Subcortical Brain Alterations Across Copy Number Variants Converge With Those in Severe Mental Illnesses

Copy number variants (CNVs) —the duplication or deletion of sequences of the genome—are associated with an increased risk of developing severe mental illnesses (SMI) including schizophrenia, bipolar, and major depressive disorders. Little is known about how different CNVs conferring risk for the same SMI may affect brain s tructures and how these alterations relate to the level of disease risk conferred by CNVs. To address this, we investigated gross volume, vertex-level thickness, and surface maps of subcortical structures in 11 CNVs and six SMIs.

Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kuldeep Kumar, Claudia Modenato, Clara Moreau, Christopher Ching, Carrie Bearden, Paul M. Thompson, Sebastien Jacquemont Source Type: research