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A longer-chain acylated derivative of Dictyostelium differentiation-inducing factor-1 enhances the antimalarial activity against Plasmodium parasites
In this study, we synthesised DIF-1(+3) (1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl) nonan-1-one). We then evaluated the effects of DIF-1(+3) in vitro on Plasmodium falciparum and in vivo over 7 days (50-100 mg/kg/day) in a mouse model of Plasmodium berghei. DIF-1(+3) exhibited a half-maximal inhibitory concentration of approximately 20-30 % of DIF-1(+2) in three laboratory strains with a selectivity index > 263, including in strains resistant to chloroquine and artemisinin. Parasite growth and multiplication were almost completely suppressed by treatment with 100 mg/kg DIF-1(+3). The survival time of infected mice w...
Source: Biochemical Pharmacology - May 2, 2024 Category: Drugs & Pharmacology Authors: Naoko Yoshida Haruhisa Kikuchi Makoto Hirai Betty Balikagala Denis A Anywar Hikari Taka Naoko Kaga Yoshiki Miura Naoyuki Fukuda Emmanuel I Odongo-Aginya Yuzuru Kubohara Toshihiro Mita Source Type: research

Green synthesized silver nanoparticles of < em > Terminalia bellirica < /em > leaves extract: synthesis, characterization, < em > in-silico < /em > studies, and antimalarial activity
In conclusion, this novel class of AgNPs may be used as a potential therapeutic replacement for the treatment of malaria.PMID:38696111 | DOI:10.1080/21691401.2024.2339429 (Source: Artificial Cells, Nanomedicine and Biotechnology)
Source: Artificial Cells, Nanomedicine and Biotechnology - May 2, 2024 Category: Biotechnology Authors: Sujeet Singh Hemant Arya Welka Sahu K Sony Reddy Surendra Nimesh Bader Saud Alotaibi Mohammed Ageeli Hakami Hassan H Almasoudi Khater Balatone Gezira Hessien Mohammad Raghibul Hasan Summya Rashid Tarun Kumar Bhatt Source Type: research

Health impacts of war: case studies of New Zealand veterans of the First World War
CONCLUSION: These 10 selected cases reiterate how severe and extensive the morbidity burden for military personnel in WWI could be. Also illustrated is how the morbidity could contribute to adverse impacts on some of their lives after returning to New Zealand.PMID:38696832 | DOI:10.26635/6965.6514 (Source: New Zealand Medical Journal)
Source: New Zealand Medical Journal - May 2, 2024 Category: General Medicine Authors: Nick Wilson Jennifer A Summers Christine Clement George Thomson Source Type: research

Molecules, Vol. 29, Pages 2107: Differential Anti-Fibrotic and Remodeling Responses of Human Dermal Fibroblasts to Artemisia sp., Artemisinin, and Its Derivatives
a Dominko Fibrosis is a ubiquitous pathology, and prior studies have indicated that various artemisinin (ART) derivatives (including artesunate (AS), artemether (AM), and dihydroartemisinin (DHA)) can reduce fibrosis in vitro and in vivo. The medicinal plant Artemisia annua L. is the natural source of ART and is widely used, especially in underdeveloped countries, to treat a variety of diseases including malaria. A. afra contains no ART but is also antimalarial. Using human dermal fibroblasts (CRL-2097), we compared the effects of A. annua and A. afra tea infusions, ART, AS, AM, DHA, and a liver metabolite of ART, deox...
Source: Molecules - May 2, 2024 Category: Chemistry Authors: Pamela Weathers Melissa Towler Bushra Hafeez Kiani David Dolivo Tanja Dominko Tags: Article Source Type: research

Association between telomere length and Plasmodium falciparum malaria endemicity in sub-Saharan Africans
We report on the relationship between leukocyte telomere length (LTL), genetics, and environmental factors in ethnically diverse Africans. LTL is longer in African ancestry individuals than in non-Africans and we observe a significant negative relationship between malaria endemicity and LTL, while adjusting for age, sex, and genetic ancestry. (Source: The American Journal of Human Genetics)
Source: The American Journal of Human Genetics - May 2, 2024 Category: Genetics & Stem Cells Authors: Michael A. McQuillan, Simon Verhulst, Matthew E.B. Hansen, William Beggs, Dawit Wolde Meskel, Gurja Belay, Thomas Nyambo, Sununguko Wata Mpoloka, Gaonyadiwe George Mokone, Charles Fokunang, Alfred K. Njamnshi, Stephen J. Chanock, Abraham Aviv, Sarah A. Ti Tags: Article Source Type: research

System-wide governance challenges of the Ebonyi State Malaria Elimination Programme and recommendations for malaria health system strengthening: a qualitative study among stakeholders in Ebonyi state, Nigeria
Conclusions The system-wide governance challenges and the responsible factors call for changing the ‘business as usual’ and refocusing on strengthening malaria health system governance in addressing the persisting malaria health problems in Ebonyi state (and Nigeria). (Source: BMJ Open)
Source: BMJ Open - May 2, 2024 Category: General Medicine Authors: Omale, U. I., Ogbonnaya, L. U., Iyare, O., Nnachi, O. O. Tags: Open access, Public health Source Type: research

Analyzing the impact of pesticides on the indus river: contamination levels in water, sediment, fish, and associated human health risks
This study aimed to assess the presence of eight pesticide residues at three different sites (Kalabagh, Kundian, and Chashma) in water, sediment, and the fish species (Labeo rohita) during both dry and wet seasons to measure the intensity of this pressure. Pesticide analysis was carried out using gas chromatography equipped with an electron capture detector. The results revealed the highest concentrations of pesticides during both dry and wet seasons at all sites, measuring 0.83 and 0.62 μg/l (water), 12.37 and 9.20 μg/g/dw (sediment), and 14.27 and 11.29 μg/g/ww (L. rohita), respectively. Overall, pesticide concent...
Source: Environmental Geochemistry and Health - May 2, 2024 Category: Environmental Health Source Type: research