according to the criteria approved by the World Health Organization for pregnant women. The state of intestinal microbiocenosis was assessed by a bacteriological examination of feces immediately after delivery. The content of the main representatives of the obligate microflora (bifidobacteria, lactobacilli, native intestinal ...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Comparison of the Effects of Haloperidol, Metoclopramide, Dexmedetomidine and Ginger on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy.
Authors: Naemi AR, Kashanitabar V, Kamali A, Shiva A Abstract Nausea is a mental sensation of unease and discomfort before vomiting. Vomiting refers to the return of the contents of the upper gastrointestinal tract to the mouth caused by contractions of chest and abdomen muscles. Postoperative nausea and vomiting is an unpleasant experience with high treatment costs. Therefore, this study aimed to compare the effects of haloperidol, metoclopramide, dexmedetomidine, and ginger on postoperative nausea and vomiting after laparoscopy. This double-blind clinical trial was performed on all laparoscopy candidates at Valia...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Proposing a Model for the National Hemovigilance Information System in Iran.
Authors: Asadi F, Ramezanghorbani N Abstract The present study aimed to propose a model for the national hemovigilance information system with a database approach, considering the importance and necessity of developing an information system for such a network. This is an applied, descriptive, and cross-sectional study, which was conducted in 2018. The research population comprised hemovigilance information systems in advanced countries, including the USA, UK, Australia, and France. Data were collected from library sources and the Internet from 2000 to 2018. The proposed model for the national hemovigilance informat...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

A Comparative Study of Connective Tissue Metabolism Indices in Experimental Comorbidity-Free Periodontitis and Periodontitis Combined with Thyroid Dysfunction.
Authors: Shcherba V, Kyryliv M, Bekus I, Krynytska I, Marushchak M, Korda M Abstract Periodontal disease is a chronic bacterial infection characterized by persistent inflammation, connective tissue breakdown, and alveolar bone destruction. The current study aimed to compare the connective tissue metabolism indices in rats with comorbidity-free periodontitis and in animals with periodontitis in a setting of hyper-and hypothyroidism. 12-14-week-old inbred white male rats (n=48) were included in the experiment. They were randomly divided into the following groups: control, animals with a model of periodontitis, animal...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Investigation of the Effect of Formaldehyde on the Condition of Periodontal Tissues of Woodworking Industry Workers.
This study aimed to investigate the harmful effects of formaldehyde on periodontal tissues in woodworkers who have long-term contact with formaldehyde in their professional activities. Sixty-nine men with occupational exposure to formaldehyde were examined to study the effect of formaldehyde on the human periodontal tissues, looking particularly at signs of the periodontal tissues' inflammatory process using a series of periodontal indices. The study results showed that the condition of periodontal tissues was statistically significantly worse in woodworkers who have long-term contact with formaldehyde in their professiona...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Environmental Tobacco Smoke and Educational Self-Regulation and Achievement in First Grade High School Students.
This study aims at investigating the relationship between environmental tobacco smoke in adolescents and their educational self-regulation and achievement. In this study, 770 students aged between 13 and 15 were selected and studied using the multistage sampling method. The tools used in this study consisted of four questionnaires, demographic characteristics, environmental tobacco smoke, educational self-regulation, and educational achievement. The validity and reliability of tools have been approved, and the data were analyzed using SPSS v22. The results indicated a significant inverse relationship between environmental ...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Salivary and Serum Glucose Levels in Diabetes Mellitus Patients versus Control - A Randomised Control Trial.
Authors: Kumar A, Kumar T, Bhargava M, Raj R, Vaibhav V, Kishore J Abstract Oral fluids provide a readily available and non-invasive medium for the diagnosis of a wide range of diseases and clinical situations. Diabetes mellitus is a common chronic metabolic disorder that affects millions of people. Our objective was to compare the salivary and serum glucose levels in patients with diabetes mellitus and healthy individuals. Two ml of unstimulated whole saliva was collected by the spitting method. Also, 2 ml of the patient's intravenous blood was obtained from the forearm's median cephalic vein. Both the samples wer...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Substrate Optimization in Baby Hamster Kidney Cell Culture for Foot and Mouth Disease Virus Vaccine Using the Taguchi Method.
