Subcortical Brain Alterations Across Copy Number Variants Converge With Those in Severe Mental Illnesses
Copy number variants (CNVs) —the duplication or deletion of sequences of the genome—are associated with an increased risk of developing severe mental illnesses (SMI) including schizophrenia, bipolar, and major depressive disorders. Little is known about how different CNVs conferring risk for the same SMI may affect brain s tructures and how these alterations relate to the level of disease risk conferred by CNVs. To address this, we investigated gross volume, vertex-level thickness, and surface maps of subcortical structures in 11 CNVs and six SMIs. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kuldeep Kumar, Claudia Modenato, Clara Moreau, Christopher Ching, Carrie Bearden, Paul M. Thompson, Sebastien Jacquemont Source Type: research
Longitudinal Stability of Reward-Related Resting-State Networks in Youth With Bipolar-I/II Disorder
Bipolar disorder (BD) is characterized by temporal instability of mood and energy, but the neural correlates of this instability are poorly understood. In previous cross-sectional studies, mania has been correlated with increased functional connectivity (FC) of regions key to reward processing. Here, we assess whether BD is associated with longitudinal instability within a reward-related network of interest (NOI). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Danella Hafeman, Jamie Feldman, Jessica Mak, John Merranko, Tina Goldstein, Caterina Gratton, Mary Phillips, Boris Birmaher Source Type: research
Sex Differences in a Novel Mouse Model of Bipolar Disorder
We concomitantly tackle two unmet translational-science psychiatric issues: scarce bipolar-disorder-like animal-models; mostly neglected sex differences there-in. To fill these gaps, we utilized our novel bipolar-disorder-like male mouse model based on low-dose-rotenone treatment which induces mild mitochondrial-dysfunction as robustly found in bipolar-disorder. It turned out that our regime to elicit the model in males does not induce bipolar-like behavior in females. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Galila Agam, Odeya Damri, Bayan Atawna, Mai Abu-Moch Source Type: research
Identification of Sex-Specific Vascular and Immune Signatures and Biomarkers of Mood Disorders
Major depressive disorder (MDD) and bipolar disorder (BD) affect 25% people worldwide. Available treatments targeting neurons are helpful for only 30-50% suggesting that other biological systems may be involved. Circulating inflammation is elevated in treatment-resistant individuals and neurovascular adaptations modulate cognition, mood, and stress responses. Mood disorders are associated with sex-specific symptomatology, prevalence, and treatment responses and loss of blood-brain barrier (BBB) integrity has been implicated in these disorders. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jos é L. Solano, Laurence Dion-Albert, Signature Consortium, Manon Lebel, Caroline Menard Source Type: research
Sex Differences in the Clinical Correlates of Suicidality Among Youth With Bipolar Disorder
This study examined sex differences in suicide risk, and clinical correlates of suicide risk, in a sample of youth with BD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Mikaela Dimick, Rachel Mitchell, Benjamin Goldstein Source Type: research
Sex Differences in Cognition and Psychosocial Functioning in Bipolar Disorder
Patients with bipolar disorder (BD) experience neurocognitive and social cognition impairment, significantly impacting psychosocial functioning. Although sex differences in neurocognitive performance have been described in healthy controls, the influence of sex in BD patients has been mostly neglected, with evidence being inconsistent. We explored the role of sex differences in neurocognition, social cognition and psychosocial functioning in BD. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Brisa Sole, Cristina Varo, Carla Torrent Torrent, Laura Montejo, Esther Jimenez, Anabel Martinez-Aran, Eduard Vieta Tags: SYMPOSIUM Source Type: research
Longitudinal Brain Age in Young People With First-Episode Mania Treated With Lithium or Quetiapine
Previous studies suggest that lithium may have a neuroprotective effect on regional brain areas, even in First-Episode Mania (FEM) and early stages of bipolar and schizoaffective disorders. Here, an age-related multivariate measure of brain structure (i.e., brain age) at baseline and changes over time in response to treatment were examined. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Laura Han, Niousha Dehestani, Chao Suo, Michael Berk, Lianne Schmaal Tags: Symposium Source Type: research
The Global Bipolar Cohort (GBC) —An International Collaborative Effort: Opportunities and Challenges
