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Long-term follow-up and outcome in patients with recurrent respiratory laryngeal papillomatosis.
CONCLUSIONS: More males than females suffer from respiratory papillomatosis; age of onset was either in childhood or in mid-life. Use of CO2-laser or microdebrider was the preferred surgical approach in this cohort. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29206094 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - December 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Indications and complications in relation to removal of clavicle implants.
CONCLUSIONS: The indications for clavicle plate removal are many and mainly subjective. Implant removal in patients following surgically treated clavicle fractures generally causes very few complications, and most patients seem to experience a positive effect. However, it is important to inform the patient of the risk of no remission or even a worsening, which is not an uncommon occurrence. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29206095 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - December 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Danish translation of the Foot and Ankle Outcome Score.
CONCLUSIONS: The translation of the FAOS questionnaire into Danish was done in accordance with best practice and has excellent repeatability in patients treated for ankle fractures. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29206096 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - December 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

A closed-claim analysis of complaints after paediatric antebrachial fractures.
CONCLUSIONS: Two thirds of all complaints were due to normal fracture sequelae; thus, patient anticipation should be accommodated by thorough patient information. Mid-diaphyseal fractures of the forearm are overrepresented among the acknowledged complaints. Casting seems to be preferred to splinting. However, more awareness of these fractures using routinely performed radiographs at the first visit to the emergency room and at follow-up could avoid complaints as well as doctor's delay. FUNDING: none. 
TRIAL REGISTRATION: not relevant. PMID: 29206097 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - December 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Monoclonal B-cell lymphocytosis; not the same as B-cell chronic lymphocytic leukaemia.
CONCLUSIONS: The findings of this study indicate that a sizeable fraction of MBL patients are diagnosed inaccurately with CLL, even after the introduction of the MBL diagnosis. FUNDING: The Danish Cancer Society. TRIAL REGISTRATION: not relevant. PMID: 29206098 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - December 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Implementation of evidence-based knowledge in  general practice.
Implementation of evidence-based knowledge in general practice. Dan Med J. 2017 Dec;64(12): Authors: Le JV Abstract Keeping up with the evidence and implementing it into the daily care for patients are fundamental prerequisites for delivering a high quality of care in general practice. However, despite many years of research into dissemination and implementation of evidence-based recommendations, significant challenges remain. In recent years, organisational factors have become widely acknowledged as vitally important for ensuring successful implementation. Further knowledge is needed to understan...
Source: Danish Medical Journal - December 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Exploring the Use of Ingenol Mebutate to Prevent Non-Melanoma Skin Cancer.
Authors: Ali Z Abstract Asthma is a serious global health issue and the most prevalent chronic disorder among Danish pregnant women. Exacerbations of asthma during pregnancy have been associated with increased risk of adverse pregnancy and perinatal outcomes, and by that making asthma a potential serious medical condition during pregnancy. Monitoring of asthma every four to six weeks is recommended during pregnancy, although evidence is lacking that following this recommendation will improve pregnancy outcome and, not least, be beneficial for all pregnant women with asthma. PMID: 29206100 [PubMed - in process] ...
Source: Danish Medical Journal - December 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Cholecystectomy for uncomplicated gallbladder stones does not follow evidence-based recommendations.
CONCLUSIONS: Our results may represent overtreatment and/or incorrect selection of patients suitable for surgery. More and larger prospective cohort studies are warranted to elucidate the indications for cholecystectomy in uncomplicated gallbladder stones. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29115203 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - November 9, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Use of the smartphone application "Pregnant with Diabetes".
CONCLUSIONS: Easily accessible patient information made available via app technology reaches the patients and may contribute to improved pregnancy planning and outcome in women with pre-existing diabetes - locally, nationally and internationally. FUNDING: The app was sponsored by Novo Nordisk, Bayer A/S, Diabetes Care, Abbott, MSD Denmark, A.D.I.P.S and Rigshospitalet. TRIAL REGISTRATION: not relevant. PMID: 29115204 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - November 9, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Falls in elderly patients are not treated according to national recommendations.
