Single-operator cholangioscopy is useful for visual assessment of bile duct pathology.
CONCLUSIONS: Considering the reasonable visual success rate, SOC seems to be a useful extension of ERCP during diagnostic work-up for detection of malignant disease in the biliary tree. However, one biopsy per patient is insufficient for histological verification of common bile duct malignancy. TRIAL REGISTRATION: The Danish Health Authority (3-3013-1299/1) and The Danish Data Protection Agency (RH-2015-229). FUNDING: none. PMID: 30059003 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - August 2, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Volar plating of distal radius fractures does not restore the anatomy.
CONCLUSIONS: Volar locking plating did not restore the anatomy after distal radius fractures. The clinical implication of these findings is unclear because the functional outcome of the patients was not available. Level of evidence, level IV. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 30059004 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - August 2, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Danish general practitioners' professional attention to children of parents with depression.
This study aimed to describe general practitioners' (GPs) professional attention to children of depressed patients. METHODS: This was a survey study. We mailed ques-tion-naires to randomly selected Danish GPs. RESULTS: Among the 1,760 GPs invited, 890 (51%) partici-pated. Female GPs accounted for 45% of the respondents and 41% of the total GP population (p = 0.02). Respondents were younger than the mean GP population. A total of 94% of the GPs reported that giving attention to children of de-pressed parents was relevant, and 65% reported addressing the children's well-being during the consultation with the parent. ...
Source: Danish Medical Journal - July 4, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

The applicability of guidelines on antimicrobials provided by the Danish Health Authority.
CONCLUSIONS: The results of the survey indicate that knowledge and use of the guidelines are sparse, and our data from the audits underline these data. FUNDING: The Fund for the Prevention of Hospital-acquired Infections, the Danish Ministry of Health (R. no. 1406148) and the Fund for Improving Skills in Infection Control, Central Denmark Region, funded the study. TRIAL REGISTRATION: not relevant. The Danish Data Protection Agency (R. no.: 1-16-02-84-15) and the Central Denmark Region approved the project. PMID: 29961444 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - July 4, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Good midterm results of hip arthroscopy for femoroacetabular impingement.
The objective of this study was to report midterm results in a consecutive cohort and to study the relation between cartilage lesions and the conversion rate to total hip arthroplasty (THA). METHODS: Eighty-four FAI patients were followed retrospectively for 6-8 years. The conversion rate to THA, the peri-operative findings and the patient-reported outcome measures were reported. RESULTS: Fifteen of 84 (18%) patients were converted to THA. The five-year hip survival rate was 83.9% (confidence interval (CI): 75.1-91.5%). The THA group was significantly older, with a mean age of 46.9 years (CI: 42.8-50.8 years) compa...
Source: Danish Medical Journal - June 13, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Motor function tests for 0-2-year-old children - a systematic review.
CONCLUSIONS: For implementation in the DPCHEP, five motor function tests were potentially adequate. However, the time consumption and extensive use of tools render three of the five tests unsuitable for implementation in the existing programme. The two remaining tests, the ASQ and the EMQ, are parent questionnaires. We suggest that these should be pilot tested with a view to their subsequent implementation in the DPCHEP. It may be considered to present the test elements in a more manageable and systematic way, possibly with illustrations. PMID: 29886879 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - June 13, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Prevalence of sarcopenia in a Danish geriatric out-patient population.
Authors: Christensen MG, Piper KS, Dreier R, Suetta C, Andersen HE Abstract INTRODUCTION: The prevalence of sarcopenia varies extensively depending on the definitions and studied populations. The aim of this study was to assess the prevalence of sarcopenia in a Danish geriatric out-patient population using criteria from the European Working Group on Sarcopenia (EWGSOP). METHODS: Patients referred to a geriatric out-patientclinic were included. Using the EWGSOP´s recommendations, appendicular skeletal muscle mass (ASM), hand-grip strength (HGS) and gait speed (ten-meter walk (GS)) were assessed. Skeletal m...
Source: Danish Medical Journal - June 13, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Limited use of surgeon's advice on exercise for knee osteoarthritis.
Authors: Ryaa S, Ingelsrud LH, Skou ST, Roos EM, Troelsen A Abstract INTRODUCTION: The Good Life with osteoArthritis in Denmark (GLA:D) programme consists of patient education and supervised exercise therapy and adheres to clinical guidelines for knee osteoarthritis (OA). The purpose of this study was to present the treatment choice and clinical results of patients who were advised to participate in GLA:D before deciding on undergoing knee replacement. METHODS: Patient records from all patients with knee OA consulting one orthopaedic surgeon in 2015 were reviewed to identify those who were advised to seek GLA:D...
Source: Danish Medical Journal - June 13, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

