The first instrument for complex PTSD assessment: psychometric properties of the ICD-11 Trauma Questionnaire.
CONCLUSION: The results suggest good psychometric characteristics for the Portuguese version of the ITQ, and thus it can be included in protocols intended evaluating complex traumatic symptoms. PMID: 31596316 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - October 7, 2019 Category: Psychiatry Authors: Rocha J, Rodrigues V, Santos E, Azevedo I, Machado S, Almeida V, Silva C, Almeida J, Cloitre M Tags: Braz J Psychiatry Source Type: research

Psychotic and affective symptoms of early-onset bipolar disorder: an observational study of patients in first manic episode.
CONCLUSION: These findings suggest that disorganization and psychotic symptoms during the first manic episode are salient features in adolescent-onset BD, and that psychotic depression frequently may precede psychotic mania. Nevertheless, differential diagnosis with schizophrenia should be routinely ruled out in cases of early-onset first psychotic episode. PMID: 31576937 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - September 26, 2019 Category: Psychiatry Authors: Fu-I L, Gurgel WS, Caetano SC, Machado-Vieira R, Wang YP Tags: Braz J Psychiatry Source Type: research

Trichotillomania is more related to Tourette disorder than to obsessive-compulsive disorder.
CONCLUSION: We sought to challenge the DSM-5 classification of TTM and to compare TTM with both OCD and tic disorder. Some discrepancies between TTM and tic disorders notwithstanding, several arguments are in favor of a closer relationship between these two disorders than between TTM and OCD, especially when considering implications for therapy. This consideration is essential for patients. PMID: 31576938 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - September 26, 2019 Category: Psychiatry Authors: Lamothe H, Baleyte JM, Mallet L, Pelissolo A Tags: Braz J Psychiatry Source Type: research

The research output on child and adolescent suicide in Brazil: a systematic review of the literature.
CONCLUSION: Our findings indicate that the body of evidence on suicide among children and adolescents in Brazil is limited. The scientific output is of low quality, and there is a complete lack of interventional studies specifically designed for the youth population. PMID: 31576939 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - September 26, 2019 Category: Psychiatry Authors: Piccin J, Manfro PH, Caldieraro MA, Kieling C Tags: Braz J Psychiatry Source Type: research

Suicide mortality among youth in southern Brazil: a spatiotemporal evaluation of socioeconomic vulnerability.
CONCLUSION: While youth suicide is multifactorial, there are predictable geospatial and sociodemographic factors associated with high SMR among municipalities in Paraná. Suicide among youth aged 15-29 occurs in geographic clusters which are associated with socioeconomic deprivation. Rural settings with poor infrastructure and development also correlate with increased SMR clusters. PMID: 31433002 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - August 19, 2019 Category: Psychiatry Authors: Alarcão AC, Dell' Agnolo CM, Vissoci JR, Carvalho ECA, Staton CA, de Andrade L, Fontes KB, Pelloso SM, Nievola JC, Carvalho MD Tags: Braz J Psychiatry Source Type: research

Lifetime prevalence, sociodemographic predictors, and comorbidities of oppositional defiant disorder: the National Epidemiology of Iranian Child and Adolescent Psychiatric disorders (IRCAP).
CONCLUSIONS: The findings of this national population-based study confirm and extend previous findings on the prevalence, comorbidities, and sociodemographic predictors of ODD. PMID: 31433003 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - August 19, 2019 Category: Psychiatry Authors: Mohammadi MR, Salmanian M, Hooshyari Z, Shakiba A, Alavi SS, Ahmadi A, Khaleghi A, Zarafshan H, Mostafavi SA, Alaghmand A, Molavi P, Mahmoudi-Gharaei J, Kamali K, Ghanizadeh A, Nazari H, Sarraf N, Ahmadipour A, Derakhshanpour F, Riahi F, Golbon A, Kousha Tags: Braz J Psychiatry Source Type: research

