Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population
We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of th...
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Khoriah Indrihutami Krisin Chand Rizka Fahmia Mutia Rahardjani Fitria Wulandari Decy Subekti Rintis Noviyanti Amin Soebandrio Noch T Mallisa I Made Mardika Waras Budiman Irwan Suriswan Yogi Ertanto Mei-Chun Chen Tooba Murshedkar Yonas Abebe B Kim Lee Sim Source Type: research
Evaluating Malaria Rapid Diagnostic Tests and Microscopy for Detecting Plasmodium Infection and Status of Plasmodium falciparum Histidine-Rich Protein 2/3 Gene Deletions in Southeastern Nigeria
Am J Trop Med Hyg. 2024 Mar 26:tpmd230690. doi: 10.4269/ajtmh.23-0690. Online ahead of print.ABSTRACTDelays in malaria diagnosis increase treatment failures and deaths. In endemic regions, standard diagnostic methods are microscopy and malaria rapid diagnostic tests (mRDTs) detecting Plasmodium falciparum histidine-rich protein 2/3 (PFHRP2/PFHRP3), but gene deletions can allow certain parasites to remain undetected. We enlisted a cohort comprising 207 symptomatic individuals, encompassing both children and adults, at a hospital in Nnewi, Nigeria. The prevalence of parasites was determined using a highly sensitive, species-...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Moses Ikegbunam Maike Maurer Harrison Abone Dorothy Ezeagwuna Thaisa Lucas Sandri Charles Esimone Olusola Ojurongbe Tamirat Gebru Woldearegai Andrea Kreidenweiss Jana Held Rolf Fendel Source Type: research
Normal Clinical Laboratory Ranges by Age and Sex, and Impact on Study Screening Outcomes in Rural Mali
We examined hematological and clinical chemistry parameters in healthy residents at two rural vaccine trial sites: Bancoumana and Doneguebougou in Mali, West Africa. During screening of clinical studies in 2018 and 2019, peripheral blood samples from 1,192 apparently healthy individuals age 6 months to 82 years were analyzed at a laboratory accredited by the College of American Pathologists for a complete blood count, and creatinine and/or alanine aminotransferase levels. Based on manufacturers' reference range values, which are currently used in Malian clinical laboratories, abnormal values were common in this healthy pop...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: M'Bouye Doucoure Amatigue Zeguime Amadou Niangaly Merepen A Guindo Justin Y A Doritchamou Mahamadoun H Assadou Abdoulaye Katile Moussa B Kanoute Sidiki Perou Adama Ouattara Sintry Sanogo Boucary Ouologuem Souleymane Traore Bakary Dao Drissa Dembele Mamady Source Type: research
Implementation of a Randomized, Placebo-Controlled Trial of Live Attenuated Malaria Sporozoite Vaccines in an Indonesian Military Study Population
We describe the manifold challenges of enrolling and immunizing 345 soldier participants at their home base in western Indonesia before their nearly 6,000-km voyage to eastern Indonesia, where they are being monitored for incident P. falciparum and Plasmodium vivax malaria cases during 9 months of exposure. The unique regulatory, ethical, and operational complexities of this trial demonstrate the importance of thorough planning, frequent communication, and close follow-up with stakeholders. Effective engagement with the military community and the ability to adapt to unanticipated events have proven key to the success of th...
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Khoriah Indrihutami Krisin Chand Rizka Fahmia Mutia Rahardjani Fitria Wulandari Decy Subekti Rintis Noviyanti Amin Soebandrio Noch T Mallisa I Made Mardika Waras Budiman Irwan Suriswan Yogi Ertanto Mei-Chun Chen Tooba Murshedkar Yonas Abebe B Kim Lee Sim Source Type: research
Use of a health worker-targeted smartphone app to support quality malaria RDT implementation in Busia County, Kenya: A feasibility and acceptability study
by Malia Skjefte, Shawna Cooper, Stephen Poyer, Christopher Louren ço, Sam Smedinghoff, Brett Keller, Tonny Wambua, Christine Oduor, Sasha Frade, Wycliffe Waweru
Malaria rapid diagnostic tests (mRDTs) are an essential diagnostic tool in low-resource settings; however, administration and interpretation errors reduce their effectiveness.HealthPulse, a smartphone mRDT reader application, was developed by Audere to aid health workers in mRDT administration and interpretation, with an aim to improve the mRDT testing process and facilitate timely decision making through access to digitized results. Audere partnered with PSI an...
