111. Relationships Between Neural Activity and Lifetime Psychopathology Risk During an Emotional N-Back Task Are Mediated by Impulsivity and Emotional Regulation Behavioral Traits

We previously demonstrated significant relationships between working memory (WM)-related default mode network (DMN-precuneus) activity and depression-risk, and between emotional regulation (ER)-related central executive network (CEN-dorsolateral prefrontal cortex(dlPFC)) activity and depression- and mania-risk. We aimed here to determine how these relationships were mediated by behavioral traits associated with depression- and mania-risk, namely, emotional regulation and impulsivity (negative and positive urgency), in independent cohorts of young adults at risk for psychopathology.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Yvette Afriyie-Agyemang, Michele Bertocci, Satish Iyengar, Richelle Stiffler, Haris Aslam, Simona Graur, Genna Bebko, Alexander Skeba, Osasumwen Benjamin, Yiming Wang, Henry Chase, Mary Phillips Source Type: research