271. Maintenance Ketamine Infusions Demonstrate Sustained Antidepressant Efficacy in a Real-World Treatment-Resistant Unipolar and Bipolar Depression Sample

Intravenous, subanesthetic-dose ketamine has demonstrated rapid and robust antidepressant effects in patients with treatment-resistant major depressive disorder (TRD) and bipolar depression (TRBD). Most analyses have analyzed the effects of acute ketamine infusions administered in 2-3 weeks, while limited research has analyzed the effectiveness of maintenance ketamine infusions. Herein, we present real-world data demonstrating sustained antidepressant effects following maintenance ketamine infusions in patients with TRD and TRBD.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research