CRISPR-Based Assay for Rapid and Inexpensive Malaria Testing
Researchers at the Harvard Wyss Institute have developed a rapid, inexpensive, and very sensitive malaria test that harnesses the power of CRISPR. The new technique does not require complicated sample preparation or processing, and it could allow for rapid on-site testing in low resource regions, aiding the campaign to eliminate malaria. Determining where malaria is being contracted is key to eradicating and treating it. However, such regions are usually remote and typically lack medical resources, making testing challenging. Current tests for malaria have poor sensitivity and often require expensive and cumbersome lab ...
Source: Medgadget - September 22, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Public Health Source Type: blogs

Whom Can We Trust? COVID-19, Politics, and the Decay of Federal Science
by Craig Klugman, Ph.D. Since 1927, the agency now known as the Food and Drug Administration became the federal agency responsible for the safety of food for human consumption, drugs, and  therapeutic devices. Started in 1946, the Centers for Disease Control & Prevention opened to fight communicable diseases (starting with malaria) in the U.S. and around the world. Together, these two agencies are among the most respected scientific institutions in the world. At least they were until the last few weeks.  On August 23, FDA commissioner Stephen Hahn announced emergency a...
Source: - September 3, 2020 Category: Medical Ethics Authors: Craig Klugman Tags: Featured Posts Institutions, Centers, Funding Politics Public Health #covid19 #diaryofaplagueyear COVID-19 Source Type: blogs

New Cato Book: Ten Global Trends Every Smart Person Should Know: And Many Others You Will Find Interesting
In conclusion, I hope that you will buy this book and share it with your family and friends. It is meant to be a conversation piece. Instead of gathering dust on a bookshelf, it is designed to lie on a living room table (like so many architecture and interior design books), for visitors to see and discuss over a martini or glass of wine. I hope that it will alleviate some depression and anxiety, spark a fact ‐​filled discussion around the dining room table, and maybe even change some minds. Strangers things have happened. Cheers! (Source: Cato-at-liberty)
Source: Cato-at-liberty - August 31, 2020 Category: American Health Authors: Marian L. Tupy Source Type: blogs

Mosquito: more than a bug
Anopheles mosquito, a vector of Malaria   In one half of the world, the mosquito is seen to most as a minor annoyance, but for others, mosquitoes are synonymous with disease, pain, and death. Today is the World Mosquito Day and the perfect reminder of the devastating impact of such diseases as Malaria, Zika, and various kinds of Encephalitis for which mosquitoes are a major vector. Malaria – a headline disease Malaria is the headline disease associated with mosquitoes and it was on this very day in 1897 that Sir Ronald Ross discovered that female mosquitoes can transmit malaria between h...
Source: GIDEON blog - August 20, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Source Type: blogs

Be vigilant about bug spray
Ticks and mosquitoes don’t care about COVID-19 safety protocols. They don’t care that people are trying to squeeze out the last moments of this restrictive summer by getting outdoors, hiking, or just sitting on their decks at night and feeling something that’s close to normal. COVID-19 has commanded our attention and caused people to adapt their behaviors to prevent one major health concern, but it doesn’t mean others have been eliminated. “Masks and social distancing will do nothing to protect you from what ticks and mosquitoes potentially carry,” says Dr. Todd Ellerin, director of infe...
Source: Harvard Health Blog - August 7, 2020 Category: Consumer Health News Authors: Steve Calechman Tags: Autoimmune diseases Prevention Safety Source Type: blogs

A bizarre right wing obsession
As we know,  Resident Dump is prone to magical thinking -- whatever pops into his head, that he says aloud, becomes true by the God-like power of his words. Three million illegal aliens voted for Hillary Clinton. His inaugural crowd was the biggest ever. The coronavirus is just going to disappear, you'll see, it will be like magic . . .I could go on endlessly but you already know that he's insane. So one of the nonsensical ideas that popped into his head was that an anti-malarial drug, hydroxychloroquine, is actually a miracle cure for Covid-19. That is biologically completely implausible -- it is toxic to the metazoa...
Source: Stayin' Alive - July 28, 2020 Category: American Health Source Type: blogs

