383. Symptom Severity for Psychosis Biotype 3 Shows Unique Associations With Environmental Exposures as Measured By the Exposome Score for Schizophrenia
The identification of environmental risk factors is as an important step in investigating potential causal pathways for disease states. A recently-developed, “exposome” (ES-SCZ) model of environmentally-associated psychosis-spectrum risk, accounting for correlations between risk factors themselves, has shown promise for capturing dose-dependent risk. The Bipolar and Schizophrenia Network for Intermediate Phenotypes (BSNIP) consortium has identified d istinct psychosis biotypes clustered according to differences in cognitive, eye tracking and physiological biomarkers, which may capture biologically-defined differences i...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Bryan Kromenacker, Walid Yassin, Brett A. Clementz, Matcheri Keshavan, Elena I. Ivleva, Elliot Gershon, Jennifer McDowell, Sarah Keedy, Godfrey Pearlson, S. Kristian Hill, Carol A. Tamminga Source Type: research
275. Plasma Levels of FGF21 and GDF15 are Elevated in Patients With Bipolar and Treatment-Resistant Depression
Fibroblast-Growth-Factor 21 (FGF21) and Growth-Differentiation-Factor 15 (GDF15) have emerged as potential biomolecules of interest in mood disorders, particularly treatment-resistant depression (TRD) and bipolar disorder (BD). FGF21, known for metabolic regulation in conditions like obesity and diabetes, is now being explored for its role in mood disorders. GDF15, a multifaceted protein involved in cellular functions, has implications in stress response and inflammation, both relevant to mood disorders. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Francisco Cruz Avi ña, Francisco da Silva, Rafaela C. Cordeiro, Bashar Asir, Giovana Zunta-Soares, Jair Soares, Giselli Scaini, Joao Quevedo Source Type: research
271. Maintenance Ketamine Infusions Demonstrate Sustained Antidepressant Efficacy in a Real-World Treatment-Resistant Unipolar and Bipolar Depression Sample
Intravenous, subanesthetic-dose ketamine has demonstrated rapid and robust antidepressant effects in patients with treatment-resistant major depressive disorder (TRD) and bipolar depression (TRBD). Most analyses have analyzed the effects of acute ketamine infusions administered in 2-3 weeks, while limited research has analyzed the effectiveness of maintenance ketamine infusions. Herein, we present real-world data demonstrating sustained antidepressant effects following maintenance ketamine infusions in patients with TRD and TRBD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Sipan Haikazian, Joshua Di Vincenzo, David Chen-Li, Danica Johnson, Rodrigo B. Mansur, Roger McIntyre, Joshua Rosenblat Source Type: research
175. Preliminary Data Suggests Repeated Electroconvulsive Shock Increases C-Fos Activation of Mouse Parvalbumin Interneurons in the Hippocampus and Prefrontal Cortex
Electroconvulsive therapy (ECT) has been used for more than 80 years as a highly effective treatment for drug-resistant psychiatric disorders such as depression, bipolar disorder, schizophrenia, and catatonia. Despite this treatment ’s remarkable efficacy, its mechanism of action remains unknown. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Noah Kabbaj, Oliver J. Krentzman, John Bilbily, Jordan G. McCall Source Type: research
166. Arterial Stiffness as an Index of Inflammation in Patients With Treatment Resistant Bipolar Depression
Cardiovascular disease (CVD) is the leading cause of death worldwide. Patients with mood disorders have a higher risk of developing CVD compared to the general population. Increased inflammation and subsequent endothelial dysfunction contribute to this increased risk. In a randomized, double-blind, placebo-controlled trial, we demonstrated the efficacy of escitalopram (ESC) + Celecoxib (CBX) compared to ESC + placebo (PBO) in patients with treatment-resistant bipolar depression disorder (TRBDD). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Nausheen Baig, James Sinacore, Angelos Halaris Source Type: research
165. Examining the Relationship Between Cardiovascular Risk Factors and Suicide Phenotypes Among Youth With Mood Disorders
This study examined the association between cardiovascular risk with self-harm in a controlled sample of youth with mood disorders (bipolar disorder or major depressive disorder). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Mikaela Dimick, Kody G. Kennedy, Simin Jin, Benjamin Goldstein Source Type: research
138. Emotional Experience in Youth at Increased Familial Risk for Bipolar Disorder
Early emotional experiences preceding the onset of bipolar disorder and potentially contributing to core symptoms of emotional liability and dysregulation are not well understood. We hypothesized that individuals with a higher familial risk for bipolar disorder I (i.e., high-risk) would exhibit early differences in emotional experiences compared to youth without such a family history (i.e., low-risk). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jennifer Siegel-Ramsay, Amy Bichlmeier, Lucy Chibib, Savannah Layfield, Siyan He, Wade Weber, Caleb Adler, David Fleck, Tricia L. Nick, Luis R. Patino, Gregory Fonzo, Elizabeth Lippard, Charles Nemeroff, Jorge Almeida, Melissa DelBello, Stephen Strakowski Source Type: research
137. Toxoplasma Gondii IgG Serointensity in Seropositive Patients and Cognitive Function in Patients With Bipolar Disorder
Cognitive dysfunction is a major predictor of functional deterioration in bipolar disorder (BD), as previously reported in schizophrenia. Associations between Toxoplasma gondii (T.gondii) seropositivity and serointensity and cognitive dysfunction were found across diagnostic boundaries. In contrast to other conditions, no study has yet reported any significant association between T. gondii IgG serointensity and seropositivity (hallmarks of chronic latent infection) with cognitive function in BD, in part because mood state heterogeneity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Mariam Mikadze, Paul Rensch, Nina Dalkner, Tatjana Stross, Niel Constantine, Aline Dagdag, Abhishek Wadhawan, Farooq Mohyuddin, Armin Birner, Frederike T. Fellendorf, Melanie Lenger, Alexander Maget, Annamaria Painold, Robert Queissner, Franziska Schmiedh Source Type: research