This study was conducted to investigate the effect of chemical components as supplements using the experimental design method, which aimed at reducing the number of experiments. For this purpose, supplements including chemical components using four levels, with three replications in suspension and batch culture conditions, were examined for 72 hours using the Taguchi experimental design method. From the experiments, it was concluded that the culture media composition had a significant impact on final cell count and pH. High concentrations of different media composition alone were insufficient to ensure higher cell count. A...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Impact of Early Childhood Caries on Oral Health-Related Quality of Life of Children and Caregivers Residing in Rural and Urban Areas of the Rangareddy District.
Authors: Tabassum SN, Tupalli AR, Cheruku SR, Abidullah M, Rajajee K, Hussain TA Abstract Early childhood caries is a condition that impacts oral health-related quality of life of children's development and well being and also affects parents' work hours and poses a financial burden on them. Our objective was to study and compare the impact of early childhood caries on the quality of life of preschool children aged 22-70 months and their caregivers in an urban and rural population using the early childhood oral health impact scale. The study was conducted on children of the Rangareddy district, Telangana state, age...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Justification of Genetic Factors for Predicting the Risk of Acute Bleeding in Peptic Ulcer Disease.
Authors: Grynchuk FV, Dutka II, Panchuk II, Volkov RA, Sheremet MI, Maksymyuk VV, Tarabanchuk VV, Bilyk II, Myshkovskii YM Abstract PAI genotyping for the G43A and 4G/5G polymorphisms was performed in 60 patients with peptic ulcer disease: 12 with an uncomplicated ulcer, 5 with perforation, the rest with ongoing bleeding. Fourteen patients had recurrent bleeding. The 5G/5G and G43A genotypes were not detected in patients with uncomplicated ulcers. All patients with ulcer perforation had the G43G genotype, 60% of patients had the 4G/4G genotype, and the rest of them had the 4G/5G and 5G/5G genotypes. The number of c...
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Paraparesis and Disseminated Osteolytic Lesions Revealing Cholangiocarcinoma: A Case Report.
We report the case of a patient with disseminated osteolytic lesions who was admitted to the Neurology Department for progressive paraparesis. On the computed tomography examination, specific features for cholangiocarcinoma were described, confirmed later by the histopathological aspect of the bone lesions. PMID: 32742524 [PubMed - in process] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - August 4, 2020 Category: General Medicine Tags: J Med Life Source Type: research

18th Congress of the Academy for Multidisciplinary Neurotraumatology: 26-28 February 2020 | Cairo | Egypt.
Authors: Cretoiu D PMID: 32728401 [PubMed - in process] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - August 1, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Current Trends on Glomerulosclerosis Regression.
This article explores the renin-angiotensin-aldosterone system with plasminogen activator-inhibitor-1 interaction and the potential significance of these interactions in the pathogenesis of progressive renal disease and remodeling of renal sclerosis. PMID: 32728402 [PubMed - in process] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - August 1, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Making Things Easier: A Simple Novel Method to Fix a Dorsiflexion Osteotomy of the First Metatarsal.
We present our results using a varisation staple (Biomet©) as an alternative fixation device. We performed a retrospective outcome analysis of a consecutive series of 10 cavovarus feet that underwent a dorsiflexion osteotomy (dorsal closing wedge) of the first metatarsal fixed with two varisation staples. The results were measured at a mean three monthly follow-ups and included union and complication rates, as well as clinical and radiographic assessment of cavus deformity correction. There was a 100% union rate with no complications or cases of delayed union. No metalwork removal was requested in any case at follow-u...
Source: Journal of Medicine and Life - August 1, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Prevalence of 25-OH-Vitamin D and Calcium Deficiency in Adolescent Idiopathic Scoliosis.
Authors: Herdea A, Charkaoui A, Ulici A Abstract Several etiologies have been proposed as a basis and evolution theory for the development of adolescent idiopathic scoliosis, but limited data were published until now that link vitamin D and calcium deficiency to this condition. The present study aims to evaluate the relationship between 25-OH-Vitamin D, total calcium, and the following data: Cobb angle, age, and patient sex. The seasonal variation for vitamin D will also be taken into consideration. A total of 101 patients with a mean age of 11.61 ± 2.33 years had vitamin D and calcium levels tested. The mea...
Source: Journal of Medicine and Life - August 1, 2020 Category: General Medicine Tags: J Med Life Source Type: research

A Possible Future in Medical, Psycho-Social and Moral Fields.
Authors: Purcarea VL PMID: 32341692 [PubMed - in process] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Takotsubo Cardiomyopathy: A Brief Review.