Zombie lies eat my brain
Hydroxychloroquine flunks Phase III trial in mild-to-moderate Covid-19The study adds to the growing body of evidence that the drug, promoted early in the pandemic by President Trump, is ineffective, despite its getting a briefly renewed lease on life earlier this month thanks to a retrospective analysis.  Results of new clinical trial published late last week have found that hydroxychloroquine – the malaria and autoimmune disease drug that President Donald Trump promoted as a potential “game changer” early in the Covid-19 pandemic – not only failed to improve outcomes in those with mild-to...
Source: Stayin' Alive - July 27, 2020 Category: American Health Source Type: blogs

Fight Aging! Newsletter, July 6th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - July 5, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Far Too Little Consideration is Given to the Failure of the Immune System in the Old
There is no situation so terrible that it will not be silently accepted as set in stone, only given that it has lasted for long enough to become routine. So it is with aging, and all of the pain, suffering, and death that accompanies it. The present furor surrounding COVID-19 is unusual for casting at least a little light upon the point that infectious disease largely kills older people, and in very large numbers, year in and year out. In the normal course of affairs, no-one cares until it is their turn to be old, frail, and vulnerable. The immune system decays with age, becoming simultaneously overactive (inflammag...
Source: Fight Aging! - July 3, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

The Itchy, Bumpy Blues: How to Treat and Prevent Mosquito Bites and Related Conditions
Mosquito bites may be a nuisance, but fortunately, in the U.S., they tend to amount to nothing more than that. Upon being bitten, most Americans experience a bit of swelling and itchiness, and nothing more. However, there are exceptions to this, including stronger allergic reactions to bites and cases of mosquito-borne illness.  Insect and arachnid bites, including ticks, account for approximately 2,000 cases of malaria and 30,000 cases of Lyme disease in the U.S. annually. In addition, millions of people worldwide die of malaria each year. It is helpful to protect yourself against insect bites, not only to avoid pesk...
Source: Conversations with Dr Greene - June 7, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog Environmental Health Insect Bites & Stings Insects & Animals Outdoor Safety Source Type: blogs

Scientist Interview: Studying the Biochemistry of Insects with Michael Kanost
Insects vastly outnumber people on our planet. Some are pests, but many are key parts of their ecosystems, and some may even hold secrets for developing new materials that researchers could use in the medical field. Michael Kanost, Ph.D. , a professor of biochemistry and molecular biophysics at Kansas State University in Manhattan, Kansas, has been researching the biochemistry of insects for more than 30 years. His lab studies the tobacco hornworm, a mosquito that carries malaria, and the red flour beetle to better understand insect exoskeletons and immune systems. In a video interview, Dr. Kanost explains why ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 3, 2020 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology Cool Creatures Cool Videos Source Type: blogs

Detection dogs
There was an interview on BBC Breakfast last week with a detection dog, or, strictly, with someone fromMedical Detection Dogs, accompanied by a detection dog.  Dogs have been used to " sniff out " malaria and Parkinson's, and there are investigations into whether they can be trained to detect COVID-19.There are details of that trial, which involves the University of Durham, the London School of Hygiene and Tropical Medicine, and Medical Detection Dogs,on this Government webpage. So what is in the literature?   A PubMed search for detection dog finds some papers, but also a lot about detec...
Source: Browsing - May 24, 2020 Category: Databases & Libraries Source Type: blogs

Adverse effects of hydroxychloroquine
In case you were ever stupid enough to follow Trump’s lead you would have already injected ultraviolets in your eyeballs by now to save you from Covid and maybe bathed in Domestos or sulfuric acid or both! Anyway, his latest bullshine claim is that he’s been taking the antimalarial drug hydroxychloroquine to keep Covid at bay. Well, for starters there is no evidence that this drug acts as a prophylactic against infection with SARS CoV-2 or indeed any pathogen other than the causative agent of otherwise drug-resistant malaria. It’s primary use is in treating lupus. There was some testing done weeks ago to...
Source: David Bradley Sciencebase - Songs, Snaps, Science - May 19, 2020 Category: Science Authors: David Bradley Tags: Health and Medicine Source Type: blogs

