Uncovering novel drug targets for bipolar disorder: a Mendelian randomization analysis of brain, cerebrospinal fluid, and plasma proteomes
CONCLUSIONS: Our study identified druggable proteins for BD, including MCTP1, DNM3, and PDF in the brain; CTSF, AGRP, and FRZB in cerebrospinal fluid; and LMAN2L, NCAM1, and TIMP4 in plasma, delineating promising avenues to development of novel therapies.PMID:38720515 | DOI:10.1017/S0033291724001077 (Source: Psychological Medicine)
Source: Psychological Medicine - May 9, 2024 Category: Psychiatry Authors: Tingting Jia Tiancheng Liu Shiyi Hu Yongjun Li Peixi Chen Fengqin Qin Yongji He Feng Han Chengcheng Zhang Source Type: research
Functional connectivity of the amygdala subnuclei in various mood states of bipolar disorder
Molecular Psychiatry, Published online: 09 May 2024; doi:10.1038/s41380-024-02580-yFunctional connectivity of the amygdala subnuclei in various mood states of bipolar disorder (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - May 9, 2024 Category: Psychiatry Authors: Sidney Krystal Laure Gracia Camille Piguet Chantal Henry Mariana Alonso Mircea Polosan Julien Savatovsky Josselin Houenou Pauline Favre Source Type: research
Towards a natural treatment for mania: red onion husk extract modulates neuronal resilience, redox signalling, and glial activation
This study aimed to assess the safety and therapeutic potential of red onio... (Source: International Journal of Bipolar Disorders)
Source: International Journal of Bipolar Disorders - May 9, 2024 Category: Psychiatry Authors: Chukwuma Raphael Ekeanyanwu, Chidinma Lynda Ekeanyanwu and Kingsley Nnaemeka Ugochukwu Tags: Research Source Type: research
Paper-in-Tip Bipolar Electrospray Mass Spectrometry for Real-Time Chemical Reaction Monitoring
Angew Chem Int Ed Engl. 2024 May 8:e202318169. doi: 10.1002/anie.202318169. Online ahead of print.ABSTRACTCapturing short-lived intermediates at the molecular level is key to understanding the mechanism and dynamics of chemical reactions. Here, we have developed a paper-in-tip bipolar electrolytic electrospray mass spectrometry platform, in which a piece of triangular conductive paper incorporated into a plastic pipette tip serves not only as an electrospray emitter but also as a bipolar electrode (BPE), thus triggering both electrospray and electrolysis simultaneously upon application of a high voltage. The bipolar electr...
Source: Angewandte Chemie - May 8, 2024 Category: Chemistry Authors: Yun Li Lixuan Zhu Xiaomeng Wu Zhiming Zhang Ruijin Pu Yajun Zheng Zhiping Zhang Source Type: research
Paper-in-Tip Bipolar Electrospray Mass Spectrometry for Real-Time Chemical Reaction Monitoring
Angew Chem Int Ed Engl. 2024 May 8:e202318169. doi: 10.1002/anie.202318169. Online ahead of print.ABSTRACTCapturing short-lived intermediates at the molecular level is key to understanding the mechanism and dynamics of chemical reactions. Here, we have developed a paper-in-tip bipolar electrolytic electrospray mass spectrometry platform, in which a piece of triangular conductive paper incorporated into a plastic pipette tip serves not only as an electrospray emitter but also as a bipolar electrode (BPE), thus triggering both electrospray and electrolysis simultaneously upon application of a high voltage. The bipolar electr...
Source: Angewandte Chemie - May 8, 2024 Category: Chemistry Authors: Yun Li Lixuan Zhu Xiaomeng Wu Zhiming Zhang Ruijin Pu Yajun Zheng Zhiping Zhang Source Type: research
Bipolar conjugated microporous polymer anchoring graphene hybrids for high-performance zinc –organic batteries
J. Mater. Chem. A, 2024, Advance Article DOI: 10.1039/D4TA01952K, PaperChengmin Hu, Yumin Chen, Ziyang Song, Ling Miao, Hui Duan, Yaokang Lv, Li Xie, Mingxian Liu, Lihua Gan A superior molecular design allows a bipolar conjugated microporous polymer to be firmly anchored on the rGO surface. The unique anchoring structure realizes alternate Zn2+/CF3SO3− ion storage while providing high capacity and an ultra-long lifespan for zinc –organic batteries. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - J. ...