Difficulties in activities of daily living are associated with stigma in patients with Parkinson's disease who are candidates for deep brain stimulation.
CONCLUSIONS: Although causal assumptions are not appropriate for cross-sectional studies, the results suggest that ADL difficulties could contribute to greater stigma in PD patients with refractory motor symptoms who are candidates for DBS. PMID: 31389495 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - August 5, 2019 Category: Psychiatry Authors: da Silva AG, Leal VP, da Silva PR, Freitas FC, Linhares MN, Walz R, Malloy-Diniz LF, Diaz AP, Palha AP Tags: Braz J Psychiatry Source Type: research

Depression and quality of life in older adults on hemodialysis.
bu KC Abstract OBJECTIVE: Depression is highly prevalent in hemodialysis patients, but few studies have evaluated older hemodialysis patients. The aim of this study was to evaluate the prevalence of depression, its associated factors and its impact on quality of life in an older population on hemodialysis. METHODS: This was a cross-sectional study including 173 hemodialysis patients aged 60 years or older in Recife, Brazil. Depression was evaluated using the Mini-International Neuropsychiatric Interview when depressive symptoms (according to the 5-item Geriatric Depression Scale) were present. Quality of life...
Source: Revista Brasileira de Psiquiatria - August 5, 2019 Category: Psychiatry Authors: Alencar SBV, de Lima FM, Dias LDA, Dias VDA, Lessa AC, Bezerra JM, Apolinário JF, de Petribu KC Tags: Braz J Psychiatry Source Type: research

Self-injurious behavior and related mortality in children under 10 years of age: a retrospective health record study in Brazil.
CONCLUSION: These results highlight the relevance of creating measures to better understand SIB and related mortality in this age group. They also reveal the vulnerability of children in Brazil and warrant further studies to address these issues. PMID: 31389497 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - August 5, 2019 Category: Psychiatry Authors: Studart-Bottó P, Martins-Junior DF, Sarmento S, Argolo L, Galvão-de-Almeida A, Miranda-Scippa  Tags: Braz J Psychiatry Source Type: research

Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results.
CONCLUSION: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries. PMID: 31389498 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - August 5, 2019 Category: Psychiatry Authors: Battel L, Swartz J, Anes M, Manfro PH, Rohde LA, Viduani A, Mondelli V, Kieling C Tags: Braz J Psychiatry Source Type: research

At-risk drinking and current cannabis use among medical students: a multivariable analysis of the role of personality traits.
Abstract OBJECTIVE: To explore the role of personality traits in at-risk drinking and current cannabis use among medical students. METHODS: This cross-sectional study evaluated 707 medical students from two universities. Multiple logistic regression models for at-risk drinking and current cannabis use were constructed including sociodemographic, psychiatric, and personality variables. RESULTS: At-risk drinking and current cannabis use were reported by 19.3% and 14.9% of participants, respectively. Models including Big Five measures showed associations of at-risk drinking with higher extraversion (p
Source: Revista Brasileira de Psiquiatria - July 15, 2019 Category: Psychiatry Authors: Schwarzbold ML, Haas GM, Barni RS, Biava P, Momo AC, Dias TM, Ayodele TA, Diaz AP, Vicente F Tags: Braz J Psychiatry Source Type: research

Body self-image disturbances in women with prolactinoma.
CONCLUSION: Symptomatic patients showed higher body dissatisfaction, but lower body self-image distortion. The presence of symptoms may have been responsible for increased body awareness. The perception of body shape could have triggered feelings of dissatisfaction compared to an ideal lean body. Therefore, a distorted body self-image might not necessarily result in body dissatisfaction in women with prolactinomas. PMID: 31314867 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - July 15, 2019 Category: Psychiatry Authors: Pereira HS, Naliato EC, Moraes AB, Gadelha MR, Vieira Neto L, Almeida RM, Nardi AE, Violante AH Tags: Braz J Psychiatry Source Type: research