COVID-19 and Opening the Country: Lessons from 1918 Philadelphia
By CHADI NABHAN, MD, MBA, FACP Everyone has an opinion on whether and when we should open the country. Never in the history of America have we had so many “correct” theories and experts to pontificate on a new pandemic. But somehow, few seem to recall history or attempt to learn from it. Over a century ago, almost 100 million people out of a world population of 1.8 billion lost their lives to the so-called “Spanish Flu”. At 8.5 million casualties, the death toll from World War I pales in comparison. In the US alone, we lost over 675,000 people in one year to this pandemic. In fact, we lost mor...
Source: The Health Care Blog - May 3, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy Chadi Nabhan Pandemic Philadelphia Spanish Flu Source Type: blogs

No spleen? What you need to know to stay healthy
Due to injury or necessary surgery (splenectomy), some people are lacking a spleen, the organ that filters the bloodstream and helps the body fight infection. You do not need your spleen to live a normal, healthy life. However, since the spleen performs some important tasks, people who do not have one are urged to take certain precautions. What is a spleen? The spleen is a fist-sized organ that sits under your rib cage on the left side of your abdomen. Unlike the stomach, liver, or kidneys, it is not directly connected to the other organs in your abdomen. Instead, the spleen is connected to your blood vessels, with an arte...
Source: Harvard Health Blog - April 24, 2020 Category: Consumer Health News Authors: Elise Merchant, MD Tags: Health Infectious diseases Managing your health care Prevention Vaccines Source Type: blogs

Keeping Kids Healthy in the Age of Coronavirus: Dr. Greene on The People ’ s Pharmacy
Transcript [00:00:00] Joe Graedon: I’m Joe Graedon. [00:00:01] Terry Graedon: And I’m Terry Graedon. Welcome to this podcast of the People’s Pharmacy. [00:00:06] Joe Graedon: You can find previous podcasts and more information on a range of health topics at  [00:00:14] How’s your family holding up during the coronavirus pandemic? Isolation can be especially challenging for children. [00:00:22] This is the People’s Pharmacy with Terry and Joe Graedon. [00:00:33] Terry Graedon:  Children appear less susceptible than older adults to serious complications of COVID-19...
Source: Conversations with Dr Greene - April 21, 2020 Category: Child Development Authors: Alan Greene MD Tags: Dr. Greene's Blog COVID COVID-19 Viral Infection Source Type: blogs

My Experiences with Hydroxychloroquine Urge Caution and Ethical Research into COVID19 Therapies
by Keisha Ray, Ph.D. I take the drug hydroxychloroquine, brand name Plaquenil, for an autoimmune disease. Hydroxychloroquine was once used to treat malaria and is now commonly used to treat a range of inflammatory disorders like lupus and rheumatoid arthritis. If this drug sounds familiar it is likely because it has frequently been in the news as a potential therapy for COVID19. During multiple press conferences the president has touted this drug as a potential cure for COVID19. Medical professionals like Dr.… (Source:
Source: - April 20, 2020 Category: Medical Ethics Authors: Keisha Ray Tags: Ethics Featured Posts Health Care Health Policy & Insurance Human Subjects Research & IRBs Informed Consent Pharmaceuticals Politics Public Health #covid19 #diaryofaplagueyear COVID-19 Source Type: blogs

