111. Relationships Between Neural Activity and Lifetime Psychopathology Risk During an Emotional N-Back Task Are Mediated by Impulsivity and Emotional Regulation Behavioral Traits
We previously demonstrated significant relationships between working memory (WM)-related default mode network (DMN-precuneus) activity and depression-risk, and between emotional regulation (ER)-related central executive network (CEN-dorsolateral prefrontal cortex(dlPFC)) activity and depression- and mania-risk. We aimed here to determine how these relationships were mediated by behavioral traits associated with depression- and mania-risk, namely, emotional regulation and impulsivity (negative and positive urgency), in independent cohorts of young adults at risk for psychopathology. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Yvette Afriyie-Agyemang, Michele Bertocci, Satish Iyengar, Richelle Stiffler, Haris Aslam, Simona Graur, Genna Bebko, Alexander Skeba, Osasumwen Benjamin, Yiming Wang, Henry Chase, Mary Phillips Source Type: research
110. Heart-Brain Connections in Youth With Bipolar Disorder
We examined heart-brain connections in a sample of youth with bipolar disorder (BD) and healthy controls (HC). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kody G. Kennedy, Bradley J. MacIntosh, Benjamin I. Goldstein Source Type: research
109. Differential Diagnosis of Bipolar Disorder From MDD Using RNA Editing Blood Biomarkers: An External Validation Study
The objective of this study is to clinically validate the already-selected panel of blood biomarkers in an independent multicentric cohort. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Dinah Weissmann, Nicolas Salvetat, Francisco Checa Robles, Christopher Cayzac, Benjamin Dubuc, Diana Vetter, Lara Herrmann, Aur élie Reymond-Delacretaz, Jean-Philippe Lang, Franziska Gamma Source Type: research
108. Lateral Ventricles Laterality Index is Associated With Myelin Content in Individuals With Bipolar and Depressive Disorders
Previous studies provided inconsistent information regarding lateral ventricle asymmetry and its relationship to other brain indices in individuals with mood disorders. No study so far investigated how lateral ventricular asymmetry is related to cortical myelin content. The goal of this study was to compare lateral ventricular asymmetry in individuals with bipolar (BD) and depressive (DD) disorders versus healthy controls (HC) and examine its association with cortical myelin. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Anna Manelis, Hang Hu, Rachel Miceli, Minjie Wu, Satish Iyengar, Holly Swartz Source Type: research
106. Neural Markers of Mania That Distinguish Inpatient Adolescents With Bipolar Disorder From Those With Other Psychopathology
Pediatric bipolar disorder (BD) is difficult to distinguish from other psychiatric disorders, a challenge which can result in delayed or incorrect interventions. Using neuroimaging we aimed to identify neural measures differentiating a rarified sample of inpatient adolescents with BD from other inpatient psychopathology (OP) and healthy adolescents (HC) during a reward task. We hypothesized reduced subcortical and elevated cortical activation in BD relative to other groups, and that these markers will be related to mania scores. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Michele Bertocci, Renata Rozovsky, Maria Wolfe, Halimah Abdul-waalee, Mariah Chobany, Greeshma Malgireddy, Jonathan Hart, Alexander Skeba, Tyler Brady, Brianna Lepore, Amelia Versace, Henry Chase, Boris Birmaher, Mary Phillips, Rasim Somer Diler Source Type: research
105. Enhancing Affective Cognitive Control in Bipolar Disorder Using Transcranial Alternating Current Stimulation (tACS): Preliminary Evidence From a Randomized, Sham-Controlled Clinical Trial
Cognitive control in affective contexts is compromised in individuals with bipolar disorder (BD), contributing to mood lability and impaired functioning. EEG studies show that frontal theta-gamma phase-amplitude coupling (PAC) is a key neural mechanism supporting cognitive control and is significantly reduced in BD during socio-emotional processing. Emerging data suggest that tACS targeting theta-gamma PAC can improve cognitive control in healthy and aging humans, so we tested this hypothesis in a randomized, double-blind, sham-controlled pilot in BD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Ivy Tso, Jacob Kraft, Laura Locarno, Takakuni Suzuki, Justin Riddle, Soo-Eun Chang, Melvin McInnis, Flavio Frohlich, Stephan Taylor Source Type: research
104. Modafinil Exerts Dose-Dependent Effects on Risk-Taking as Measured by the Human Iowa Gambling Task
Poor decision-making driving increased risk-taking is a hallmark symptom of many psychiatric disorders, quantifiable by the Iowa Gambling Task (IGT), and linked to real-world outcomes e.g., suicide and drug use. Identifying remediating treatments for people with such disorders (e.g., schizophrenia, bipolar disorder, HIV etc.), is vital toward improving their lives. Modafinil is an atypical stimulant that can improve cognition, but animal studies suggest high doses increase risk-taking. We hypothesized a dose-dependent effect of modafinil in risk-taking of healthy people such that higher doses would impair, while lower dose...