CONCLUSIONS: Only few fall patients were screened according to DHA recommendations. ED staff´s adherence to guidelines concerning fall risk assessment is poor. Fall patients in a socioeconomically deprived area were younger and had higher fracture and heart failure incidences. FUNDING: This study received funding from the public Regional Research Foundation, Region Zealand, Denmark. TRIAL REGISTRATION: not relevant. PMID: 29115205 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - November 9, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Bronchoscopy in children suspected of lower airway aspiration.
CONCLUSIONS: The majority of the children in our study were in the 0-3-year age group. A raised suspicion of a foreign body in the lower airways should always trigger bronchoscopy. At admittance, not all patients present with respiratory symptoms. Although no deaths were observed, lower airway foreign body in small children remain a potentially life-threatening condition. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29115206 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - November 9, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Self-evaluated competence in trauma reception.
CONCLUSIONS: The results indicate that, at the point of sampling, trauma reception in Denmark was handled by AN specialists in the majority of cases, but by surgical trainees. Self-perceived competencies evaluation revealed preparedness to perform damage control resuscitation, but discrepancies in the ability to perform surgical damage control procedures. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29115207 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - November 9, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Prevalence of neovascular age-related macular degeneration and geographic atrophy in Denmark.
CONCLUSIONS: We expect a steady growth in the prevalence of neovascular AMD and geographic atrophy in Denmark due to an ageing population. These numbers emphasise the importance of disease prevention, careful planning of health service activities and continuing research. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 29115208 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - November 9, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Exploring the use of ingenol mebutate to prevent non-melanoma skin cancer.
In conclusion, the thesis highlights ingenol mebutate's potential as a prophylactic remedy for non-melanoma skin cancer with promise to support primary preventative efforts in reducing non-melanoma skin cancer incidence. PMID: 29115209 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - November 9, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Surgeon-performed ultrasonography.
Authors: Todsen T Abstract Surgeons are increasingly using ultrasonography (US) in their clinical management of patients. However, US is a very user-dependent imaging modality and proper skills of the US operator are needed to ensure quality in patient care. This thesis explores the validity evidence for assessment of competence in abdominal and head & neck ultrasonography using the Objective Structured Assessment of Ultrasound Skills (OSAUS) scale. With the use of Messick's unitary framework of validity, five sources of validity evidence were explored: test content, response processes, inter-nal structure, rel...
Source: Danish Medical Journal - November 9, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Measurement of Gastrointestinal Hormones.
Authors: Albrechtsen NJW Abstract Towards the end of the 20th century, the number of subjects with diabetes and obesity rose exponentially. The discoveries of insulin- and appetite-modulating chemical signals, including glucagon-like peptide-1 (GLP-1), secreted from the gastrointestinal system, led to development of a new group of drugs which now are being used for glucose-lowering therapy and weight loss. Understanding of the physiology of gut derived signals and their pathophysiologi-cal importance requires accurate measurements of their circulat-ing levels. However, the assessment of these gut-derived hor-mones ...
Source: Danish Medical Journal - November 9, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Prehospital interventions before and after implementation of a physician-staffed helicopter.
This study aimed to assess the potential impact of advanced prehospital interventions by comparing the proportion of patients who received those interventions before and after the HEMS implementation. METHODS: A post-hoc analysis of a prospective before-after study. We included trauma patients with Injury Severity Scores above three who had been admitted to seven emergency departments or one level 1 trauma centre in the course of a five-month period before and a 12-month period after the HEMS implementation. We compared the proportion of patients receiving at least one of 14 predefined advanced interventions between th...
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Anaesthesia in patients undergoing esophago-gastro-duodenoscopy for suspected bleeding.
CONCLUSIONS: We found considerable variation in daily clinical practice of anaesthesia for patients undergoing EGD for suspected UGIB. The fact that anaesthesia for UGIB is a complex emergency procedure may underline the need for development of an international or at least a national guideline. FUNDING: The study received financial support from Karner's Foundation, Denmark. TRIAL REGISTRATION: not relevant. PMID: 28975884 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

PET-CT findings in patients with polymyalgia rheumatica without symptoms of cranial ischaemia.