COVID-19: Hidden Coinfections and Chain Reactions Parasitic Infectious Relationships within Us
By SIMON YU, MD, LT COL, USA (Ret) Dr. Tom Frieden, former director of the Centers for Disease Control and Prevention (CDC), opened up a new front in the Coronavirus War by saying we don’t just need to treat the acute disease, we need to treat the underlying conditions that make people more susceptible to serious disease progression. He focused on heart disease, and managing mitigating risk factors such as CVD, diabetes, hypertension and smoking in order to increase people’s odds for recovery. The initial focus has been pneumonia and acute respiratory distress syndrome (ARDS), with risk factors including ast...
Source: The Health Care Blog - April 15, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 CDC chronic disease holistic care Pandemic SDoH Source Type: blogs

Drugs for COVID-19: A Publishing Epidemic
As of April 9, PubMed listed 2,868 scientific publications which incorporate the word “COVID”.   323 of these (11.3%) were related to drugs under study for treatment of the disease. No fewer than thirty-one such drugs had been proposed since this pandemic first appeared on the planet four months earlier.    Graph 1 depicts the cumulative numbers of COVID-19 infection (per 100,000 global population) and introductions of relevant drugs into the Literature during February 14 to April 3. Note that both increased by a factor of approximately 16-fold during this perio...
Source: GIDEON blog - April 12, 2020 Category: Databases & Libraries Authors: Uri Blackman Tags: Epidemiology Graphs Source Type: blogs

Combating COVID-19 Misinformation with Disassociation
Matthew FeeneyDeadly misinformation spread across social media long before COVID-19 emerged, but amid the ongoing pandemic attempts to tackle such content are once again in the limelight. These efforts provide an opportunity for classical liberals to emphasize the importance of freedom of association and to prepare for discussions about how private institutions handle misinformation amid a  crisis.Too often we think of the freedom of speech to be a  freedom that protects speakers from government censorship. And while the freedom to speak is a necessary condition for a functioning liberal society it&rsqu...
Source: Cato-at-liberty - April 1, 2020 Category: American Health Authors: Matthew Feeney Source Type: blogs

Words of courage for medical students and residents
About 15 years ago, I spent a few weeks at a small community hospital in Zambia, helping to staff the primary care clinic and attend some of the rounds on the small inpatient units there.   The inpatient pediatrics unit was full of young children suffering from malaria or measles, often both.  One particularly stark evening, […]Find jobs at  Careers by  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 30, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="" rel="tag" > Deborah Edberg, MD < /a > < /span > Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs

Podcast: Don ’ t Let Coronavirus Impact Your Mental Health
 It’s often said that fear is the most dangerous virus on the planet. While a relatively small percentage of people will contract the new coronavirus, or COVID-19, the fear it provokes will chip away at the mental health of nearly everyone who hears about it. So why does COVID-19 inspire so much fear when there are other diseases lurking in the shadows? And what can we do about it? In today’s podcast, our guest Dr. David Batman, a registered medical practitioner in the U.K., discusses how this high level of unprecedented global panic is being intensified by the non-stop media, and specifically, social media....
Source: World of Psychology - March 26, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: Anxiety and Panic General Health-related Interview Podcast The Psych Central Show Source Type: blogs

Hydroxychloroquine reduces viral load in COVID-19 patients
Chloroquine (and a derivative, hydroxychloroquine) has been used for years in the treatment of malaria. The drug is also known to block the entry of many viruses into cells. A small clinical trial has revealed it to be effective in reducing viral loads in COVID-19 patients. Entry of enveloped viruses into cells requires fusion of […] (Source: virology blog)
Source: virology blog - March 19, 2020 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antiviral chloroquine coronavirus CoV COVID-19 hydroxychloroquine malaria SARS-CoV-2 viruses Source Type: blogs

Technology and Cooperation Help Fight the Pandemic
Chelsea FollettThe pandemic caused by the new coronavirus (COVID-19) from Wuhan, China, is now a serious and global problem. And that problem has been made even worse by a culture of constant alarmism making it hard to distinguish real threats from exaggerated claims, as the well ‐​known science writer Matt Ridley has pointed out. But even when faced with the genuine threat of a pandemic, there are reasons to take heart and think that humanity will rise to the challenges ahead.First, humanity has never been better prepared technologically to deal with a pandemic. We are fortunate to live in an age o...
Source: Cato-at-liberty - March 13, 2020 Category: American Health Authors: Chelsea Follett Source Type: blogs

