Cell-specific localization of β-synuclein in the mouse retina
Abstractβ-synuclein, a member of the synuclein family, is frequently co-expressed with α-synuclein in the neural system, where it serves to inhibit abnormal aggregation of α-synuclein in neurodegenerative diseases. Beyond its role in pathological conditions, β-synuclein plays various functions independe ntly of α-synuclein. In our investigation, we discovered a broader expression of β-synuclein in the mouse retina compared to α-synuclein. This widespread pattern implies its potential significance in the retina. Through detailed examination via light- and electron-microscopic immunocytochemistry, we identified β-syn...
Source: Anatomy and Embryology - May 4, 2024 Category: Anatomy Source Type: research
Circulating metabolite abundances associated with risks of bipolar disorder, schizophrenia, and depression: a Mendelian randomization study
Preventive measures and treatments for psychiatric disorders are limited. Circulating metabolites are potential candidates for biomarker and therapeutic target identification, given their measurability and essential roles in biological processes. (Source: Biological Psychiatry)
Source: Biological Psychiatry - May 3, 2024 Category: Psychiatry Authors: Tianyuan Lu, Yiheng Chen, Satoshi Yoshiji, Yann Ilboudo, Vincenzo Forgetta, Sirui Zhou, Celia MT. Greenwood Tags: Archival Report Source Type: research
Functioning and neurocognition in very early and early-life onset bipolar disorders: the moderating role of bipolar disorder type
This study suggests that functional remediation may be prioritized for individuals with midlife-onset BD I and very early life onset BD 2 and NOS. (Source: European Child and Adolescent Psychiatry)
Source: European Child and Adolescent Psychiatry - May 3, 2024 Category: Psychiatry Source Type: research
Exploring the Full Potential of Radiofrequency Technology: A Practical Guide to Advanced Radiofrequency Ablation for Complex Ventricular Arrhythmias
AbstractPurpose of ReviewPercutaneous radiofrequency (RF) catheter ablation is an established strategy to prevent ventricular tachycardia (VT) recurrence and ICD shocks. Yet delivery of durable lesion sets by means of traditional unipolar radiofrequency ablation remains challenging, and left ventricular transmurality is rarely achieved. Failure to ablate and eliminate functionally relevant areas is particularly common in deep intramyocardial substrates, e.g. septal VT and cardiomyopathies. Here, we aim to give a practical-orientated overview of advanced and emerging RF ablation technologies to target these complex VT subst...
Source: Current Cardiology Reports - May 3, 2024 Category: Cardiology Source Type: research
The comparison of hot and cold executive functions in patients with bipolar II disorder, borderline personality disorder, and healthy individuals
CONCLUSION: These findings underline the differences between the two mentioned disorders based on the hot EFs, which may indicate further disorder in the emotional information processing system among the BPD patients.PMID:38694401 | PMC:PMC11060245 | DOI:10.1097/MS9.0000000000001981 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Ayyub Sabbah Shekoofeh Mottaghi Parviz Ghaedi Melika Ghalandari Source Type: research
Association of red blood cell distribution width with mortality among multiple trauma patients
CONCLUSION: Our study does not report a significant increase in RDW among 24 h and 30-day mortality and survivor patients. ISS was significantly different among the two groups.PMID:38694369 | PMC:PMC11060276 | DOI:10.1097/MS9.0000000000001650 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Mohammad K Shahmoradi Parham Khoshdani Farahani Haleh Pak Masoud Sharifian Mania Beiranvand Source Type: research
A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of the Acute Antisuicidal and Antidepressant Effects of Intranasal (R,S)-Ketamine in Severe Unipolar and Bipolar Depression With and Without Comorbid Alcohol Use Disorder
Conclusion: IN ketamine induced rapid antidepressant effects compared to placebo but did not significantly alter SI scores. The treatment was well tolerated. Continued investigation with IN ketamine as a practical alternative to current formulations is warranted.Trial Registration: ClinicalTrials.gov identifier: NCT03539887.PMID:38696221 | DOI:10.4088/JCP.23m14974 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Gregory H Jones Courtney M Vecera Ana C Ruiz Hanjing E Wu Sophia I McInturff Maria J Orejarena Kacy A Smith Jair C Soares Carlos A Zarate Scott D Lane Rodrigo Machado-Vieira Source Type: research
The comparison of hot and cold executive functions in patients with bipolar II disorder, borderline personality disorder, and healthy individuals
CONCLUSION: These findings underline the differences between the two mentioned disorders based on the hot EFs, which may indicate further disorder in the emotional information processing system among the BPD patients.PMID:38694401 | PMC:PMC11060245 | DOI:10.1097/MS9.0000000000001981 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Ayyub Sabbah Shekoofeh Mottaghi Parviz Ghaedi Melika Ghalandari Source Type: research
Association of red blood cell distribution width with mortality among multiple trauma patients
CONCLUSION: Our study does not report a significant increase in RDW among 24 h and 30-day mortality and survivor patients. ISS was significantly different among the two groups.PMID:38694369 | PMC:PMC11060276 | DOI:10.1097/MS9.0000000000001650 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Mohammad K Shahmoradi Parham Khoshdani Farahani Haleh Pak Masoud Sharifian Mania Beiranvand Source Type: research