CONCLUSIONS: PET-CT is a sensitive imaging technique in PMR patients. Symptoms and PET-CT findings do not correlate in PMR. Steroid treatment prior to PET-CT reduces the scan's ability to demonstrate inflammation in PMR patients. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 28975885 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Intra-corporeal anastomosis in laparoscopic surgery for benign colorectal disease.
CONCLUSION: A total laparoscopic approach to benign lower gastrointestinal diseases with intra-corporeal ana-stomosis was feasible. FUNDING: none. TRIAL REGISTRATION: The trial is registered with the Danish Data Protection Agency. PMID: 28975886 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Quality assurance of the Western Denmark Heart Registry, a population-based healthcare register.
CONCLUSIONS: The quality control of the WDHR revealed that overall data errors were lower than 3% and for procedure-specific registrations including indications and complications, the error rate was below 1.5%. The WDHR is valid and may be used in contemporary epidemiological studies. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 28975887 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Self-perceived readiness to perform at the attending level following surgical specialist training in Denmark.
CONCLUSIONS: A worryingly high number of graduates did not feel ready to undertake their role as a gastrointestinal surgical specialist. Adequate supervision seems to play a crucial role in education. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 28975888 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

The evolution of the sentinel node procedure in the treatment of breast cancer.
Authors: Tvedskov TF Abstract This thesis is based on 10 original articles, of which 3 were previously included in the PhD thesis "Staging of women with breast cancer after introduction of sentinel node guided axillary dissection". In the PhD thesis is was shown that the introduction of sentinel lymph node dissection (SLND) in the treatment of breast cancer in Denmark has resulted in an increased identification of patients with micrometastases or isolated tumor cells (ITC) in the lymph nodes. Not all these small metastases are likely to disseminate to non-sentinel nodes. This thesis provides evidence that...
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Identification and validation of novel prognostic markers in Renal Cell Carcinoma.
Authors: Rabjerg M Abstract Kidney cancer (Renal Cell Carcinoma (RCC)) is one of the most deadly malignancies due to frequent late diagnosis and poor treatment options. Histologically, RCC embraces a wide variety of different subtypes with the clear cell variant (ccRCC) being the most common, accounting for 75-90% of all RCCs. At present, the surveillance protocols for follow-up of RCC patients after radical nephrectomy are based on the American Joint Committee on Cancers (AJCC) pathological tumor-node-metastasis (TNM) classification system. Other comprehensive staging modalities have emerged and have been implemen...
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Local immune response in cutaneous basal cell carcinoma.
CONCLUSION: To summarize it has been shown, with these studies on the local immune response upon BCC development, that an immunologic response is generated in line with BCC being an immunogenic tumor. This response is not specific, though. Additionally, BCC is capable of generating a protective niche in the microenvironment composed of both T-regs and CAFs breeding local immunosuppression and hindering of adequate anti-tumor response. In a clinical perspective, further research in improving immunotherapy for BCC is promising since an immunological response is present but needs to be reactivated. PMID: 28975891 [PubMed ...
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Introducing Standing Weight-bearing MRI in the Di-agnostics of Low Back Pain and Degenerative Spinal Disorders.
Authors: Hansen BB Abstract This PhD thesis is based on three scientific papers. In 2011 the Parker Institute the department of rheumatology introduced standing weight-bearing MRI (G-Scan, ESAOTE, Genova, Italy) in the diagnostic of low back pain patients. Unfortunately, we experienced a substantial risk of fainting (orthostatic syncope) during standing pMRI. In paper 1 we present in an observational study that the risk of fainting (19%) during standing pMRI could almost be eliminated by the use of an external pneumatic compression device (2%). The lumbar lordosis in the standing position is a significant contribut...
Source: Danish Medical Journal - October 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Infant botulism in Denmark from 1995 to 2015.
