Fe-single-atom catalysts boosting electrochemiluminescence via bipolar electrode integrated with its peroxidase-like activity for bioanalysis
Biosens Bioelectron. 2024 Apr 30;258:116351. doi: 10.1016/j.bios.2024.116351. Online ahead of print.ABSTRACTMultifunctional single-atom catalysts (SACs) have been extensively investigated as outstanding signal amplifiers in bioanalysis field. Herein, a type of Fe single-atom catalysts with Fe-nitrogen coordination sites in nitrogen-doped carbon (Fe-N/C SACs) was synthesized and demonstrated to possess both catalase and peroxidase-like activity. Utilizing Fe-N/C SACs as dual signal amplifier, an efficient bipolar electrode (BPE)-based electrochemiluminescence (ECL) immunoassay was presented for determination of prostate-spe...
Source: Biosensors and Bioelectronics - May 5, 2024 Category: Biotechnology Authors: Xiaodong Chen Huijuan Xv Can Li Linghui Kong Chunxiang Li Feng Li Source Type: research
An algorithm for pharmacological treatment of mania during hospitalisation
Dan Med J. 2024 Apr 11;71(5):A08230525. doi: 10.61409/A08230525.ABSTRACTCurrent evidence for pharmacological treatment of mania during hospitalisation is insufficient as there are no larger well-designed randomised trials of comparative medical treatments of mania during inpatient stays. Moreover, there is considerable variation in pharmacological medication in clinical practice during hospitalisation for mania. Based on a hospital data overview, a systematic search of the literature and a three-day consensus meeting, this narrative review proposed an algorithm for optimised pharmacological treatment of mania during hospit...
Source: Danish Medical Journal - May 5, 2024 Category: General Medicine Authors: Lars Vedel Kessing Ellen Margrethe Christensen Sarah Krarup Krarup Natacha Kyster Lykke Pedersen Christian Legind Line Hansen Birgitte Vejstrup Maria Faurholt-Jepsen Lone Baandrup Ulla Knorr Source Type: research
Fe-single-atom catalysts boosting electrochemiluminescence via bipolar electrode integrated with its peroxidase-like activity for bioanalysis
Biosens Bioelectron. 2024 Apr 30;258:116351. doi: 10.1016/j.bios.2024.116351. Online ahead of print.ABSTRACTMultifunctional single-atom catalysts (SACs) have been extensively investigated as outstanding signal amplifiers in bioanalysis field. Herein, a type of Fe single-atom catalysts with Fe-nitrogen coordination sites in nitrogen-doped carbon (Fe-N/C SACs) was synthesized and demonstrated to possess both catalase and peroxidase-like activity. Utilizing Fe-N/C SACs as dual signal amplifier, an efficient bipolar electrode (BPE)-based electrochemiluminescence (ECL) immunoassay was presented for determination of prostate-spe...
Source: Biosensors and Bioelectronics - May 5, 2024 Category: Biotechnology Authors: Xiaodong Chen Huijuan Xv Can Li Linghui Kong Chunxiang Li Feng Li Source Type: research
An algorithm for pharmacological treatment of mania during hospitalisation
Dan Med J. 2024 Apr 11;71(5):A08230525. doi: 10.61409/A08230525.ABSTRACTCurrent evidence for pharmacological treatment of mania during hospitalisation is insufficient as there are no larger well-designed randomised trials of comparative medical treatments of mania during inpatient stays. Moreover, there is considerable variation in pharmacological medication in clinical practice during hospitalisation for mania. Based on a hospital data overview, a systematic search of the literature and a three-day consensus meeting, this narrative review proposed an algorithm for optimised pharmacological treatment of mania during hospit...
Source: Danish Medical Journal - May 5, 2024 Category: General Medicine Authors: Lars Vedel Kessing Ellen Margrethe Christensen Sarah Krarup Krarup Natacha Kyster Lykke Pedersen Christian Legind Line Hansen Birgitte Vejstrup Maria Faurholt-Jepsen Lone Baandrup Ulla Knorr Source Type: research
Cell-specific localization of β-synuclein in the mouse retina
Brain Struct Funct. 2024 May 4. doi: 10.1007/s00429-024-02799-z. Online ahead of print.ABSTRACTβ-synuclein, a member of the synuclein family, is frequently co-expressed with α-synuclein in the neural system, where it serves to inhibit abnormal aggregation of α-synuclein in neurodegenerative diseases. Beyond its role in pathological conditions, β-synuclein plays various functions independently of α-synuclein. In our investigation, we discovered a broader expression of β-synuclein in the mouse retina compared to α-synuclein. This widespread pattern implies its potential significance in the retina. Through detailed exa...
Source: Brain Structure and Function - May 4, 2024 Category: Neuroscience Authors: Wenhui Zhong Qingwen Yang Fenglan Wang Xin Lin Zhongqun Chen Jing Xue Wenna Zhao Xiaoqing Liu Bilin Rao Jun Zhang Source Type: research
Cell-specific localization of β-synuclein in the mouse retina
Brain Struct Funct. 2024 May 4. doi: 10.1007/s00429-024-02799-z. Online ahead of print.ABSTRACTβ-synuclein, a member of the synuclein family, is frequently co-expressed with α-synuclein in the neural system, where it serves to inhibit abnormal aggregation of α-synuclein in neurodegenerative diseases. Beyond its role in pathological conditions, β-synuclein plays various functions independently of α-synuclein. In our investigation, we discovered a broader expression of β-synuclein in the mouse retina compared to α-synuclein. This widespread pattern implies its potential significance in the retina. Through detailed exa...
Source: Brain Structure and Function - May 4, 2024 Category: Neuroscience Authors: Wenhui Zhong Qingwen Yang Fenglan Wang Xin Lin Zhongqun Chen Jing Xue Wenna Zhao Xiaoqing Liu Bilin Rao Jun Zhang Source Type: research
Medical comorbidities in bipolar disorder (BIPCOM): clinical validation of risk factors and biomarkers to improve prevention and treatment. Study protocol
BIPCOM aims to (1) identify medical comorbidities in people with bipolar disorder (BD); (2) examine risk factors and clinical profiles of Medical Comorbidities (MC) in this clinical group, with a special focus... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - May 4, 2024 Category: Psychiatry Authors: Giovanni de Girolamo, Ole A. Andreassen, Michael Bauer, Paolo Brambilla, Stefano Calza, Nicholas Citer à, Rosa Corcoy, Andrea Fagiolini, Miguel Garcia-Argibay, Ophélia Godin, Florian Klingler, Nene F. Kobayashi, Henrik Larsson, Marion Leboyer, Silke Mat Tags: Study Protocol Source Type: research