Source: RSC - J. Mater. Chem. latest articles - May 8, 2024 Category: Chemistry Authors: Chengmin Hu Source Type: research
The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review
CONCLUSION: This systematic review revealed that blood-based biomarkers are associated with markers of WM deficits observed in BD. Longitudinal studies investigating the potential clinical utility of these specific biomarkers are encouraged.PMID:38712923 | DOI:10.47626/1516-4446-2023-3267 (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 7, 2024 Category: Psychiatry Authors: Mohammad Ali Renata Husnudinov Bianca Wollenhaupt-Aguiar Benicio N Frey Source Type: research
Collaborative care approaches for people with severe mental illness
CONCLUSIONS: This review does not provide evidence to indicate that collaborative care is more effective than standard care in the medium term (at 12 months) in relation to our primary outcomes (quality of life, mental state and psychiatric admissions). The evidence would be improved by better reporting, higher-quality RCTs and the assessment of underlying mechanisms of collaborative care. We advise caution in utilising the information in this review to assess the effectiveness of collaborative care.PMID:38712709 | DOI:10.1002/14651858.CD009531.pub3 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 7, 2024 Category: General Medicine Authors: Siobhan Reilly Charley Hobson-Merrett Bliss Gibbons Ben Jones Debra Richards Humera Plappert John Gibson Maria Green Linda Gask Peter J Huxley Benjamin G Druss Claire L Planner Source Type: research
Homocysteine, hopelessness, rumination, affective temperaments, and clinical course in patients with bipolar disorder-1
CONCLUSIONS: The findings may lead clinical efforts and future clinical trials to explore and intervene in related sources and presentations of BD-1's adverse consequences.PMID:38713772 | DOI:10.1080/08039488.2024.2347633 (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - May 7, 2024 Category: Psychiatry Authors: Esat Fahri Ayd ın Halil Özcan Sinan Y ılmaz Seda A şkın Tu ğba Koca Laçin Elif Nur Topu Source Type: research
The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review
CONCLUSION: This systematic review revealed that blood-based biomarkers are associated with markers of WM deficits observed in BD. Longitudinal studies investigating the potential clinical utility of these specific biomarkers are encouraged.PMID:38712923 | DOI:10.47626/1516-4446-2023-3267 (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 7, 2024 Category: Psychiatry Authors: Mohammad Ali Renata Husnudinov Bianca Wollenhaupt-Aguiar Benicio N Frey Source Type: research
Collaborative care approaches for people with severe mental illness
CONCLUSIONS: This review does not provide evidence to indicate that collaborative care is more effective than standard care in the medium term (at 12 months) in relation to our primary outcomes (quality of life, mental state and psychiatric admissions). The evidence would be improved by better reporting, higher-quality RCTs and the assessment of underlying mechanisms of collaborative care. We advise caution in utilising the information in this review to assess the effectiveness of collaborative care.PMID:38712709 | PMC:PMC11075124 | DOI:10.1002/14651858.CD009531.pub3 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 7, 2024 Category: General Medicine Authors: Siobhan Reilly Charley Hobson-Merrett Bliss Gibbons Ben Jones Debra Richards Humera Plappert John Gibson Maria Green Linda Gask Peter J Huxley Benjamin G Druss Claire L Planner Source Type: research
Homocysteine, hopelessness, rumination, affective temperaments, and clinical course in patients with bipolar disorder-1
CONCLUSIONS: The findings may lead clinical efforts and future clinical trials to explore and intervene in related sources and presentations of BD-1's adverse consequences.PMID:38713772 | DOI:10.1080/08039488.2024.2347633 (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - May 7, 2024 Category: Psychiatry Authors: Esat Fahri Ayd ın Halil Özcan Sinan Y ılmaz Seda A şkın Tu ğba Koca Laçin Elif Nur Topu Source Type: research
The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review
CONCLUSION: This systematic review revealed that blood-based biomarkers are associated with markers of WM deficits observed in BD. Longitudinal studies investigating the potential clinical utility of these specific biomarkers are encouraged.PMID:38712923 | DOI:10.47626/1516-4446-2023-3267 (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 7, 2024 Category: Psychiatry Authors: Mohammad Ali Renata Husnudinov Bianca Wollenhaupt-Aguiar Benicio N Frey Source Type: research
Homocysteine, hopelessness, rumination, affective temperaments, and clinical course in patients with bipolar disorder-1
CONCLUSIONS: The findings may lead clinical efforts and future clinical trials to explore and intervene in related sources and presentations of BD-1's adverse consequences.PMID:38713772 | DOI:10.1080/08039488.2024.2347633 (Source: Nordic Journal of Psychiatry)
Source: Nordic Journal of Psychiatry - May 7, 2024 Category: Psychiatry Authors: Esat Fahri Ayd ın Halil Özcan Sinan Y ılmaz Seda A şkın Tu ğba Koca Laçin Elif Nur Topu Source Type: research
The association of blood biomarkers with cerebral white matter and myelin content in bipolar disorder: a systematic review
CONCLUSION: This systematic review revealed that blood-based biomarkers are associated with markers of WM deficits observed in BD. Longitudinal studies investigating the potential clinical utility of these specific biomarkers are encouraged.PMID:38712923 | DOI:10.47626/1516-4446-2023-3267 (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 7, 2024 Category: Psychiatry Authors: Mohammad Ali Renata Husnudinov Bianca Wollenhaupt-Aguiar Benicio N Frey Source Type: research