CONCLUSIONS: Infant botulism is probably underdiagnosed. Increased awareness is crucial to be able to recognise the condition. The time delay from hospital admission to administration of BIG-IV is challenging. Studies have shown that BIG-IV reduces both mean duration of intensive care and mean length of hospital stay; however, this was not confirmed in our work due to the limited number of patients. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 28874241 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - September 8, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Effects of low-dose recombinant human erythropoietin treatment on cognitive performance.
CONCLUSIONS: In this small study, we found no significant effect of low-dose or micro-dose rhEpo on visual attention, cognitive performance in complex cognitive tasks or self-experienced cognitive performance compared with placebo. FUNDING: The Aase and Ejnar Danielsen's Foundation. Danish Ministry of Science, Innovation and Higher Education. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03093506. PMID: 28874242 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - September 8, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Central regional anaesthesia in patients with aortic stenosis - a systematic review.
CONCLUSIONS: To the best of our knowledge, there is no clinical evidence supporting the notion that central regional anaesthesia has any adverse effects on patients with aortic stenosis. Carefully managed neuroaxial blockade could become a useful alternative to general anaesthesia in this patient group. However, evidence is sparse and of questionable quality. Large prospective randomised clinical trials are required to establish best practise. PMID: 28874243 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - September 8, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

The Interplay between Fasting Glucose, Echocardiography, and Biomarkers: Pathophysiological Considerations and Prognostic Implications.
CONCLUSIONS: FPG influenced the interplay between subclinical echocardiographic abnormalities, circulating biomarkers, and cardiovascular outcomes at multiple stages, in this cohort of apparently healthy, elderly subjects. Newly diagnosed diabetes, but not impaired fasting glucose, was associated with adverse subclinical changes. The associations between structural echocardiographic abnormalities and biomarker concentrations were stronger in subjects with hyperglycemia. NT-proBNP, but not echocardiographic measures or hs-TnT, provided discriminative improvement on top of traditional cardiovascular risk factors. FPG further...
Source: Danish Medical Journal - September 8, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Prosthetic Joint Infection following Total Hip Arthroplasty - Incidence, Mortality and Validation of the Diagnosis in the Danish Hip Arthroplasty Register.
In conclusion, the incidence of PJI is approximately 40% higher than that reported by the NRP and the DHR. By linkage of the DHR and the microbiology databases, the validity of the PJI diagnosis can be improved notably. By such a combination of data from the DHR and the microbiology databases, we show that the incidence of PJI does not seem to be increasing and that revision for PJI is associated with a high mortality. PMID: 28874245 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - September 8, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Early-onset Coronary Artery Disease Clinical and Hereditary Aspects.
Authors: Christiansen MK Abstract A family history of coronary artery disease (CAD) is an important risk factor for adverse coronary events, in particular if the disease has an early onset. The risk of CAD is influenced by genetic and environmental factors with a greater genetic contribution earlier in life. Through recent years the advances in genetic techniques has led to an increased understanding of the genetic background of CAD, which may potentially be translated into clinical use. The studies of this thesis aimed to investigate the burden of conventional risk factors and control in early-onset CAD (i.e. 55/6...
Source: Danish Medical Journal - September 8, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Validation of the Danish version of Inflammatory Bowel Disease Self-assessment Scale.
CONCLUSION: The Danish version of the IBD-F is a valid tool for use in Danish patients with IBD. FUNDING: This study was funded in part by an unrestricted grant from Takeda, Denmark. TRIAL REGISTRATION: not relevant. PMID: 28869029 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - September 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Use of coercion at Danish psychiatric wards by day of week and time of day.
CONCLUSIONS: The initiation of coercion was lower during evenings, nights and weekends, but different coercive types and hospitals followed different diurnal patterns, which indicates unexplained variations. FUNDING: The establishment of the data set was funded by the Public Health Officers North. TRIAL REGISTRATION: not relevant. PMID: 28869030 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - September 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Cost analysis of bariatric surgery in Denmark made with a decision-analytic model.