The Global Bipolar Cohort (GBC) is an international collaborative effort, uniting research institutions since its inception in 2019, with established longitudinal and cross-sectional cohorts in multiple countries spanning North America, Europe, and Australia. The primary objectives include identifying global best practices to enhance treatment outcomes for bipolar disorder (BD) patients and perpetuating collaborative efforts among member institutions. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Balwinder Singh Source Type: research
Heterogeneity as a Marker of Brain Function and Treatment Outcomes in Psychiatric Disorders
A growing body of research emphasizes the unique neurobiological variability which defines the critical differences in cognition and behavior across individuals. Recent work demonstrated that individual variability is greater in individuals with schizophrenia spectrum disorder (SSD), autism spectrum disorders (ASD), and bipolar disorder. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Colin Hawco, Maria Teodora Secara, Julia Gallucci, Christin Schifani, Iska Moxon-Emre, George Foussias, James Gold, Anil Malhotra, Robert Buchanan, Daniel Blumberger, Stephanie Ameis, Aristotle Voineskos Source Type: research
475. Suicidal Thoughts and Behaviors in Adolescents With Mood Disorders: Evidence From the National Comorbidity Survey Adolescent Supplement
This study aims to examine the clinical correlates of suicidal thoughts and behaviors (STB) in a nationally representative sample of youth with mood disorders and investigate potential differences between those with bipolar disorder (BD) and major depressive disorder (MDD). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Mikaela Dimick, Benjamin Goldstein, Jian-Ping He, Kathleen Merikangas Source Type: research
474. Comparison of Suicidal Risk Factors in Latino Patients With Major Depression Disorder vs. Bipolar Disorder
Despite the high prevalence of suicide in patients with Major Depressive Disorder (MDD) and Bipolar Disorder (BP), there is a lack of research on suicidal risk factors within the Latino population. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Luis Alberto De La Garza Garcia, Guillermo Sanchez Torres, Gerardo Quintanilla, Sofia Jezzini Martinez, Alfonso Ontiveros, Monica Hernandez, Antonio Ali Perez Maya, Patricio Zarate Garza Source Type: research
458. The Impact of the Number of Previous Illness Episodes on Outcome in Electroconvulsive Therapy (ECT) in Psychosis, Mania, Depression, Psychotic Depression, and Catatonia: A Naturalistic Transdiagnostic Analysis
Electroconvulsive Therapy (ECT) is an effective treatment for mood and psychotic disorders but there is growing evidence of treatment resistance to ECT. We aim to investigate the relationship between the number of previous illness episodes and the relative symptomatic improvement after acute ECT treatment. We hypothesized that the number of previous illness episode is inversely correlated with symptomatic improvement. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Birong Chen, Xiaowei Tan, Phern Chern Tor Source Type: research
449. Replication of Hallucination Severity Associating With Reduced Auditory-Language Cortex Connectivity in a Biological Subtype of Psychotic Disorders
Altered properties of auditory and language brain systems may contribute to auditory hallucinations. Previously both common and psychosis subgroup-specific functional connectivity associations were found with hallucination severity in the Bipolar Schizophrenia Network on Intermediate Phenotypes-1 (B-SNIP-1) sample (Okuneye et al., 2020). Subgroups included diagnosis (schizophrenia, schizoaffective, bipolar) or the three B-SNIP Biotype groups based on neurobiological similarity. All patients showed increased connectivity within left auditory regions associated with greater hallucination severity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Isaac Toscano, Carol Tamminga, Elena Ivleva, Brett Clementz, Jennifer McDowell, Godfrey Pearlson, Matcheri Keshavan, Elliot Gershon, Sarah Keedy Source Type: research
440. Sex Differences in Gene Expression Across the Striatum in Psychosis
Psychosis is a defining feature of schizophrenia and highly prevalent in bipolar disorder. Despite known sex differences in the symptoms and progression of these disorders, little is known about the underlying molecular mechanisms driving these differences. Prior work from our group identified diurnal alterations in gene expression across the human striatum in psychosis. Here, we investigated sex differences in the transcriptome within striatal subregions in subjects with psychosis. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kyle Ketchesin, Megan Perez, Wei Zong, Madeline Scott, Marianne Seney, RuoFei Yin, Mariah Hildebrand, Kelly Cahill, Vaishnavi Shankar, Jill Glausier, David Lewis, George Tseng, Colleen McClung Source Type: research
406. Cerebellar Dysconnectivity in Schizophrenia – Bipolar Disorder Spectrum is Associated With Cognitive and Clinical Variables
In this study, we examined cerebellar FC changes in the SCZ –BD spectrum and their association with cognitive and clinical variables. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Giulia Cattarinussi, Annabella Di Giorgio, Fabio Sambataro Source Type: research