The use of a perioperative supra-physiological dose of glucocorticoid is not supported by evidence - a systematic review.
CONCLUSION: No evidence supports the preoperative use of SDS in patients receiving chronic glucocorticoid therapy. PMID: 29886882 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - June 13, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

A nationwide study of the quality of surgical guidelines and written patient information.
CONCLUSIONS: CPGs and PILs are highly available in Danish departments that perform cancer surgery. However, this study revealed that local CPGs lacked discharge criteria, and the majority of the PILs were considered of poor quality, suggesting that post-operative management after cancer surgery is of varying quality. FUNDING: not relevant. TRIAL REGISTRATION: not relevant. PMID: 29886883 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - June 13, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

The risk of skin tear in Dupuytren's disease when treated with collagenase.
CONCLUSIONS: There is a significantly higher relative risk of skin tear when the contracture is ≥ 60° and when the contracture is ≥ 60° and located at the PIP joint. The most important factor regarding the risk of skin tear is the degree of the contracture. FUNDING: none. TRIAL REGISTRATION: approved by the Danish Data Protection Agency. PMID: 29726315 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - May 8, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Correlation of radiological and clinical measurement of genu valgum in children.
CONCLUSIONS: We found a poor correlation between clinical examinations and HKA angles as data were corrected for leg length. More studies are needed to provide clear recommendations for following children with malalignment. FUNDING: none. TRIAL REGISTRATION: The study was registered with the Danish Data Protection Agency. PMID: 29726316 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - May 8, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Anaesthesia practice in Denmark for relocation of the dislocated hip after total hip arthroplasty.
CONCLUSIONS: Provision of anaesthesia for relocation of a dislocated THA varies across Denmark. Few anaesthesi-ologists have access to a local guideline. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29726317 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - May 8, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

The use of olfactory testing when diagnosing Parkinson's disease - a systematic review.
CONCLUSIONS: Olfactory test can be a valuable ancillary tool in the diagnostic process in PD. In a clinical setting, the identification part from Sniffin' Sticks 16 is the most usable because it may be conducted quickly and independently of disease duration and severity. Before using an olfactory test in a clinical setting, it is necessary to adjust the odours to the patient population, and to establish the optimal specificity-adjusted cut-off. PMID: 29726318 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - May 8, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Safety and feasibility of home-based chemotherapy.
CONCLUSIONS: Our study demonstrates that home-based chemotherapy is feasible and safe and that it might be a valuable alternative to treatment at an outpatient clinic. FUNDING: This study was supported by a grant from Roche. TRIAL REGISTRATION: not relevant. PMID: 29726319 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - May 8, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Preferences for prenatal testing among pregnant women, partners and health professionals.
CONCLUSIONS: As safety seems to affect the majority of pregnant couples' choice behaviour, thorough pre-test counselling by trained health professionals is of paramount importance. FUNDING: Aarhus University and The Foundation of 17-12-1981. TRIAL REGISTRATION: This study was registered with the Danish Data Protection Agency (1-16-02-586-13/ 2007-58-0010). PMID: 29726320 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - May 8, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Correction to: Quality assessment of home births in Denmark.
Authors: Jensen S, Colmorn LB, Schroll AM, Krebs L Abstract Correction per 30 April 2018. In a letter from Ole Olsen et al [1] it was disclosed, that there were mathematical errors in the incidences of complications among nulliparous women with hospital births presented in Table 2. Incidences and p-values have been recalculated, and the errors in Table 2 have been corrected. We apologise for this. The corrections did not lead to any other changes in the manuscript [1]. PMID: 29726321 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - May 8, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Clinical presentation, management and prognosis of patients with cardiac sarcoidosis.
Authors: Ghanizada M, Rossing K, Bundgaard H, Gustafsson F Abstract INTRODUCTION: The course and prognosis of cardiac sarcoidosis (CS) are sparsely described. The purpose of this study was to assess the clinical presentation, treatment response and prognosis for patients with CS. METHODS: This was a single-centre retrospective study of patients with CS from 2006 to 2016. A total of 197 patients with a sarcoidosis diagnosis were screened, and 17 patients (mean age 46.9 years, 59% men) were diagnosed with CS based on Japanese Ministry of Health and Welfare criteria; 53% were diagnosed by a positive MRI, 29% by en...
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Research integrity among PhD students within clinical research at the University of Southern Denmark.
CONCLUSIONS: Results indicate that, albeit at a low frequency, research misconduct involving PhD students is taking place. Likewise, a high fraction of respondents reported to have been under pressure regarding authorships, which points to questionable research practices in clinical research. FUNDING: not relevant. TRIAL REGISTRATION: not relevant. PMID: 29619924 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