CONCLUSIONS: In Denmark, bariatric surgery is cost-effective at ten years and may produce a significant reduction in healthcare costs over the course of a lifetime in persons with severe obesity. FUNDING: Synergus AB received support for economic model development from Covidien AG (now part of Medtronic). TRIAL REGISTRATION: not relevant. PMID: 28869031 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - September 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Tissue - engineering as an adjunct to pelvic reconstructive surgery.
CONCLUSION: In two rat abdominal wall models, cells from autologous MFFs, seeded on the quickly degradable MPEG-PLGA scaf-fold, survived implantation and contributed to the regenerative process by forming extra striated muscle fibers and influencing the biomechanical properties of the regenerated tissue. Consequently, MFFs seeded on an MPEG-PLGA scaffold is a potentially advantageous cell-delivering strategy to regenerate tissue at pelvic reconstructive surgery. In three rat abdominal wall models, a long-term degradable PCL scaffold caused a marked foreign-body response and formed a neo-tissue PCL construct that provided b...
Source: Danish Medical Journal - September 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Life course of children with parental multiple sclerosis.
CONCLUSION: Growing up with a parent with MS can have both beneficial and adverse influences on children late into adulthood. On the one hand, the educational achievements of MS offspring are either better or similar to those of reference children because they attained better grades and similar educational levels. Also, some of the young adults interviewed found advantages to having learned to be responsible. On the other hand, we found an ad-verse association regarding employment, disability pension, and income. Also, the young adults interviewed had experiences of caring for and of practicing restraint toward the parent ...
Source: Danish Medical Journal - September 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Plasticity and function of human skeletal muscle in relation to disuse and rehabilitation: Influence of ageing and surgery.
Authors: Suetta C Abstract In order to study the influence of disuse and aging on skeletal muscle homeostasis, different human models were employed. Effects of chronic disuse were investigated in elderly patients suffering from uni-lateral hip-osteoarthritis, whereas the effect of short-term disuse (4 and 14 days of unilateral lower limb immobilisation) was assessed in healthy young and old individuals. In summary, chronic muscle disuse in the elderly was associated with marked quantitative as well as qualitative neuromuscular impairments. More specifically, decreases were observed in muscle strength, quadriceps mu...
Source: Danish Medical Journal - September 6, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Adaptive process triage system cannot identify patients with gastrointestinal perforation.
CONCLUSION: ADAPT is incapable of identifying one of the most critically ill patient groups in need of emergency abdominal surgery. FUNDING: none. TRIAL REGISTRATION: HEH-2013-034 I-Suite: 02336. PMID: 28673376 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - July 5, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Low incidence of perineal hernia repair after abdominoperineal resection for rectal cancer.
CONCLUSIONS: The incidence of perineal hernia repair was below 1% after conventional abdominoperineal resection and proctocolectomy. PROMS and risk of recurrence may benefit from centralising perineal hernia repair. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 28673377 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - July 5, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Newly diagnosed obstructive sleep apnoea and type 2 diabetes mellitus.
CONCLUSIONS: AHI, ESS and ODI were similar in type 2 DM and the non-diabetic group. The prevalence of type 2 DM was lower than expected. Attention of healthcare providers to the association between type 2 DM and OSA is needed. FUNDING: The study was funded by the Central Region Denmark Region Research Fund. TRIAL REGISTRATION: not relevant. PMID: 28673378 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - July 5, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Return to work after lumbar disc surgery is related to the length of preoperative sick leave.
CONCLUSION: The present analysis suggests that the return-to-work rate after lumbar disc herniation surgery is affected by the length of sick leave. FUNDING: none. TRIAL REGISTRATION: This study was registered with the Danish Data Protection Agency. PMID: 28673379 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - July 5, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Possible adverse effects of the quadrivalent human papillomavirus vaccine in the Region of Southern Denmark: a retrospective, descriptive cohort study.
CONCLUSIONS: The patients reported a wide range of symptoms. We found an overall low prevalence of POTS. It should be further investigated whether these patients might suffer from a functional disorder rather than from adverse effects associated with the vaccine. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 28673380 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - July 5, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Biomarkers of Necrotising Soft Tissue Infections Aspects of the Innate Immune Response.