Credit Card Sized Diagnostic Lab Plugs into Smartphone
Researchers at the University of Cincinnati have developed a tiny portable diagnostic device that can detect the presence of specific pathogens in a saliva sample, and relay the results to a doctor when plugged into a smartphone. The device can potentially diagnose a wide array of diseases, including malaria, HIV and Lyme disease, and could be useful for point-of-care testing and even self-testing. A custom app can relay the results of tests to one’s doctor for nearly instant diagnostic results. The technology includes single-use plastic chips that a user places in their mouth to load a saliva sample before pluggi...
Source: Medgadget - February 7, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Pathology Psychiatry Source Type: blogs

Two doctors I met in Paris
Not in person, as both are rather historical, but when in Paris, I encountered:Dr Alphonse LaveranandDr Paul GachetDr Laveran has a square named after him, adjacent to the Ecole de Val de Grace, a school of military medicine, where he worked after serving in the army as a physician, and where his father had held the same post.   Paris is good at telling you who a street is named after, so the street sign tells you he was the first French winner of theNobel Prize for Medicine or Physiology.  He won it for identifying both malaria and sleeping sickness as caused by parasites.Dr Gachet has aportrait in the...
Source: Browsing - January 20, 2020 Category: Databases & Libraries Source Type: blogs

Fight Aging! Newsletter, January 20th 2020
This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - January 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Theorizing on Historical Trends in Body Temperature, Burden of Inflammation, and Life Expectancy
In this study, we analyzed 677,423 human body temperature measurements from three different cohort populations spanning 157 years of measurement and 197 birth years. We found that men born in the early 19th century had temperatures 0.59°C higher than men today, with a monotonic decrease of -0.03°C per birth decade. Temperature has also decreased in women by -0.32°C since the 1890s with a similar rate of decline (-0.029°C per birth decade). Although one might posit that the differences among cohorts reflect systematic measurement bias due to the varied thermometers and methods used to obtain temperatures, we...
Source: Fight Aging! - January 17, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Another Candidate for the Micro-Sample Diagnostics Market; CBC Results in Minutes
The Theranos fiasco (see:The rise and fall of Theranos, the blood-testing startup that went from Silicon Valley darling to facing fraud charges) served to cast a pall over the micro-sample diagnostics market. Now comes news about an Israeli company with a similar strategy but this time with an instrument providing a complete blood count (CBC) and a green light from the FDA (see:Unlike Theranos, startup ’s blood test device ‘delivers on promise’ with FDA nod). Below is an excerpt from the article:Israeli startupSight Diagnostics has received US Food and Drug Administration clearance to market a blood ...
Source: Lab Soft News - December 11, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: AI Clinical Lab Testing Diagnostics Food and Drug Administration Healthcare Information Technology Healthcare Innovations Medical Research Point-of-Care Testing Source Type: blogs

Top 10 Technologies We Are Excited About
We cover a lot of news and announcements about digital health technologies to provide context for you. Even within The Medical Futurist team, there are favorite technologies and trends. And we thought it would be time to share the technologies we’re excited about! With advancements in exoskeleton technology, A.I.’s ever-increasing importance in healthcare and technologies like 5G and quantum computing soon going mainstream, there’s much to be excited about! Without further ado, let’s jump in! 1. Quantum Computing: faster, cheaper and safer Late last month, Google claimed “quantum suprema...
Source: The Medical Futurist - December 3, 2019 Category: Information Technology Authors: Prans Tags: Future of Medicine digital health Healthcare technology digital technology Source Type: blogs

Smart Microscope Learns to Diagnose Infectious Diseases
Experienced professionals tend to be better than rookies partly because they know how to use the tools of their trade more effectively. Cytologists who evaluate cells under a microscope become more consistent and accurate when they know how to prep their apparatus to produce clear images. Researchers at Duke University have now given a microscope the capability to intelligently adjust its settings, including the light angles, color, and patterns, to achieve optimal results when classifying healthy and malaria infected red blood cells. The system is designed to address the capabilities of a digital camera, rather than th...
Source: Medgadget - November 22, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Pathology Public Health Source Type: blogs

