449. Replication of Hallucination Severity Associating With Reduced Auditory-Language Cortex Connectivity in a Biological Subtype of Psychotic Disorders

Altered properties of auditory and language brain systems may contribute to auditory hallucinations. Previously both common and psychosis subgroup-specific functional connectivity associations were found with hallucination severity in the Bipolar Schizophrenia Network on Intermediate Phenotypes-1 (B-SNIP-1) sample (Okuneye et al., 2020). Subgroups included diagnosis (schizophrenia, schizoaffective, bipolar) or the three B-SNIP Biotype groups based on neurobiological similarity. All patients showed increased connectivity within left auditory regions associated with greater hallucination severity.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research