The validity of the diagnosis of heart failure (I50.0-I50.9) in the Danish National Patient Register.
CONCLUSIONS: The HF diagnoses (I50.0-I50.9) in the DNPR should be used with caution if validation is not possible. However, restricting analyses to patients registered with a primary diagnosis of HF or patients discharged from cardiology units may be a useful alternative in population-based studies. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29619925 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Parenteral nutrition and insulin per protocol improve diabetes management after total pancreatectomy.
CONCLUSIONS: After total pancreatectomy, PN with insulin treatment per protocol improves glycaemic control compared with glucose infusion and reduces the number of non-infectious post-operative complications without increasing hypoglycaemia. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29619926 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Joinpoint regression analysis of suicides in Denmark during 1980-2015.
CONCLUSIONS: The suicide rate fell sharply between 1980 and 1999 in Denmark, but since then the decrease has been modest, especially since 2007. Further reduction in the suicide rate requires new and effective measures. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29619927 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Studies of upper limb pain in occupational medicine, in general practice, and among computer operators 
.
This study indicates the role of nerve afflictions in computer-related upper limb disorders.
The most frequent pattern in the first two studies was in accordance with brachial plexopathy. Therefore additional analyses addressed the relation of this condition to me-chanical exposures at work. Whether assessed as the extent during the workday or days per week, many exposures, in particular adverse upper limb postures, repetitive work, work pace, and the use of force, were significant risk indicators for brachial plexopathy with clear dose-response relationships.
The identification of patterns of physical findings that re...
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Depression, stroke, and dementia in patients with myocardial infarction.
In conclusion, we found that preceding depression was associated with moderately increased mortality after MI, and that 
was associated with an increased risk of stroke and vascular dementia, but not dementia from other causes. PMID: 29619929 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Neurological and psychiatric comorbidity in patients with heart failure: risk and prognosis.
In conclusion, the DNPR contains data on several cardiovascular diagnoses and cardiac interventions recorded with high PPVs. Our data also suggest that a history of depression is an adverse prognostic factor for death in patients with heart failure and low LVEF. Finally, heart failure emerged as a risk factor for all-cause dementia as well as for both ischemic and hemorrhagic stroke. PMID: 29619930 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Approaches to radiotherapy in metastatic spinal cord compression.
Authors: Suppl MH Abstract Metastatic spinal cord compression is caused by the progression of metastatic lesions within the vicinity of the spinal cord. The consequences are very severe with loss of neurological function and severe pain. The standard treatment is surgical intervention followed by radiotherapy or radiotherapy alone. However, the majority of patients are treated with radiotherapy only due to contraindications to surgery and technical inoperability. Stereotactic body radiotherapy is a technology to deliver higher radiation dose to the radiotherapy target with the use of spatial coordinates. This modal...
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Mortality and morbidity in patients with osteogenesis imperfecta in Denmark.
Conclusion: The all-cause hazard ratio for premature death in OI was 2.9 compared to the reference population. There was an increased risk of death due to respiratory diseases, gastrointestinal diseases and death following trauma. 
2) Study 2 aimed to compare the fracture rates across the lifespan of patients with OI with that of the general population. Using a nationwide, registry-based, cohort study design, we counted all fractures registered from 1995 in the National Patient Register. The study included the same population as in study 1, but patients who died before 1995 were excluded. We identified 644 patients
 ...
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Monitoring ovarian cancer patients during chemotherapy and follow-up with the serum tumor marker CA125.
Authors: Abu Hassaan SO Abstract Cancer antigen 125 (CA125) is frequently used in the routine monitoring of patients with epithelial ovarian cancer (EOC). The potential benefit is based on the assumption that changes in serial concentrations may provide early and reliable information on tumor growth expediting an early and potentially effective treatment. However, it has remained a challenge to interpret increments in concentrations that correlate with increasing tumor burden in the individual patient. It has been hypothesized that CA125 assessment criteria taking the random variation (analytical and biological) in...
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Assessing synovitis with conventional static and dynamic contrast-enhanced magnetic resonance imaging in knee osteoarthritis.
Authors: Riis RG Abstract Knee osteoarthritis (KOA) is one of the most common causes of physical disability in the elderly population. With an increasing ageing and obese population, the prevalence of KOA is expected to rise substantially. The needs for a better understanding of the disease and tools that can predict the course of the disease, for example following treatment, are therefore imperative. 

