Po-06-152 performance of the first bipolar nanosecond pulsed field ablation (nspfa) clamp in a chronic porcine model
Nanosecond Pulsed Field Ablation (nsPFA) is a novel nonthermal modality that utilizes ultrashort pulses of electrical energy to ablate cells while sparing acellular tissue. The nsPFA bipolar clamp delivers nsPFA pulses between parallel jaws in a 1.25 second ablation cycle independent of tissue thickness to create contiguous, transmural lesions. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Gansevoort H. Dunnington, Swami Gnanashanmugam, David Danitz, Lauren Johnston, Darrin Uecker, Jeffrey Litt, Anita Crompton, Mike Smith, Ilya Getsin, Niv Ad Source Type: research
Po-06-148 fieldbending: a novel bipolar pulsed field electrode configuration to improve tolerability
Tolerability of PFA remains a fundamental challenge as far-field stimulation of excitable tissue can cause discomfort and/or involuntary movement interfering with workflow efficiency. The FieldBending (FB) design by Field Medical Inc. (Cardiff, CA) features an electrode in the catheter's saline irrigation lumen, a non-conductive distal tip, and an external electrode. Current flows from the 3mm external ring, located 4mm proximal to the distal tip, to the internal electrode. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Roya Kamali, Jacob S. Koruth, Iwanari Kawamura, Eduardo Jimenez, Quyen Nguyen, Bart Schade, Shakeeb Bin Hasan, Steven R. Mickelsen Source Type: research
Po-06-143 safety and efficacy evaluation of a novel large tip focal bipolar force sensing pulsed field ablation catheter in a chronic porcine model
Pulsed field ablation (PFA) is a promising alternative to thermal ablation. Due to variation in catheter design and energy delivery, systems must be evaluated separately. Safety and efficacy of a novel large-tip force sensing ablation catheter for bipolar PFA needs to be established. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Rahul Bhardwaj, Jalaj Garg, Jonathan C. Hsu, Tushar Sharma, Paras Parikh, Assaf Govari, Joe Keyes, Christopher Beekler, Terrence Troutman, Qi Chen, Andres Altmann, Eric Manirasith, Hiroshi Nakagawa, Luigi Di Biase, William R. Maddox, Devi G. Nair Source Type: research
Po-06-136 achieving transmural ablation of the left ventricle: a preclinical assessment of bipolar pulsed field ablation
Bipolar radiofrequency ablation can increase lesion depth at the risk of septal rupture, charring and steam pops. Ventricular pulsed field ablation (PFA) is promising, but studies have largely failed to achieve transmural left ventricular (LV) lesions. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Moritz Nies, Keita Watanabe, Iwanari Kawamura, Marc A. Miller, Srinivas R. Dukkipati, William Whang, Vivek Y. Reddy, Jacob S. Koruth Source Type: research
Po-06-114 redefining atrial substrate assessment in the omnipolar mapping era
Left atrial (LA) low voltage area (LVA) burden correlates with AF recurrence risk post pulmonary vein isolation. Adjunctive ablation targeting LVAs, has been reported to improve outcomes. A bipolar voltage (BiV) threshold of 0.5mV is commonly employed to define LVAs, however BiV is influenced by multiple factors including atrial rhythm and technical factors. Omnipolar technology (OT) overcomes many limitations of BiV mapping, however there is little data on equivalent OT thresholds. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Haseeb Valli, Mahmoud Ehnesh, Zhong Chen, Wajid Hussain, David G. Jones, Tom Wong, Caroline H. Roney, Shouvik Haldar Source Type: research
Po-05-171 novel approach for intra-operative high-density mapping using omnipolar technology
Atrial conduction abnormalities are common among patients with congenital heart disease, predisposing them to arrhythmias. In clinical practice, substrates are usually identified during electrophysiological mapping procedures using bipolar electrograms (EGM). Recently, omnipolar EGM are more frequently used to overcome directional sensitivity of bipolar EGM. Maximal bipolar voltage is then mathematically extracted in cliques of 4 adjacent electrodes. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Mathijs S. van Schie, Roxanne Zwijnenburg, Paulus Knops, Nawin Ramdat Misier, Yannick Taverne, Natasja M. De Groot Source Type: research
Po-05-147 unipolar electrogram guided radiofrequency with the novel tacti-flextm catheter can tailor rf energy delivery
Radiofrequency ablation (RFA) is commonly guided by indirect measures such as impedance drop, duration, bipolar-EGM attenuation and RF delivery may vary depending on operator practice (OP). Animal studies show RF application resulting in complete loss of the negative component of the unipolar-EGM (UEGM), correlates with tissue-specific electrical non-excitability, and with additional 3 seconds (U+3) predicts transmural necrosis. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Arsalan Derakhshan, Hagai Yavin, Arwa Younis, Jakub Sroubek, Pasquale Santangeli, Sean Esposito, Zachary Koch, Ellie Holstine, Hayley Bryce, Oussama M. Wazni, Christine Tanaka-Esposito Source Type: research
Po-05-105 integrating novel imaging software for assessing left atrial wall thickness to optimize ablation strategies