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Samantha Ayoub, William Perry, Arpi Minassian, Jared Young Source Type: research
103. Correlations Between Brain-Derived Neurotrophic Factor and Perceived Stress in Treatment-Resistant Bipolar Depression
We examined the association between BDNF serum levels including SNP rs1519480 and perceived stress in treatment-resistant bipolar depression disorder (TRBDD). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Anton Shkundin, Heather Wheeler, James Sinacore, Anna Jevtic, Angelos Halaris Source Type: research
102. Insulin Receptor Substrate 1 (IRS1) Isolated From Neuronally Derived Exosomes is Associated With Mood State in Bipolar Disorder
Insulin resistance and metabolic dysfunction have been bidirectionally linked to mood disorders. The majority of this literature has examined markers of insulin resistance in the periphery. However, insulin and glucose dynamics within the brain may be distinct from peripheral processes, and could have unique associations with psychiatric symptoms. In this pilot study we examine associations of neuronal exosome-derived total and phosphorylated insulin receptor substrate 1 (IRS1, P-IRS1) with mood symptoms, and with peripheral markers of insulin resistance in seven individuals with bipolar disorder. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Thalia Robakis, Kathleen Watson, Erez Eitan, Alison Myoraku, Fahim Abbasi, Joanna M. Biernacka, Mark A. Frye, Natalie Rasgon Source Type: research
101. Influence of Childhood Maltreatment on Morphometry and Brain Network Architecture in Bipolar Disorder
Childhood maltreatment (MAL) is common in individuals with bipolar disorder (BP) and is associated with earlier onset, more severe course, and more comorbidities. The aim of this study was to test whether BP patients with MAL represent a distinct ecophenotype with different neurobiological signatures than non-MAL patients with BP. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kyoko Ohashi, Kathryn Eve Lewandowski, Elizabeth Bolger, Ann K. Shinn, Alaptagin Khan, Martin Teicher Source Type: research
100. Prevalence of Psychopathology in Relatives of Patients With Bipolar Disorder in Mexican Population
It has been shown that bipolar disorder (BD) has a higher heritability within families that have BD present. There are a few studies that look for at the prevalence of other psychopathologies in relatives of BD patients in the Latino population. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Victor Alfonso Perez Silva, Alfonso Ontiveros, Luis Alberto De La Garza Garcia, Guillermo Sanchez Torres, Sofia Jezzini Martinez, Ricardo Ruiz Meza, Patricio Zarate Garza, Michael Escamilla Source Type: research
99. Heightened Circulating Levels of Inflammatory Cytokines in Adolescents With Familial Susceptibility to Bipolar Disorder
Individuals with Bipolar Disorder (BD) have been reported to exhibit alterations in both central and peripheral immune proteins. Notably, children with a parent affected by BD, especially those who later develop a mood disorder, show an abnormal neuroimmune state. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Francisco Eliclecio Rodrigues da Silva, Rafaela Carneiro Cordeiro, Giovana Zunta-Soares, Jair C. Soares, Joao de Quevedo, Giselli Scaini Source Type: research
98. Transcriptomic Changes Associated With Suicide Death in the Postmortem Prefrontal Cortex of Individuals With Bipolar Disorder
This study aimed at assessing transcriptomic changes associated with suicide death (SD) in the brains of individuals with a diagnosis with bipolar disorder (BD), with the ultimate goal of identifying a SD signature that can inform future treatment development (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Camila Nayane Lima, Alexandre Rubinstein, Laura Stertz, Salahudeen Mirza, Bruno Kluwe-Schiavon, Christopher Busby, Rohit Jha, Alexandra Del Favero-Campbell, Apurva Kumar, Mohammad Farhan, Esther Soyebo, Consuelo Walss-Bass, Jair C. Soares, Gabriel R. Frie Source Type: research
97. Insulin Receptor Substrate in Bipolar 1 and 2 Disorder
Despite notable clinical differences between Bipolar 1 and 2 disorders, the biological mechanisms —particularly the endocrinologic mechanisms related to the heightened risk of metabolic conditions—have not been thoroughly examined. The insulin receptor substrate in brain-enriched exosomes (L1CAM+) was recently identified as a new biomarker in individuals with major depressive disorder, yet i t has not been studied in the context of bipolar disorder. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Bora Kim, Katie Watson, Natalie Rasgon Source Type: research
495. Latent Class Analysis of Mania Symptoms: A Lifespan Perspective on Bipolar Disorder
This study investigates the structures of mania, a central component of BPD, across the lifespan. Utilizing data from the National Comorbidity Survey, we explore latent symptom classes and their association with clinical variables in both adults and adolescents. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Yunna Kwan, Lihong Cui, Andrew Leroux, Ian Hickie, Kathleen Merikangas Source Type: research