New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview
Pharmacol Rev. 2024 May 2;76(3):323-357. doi: 10.1124/pharmrev.120.000007.ABSTRACTOver the last six decades, lithium has been considered the gold standard treatment for the long-term management of bipolar disorder due to its efficacy in preventing both manic and depressive episodes as well as suicidal behaviors. Nevertheless, despite numerous observed effects on various cellular pathways and biologic systems, the precise mechanism through which lithium stabilizes mood remains elusive. Furthermore, there is recent support for the therapeutic potential of lithium in other brain diseases. This review offers a comprehensive ex...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Analia Bortolozzi Giovanna Fico Michael Berk Marco Solmi Michele Fornaro Joao Quevedo Carlos A Zarate Lars V Kessing Eduard Vieta Andre F Carvalho Source Type: research
A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of the Acute Antisuicidal and Antidepressant Effects of Intranasal (R,S)-Ketamine in Severe Unipolar and Bipolar Depression With and Without Comorbid Alcohol Use Disorder
Conclusion: IN ketamine induced rapid antidepressant effects compared to placebo but did not significantly alter SI scores. The treatment was well tolerated. Continued investigation with IN ketamine as a practical alternative to current formulations is warranted.Trial Registration: ClinicalTrials.gov identifier: NCT03539887.PMID:38696221 | DOI:10.4088/JCP.23m14974 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Gregory H Jones Courtney M Vecera Ana C Ruiz Hanjing E Wu Sophia I McInturff Maria J Orejarena Kacy A Smith Jair C Soares Carlos A Zarate Scott D Lane Rodrigo Machado-Vieira Source Type: research
New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview
Pharmacol Rev. 2024 May 2;76(3):323-357. doi: 10.1124/pharmrev.120.000007.ABSTRACTOver the last six decades, lithium has been considered the gold standard treatment for the long-term management of bipolar disorder due to its efficacy in preventing both manic and depressive episodes as well as suicidal behaviors. Nevertheless, despite numerous observed effects on various cellular pathways and biologic systems, the precise mechanism through which lithium stabilizes mood remains elusive. Furthermore, there is recent support for the therapeutic potential of lithium in other brain diseases. This review offers a comprehensive ex...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Analia Bortolozzi Giovanna Fico Michael Berk Marco Solmi Michele Fornaro Joao Quevedo Carlos A Zarate Lars V Kessing Eduard Vieta Andre F Carvalho Source Type: research
A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of the Acute Antisuicidal and Antidepressant Effects of Intranasal (R,S)-Ketamine in Severe Unipolar and Bipolar Depression With and Without Comorbid Alcohol Use Disorder
Conclusion: IN ketamine induced rapid antidepressant effects compared to placebo but did not significantly alter SI scores. The treatment was well tolerated. Continued investigation with IN ketamine as a practical alternative to current formulations is warranted.Trial Registration: ClinicalTrials.gov identifier: NCT03539887.PMID:38696221 | DOI:10.4088/JCP.23m14974 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Gregory H Jones Courtney M Vecera Ana C Ruiz Hanjing E Wu Sophia I McInturff Maria J Orejarena Kacy A Smith Jair C Soares Carlos A Zarate Scott D Lane Rodrigo Machado-Vieira Source Type: research
New Advances in the Pharmacology and Toxicology of Lithium: A Neurobiologically Oriented Overview
Pharmacol Rev. 2024 May 2;76(3):323-357. doi: 10.1124/pharmrev.120.000007.ABSTRACTOver the last six decades, lithium has been considered the gold standard treatment for the long-term management of bipolar disorder due to its efficacy in preventing both manic and depressive episodes as well as suicidal behaviors. Nevertheless, despite numerous observed effects on various cellular pathways and biologic systems, the precise mechanism through which lithium stabilizes mood remains elusive. Furthermore, there is recent support for the therapeutic potential of lithium in other brain diseases. This review offers a comprehensive ex...
Source: Pharmacological Reviews - May 2, 2024 Category: Drugs & Pharmacology Authors: Analia Bortolozzi Giovanna Fico Michael Berk Marco Solmi Michele Fornaro Joao Quevedo Carlos A Zarate Lars V Kessing Eduard Vieta Andre F Carvalho Source Type: research
A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of the Acute Antisuicidal and Antidepressant Effects of Intranasal (R,S)-Ketamine in Severe Unipolar and Bipolar Depression With and Without Comorbid Alcohol Use Disorder
Conclusion: IN ketamine induced rapid antidepressant effects compared to placebo but did not significantly alter SI scores. The treatment was well tolerated. Continued investigation with IN ketamine as a practical alternative to current formulations is warranted.Trial Registration: ClinicalTrials.gov identifier: NCT03539887.PMID:38696221 | DOI:10.4088/JCP.23m14974 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 2, 2024 Category: Psychiatry Authors: Gregory H Jones Courtney M Vecera Ana C Ruiz Hanjing E Wu Sophia I McInturff Maria J Orejarena Kacy A Smith Jair C Soares Carlos A Zarate Scott D Lane Rodrigo Machado-Vieira Source Type: research