Inflammation has over the last years been recognised as an important factor for both the symptomatology and disease course in KOA. Synovitis, inflammation of the synovium, is the hallmark of intra-articular infl...
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Tourette syndrome in a longitudinal perspective. Clinical course of tics and comorbidities, coexisting psychopathologies, phenotypes and predictors.
Conclusion: The clinical course of TS during adolescence was confirmed, with solid evidence, with decline in tics, OCD and ADHD severity. We provide evidence of considerable coexisting psychopathologies requiring clinical support and partial remissions and subthreshold symptoms requiring monitoring and clinical guidance to assist the young adults in promoting a healthy transition into early adulthood. Furthermore we provide predictors for the clinical course of TS to be used in the preventive efforts, early intervention and allocation of resources improving quality of life for the children and their families. PMID: 296...
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Intravenous iron treatment in the puerperium.
In conclusion, iron isomaltoside seems to be associated with improved patient-reported outcomes compared to oral iron treatment, and in severe postpartum anaemia intravenous iron seems promising as an alternative to red blood cell transfusion. PMID: 29619936 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

The impact of surgery on quality of life, esophageal motility, and tracheal anatomy and airflow in patients with benign nodular goiter.
Authors: Sorensen JR Abstract Surgery - is it any good for goiter? In patients with goiter the benefits of thyroid surgery have previously rarely been investigated, as only few alternatives existed. However, the increasing evidence of the advantages with non-surgical substitutes with lower costs and preferable risk profiles prompted us to investi-gate the evidence base for thyroid surgery thoroughly. This thesis consists of three published studies investigating the impact of thyroidectomy on: 1) changes in disease-specific quality of life, 2) swallowing symptoms and esophageal motility, and 3) tracheal anatomy and ...
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Sunscreen use at Danish beaches and how to improve coverage.
Authors: Heerfordt IM Abstract Exposure to ultraviolet radiation (UVR) from the sun is the main risk factor for development of skin cancer. The incidence of skin cancer in Denmark and worldwide is high and increasing. The overall aim was to achieve basic knowledge about sun protection with sunscreen among beachgoers in Denmark. Other aims were to establish a method to investigate sunscreen distribution on the body and to test two approaches to optimize the used amount and body distribution of sunscreen. Furthermore, time and duration of a beach visit and use of protective clothes among beachgoers were determined to...
Source: Danish Medical Journal - April 7, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