We have previously elucidated that PV gaps following PV isolation (PVI) are strongly associated with PV wall thickness (PVWT) as measured on 2D-CT images, which exhibits a weak correlation with bipolar voltage amplitudes. Consequently, we proposed a tailored PVI approach based on bipolar voltage amplitude. However, this method has the potential to prolong the time needed for voltage data collection and may not accurately reflect PVWT. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Moyuru Hirata, Ryuta Watanabe, Koichi Nagashima, Yuji Wakamatsu, Shu Hirata, MASANARU SAWADA, Sayaka Kurokawa, Yasuo Okumura Source Type: research
Po-04-092 characterization of unipolar voltage values in the human left atrium
In contrast to catheter recording of endocardial bipolar (Bip) signals, unipolar (Unip) sensing allows to record electrical activity from the endo to the epicardium. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Christian Adams, Juan Cabrera, Boris Hernandez, Carlos A. Tapias, William F. Bautista Vargas, Valentina Stozitzky, Luis Saenz Source Type: research
Po-04-086 electrographic flow metrics alone predict recurrence more strongly than clinical parameters
Traditional clinical parameters have not consistently predicted atrial fibrillation (AF) ablation outcomes in part because they are not measures of pathophysiologic mechanisms of disease and underlying substrate. Leaving Electrographic Flow (EGF)-identified extra-pulmonary vein (PV) sources unablated has been shown to result in more AF recurrence. Electrographic Flow Consistency (EGFC) measures the stability of flow vectors over space and time during AF and has been shown to correlate with high-density bipolar voltage mapping. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Mike Mangrum, Steven Castellano, Melissa H. Kong Source Type: research
Po-04-122 pulsed field ablation dose-response safety and efficacy characterization of a novel large spherical tip mapping and contact force-sensing catheter
Pulsed Field Ablation (PFA) requires a pulse sequence with specific parameters (pulse width, and voltage, etc.) and is unique to catheter geometries and electrode configurations. A novel large spherical tip catheter with integrated mapping capabilities and contact force-sensing (OMNYPULSETM) was developed with 12-electrodes for bi-phasic bipolar PFA. Dosage requirements to create safe and efficacious lesions in a pre-clinical model will help to direct the clinical dosages and utility of this novel catheter. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Jonathan C. Hsu, Rahul Bhardwaj, Mark Lee, Assaf Govari, Andres Altmann, Christopher Beekler, Joseph Keyes, Tushar Sharma, Paras Parikh, Terrence Troutman, Qi Chen, Farshad Raissi, Rajesh Banker Source Type: research
Po-04-106 role of peak frequency analysis in functional substrate mapping during sinus rhythm to detect critical isthmus of atypical atrial tachycardia; findings from a novel automated annotation algorithm to detect near field signals
Functional substrate mapping during sinus rhythm is an emerging method to predict the critical isthmus (CI) of re-entrant ATs. Automated peak frequency (PF) analysis of bipolar EGMs is a novel tool which is mainly based on differentiation of near field (NF) signals from far field signals. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Hikmet Yorgun, Sinem Kilic, Cem Çöteli, KUDRET AYTEMIR Source Type: research
Po-02-062 anodal capture decreases left ventricular contractility during left bundle branch area pacing
Left bundle branch area pacing (LBBAP) can be delivered via unipolar or bipolar polarity, and bipolar may result in anodal capture. Limited data is available regarding the acute hemodynamic and electrical effects of LBBAP with anodal capture. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Zachary I. Whinnett, Robert Waxman, Richard N. Cornelussen, Paul Foley, Badri Chandrasekaran, Pugazhendhi Vijayaraman, Gaurav A. Upadhyay, Robert D. Schaller, Rafal Gardas, Travis D. Richardson, DAnne Kudlik, Patrick Zimmerman, James Burrell, Jonathan C. Source Type: research
Po-02-150 novel utilization of ensitetm ot near field software for frequency analysis around the pulmonary veins in patients with atrial fibrillation
Omnipolar mapping technology (OT) uses both unipolar and bipolar signals to obtain omnipolar signals, directions, and speeds. OT Near Field (NF) is a new software (EnSiteXTM, Abbott, St. Paul, MN, USA) which can analyze frequencies to distinguish between NF and far field (FF) potentials. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Shingo Maeda, Mihoko Kawabata, Tatsuaki Kamata, Kaoru Okishige, Jackson J. Liang, Ruben Casado Arroyo, Hirotsugu Atarashi, Koji Kumagai, Kenzo Hirao Source Type: research
Po-02-104 endo-epicardial bipolar radiofrequency catheter ablation: optimal settings for transmural lesion depth
Conventional unipolar radiofrequency ablation (RFA) for VT, with lesion depths approaching 6-8 mm, may fail to eliminate VTs with deep intramural critical components. Bipolar-RFA for intraseptal and summit VTs has emerged as an alternative method providing effective lesions. However, optimal ablation parameters have yet to be defined for LV endo-epicardial ablation in regards to lesion depth as well as procedural safety. (Source: Heart Rhythm)
Source: Heart Rhythm - May 1, 2024 Category: Cardiology Authors: Istok Menkovic, Maxime Cerantola, Marcio L. Sturmer, Alexios E. Hadjis Source Type: research