The objective was to investigate aspects of the innate immune response in patients with NSTI, focusing on biomarkers as prognostic markers of disease severity and mortality. The overall hypothesis was that plasma biomarkers, representing the early innate immune response, can be used as prognostic markers of disease severity and mortality assessed by ICU scoring systems (SAPS II and SOFA score), the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score, presence of septic shock, microbial aetiology, renal replacement therapy, and amputation.   In Study 1, we assessed the following acute-phase proteins in 1...
Source: Danish Medical Journal - July 5, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Rational use of dopamine in hypotensive newborns: Improving our understanding of the effect on cerebral autoregulation.
This study found an association between dopamine therapy and impaired cerebral autoregulation. (III) An experimental animal study examining whether dopamine affected cerebral autoregulation in newborn piglets with low blood pressure. We found that dopamine did not negatively affect cerebral venous saturation, cerebral blood flow, or cerebral autoregulation capacity in hypotensive newborn piglets. (IV) An in vitro experiment where middle cerebral arteries from newborn piglets were examined by wire myography and pressure myography. In the wire myograph, increasing concentrations of dopamine caused a biphasic response: starti...
Source: Danish Medical Journal - July 5, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Preoperative embolization in surgical treatment of metastatic spinal cord compression.
In conclusion the findings of this thesis demonstrate that preoperative embolization in patients with symptomatic spinal metastasis independent of primary tumor diagnosis does not reduce intraoperative blood loss and the need for allogenic RBC transfusion significantly, but does reduce the surgery time. However, a small reduction of intraoperative blood loss was observed in the hypervascular metastases. This tendency could be underestimated because of the study design and furthermore the tendency may be enhanced in metastases of only the most pronounced hypervascularity. The findings furthermore support that perioperative ...
Source: Danish Medical Journal - July 5, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Testosterone therapy of men with type 2 diabetes mellitus - a randomized, double-blinded, placebo-controlled study.
In conclusion, testosterone replacement therapy is indicated in men with clinically symptomatic hypogonadism regardless of status for T2D. PMID: 28673384 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - July 5, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Development and evaluation of an endoscopic surgery course for medical students.
The objective of this study was to develop and evaluate a course in endoscopic surgery for medical students. METHODS: Kern's six-step approach in curriculum development was used. A course including interactive, faculty-led didactic sessions (14 hours, distributed over three days) and simulation-based basic skills training in endoscopic surgery (nine hours, distributed over four sessions) was developed. Knowledge was tested using a 35-item test before and after the course, and finally the course was evaluated electronically. The project group in cooperation with the faculty -developed the goals and objectives, the test ...
Source: Danish Medical Journal - June 2, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

Adherence to local antimicrobial guidelines for initial treatment of community-acquired infections.
Authors: Hagen TL, Hertz MA, Uhrin GB, Dalager-Pedersen M, Schønheyder HC, Nielsen H Abstract INTRODUCTION: Adherence to antimicrobial guidelines is key to ensuring a correct treatment of severe infections and to lessening misuse of broad-spectrum antimicrobials. We conducted a retrospective cross-sectional study at the Emergency Department of Aalborg University Hospital, North Denmark Region. Our aim was to examine adherence to local antimicrobial guidelines in the empirical treatment of community-acquired infections and to identity any predictors of guideline non-adherence. METHODS: We identified 1,555...
Source: Danish Medical Journal - June 2, 2017 Category: General Medicine Tags: Dan Med J Source Type: research

The impact of acute high-risk abdominal surgery on quality of life in elderly patients.
CONCLUSIONS: The self-reported quality of life in elderly survivors six months after AHA surgery was surprisingly good in a small study where all findings should be interpreted with precaution. The majority had no change in residential status. Our study may provide useful information for surgeons advising elderly patients and their families about realistic outcomes following AHA surgery. FUNDING: none. TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency and registered with clinicaltrials.gov. PMID: 28566117 [PubMed - in process] (Source: Danish Medical Journal)
Source: Danish Medical Journal - June 2, 2017 Category: General Medicine Tags: Dan Med J Source Type: research