Incidence of depression in patients with hepatitis C treated with direct-acting antivirals.
CONCLUSIONS: The findings of this study highlight the importance of screening for new depression among patients receiving new DAAs, and identify potential associated risk factors. PMID: 31314868 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - July 15, 2019 Category: Psychiatry Authors: Egmond E, Mariño Z, Navines R, Oriolo G, Pla A, Bartres C, Lens S, Forns X, Martin-Santos R Tags: Braz J Psychiatry Source Type: research

Biological bases for a possible effect of cannabidiol in Parkinson's disease.
CONCLUSIONS: Additional research is needed to elucidate the potential effectiveness of CBD in PD and the underlying mechanisms involved. PMID: 31314869 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - July 15, 2019 Category: Psychiatry Authors: Ferreira-Junior NC, Campos AC, Guimarães FS, Del-Bel E, Zimmermann PMDR, Brum Junior L, Hallak JE, Crippa JA, Zuardi AW Tags: Braz J Psychiatry Source Type: research

Combined influence of illness duration and medication type on visual sensitivity in schizophrenia.
This study is part of a large-scale study investigating visual sensitivity in schizophrenia. Here we aimed to investigate the combined effects of illness duration and antipsychotic use on contrast sensitivity function. METHODS: Data were collected from 50 healthy controls and 50 outpatients with schizophrenia (classified according to illness duration and medication type) aged 20-45 years old. The contrast sensitivity function was measured for spatial frequencies ranging from 0.2 to 20 cycles per degree using linear sine-wave gratings. RESULTS: Patients with an illness duration> 5 years had more pronounced defi...
Source: Revista Brasileira de Psiquiatria - July 1, 2019 Category: Psychiatry Authors: Almeida NL, Fernandes TP, Lima EH, Sales HF, Santos NA Tags: Braz J Psychiatry Source Type: research

Megacities, migration and an evolutionary approach to bipolar disorder: a study of Sardinian immigrants in Latin America.
ndo L Abstract OBJECTIVE: To determine whether people with a Sardinian genetic background who live in the megacities of South America have a higher frequency of hypomania than residents of Sardinia. METHODS: A community survey of Sardinian immigrants was carried out in four Brazilian metropoles (n=218) and Buenos Aires (n=306). The results were compared with those of a study involving a similar methodology (Mood Disorder Questionnaire [MDQ] as a screening tool) conducted in seven Italian regions, including a sub-sample from Sardinia. RESULTS: There was a higher prevalence of lifetime hypomania among Sard...
Source: Revista Brasileira de Psiquiatria - July 1, 2019 Category: Psychiatry Authors: Carta MG, Moro MF, Piras M, Ledda V, Prina E, Stocchino S, Orrù G, Romano F, Brasesco MV, Freire RC, Nardi AE, Tondo L Tags: Braz J Psychiatry Source Type: research

Latin American and Spanish-speaking perspectives on the challenges of global psychiatry.
Baldomero E Abstract The multi-faceted phenomenon known as globalization has a particular impact on the conceptual and practical development of mental health disciplines in general, and psychiatry in particular, across different world regions. To be theoretically and functionally effective, global psychiatry requires an integration of its different components. To such objective, and after a brief review of continental European and Anglo-Saxon contributions, this article examines the history, characteristics, and contributions of Latin/Iberian American and Spanish-speaking psychiatry, in order to substantiate its r...
Source: Revista Brasileira de Psiquiatria - July 1, 2019 Category: Psychiatry Authors: Alarcón RD, Lolas F, Mari JJ, Lázaro J, Baca-Baldomero E Tags: Braz J Psychiatry Source Type: research

Chronotype in bipolar disorder: an 18-month prospective study.
CONCLUSION: This study indicated that evening chronotype predicts a poor prognostic for BD. It reinforces the relevance of treating rhythm disruptions even during euthymia to improve patient quality of life and prevent mood episodes. PMID: 31269097 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - July 1, 2019 Category: Psychiatry Authors: Melo MC, Garcia RF, Araújo CF, Luz JH, Bruin PF, Bruin VM Tags: Braz J Psychiatry Source Type: research