Source: PLoS One - March 26, 2024 Category: Biomedical Science Authors: Malia Skjefte Source Type: research
Rapid assessment of the blood-feeding histories of wild-caught malaria mosquitoes using mid-infrared spectroscopy and machine learning
The degree to which Anopheles mosquitoes prefer biting humans over other vertebrate hosts, i.e. the human blood index (HBI), is a crucial parameter for assessing malaria transmission risk. However, existing techn... (Source: Malaria Journal)
Source: Malaria Journal - March 26, 2024 Category: Infectious Diseases Authors: Emmanuel P. Mwanga, Idrisa S. Mchola, Faraja E. Makala, Issa H. Mshani, Doreen J. Siria, Sophia H. Mwinyi, Said Abbasi, Godian Seleman, Jacqueline N. Mgaya, Mario Gonz ález Jiménez, Klaas Wynne, Maggy T. Sikulu-Lord, Prashanth Selvaraj, Fredros O. Okumu Tags: Research Source Type: research
Clinical and economic burden of respiratory syncytial virus in children aged 0 –5 years in Italy
ConclusionsThese findings derived from the real clinical practice in Italy confirmed that RSV has an important epidemiological, clinical, and economic burden among children aged 0 –5 years. While the complex management of at-risk infants was confirmed, our data also highlighted the significant impact of RSV infection in infants born at term or otherwise healthy, demonstrating that all infants need protection against RSV disease, reducing then the risk of medium and long-ter m complications, such as wheezing and asthma. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 25, 2024 Category: Pediatrics Source Type: research
Prevalence of non-falciparum malaria infections among asymptomatic individuals in four regions of Mainland Tanzania
Recent studies point to the need to incorporate the detection of non-falciparum species into malaria surveillance activities in sub-Saharan Africa, where 95% of the world ’s malaria cases occur. Although malari... (Source: Parasites and Vectors)
Source: Parasites and Vectors - March 23, 2024 Category: Microbiology Authors: Zachary R. Popkin-Hall, Misago D. Seth, Rashid A. Madebe, Rule Budodo, Catherine Bakari, Filbert Francis, Dativa Pereus, David J. Giesbrecht, Celine I. Mandara, Daniel Mbwambo, Sijenunu Aaron, Abdallah Lusasi, Samwel Lazaro, Jeffrey A. Bailey, Jonathan J. Tags: Brief Report Source Type: research
A nanochitosan-D-galactose formulation increases the accumulation of primaquine in the liver
Antimicrob Agents Chemother. 2024 Mar 22:e0091523. doi: 10.1128/aac.00915-23. Online ahead of print.ABSTRACTPrimaquine is the mainstream antimalarial drug to prevent Plasmodium vivax relapses. However, this drug can induce hemolysis in patients with glucose-6-phosphate dehydrogenase deficiency. Nanostructure formulations of primaquine loaded with D-galactose were used as a strategy to target the drug to the liver and decrease the hemolytic risks. Nanoemulsion (NE-Pq) and nanochitosan (NQ-Pq) formulations of primaquine diphosphate containing D-galactose were prepared and characterized by their physicochemistry properties. P...