Authors: Amin HZ, Amin LZ, Pradipta A Abstract Takotsubo cardiomyopathy is a reversible cardiomyopathy with a unique morphological feature of the left ventricle characterized by an apical ballooning appearance known for approximately known 25 years. Catecholamine drive plays an essential role in the pathogenesis and pathophysiology of Takotsubo cardiomyopathy; hence, it is also called stress cardiomyopathy. Physical stress could also have an impact and leads to a greater variety of characteristics in Takotsubo cardiomyopathy. Supportive and symptomatic medication remains the mainstay therapy with priority to improv...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Role of Quantitative EEG in the Diagnosis of Neuropsychiatric Disorders.
Authors: Livint Popa L, Dragos H, Pantelemon C, Verisezan Rosu O, Strilciuc S Abstract Quantitative electroencephalography (QEEG) is a modern type of electroencephalography (EEG) analysis that involves recording digital EEG signals which are processed, transformed, and analyzed using complex mathematical algorithms. QEEG has brought new techniques of EEG signals feature extraction: analysis of specific frequency band and signal complexity, analysis of connectivity, and network analysis. The clinical application of QEEG is extensive, including neuropsychiatric disorders, epilepsy, stroke, dementia, traumatic brain i...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Sociodemographic Determinants and Students' Perception Regarding Legislative Changes.
Authors: Parvu S Abstract The frequency of legislation changes and their utility is a subject of interest and always under debate with pro and contra arguments. In the current study, the perception of students regarding medical legislation changes was analyzed. In general, no statistically significant differences were found between the sub-groups of students, thus underlining a unitary perception. The general perception is that changes in legislation are made too often. Moreover, only a small part of the analyzed group agrees on the utility of these changes. Finally, it seems that income is the main driver for stud...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Influence of Diffuse Nontoxic Goiter on the State of Protective Mechanisms of the Oral Cavity in Children.
In conclusion, a violation of the local protective mechanisms of the oral cavity is observed in children with diffuse nontoxic goiter. Also, the increase in the severity of dental pathology leads to increased tension of local protective and compensatory reactions. PMID: 32341696 [PubMed - in process] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Does CT Reduce the Rate of Negative Laparoscopies for Acute Appendicitis? A Single-Center Retrospective Study.
Authors: Wagner PJ, Haroon M, Morarasu S, Eguare E, Al-Sahaf O Abstract In surgical practice, surgeons request CT scans to rule out acute appendicitis, even in young patients. We aimed to assess the feasibility of using a CT scan to reduce the rate of negative laparoscopies in patients younger than 40 with equivocal signs of acute appendicitis. Therefore, we conducted a retrospective observational study on the patients admitted with a provisional diagnosis of acute appendicitis. Patients younger than 40 and with the Alvarado score between 3 and 6 were included. These were divided into two groups: those who had or d...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Alpha-Lipoic Acid as a Means of Influence on Systemic Inflammation in Type 2 Diabetes Mellitus Patients with Prior Myocardial Infarction.
Authors: Altunina NV, Lizogub VG, Bondarchuk OM Abstract Patients with combined coronary heart disease and diabetes mellitus make up a growing segment of the population and require a comprehensive treatment approach. Patients with concurrent diabetes mellitus and coronary heart disease have a worse projection. Under these conditions, the incidence of recurrent myocardial infarction, early disability due to complications, and the risk of coronary death are increased. Therefore, the priority task is to find ways to optimize drug treatment of this category of patients, taking into account the impact of drugs on the pa...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Misleading Epidemiological and Statistical Evidence in the Presence of Simpson's Paradox: An Illustrative Study Using Simulated Scenarios of Observational Study Designs.
This study empirically illustrates the mechanism by which epidemiological effect measures and statistical evidence can be misleading in the presence of Simpson's paradox and identify possible alternative methods of analysis to manage the paradox. Three scenarios of observational study designs, including cross-sectional, cohort, and case-control approaches, are simulated. In each scenario, data are generated, and various methods of epidemiological and statistical analyses are undertaken to obtain empirical results that illustrate Simpson's paradox and mislead conclusions. Rational methods of analysis are also performed to i...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Perspectives on Using Platelet-Rich Plasma and Platelet-Rich Fibrin for Managing Patients with Critical Lower Limb Ischemia After Partial Foot Amputation.