The challenge of measurement in psychiatry: the lifetime accomplishments of Per Bech (1942-2018).
PMID: 31269098 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - July 1, 2019 Category: Psychiatry Authors: Fleck MP, Carrozzino D, Fava GA Tags: Braz J Psychiatry Source Type: research

Bullying among adolescents: are the victims also perpetrators?
CONCLUSION: The adolescents identified as victims did not generally attack other students, i.e., did not identify themselves as perpetrators. The high prevalence of maltreatment and bullying detected in this study, especially the verbal, social, and physical types, underscores the need for interventions addressing bullying in schools. PMID: 31188920 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - June 10, 2019 Category: Psychiatry Authors: Reisen A, Viana MC, Santos-Neto ETD Tags: Braz J Psychiatry Source Type: research

Schneider's first-rank symptoms as predictors of remission in antipsychotic-naive first-episode psychosis.
CONCLUSION: Specific FRS may predict remission after treatment in FEP patients. This finding could give new importance to Kurt Schneider's classic work by contributing to future updates of diagnostic protocols and improving estimation of prognosis. PMID: 31166544 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 30, 2019 Category: Psychiatry Authors: Malinowski FR, Tasso BC, Ortiz BB, Higuchi CH, Noto C, Belangero SI, Bressan RA, Gadelha A, Cordeiro Q Tags: Braz J Psychiatry Source Type: research

How do stress, sleep quality, and chronotype associate with clinically significant depressive symptoms? A study of young male military recruits in compulsory service.
Abstract OBJECTIVE: Although studies have shown an association between poor sleep and chronotype with psychiatric problems in young adults, few have focused on identifying multiple concomitant risk factors. METHODS: We assessed depressive symptoms (Beck Depression Inventory [BDI]), circadian typology (Morningness-Eveningness Questionnaire [MEQ]), sleep quality (Pittsburgh Sleep Quality Index [PSQI]), perceived stress (Perceived Stress Scale [PSS]), social rhythm (Social Rhythm Metrics [SRM]), and salivary cortisol (morning, evening and night, n=37) in 236 men (all 18 years old). Separate analyses were conduct...
Source: Revista Brasileira de Psiquiatria - May 30, 2019 Category: Psychiatry Authors: Tonon AC, Carissimi A, Schimitt RL, de Lima LS, Pereira FDS, Hidalgo MP Tags: Braz J Psychiatry Source Type: research

Correlation between CSF biomarkers of Alzheimer's disease and global cognition in a psychogeriatric clinic cohort.
Abstract OBJECTIVE: The relationship between biomarkers of amyloid-beta aggregation (Aβ1-42) and/or neurodegeneration (Tau protein) in cerebrospinal fluid (CSF) and cognitive decline is still unclear. We aimed to ascertain whether CSF biomarkers correlate with cognitive performance in healthy and cognitively impaired subjects, starting from clinical diagnoses. METHODS: We tested for correlation between CSF biomarkers and Mini-Mental State Examination (MMSE) scores in 208 subjects: 54 healthy controls, 82 with mild cognitive impairment (MCI), 46 with Alzheimer's disease (AD), and 26 with other dementias (...
Source: Revista Brasileira de Psiquiatria - May 30, 2019 Category: Psychiatry Authors: Radanovic M, Oshiro CA, Freitas TQ, Talib LL, Forlenza OV Tags: Braz J Psychiatry Source Type: research

Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review.
CONCLUSION: These protocols were considered safe and add interesting new evidence to the growing body of mPFC rTMS literature. However, the small number and low methodological quality of the studies indicate the need for further research. PMID: 31166547 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 30, 2019 Category: Psychiatry Authors: Marques RC, Vieira L, Marques D, Cantilino A Tags: Braz J Psychiatry Source Type: research

Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents.
ani H Abstract OBJECTIVE: Cocaine use disorders (CUDs) represent a major public health problem in many countries. To better understand the interaction between the environmental modulations and phenotype, the aim of the present study was to investigate the DNA methylation pattern of CUD patients, who had concomitant cocaine and crack dependence, and healthy controls. METHODS: We studied DNA methylation profiles in the peripheral blood of 23 CUD patients and 24 healthy control subjects using the Illumina Infinium HumanMethylation450 BeadChip arrays. RESULTS: Comparison between CUD patients and controls rev...
Source: Revista Brasileira de Psiquiatria - May 16, 2019 Category: Psychiatry Authors: Camilo C, Maschietto M, Vieira HC, Tahira AC, Gouveia GR, Feio Dos Santos AC, Negrão AB, Ribeiro M, Laranjeira R, Vallada H, Brentani H Tags: Braz J Psychiatry Source Type: research

Structural and functional neuroimaging studies in generalized anxiety disorder: a systematic review.
CONCLUSIONS: Longitudinal neuroimaging studies with larger samples of both juvenile and adult GAD patients, as well as at risk individuals and unaffected relatives, should be carried out in order to shed light on the specific biological signature of GAD. PMID: 31116259 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 16, 2019 Category: Psychiatry Authors: Madonna D, Delvecchio G, Soares JC, Brambilla P Tags: Braz J Psychiatry Source Type: research

Introducing the evidence-based population health tool of the Lower-Risk Cannabis Use Guidelines to Brazil.
Abstract Cannabis is the most commonly used illegal drug, and is associated with well-documented adverse health outcomes, both acute and chronic. Cannabis use prevalence in Brazil is lower than in high-use regions in the Americas (e.g., North America), but concentrated among young people. Frameworks for cannabis control are increasingly shifting towards public health-oriented principles, with some countries undertaking respective policy reforms. These frameworks require a continuum of population-level interventions (e.g., prevention and treatment) including targeted prevention of adverse health outcomes among user...
Source: Revista Brasileira de Psiquiatria - May 16, 2019 Category: Psychiatry Authors: Fischer B, Malta M, Messas G, Ribeiro M Tags: Braz J Psychiatry Source Type: research

Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial.
CONCLUSION: In this secondary analysis of a primary efficacy study, PD was a common comorbidity among those with MDD, but was not a significant predictor of functional outcomes. This study adds to the limited literature on PD in randomized controlled trials for MDD. CLINICAL TRIAL REGISTRATION: ACTRN12612000283875. PMID: 31116261 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 16, 2019 Category: Psychiatry Authors: Kavanagh BE, Williams LJ, Berk M, Turner A, Jackson HJ, Mohebbi M, Kanchanatawan B, Ashton MM, Ng CH, Maes M, Berk L, Malhi GS, Dowling N, Singh AB, Dean OM Tags: Braz J Psychiatry Source Type: research

Effects of mindfulness-based stress reduction combined with music therapy on pain, anxiety, and sleep quality in patients with osteosarcoma.
CONCLUSION: MBSR combined with MT significantly alleviated clinical symptoms, and could be considered a new, effective psychotherapeutic intervention for patients with osteosarcoma. PMID: 31116262 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 16, 2019 Category: Psychiatry Authors: Liu H, Gao X, Hou Y Tags: Braz J Psychiatry Source Type: research

Corrigendum.
Authors: Abstract [This corrects the article doi: 10.1590/1516-4446-2018-0221]. PMID: 31116263 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - May 16, 2019 Category: Psychiatry Tags: Braz J Psychiatry Source Type: research

Contributions of parenting styles and parental drunkenness to adolescent drinking.
CONCLUSIONS: Non-authoritative parenting style and parental drunkenness seem to play an important role in adolescents' binge drinking behavior. At the population level, parenting style appears associated with a greater contribution to this behavior among adolescents. Prevention strategies targeting parental drunkenness may be bolstered if a broader approach including parenting styles is in place. PMID: 30994851 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - April 15, 2019 Category: Psychiatry Authors: Zuquetto CR, Opaleye ES, Feijó MR, Amato TC, Ferri CP, Noto AR Tags: Braz J Psychiatry Source Type: research