The psychological impact of body contouring surgery.
CONCLUSIONS: The reported quality of life is of considerable importance to patients undergoing body contouring surgery after massive weight loss. Our findings may pro-vide useful information for surgeons and healthcare professionals allowing them to develop patient education programmes, reduce discrepancies in patient expectations and improve patient satisfaction. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29510802 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Preoperative inspiratory muscle training prevents pulmonary complications after cardiac surgery - a systematic review.
CONCLUSIONS: Preoperative inspiratory muscle training may reduce the risk of developing pneumonia and atelectasis. However, more trials are needed to support and strengthen the evidence found in this systematic review before routine implementation of this kind of training preoperatively. PMID: 29510803 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Validity and reliability of an ultrasound measurement of the free length of the Achilles tendon.
CONCLUSIONS: The ultrasound measurement of the free part of the Achilles tendon showed good reliability and accuracy. For comparison between groups of non-injured subjects, differences of> 5 mm can be detected. For repeated assessment of individual subject differences ≥ 13 mm can be detected. FUNDING: none. TRIAL REGISTRATION: Institutional Review Board of Zealand, Denmark, Ref. no: SJ-318. PMID: 29510804 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Thyroid fine-needle aspiration and The Bethesda Classification System.
CONCLUSIONS: The Danish "Suspicious" group contains a broad spectrum of BG with varying malignancy risk. The results indicate a need for standardisation of the Danish FNA classification. A national introduction of the TBCS might secure an international and comparable standard. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29510805 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Testicular microlithiasis in patients with testicular cancer in the United Kingdom and in Denmark.
This study's objective was to investigate TML histology prevalence in testicular cancer patients in two European populations. METHODS: We analysed archived histopathology orchiectomy specimens from 152 patients diagnosed with testicular cancer at Fredericia Hospital in Denmark from 2004 to 2014, and 106 patients diagnosed at St Thomas' Hospital in London from 2011 to 2015. RESULTS: The Danish patients' median age was 37 years (range: 16-74 years) and the English patients' 36 years (range: 18-78 years). In the Danish patients, 29 (19.1%) had TML, and in the English patients, 43 (40.6%) had TML (p
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Feasibility and safety of outpatient breast cancer surgery.
Authors: Duriaud HM, Kroman N, Kehlet H Abstract INTRODUCTION: Improvement in perioperative care programmes has facilitated post-operative recovery and use of short-term or outpatient procedures. The aim of this study was to assess the feasibility and safety of an outpatient breast cancer programme in patients referred to a large breast cancer unit. METHODS: After an introduction period involving 554 consecutive patients, all patients operated from 1 November 2015 to 30 June 2016 (a total 483 patients) were treated with multimodal oral analgesia, preoperative high-dose glucocorticoids and no routine use of drai...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

From acute to chronic postsurgical pain: the significance of the acute pain response.
Authors: Blichfeldt-Eckhardt MR Abstract The thesis comprises an overview and four papers, all published or submitted for publication in international peer-reviewed scientific journals.
 
Chronic pain after surgery is a common and debilitating complication after many types of surgery. The cause and pathology behind is still mainly uncovered, though several risk factors have been proposed. One of the strongest risk factors for persistent postsurgical pain is the intensity of the acute pain response though the mechanisms involved remain unsettled. The acute pain response consists of several different types of pai...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Aetiology and treatment of severe postpartum haemorrhage.
In conclusion, an improved diagnosis of the causes of PPH especially retained placenta, together with an early recognition and treatment of coagulopathy, seem to be important in reducing severe PPH in an aim to minimize associated maternal morbidity. PMID: 29510809 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Structural joint damage and hand bone loss in patients with rheumatoid arthritis.
Authors: Shabanzadeh DM Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by pain, swelling and progressive destruction of the joints leading to loss of function and invalidity. The bone destruction in RA is characterised by two distinct features: structural joint damage and hand bone loss, and their prevention is an important treatment goal. Inhibitors of tumour necrosis factor alpha (TNF-inhibitors) have markedly improved the treatment options in RA patients who fail treatment with conventional synthetic Disease Modifying Anti Rheumatic Drugs (sDMARDS), but their effectiveness with ...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Evaluation of new ultrasound techniques for clinical imaging in selected liver and vascular applications.
Authors: Brandt AH Abstract This PhD project is based on a longstanding collaboration between physicists and engineers from the Center of Fast Ultrasound Imaging (CFU) at the Technical University of Denmark and medical doctors from the department of Radiology at Rigshospitalet. The intent of this cooperation is to validate new ultrasonic methods for future clinical use. 
Study I compares two B-mode ultrasound methods: the new experimental technique Synthetic Aperture Sequential Beam-forming combined with Tissue Harmonic Imaging (SASB-THI), and a conventional technique combined with THI. While SASB reduces the amo...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Blowout fractures - clinic, imaging and applied anatomy of the orbit.
Authors: Felding UNA Abstract Isolated fractures of the orbital floor or medial wall are often referred to as blowout fractures (BOFs). Debilitating double vision and aesthetic deformity may affect the patients' quality of life and daily living skills, for instance, working or driving a car. The management of blowout fractures is, however, challenging, since not all fractures demand surgery. Some patients may have symptoms which subside, or may never develop symptoms. Due to a lack of evidence, there are still considerable differences in opinion on the criteria for surgery. The selection of patients for surgery is ...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Electronic monitoring in bipolar disorder.
Authors: Faurholt-Jepsen M Abstract Major reasons for the insufficient effects of current treatment options in bipolar disorder include delayed intervention for prodromal depressive and manic symptoms and decreased adherence to psychopharmacological treatment. The reliance on subjective information and clinical evaluations when diagnosing and assessing the severity of depressive and manic symptoms calls for less biased and more objective markers. By using electronic devices, fine-grained data on complex psychopathological aspects of bipolar disorder can be evaluated unobtrusively over the long term. Moreover, elect...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