Authors: Goshchynsky V, Migenko B, Lugoviy O, Migenko L Abstract The problem of lower limb preservation with symptoms of critical ischemia, resulting in necrosis of the distal foot portion, remains open. These cases require solving few tactical questions, such as the primary revascularization method, limb-preserving amputation, stimulation of regeneration, and finally, determining the criteria for auto-dermal transplantation. We analyzed 29 patient cases with critical lower limb ischemia of fourth grade, according to the Fontaine classification (or the sixth category according to Rutherford's classification), who u...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Influence of Metformin to the Transcriptional Activity of the mTOR and FOX3 Genes in Parapancreatic Adipose Tissue of Streptozotocin-Induced Diabetic Rats.
Authors: Putilin DA, Evchenko SY, Fedoniuk LY, Tokarskyy OS, Kamyshny OM, Migenko LM, Andreychyn SM, Hanberher II, Bezruk TO Abstract The mammalian target of rapamycin is not only a central regulator of lipid metabolism that controls the processes of adipogenesis and lipolysis but also a regulator of the immunometabolism of immune cells that infiltrate adipose tissue. In turn, the level of progression of diabetes is significantly influenced by the Treg subpopulation, the complexity and heterogeneity of which is confirmed by the detection of numerous tissue-specific Tregs, including the so-called VAT Tregs (visceral...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Localization of Impacted Canines - A Comparative Study of Computed Tomography and Orthopantomography.
Authors: Mohammed AK, Sravani G, Vallappareddy D, Rao AR, Qureshi A, Prasad AN Abstract Our aim was to evaluate the location of impacted canines and their proximity to the lateral and central incisor to assess the prognosis of the impacted canine and compare the reliability of 2D versus 3D imaging solutions. We carried a prospective study on 17 subjects with impacted maxillary canines. Later, the patients underwent radiologic examination, i.e., sectional computed tomography and orthopantomography. The obtained records were compared regarding the location of the impacted maxillary canine, the proximity and resorptio...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Role of Polysomnography in Identifying Sleep Disorders in Children with Migraine.
The objective of this study consisted of the evaluation of a possible correlation between migraine and sleep disorders in children, as reflected by sleep architecture and electroencephalographic patterns. Eighteen patients aged five to seventeen were recruited for the migraine group, and sixteen age-matched patients with no criteria for migraine or any underlying organic disorder, diagnosed with emotional disorders, were enrolled in the control group. All patients underwent inpatient full night polysomnographic recordings, the results of which were analyzed using appropriate statistical methods. Patients in the migraine gr...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Signification of Serum Alpha-Fetoprotein Levels in Cases of Compensated Cirrhosis and Hepatitis C Virus without Hepatocellular Carcinoma.
Authors: Manuc D, Preda CM, Sandra I, Baicus C, Cerban R, Constantinescu I, Olteanu AO, Ciora CA, Manuc T, Chiriac DE, Chifulescu AE, Diculescu M, Tieranu C, Negreanu L, Oprea-Calin G, Manuc M Abstract AFP (alpha-fetoprotein) levels are increased during the development of HCC (hepatocellular carcinoma); nonetheless, it can also be produced by non-tumoral hepatocytes in conditions of high cell turnover. Our study aims to provide additional data regarding the causes of elevated AFP in patients with liver cirrhosis due to hepatitis C virus (HCV) infection. We conducted an observational prospective cohort study that in...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Clinico-Epidemiological Profile of Patients with Gonorrhoea and Challenges in the Management of Neisseria gonorrhoeae Infection in an STI clinic, Ternopil, Ukraine (2013-2018).
Authors: Boiko I, Akimova V, Mazur L, Savchenko I, Kohut I, Krynytska I Abstract Gonorrhea is the second most common sexually transmitted infection spreading worldwide and a serious public health problem. However, further data are required to improve the management of gonorrhea. Our aim was to review the features of gonococcal infection and characterize the challenges of its management. A retrospective descriptive study of the medical records of 136 adult patients with gonorrhea that visited Ternopil Regional Sexually Transmitted Infections Clinic (Ukraine) in 2013-2018 was performed. The male-to-female ratio was 6...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Elderly Patients' Perception of Previewing the Prosthetic Treatment Outcome.
Authors: Pantea M, Tancu AMC, Petre A, Imre M, Ionescu E Abstract The demographic statistics indicate that, with the industrial development and the advances in the medical field, the average life of the population has started to increase significantly; consequently, the needs of treatments in geriatric dentistry are becoming more and more significant. The purpose of this study was to evaluate patients' perception of diverse techniques used to obtain previews for final fixed prosthetic restorations: digital smile design (DSD), wax-up, indirect mock-up, temporary restorations, Computer-Aided Design (CAD). A focus gro...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

The Effect of Music Therapy and Aromatherapy with Chamomile-Lavender Essential Oil on the Anxiety of Clinical Nurses: A Randomized and Double-Blind Clinical Trial.