136. Identifying Brain Anatomical Areas Linked to Suicidal Thoughts in Bipolar Disorder Using Deep Learning Algorithms
This study uses AI to detect suicidal thoughts in Bipolar Disorder (BD) patients through structural Magnetic Resonance Imaging (sMRI) scans. Bipolar Disorder is marked by extreme mood swings and an increased risk of suicidal thoughts. Understanding these risks' neurobiological aspects is crucial for prevention and early intervention. Our research employed an open-source dataset from the “UCLA Consortium for Neuropsychiatric Phenomics LA5c Study,” using anatomical data in native space that was preprocessed by fmriprep tool. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Melanie Garcia, Joan Camprodon, Benjamin Wade Source Type: research
135. Psychiatric Medication and Physiological Responses to Alcohol in Young Adults With Bipolar Disorder
Alcohol use problems occur at higher rates in bipolar disorder than the general population. Youth with bipolar disorder may experience alcohol intoxication differently with this relating to risk for alcohol misuse. It is unclear how psychiatric medication affects response to alcohol in bipolar disorder. This preliminary study investigates physiological responses to alcohol in young adults with bipolar disorder and effects of medication. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Nadia Bibb, Dylan Kirsch, Kait Meek, Raquel Kosted, Vanessa Le, Elizabeth Lippard Source Type: research
134. Subjective Response to Alcohol: Childhood Trauma, Bipolar Disorder, and Alcohol-Related Changes in Nucleus Accumbens Functional Connectivity
This study investigated if childhood trauma relates to subjective and neural response to alcohol in young adults with bipolar disorder. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Lydia Lovelace, Raquel Kosted, Dylan Kirsch, Kait Meek, Vanessa Le, Elizabeth Lippard Source Type: research
133. Changes in Functional Connectivity Following the Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) in Bipolar I Depression: A Pilot Study
Individuals with bipolar disorder spend significantly more time depressed than (hypo)manic. Repetitive transcranial magnetic stimulation (rTMS) is an effective, FDA-cleared intervention for treatment-resistant unipolar depression, but clinical trial outcomes have been mixed for bipolar depression. This pilot study assessed the Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) in bipolar I depression, a functional MRI (fMRI) rTMS treatment recently demonstrating good efficacy for treatment of unipolar depression. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Amy Bichlmeier, Kevin Li, Caitlin DuPont, Alexa Comfort, Jennifer E. Siegel-Ramsay, Wade A. Weber, Brandon Bentzley, Nolan Williams, Irving Reti, Peter Zandi, Jorge Almeida Source Type: research
132. Multimodal Analysis of Brain Alterations in Bipolar Disorder and Associations With Clinical Symptoms and Medications
Bipolar disorder (BD) has been associated with alterations to subcortical brain volume and functional connectivity of the default-mode network (DMN). Prior studies have used varied processing methods with limited analysis of the complex clinical factors and common treatments that contribute to brain variation in BD. In this pilot multimodal analysis from the ENIGMA Bipolar Disorder Working Group (ENIGMA-BD), we examined structural and functional brain alterations in BD and their relationship to clinical symptoms and medications. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Melody J.Y. Kang, Leila Nabulsi, Genevieve McPhilemy, Fiona M. Martyn, Brian Hallahan, Ole Andreassen, Colm McDonald, Paul M. Thompson, Christopher Ching, Dara Cannon Source Type: research
131. Cognitive Improvement and Prefrontal Functional Connectivity in Individuals With Remitted Bipolar Disorder After Transcranial Infrared Laser Stimulation
Bipolar disorder involves both compromised prefrontal cortical function and disruptions in brain networks mediating cognition. Deficits in executive function and attention are present even in euthymic individuals. These neurocognitive deficits in individuals with remitted bipolar disorder may be ameliorated by targeting the prefrontal cortex with transcranial infrared laser stimulation (TILS), a safe and non-invasive intervention that enhances brain metabolic energy production. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Douglas Barrett, Roger E. Davis, Farzad Salehpour, Laura A. Gamboa, Sarah Diaz, Siyan He, Amy Bichlmeier, Lucy Chibib, Erin Logue, Jennifer E. Siegel-Ramsay, Jessica Batten, Savannah Layfield, Jorge R.C. Almeida, F. Gonzalez-Lima Source Type: research
130. Neutrophil to Lymphocyte Ratio as a Biomarker for Bipolar Depression in a Low- And Middle- Income Setting
Growing evidence suggests a link between inflammation and bipolar disorder (BD). Trials of repurposed immunomodulatory drugs in patients with BD have reported mixed results. Utilizing biomarkers to stratify treatment has been suggested as a way to personalize treatment with immunomodulatory drugs in neuropsychiatric disorders and improve outcomes. The neutrophil to lymphocyte ratio (NLR) is one such candidate biomarker but is yet to be extensively assessed in bipolar depression and in populations in low and middle-income settings. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ryan Sieg, Brett Jones, Wei Wang, Imran B. Chaudhry, Nusrat Husain, Ameer B. Khoso, Allan H. Young, Muhammad Ishrat Husain Source Type: research