von Hippel-Lindau disease: Diagnosis and factors influencing disease outcome.
Authors: Binderup MLM Abstract von Hippel-Lindau disease (vHL) is a hereditary tumor predisposition caused by mutations in the VHL tumor suppressor gene. VHL mutation-carriers are at life-long risk of multi-organ tumor development. The mainstay of vHL management is close surveillance and surgical tumor removal. The disease has been reported to be fully penetrant at 60 years of age, and has a highly variable phenotype, which complicates vHL management and causes distress and uncertainty for affected families. vHL survival has historically been poorer than the survival of the general population, with a median life ex...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Onstep repair of inguinal hernias.
Authors: Andresen K Abstract Inguinal hernias are a protrusion of the peritoneum through a weakening in the groin in which abdominal content (intestines or fat) can herniate and cause a bulge. Inguinal hernias can be painful and require surgery. Worldwide, approximately 20 million patients are operated each year, with 10,000 in Denmark. The repair of inguinal hernias causes pain and 16% of patients experience chronic pain six months after the standard, open, mesh-based Lichtenstein technique. Therefore, surgeons are trying to improve the techniques by finding new ways of operating. The Onstep method was a new metho...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Adjuvant analgesics for spine surgery.
In conclusion, dexamethasone and ketamine are potential adjuvant analgesics for postoperative pain. Possibly ketamine also inhibits the development of persistent pain. Chlorzoxazone has no immediate effect as an adjuvant in acute pain management. PMID: 29510816 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Pulmonary artery perfusion versus no pulmonary per-fusion during cardiopulmonary bypass.
Authors: Buggeskov KB Abstract 
During conventional cardiopulmonary bypass (CPB) there is no active perfusion of the pulmonary circulation and the mechanical ventilation is ceased leaving the lungs exposed to warm ischemia.
 
Pulmonary dysfunction is seen in varying degrees after major surgery, but more severe in cardiac surgery patients probably due to the effects of CPB. The evidence for effect and safety are limited, but active pulmonary artery perfusion during CPB could be beneficial for the patients' postoperative oxygenation.
Our aim was in a randomised clinical trial to assess primarily the effect of...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Ultrasonography for diagnosis, monitoring and treatment of tenosynovitis in patients with rheumatoid arthritis.
Authors: Danielsen MA Abstract Rheumatod arthritis is a chronic systemic autoimmune disease, characterized by inflammation in joints and tendon sheaths, which frequently leads to permanent and serious disability due to joint destruction, but also tendon and ligament ruptures. Clinical management of rheumatoid arthritis has traditionally been supported by biochemical and radiographic findings. However, imaging modalities like ultrasound and magnetic resonance imaging (MRI) have improved the possibility for better management of rheumatoid arthritis patients, due to higher sensitivity and specificity for detecting ong...
Source: Danish Medical Journal - March 9, 2018 Category: General Medicine Tags: Dan Med J Source Type: research