Climate Change is not an ‘ Equal Opportunity ’ Crisis
Sam Aptekar Phuoc Le By PHUOC LE, MD and SAM APTEKAR In the last fifteen years, we have witnessed dozens of natural disasters affecting our most vulnerable patients, from post-hurricane victims in Haiti to drought and famine refugees in Malawi. The vast majority of these patients suffered from acute on chronic disasters, culminating in life-threatening medical illnesses. Yet, during the course of providing clinical care and comfort, we rarely, if ever, pointed to climate change as the root cause of their conditions. The evidence for climate change is not new, but the movement for climate justice is now emerging on...
Source: The Health Care Blog - October 28, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Medical Practice Patients Climate Change equal opportunity Phuoc Le Sam Aptekar Source Type: blogs

20 Medical Technology Advances: Medicine in the Future – Part II.
Nanorobots swimming in blood vessels, in silico clinical trials instead of experimenting with drugs on animals and people, remote brain surgeries with the help of 5G networks – the second part of our shortlist on some astonishing ideas and innovations that could give us a glimpse into the future of medicine is ready for you to digest. Here, we’re going beyond the first part with medical tricorders, the CRISPR/Cas-9 gene-editing method, and other futuristic medical technologies to watch for. 11) In silico clinical trials against testing drugs on animals As technologies transform every aspect of healthcare,...
Source: The Medical Futurist - October 23, 2019 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence E-Patients Future of Medicine Future of Pharma Genomics Health Sensors & Trackers 3d printing AI bioprinting blockchain clinical trials CRISPR digital digital health drug development genetics Innovat Source Type: blogs

Case of the Week 558
This week's case presents a bit of a conundrum. The patient is a 50 year old woman with recent travel to Kenya. She presents with acute onset of fever and chills and was tested by a rapid malaria antigen test (P. falciparumand Pan-malaria antigens) and was negative. A follow-up Giemsa-stained thin blood smear from the same blood collection shows the following:Identification based on the blood smear? How might this correlate with the rapid antigen test? (Source: Creepy Dreadful Wonderful Parasites)
Source: Creepy Dreadful Wonderful Parasites - August 28, 2019 Category: Parasitology Source Type: blogs

Answer to Case 558
Answer toParasite Case of the Week 558:Plasmodium falciparummalaria,>10% parasitemia. NEGATIVE rapid antigen.Sowhy is the rapid antigen test negative???As noted by our readers, there are many possible reasons for apositive blood smear and negative rapid malaria antigen test (RDT). Here are our options, along with the reasons why each is or isn't a likely explanation in this case:This is babesiosis, and not malaria. This is a very important consideration given the morphologic similarities betweenBabesiaspp. andPlasmodium falciparum.However, the moprhologic features in this case are highly consistent withP. falciparu...
Source: Creepy Dreadful Wonderful Parasites - August 25, 2019 Category: Parasitology Source Type: blogs

Fight Aging! Newsletter, August 12th 2019
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined. Mean nonfasting cholesterol concentration was 72...
Source: Fight Aging! - August 11, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