Evaluation of affective temperament and anxiety-depression levels in fibromyalgia patients: a pilot study.
CONCLUSION: This study is the first to evaluate affective temperament features of FM patients. Evaluating temperamental traits in FM patients may help clinicians determine which patients are at risk for depression and anxiety disorders. PMID: 30994852 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - April 15, 2019 Category: Psychiatry Authors: Işık-Ulusoy S Tags: Braz J Psychiatry Source Type: research

Psychometric properties of the WHOQOL-SRPB BREF, Brazilian Portuguese version.
Abstract OBJECTIVE: To test the reliability and the discriminant and convergent validity of the abbreviated Brazilian Portuguese World Health Organization's Quality of Life Instrument - Spirituality, Religion, and Personal Beliefs module (WHOQOL-SRPB BREF). METHODS: In a sample of 404 individuals, we applied a general questionnaire, the WHOQOL-BREF, the long-form SRPB, the Brief Religious-Spiritual Coping Scale (RCOPE), and the Beck Depression Inventory (BDI). Priority was given to the 9-item SRPB assessment: its unidimensionality was tested through confirmatory factor analysis and Rasch analysis. RESULT...
Source: Revista Brasileira de Psiquiatria - April 15, 2019 Category: Psychiatry Authors: Zimpel RR, Panzini RG, Bandeira DR, Fleck MP, da Rocha NS Tags: Braz J Psychiatry Source Type: research

Predictors of quality of life in Brazilian medical students: a systematic review and meta-analysis.
CONCLUSIONS: Female medical students had lower QoL scores in the physical health and psychological domains of WHOQOL-Bref compared to male students. Specific interventions should be designed for this group as appropriate. SYSTEMATIC REVIEW REGISTRY NUMBER: PROSPERO CRD-42018102259. PMID: 30994854 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - April 15, 2019 Category: Psychiatry Authors: Solis AC, Lotufo-Neto F Tags: Braz J Psychiatry Source Type: research

Efficacy and safety of paliperidone palmitate 3-month formulation in Latin American patients with schizophrenia: A subgroup analysis of data from two large phase 3 randomized, double-blind studies.
Abstract OBJECTIVE: To analyze the efficacy and safety of paliperidone palmitate 3-monthly (PP3M) in Latin American patients with schizophrenia vs. rest-of-world (ROW). METHODS: We analyzed data from two multinational, double-blind (DB), randomized, controlled phase 3 studies including patients with schizophrenia (DSM-IV-TR) previously stabilized on PP1M/PP3M (open-label [OL] phase). Patients were randomized to PP3M or PP1M (noninferiority study A) and PP3M or placebo (study B) in DB phase. The subgroup analysis included Latin American (Argentina, Brazil, Colombia, Mexico) patients. Primary efficacy endpoints...
Source: Revista Brasileira de Psiquiatria - April 15, 2019 Category: Psychiatry Authors: Savitz AJ, Xu H, Gopal S, Nuamah I, Mathews M, Soares B Tags: Braz J Psychiatry Source Type: research

Semantic memory, but not education or intelligence, moderates cognitive aging: a cross-sectional study.
CONCLUSION: In developing countries, the use of resilience factors based only on years of education may be misleading. Sociocultural issues influence the educational system and achievement and, consequently, affect the use of this simple measure. Resilience-factor studies should consider using crystallized abilities when studying populations with sociocultural particularities. PMID: 30994856 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - April 15, 2019 Category: Psychiatry Authors: Bertola L, Ávila RT, Bicalho MAC, Malloy-Diniz LF Tags: Braz J Psychiatry Source Type: research

Contextual risk factors of depression and suicidal thoughts in Brazilian adults: a multilevel analysis.
CONCLUSIONS: In general, contextual variables, within each Brazilian state, do not seem to affect the prevalence of MDE and suicidal thoughts. PMID: 30994857 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - April 15, 2019 Category: Psychiatry Authors: Carpena MX, Martins-Silva T, Costa FS, Darley R, Loret de Mola C Tags: Braz J Psychiatry Source Type: research

Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats.
CONCLUSION: A combination of environmental stressors (HAB and PSD) may induce endophenotypes related to bipolar disorder. PMID: 30892378 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - March 14, 2019 Category: Psychiatry Authors: Rabelo-da-Ponte FD, Pessoa Gomes JM, Torres NL, Barbosa JIC, de Andrade GM, Macedo D, Ceppi B Tags: Braz J Psychiatry Source Type: research

Effects of lithium on inflammatory and neurotrophic factors after an immune challenge in a lisdexamfetamine animal model of mania.
CONCLUSION: Although Li prevented an LPS-induced increase in serum iNOS levels, its potential anti-inflammatory effects in this animal model of mania were conflicting. PMID: 30843957 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - March 7, 2019 Category: Psychiatry Authors: Bristot G, Ascoli BM, Scotton E, Géa LP, Pfaffenseller B, Kauer-Sant'Anna M Tags: Braz J Psychiatry Source Type: research

Psychological distress among transgender people in Brazil: frequency, intensity and social causation - an ICD-11 field study.
CONCLUSIONS: Gender incongruence variables were not significant predictors of distress. This result supports the recent changes proposed by the Word Health Organization in ICD-11 to move transgender conditions from the Mental and Behavioral Disorders chapter to a new chapter on Sexual Disorders and Conditions Related to Sexual Health. PMID: 30843958 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - March 7, 2019 Category: Psychiatry Authors: Lobato MI, Soll BM, Brandelli Costa A, Saadeh A, Gagliotti DAM, Fresán A, Reed G, Robles R Tags: Braz J Psychiatry Source Type: research

Aggression directed towards others vs. aggression directed towards the self: clinical differences between intermittent explosive disorder and nonsuicidal self-injury.
CONCLUSIONS: Individuals with NSSI may benefit from better management of psychiatric comorbidities, specifically depressive symptoms and social adjustment difficulties. Conversely, the treatment of individuals with IED may be improved by targeting comorbid generalized anxiety disorder. Our results provide important insight for the development of tailored interventions for specific subtypes of aggression. PMID: 30843959 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - March 7, 2019 Category: Psychiatry Authors: Medeiros GC, Seger-Jacob L, Garreto AK, Kim HS, Coccaro EF, Tavares H Tags: Braz J Psychiatry Source Type: research

Brazilian guidelines for the management of psychomotor agitation. Part 2. Pharmacological approach.
CONCLUSION: If non-pharmacological strategies fail, medications are needed to control agitation and violent behavior. Once medicated, the patient should be monitored until a tranquil state is possible without excessive sedation. SYSTEMATIC REVIEW REGISTRY NUMBER: CRD42017054440. PMID: 30843960 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - March 7, 2019 Category: Psychiatry Authors: Baldaçara L, Diaz AP, Leite V, Pereira LA, Dos Santos RM, Gomes Júnior VP, Calfat ELB, Ismael F, Périco CAM, Porto DM, Zacharias CEK, Cordeiro Q, da Silva AG, Tung TC Tags: Braz J Psychiatry Source Type: research

Pharmacokinetics of antidepressants in patients undergoing hemodialysis: a narrative literature review.
Abstract We conducted a narrative literature review on studies that specifically addressed the pharmacokinetics of antidepressants in patients on hemodialysis. The search included the MEDLINE, LILACS, and Web of Knowledge databases and combined Medical Subject Headings and free-text search terms for chronic kidney disease, end-stage renal disease, renal replacement therapy, depression, and antidepressants; it was limited to studies conducted in humans, with no language or time constraints. The search yielded 212 studies. After screening titles and abstracts, 32 studies were read in full and 11 ultimately met the i...
Source: Revista Brasileira de Psiquiatria - March 7, 2019 Category: Psychiatry Authors: Constantino JL, Fonseca VA Tags: Braz J Psychiatry Source Type: research