Source: Antimicrobial Agents and Chemotherapy - March 22, 2024 Category: Microbiology Authors: F Gomes A C Ribeiro G S Sanches H S Borges L A U Takahashi C T Daniel-Ribeiro A C Tedesco J W L Nascimento L J M Carvalho Source Type: research
A new malaria vaccination tool based on replication-competent Plasmodium falciparum parasites
EMBO Mol Med. 2024 Mar 21. doi: 10.1038/s44321-024-00056-8. Online ahead of print.NO ABSTRACTPMID:38514792 | DOI:10.1038/s44321-024-00056-8 (Source: Molecular Medicine)
Source: Molecular Medicine - March 22, 2024 Category: Molecular Biology Authors: Diana Moita Miguel Prud êncio Source Type: research
Reinvestigation of diphenylmethylpiperazine analogues of pyrazine as new class of < em > Plasmodial < /em > cysteine protease inhibitors for the treatment of malaria
RSC Med Chem. 2024 Feb 1;15(3):1022-1037. doi: 10.1039/d3md00490b. eCollection 2024 Mar 20.ABSTRACTMalaria eradication is still a global challenge due to the lack of a broadly effective vaccine and the emergence of drug resistance to most of the currently available drugs as part of the mainline artemisinin-based combination therapy. A variety of experimental approaches are quite successful in identifying and synthesizing new promising pharmacophore hybrids with distinct mechanisms of action. Based on our recent findings, the current study demonstrates the reinvestigation of a series of diphenylmethylpiperazine and pyrazine...
Source: Cell Research - March 22, 2024 Category: Cytology Authors: Hari Madhav G Srinivas Reddy Zeba Rizvi Ehtesham Jameel Tarosh S Patel Abdur Rahman Vikas Yadav Sadaf Fatima Fatima Heyat Kavita Pal Amisha Minju-Op Naidu Subbarao Souvik Bhattacharjee Bharat C Dixit Puran Singh Sijwali Nasimul Hoda Source Type: research
Biomolecular interactions between Plasmodium and human host: A basis of targeted antimalarial therapy
Ann Pharm Fr. 2024 Mar 20:S0003-4509(24)00040-3. doi: 10.1016/j.pharma.2024.03.005. Online ahead of print.ABSTRACTMalaria is one of the serious health concerns worldwide as it remains a clinical challenge due to the complex life cycle of the malaria parasite and the morphological changes it undergoes during infection. The malaria parasite multiplies rapidly and spreads in the population by changing its alternative hosts. These various morphological stages of the parasite in the human host cause clinical symptoms (anemia, fever, and coma). These symptoms arise due to the preprogrammed biology of the parasite in response to ...
Source: Annales Pharmaceutiques Francaises - March 22, 2024 Category: Drugs & Pharmacology Authors: Anamika Jain Rajeev Sharma Laxmikant Gautam Priya Shrivastava Kamalinder K Singh S P Vyas Source Type: research
Prevalence and Genetic Diversity of Simian Malaria in Wild Macaque Populations Across Thailand: Implications for Human Health
This study aims to address several research questions, including the prevalence and distribution of simian malaria in these two Thai wild macaque species, variations in infection between different macaque species and between M. fascicularis subspecies, and the genetic composition of these pathogens. Blood samples were collected from 82 M. mulatta and 690 M. fascicularis across 15 locations in Thailand, as well as two locations in Vietnam and Myanmar. We employed quantitative real-time PCR targeting the Plasmodium genus-specific 18S ribosomal RNA (rRNA) gene to detect malaria infection, with a limit of detection set at 1,21...
Source: Acta Tropica - March 22, 2024 Category: Infectious Diseases Authors: Kriangkrai Karnchaisri Nicholas P J Day Arjen M Dondorp Suchinda Malaivijitnond Mallika Imwong Source Type: research
Endothelial LAT1 (SLC7A5) Mediates S-Nitrosothiol Import and Modulates Respiratory Sequelae of Red Blood Cell Transfusion In Vivo
CONCLUSION: This is the first study showing a role for SNO transport by LAT1 in ECs in a genetic mouse model. We provide the first direct evidence for the coordination of RBC SNO export with EC SNO import via LAT1. SNO flux via LAT1 modulates RBC-EC sequestration in lungs after transfusion, and its disruption impairs blood oxygenation by the lung.PMID:38519039 | DOI:10.1055/s-0044-1782182 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - March 22, 2024 Category: Hematology Authors: Hongmei Zhu Richard L Auten Augustus Richard Whorton Stanley Nicholas Mason Cheryl B Bock Gary T Kucera Zachary T Kelleher Aaron T Vose Tim J McMahon Source Type: research