An Interview with Reason at Undoing Aging 2019
Much of the proceedings at Undoing Aging in Berlin earlier this year were recorded, but of course it takes a few months for everything to process through the queue. I briefly escaped from the conference for an ad hoc, unstructured discussion with Adam Ford of Science, Technology, and the Future, who, like the Life Extension Advocacy Foundation folk, was interviewing as many people as he could during the event. It wound up a monologue on topics that were at the top of my mind at the time, particularly the present state of funding and the transformation of our community from a primary focus on advocacy and academic research ...
Source: Fight Aging! - August 5, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Answer to Case 555 - Parasites and the Number Five
Wow - we received so many excellent comments on how parasites and the number 5 go together! Here are many of them - in no particular order - for your viewing pleasure:Pentatrichomonas hominis is a nonpathogenic intestinal flagellate named for its 5 flagella (penta from the Greek pente, meaning five + trich, pertaining to hair [flagella]). By Neil Anderson and Bernardino Rocha.There are 5 lobes of the lung, and all can be infected by Paragonimusspecies. By Brian Duresko.The are 5Plasmodiumspecies that are responsible for the bulk of malaria in humans:P. falciparum, P. vivax, P. ovale, P. malariae, andP. knowlesi(t...
Source: Creepy Dreadful Wonderful Parasites - August 1, 2019 Category: Parasitology Source Type: blogs

Digital Health And The Ebola Epidemic: How Not To Let It Go Viral
More than 1,500 deaths and 2,500 people sickened – that’s the recent account of the ebola outbreak in the Democratic Republic of Congo (DRC) raging in the country since last August, and recently declared a public health emergency of international concern. Experts say efforts to contain the virus are hindered by biological, public health, political, and cultural issues, but we looked around what digital health technologies could do to mitigate the spread and the devastation of the infectious disease. The Spaghetti-like virus… The lethal Ebola virus first appeared in 1976 around a river in Congo &nda...
Source: The Medical Futurist - August 1, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine Africa AI artificial intelligence Congo digital digital health digital maps disease disease outbreak ebola epidemic Innovation technology Source Type: blogs

Answer to Case 554
Answer to Parasite Case of the Week 554:Babesiaspecies. Without a travel history, the differential diagnosis includesPlasmodium falciparummalaria given that only ring forms are seen and there is a high parasitemia; however, the following features are supportive of babesiosis:1. Multiple (4) small forms within a single cell that are not a clear schizont form ofPlasmodium.2. Easily-identified extracellular forms.3. Lack of malaria pigmentAs Blaine mentioned, the rings are not thin and delicate as would normally be seen withP. falciparuminfection. While thicker rings are commonly seen in'older'blood (i.e., blood that was>2...
Source: Creepy Dreadful Wonderful Parasites - July 29, 2019 Category: Parasitology Source Type: blogs

How Could Digital Health Fight Against The Climate Catastrophe?
Climate change is the greatest health challenge of the 21st century, and threatens all aspects of society, says the WHO in its COP24 Special Report. What could digital health technologies do to support the fight against the climate crisis? How could healthcare processes, facilities, medical devices become more sustainable? As it is humanity’s priority to mitigate the worsening as well as the impact of rising temperatures and extreme weather events, we tried to figure out what role digital health could assume here. We found many options – and even more possibilities for future development. The climate crisis...
Source: The Medical Futurist - July 11, 2019 Category: Information Technology Authors: nora Tags: Future of Medicine air asthma climate climate catastrophe climate change climate crisis digital digital health efficient Healthcare mosquito optimize resilience solar sustainability technology Source Type: blogs

Low Cost Medical Devices for Low-Resource Regions: Interview with Prof. Saad Bhamla, Georgia Tech
Advances in medical technology continue apace, with sophisticated new medical devices and therapies becoming available on an ongoing basis. However, medical technology often comes at a premium, and for low-resource regions sometimes even relatively basic medical devices, such as hearing aids, are inaccessible because they are too expensive. Similarly, basic equipment, such as centrifuges, that are commonly used in diagnostic or medical research laboratories can cost a lot, making it unaffordable for laboratories in many countries and institutions.    These barriers to using tools commonly available elsewhere a...
Source: Medgadget - July 1, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Critical Care Diagnostics Emergency Medicine ENT Exclusive Genetics Materials Pathology Public Health Source Type: blogs