Suicidal behavior among substance users: data from the Second Brazilian National Alcohol and Drug Survey (II BNADS).
CONCLUSION: AUD, cannabis and cocaine use were significantly associated with SI and SA, even after the adjustments. Public health initiatives targeting suicide prevention should consider including assessment and management of substance misuse, and therapeutic approaches to substance misuse should include assessment of suicidality. PMID: 30785535 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - February 18, 2019 Category: Psychiatry Authors: Abdalla RR, Miguel AC, Brietzke E, Caetano R, Laranjeira R, Madruga CS Tags: Braz J Psychiatry Source Type: research

SIGMA-VB: Validity and reliability of the Brazilian Portuguese version of the Montgomery- Åsberg Depression Rating Scale using the Structured Interview Guide for the MADRS.
CONCLUSION: Our findings confirm that the SIGMA-VB is a valid and reliable instrument to assess depression severity in clinical research and practice. Its interrater reliability was similar to that of a previously published Japanese version of the SIGMA. PMID: 30785536 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - February 18, 2019 Category: Psychiatry Authors: Fernandes F, Carneiro A, Campos RN, Soeiro-de-Souza MG, Barros VB, Moreno RA Tags: Braz J Psychiatry Source Type: research

Development and psychometric evaluation of the Mandarin Chinese version of the Yale-Brown Obsessive-Compulsive Scale - Second Edition.
CONCLUSIONS: Overall, these results support the use of the Y-BOCS-II among individuals from China. Future study by an independent group is necessary to replicate these findings, as well as investigate interrater reliability and treatment sensitivity. PMID: 30785537 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - February 18, 2019 Category: Psychiatry Authors: Zhang CC, Gong H, Zhang Y, Jin H, Yang Y, Li B, Li Y, Luo X, Liu W, Fang F, Li B, Sun B, Fletcher T, La Buissonnière-Ariza V, Goodman WK, Storch EA Tags: Braz J Psychiatry Source Type: research

Psychological morbidity is the main predictor of quality of life among caregivers of individuals in first-episode psychosis: data from a year-long longitudinal study in Brazil.
CONCLUSION: Supporting an individual in FEP can have a negative impact on QoL. Maintaining caregivers' mental health and subjective evaluation of the caregiving experience must be primary goals of FEP services. Complementary studies of FEP caregivers' QoL can support the design of personalized interventions in the near future. PMID: 30785538 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - February 18, 2019 Category: Psychiatry Authors: Jorge RC, Cogo-Moreira H, Araripe Neto AG, Chaves AC Tags: Braz J Psychiatry Source Type: research

The association between adolescent suicide rates and socioeconomic indicators in Brazil: a 10-year retrospective ecological study.
CONCLUSION: Our findings suggest that socioeconomic indicators, particularly unemployment and social inequality, are relevant social determinants of suicide in adolescence. PMID: 30785539 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - February 18, 2019 Category: Psychiatry Authors: Jaen-Varas D, Mari JJ, Asevedo E, Borschmann R, Diniz E, Ziebold C, Gadelha A Tags: Braz J Psychiatry Source Type: research

Trends in suicide rates in Brazil from 1997 to 2015.
CONCLUSION: Overall, 90.6% of units of analysis had a stable or increasing trend in suicide rates from 1997 to 2015. If these trends remain, most of Brazil will fail to achieve the WHO-recommended reduction in suicide rates by 2020. PMID: 30785540 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - February 18, 2019 Category: Psychiatry Authors: Rodrigues CD, de Souza DS, Rodrigues HM, Konstantyner TCRO Tags: Braz J Psychiatry Source Type: research

The latent structure of the Young Schema Questionnaire-Short Form.
DISCUSSION: These findings offer empirical evidence supporting YSQ-SF construct validity and, consequently, its application in adults. PMID: 30785541 [PubMed - as supplied by publisher] (Source: Revista Brasileira de Psiquiatria)
Source: Revista Brasileira de Psiquiatria - February 18, 2019 Category: Psychiatry Authors: Sperb W, da Silva JA, Cogo-Moreira H, Lara DR, de Carvalho HW Tags: Braz J Psychiatry Source Type: research