This study aimed to determine the effect of music therapy and aromatherapy with chamomile - lavender essential oil on the anxiety of clinical nurses. This was a randomized, double-blind clinical trial. One hundred twenty nurses from clinical wards of Besat Hospital in Sanandaj, Iran, were selected between 2018 and 2019 by purposeful sampling. The samples were randomly assigned to three groups with different interventions, namely music therapy, both aromatherapy with chamomile-lavender essential oil and music therapy, and aromatherapy with chamomile-lavender essential oil, along with a control group as well. The anxiety of ...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

A Case Report on the Communication between Oncologists and Physiatrists in the Establishment of Functional Prognosis while Undergoing Chimeric Antigen Receptor T-cell Therapy.
We present a case and explain how communication between cancer physiatrists, oncologists, and patients can affect the expectations for functional recovery, and the importance of setting goals for recovery in a medically complex population. We present a patient who underwent aggressive chimeric antigen receptor T cell therapy, causing encephalopathy and complications. He initially required total assistance for mobility and activities of daily living. Physiatry was consulted to assist with the rehabilitation plan of care and disposition. Initially, the oncologist conveyed to the patient he would be walking in two weeks, whic...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Inferior ST-Segment Elevation Caused by Occlusion of Left Anterior Descending Artery.
We reported our observation in electrocardiographic data and coronary angiography and its changes after a percutaneous coronary intervention, and then we discuss its pathophysiologic mechanism. PMID: 32341709 [PubMed - in process] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Assessment of Cortical Auditory Function Using Electrophysiological and Neuropsychological Measurements in Children with Bone-Anchored Hearing Aids.
We present the case of a seven-year-old boy with a congenital hearing loss due to a plurimalformative syndrome, including outer and middle ear malformation. After the diagnosis of hearing loss and the audiological rehabilitation with a BAHA Attract implantable prosthesis, the cortical auditory evoked potentials were recorded. We performed a neuropsychological evaluation using the Wechsler Intelligence Scale for Children - Fourth Edition, which was applied according to a standard procedure. The P1 latency was delayed according to the age (an objective biomarker for quantifying cortical auditory function). The neuropsycholog...
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Dermoscopy and Reflectance Confocal Microscopy in the Diagnosis and Management of Nail Fold Squamous Cell Carcinoma.
Authors: Mazzilli S, Cosio T, Diluvio L, Vollono L, Gonzalez S, Di Prete M, Orlandi A, Bianchi L, Campione E Abstract The management and prognosis of squamous cell carcinoma largely depend on its invasiveness and grade of differentiation. Pigmented nail fold squamous cell carcinoma represents a therapeutic challenge, needing careful treatment to preserve nail function. Here, we report the use of dermoscopy and Reflectance Confocal Microscopy to monitor nail fold squamous cell carcinoma in situ and its response to treatment with topical imiquimod. PMID: 32341711 [PubMed - in process] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

Retraction Notice to "Congenital Double Scoliosis with 2 Bilaterally Alternant Supranumerary Hemivertebrae and 2 Supranumerary Vertebrae Treated by Growth Guiding Device" [J Med Life 12(2) (2019) 192-193].
Retraction Notice to "Congenital Double Scoliosis with 2 Bilaterally Alternant Supranumerary Hemivertebrae and 2 Supranumerary Vertebrae Treated by Growth Guiding Device" [J Med Life 12(2) (2019) 192-193]. J Med Life. 2020 Jan-Mar;13(1):112 Authors: Burnei G, Tandea V, Muntean IL, Moga M, Raducan ID, Burnei C Abstract Article J Med Life 2019; 12(2): 192-193; doi: 10.25122/jml-2019-0057 has been retracted for legal reasons. PMID: 32341712 [PubMed - in process] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - April 30, 2020 Category: General Medicine Tags: J Med Life Source Type: research

17th Congress of the Academy For Multidisciplinary Neurotraumatology: 11-12 April 2019 | Platinia Conference Hall | Cluj-Napoca | Romania.
Authors: Cretoiu D, Livint Popa L PMID: 32025245 [PubMed - in process] (Source: Journal of Medicine and Life)
Source: Journal of Medicine and Life - February 8, 2020 Category: General Medicine Tags: J Med Life Source Type: research