Microfluidic Impedance Sensor Can Monitor Sickle Cell Disease
Researchers at Florida Atlantic University have developed a microfluidic chip that can rapidly assess blood samples from sickle cell disease patients to help monitor the disease. The technique is much faster and more convenient than traditional optical microscopy assessments. Sickle cell disease affects approximately 100,000 individuals in the U.S. and millions of people throughout the world. Red blood cells in those affected become misshapen (forming a “sickle” shape) and sticky, and can block blood flow and break down. This can lead to a variety of serious symptoms, such as organ failure, stroke, and severe p...
Source: Medgadget - June 14, 2019 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Source Type: blogs

Funtabulously Frivolous Friday Five 280
Michelle Johnston Funtabulously Frivolous Friday Five 280 Michelle Johnston tosses away the papyrus and pulls out the parchment in this week's Funtabulously Frivolous Friday Five on the subject of Shakespeare and Medicine. (Source: Life in the Fast Lane)
Source: Life in the Fast Lane - May 17, 2019 Category: Emergency Medicine Authors: Michelle Johnston Tags: FFFF Literary Medicine Ague Julius Caesar King's Evil malaria Shakespeare Tetter Thersites William Shakespeare Source Type: blogs

Our Visit to WIRED Health 2019 at London ’s Francis Crick Institute
WIRED Health, now in its sixth year, returned to London’s Francis Crick Institute. The event was opened by Crick Institute director Paul Nurse who introduced the institute and its mission to understand the fundamental biology of human health and disease. The team at the Crick, consisting of 1500 researchers and three Nobel Prize winners, make up Europe’s largest biomedical research facility with an already impressive slate of research, despite being only two years old. The theme of WIRED Heath and the venue’s vision was perfectly summarized by Sir Paul, who closed his address with the charge “f...
Source: Medgadget - April 2, 2019 Category: Medical Devices Authors: Tom Peach Tags: Exclusive Medicine Public Health Society Source Type: blogs

Fight Aging! Newsletter, January 28th 2019
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - January 27, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Effective Altruism and Effective Research for Human Longevity
The effective altruism movement is a good example of the sort of thing that can only arise in the modern information-rich environment of easily available data and cheap communication. It is half a reaction against the waste, fraud, and general ineffectiveness that characterizes all too much large-scale philanthropy, and half a chance to meaningfully reexamine what everyday philanthropy can look like in an age of greater communication and knowledge. It is easy to salve the conscience by donating to a group that one believes are going to do good, and most people go no further than this. That allows charities to become ineffi...
Source: Fight Aging! - January 24, 2019 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs

Evidence-Based Satire
By SAURABH JHA Sequels generally disappoint. Jason couldn’t match the fear he generated in the original Friday the 13th. The sequel to the Parachute, a satirical piece canvassing PubMed for randomized controlled trials (RCTs) comparing parachutes to placebo, matched its brilliance, and even exceeded it, though the margin can’t be confirmed with statistical significance. The Parachute, published in BMJ’s Christmas edition, will go down in history with Jonathan Swift’s Modest Proposal and Frederic Bastiat’s Candlemakers’ Petition as timeless satire in which pedagogy punched above, indeed d...
Source: The Health Care Blog - December 22, 2018 Category: Consumer Health News Authors: at RogueRad Tags: OP-ED RogueRad Source Type: blogs

Top Digital Health Stories of 2018: From Amazon And Google To Gene-Edited Babies
Instead of mind-boggling inventions, 2018 was the year when national governments, as well as healthcare regulators, started to embrace digital health technologies at scale. The year when Google, Amazon, Apple or Microsoft competed head-to-head for the biggest chunks on the healthcare market, and when the buzzword of the year award went to the blockchain. Here’s our guide to the top digital health stories from last year. 2018: Under the spell of cosmos and microcosmos Every year, The Medical Futurist team sits down and collects the top stories of the past 12 months in healthcare. We put the novelties under the microsc...
Source: The Medical Futurist - December 11, 2018 Category: Information Technology Authors: nora Tags: Business Future of Medicine Medical Professionals Patients Policy Makers Researchers Top Lists 2018 AI artificial intelligence artificial pancreas blockchain chatbot CRISPR deep learning diabetes digital health digital he Source Type: blogs