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Malaria infection and predictor factors among Chadian nomads' children
CONCLUSIONS: Malaria remains a significant public health issue in the nomadic communities of Chad. Community education and sensitization programs within nomad communities are recommended to raise awareness about malaria transmission and control methods, particularly among those living in remote rural areas. The National Malaria Control Program (NMCP) should increase both the coverage and use of long-lasting insecticidal nets (LLINs) and seasonal malaria chemoprevention (SMC) in addition to promoting treatment-seeking behaviors in nomadic communities.PMID:38549091 | DOI:10.1186/s12889-024-18454-5 (Source: Rural Remote Health)
Source: Rural Remote Health - March 29, 2024 Category: Rural Health Authors: Azoukaln é Moukénet Kebfene Moudin é Ngarkodje Ngarasta Clement Kerah Hinzoumbe Ibrahima Seck Source Type: research

Effect of Malaria and Schistosoma mansoni Coinfection on Selected Biochemical Profiles among Patients Attending Selected Health Institutions at Dembiya, Northwest Ethiopia
CONCLUSION: Biochemical profiles in coinfection were significantly changed as compared to healthy individuals. As a result, biochemical profile tests should be utilized to monitor and manage coinfection-related problems, as well as to reduce coinfection-related morbidity and death.PMID:38549565 | PMC:PMC10978076 | DOI:10.1155/2024/9992233 (Source: Journal of Tropical Medicine)
Source: Journal of Tropical Medicine - March 29, 2024 Category: Tropical Medicine Authors: Wagaw Abebe Wossenseged Lemma Yalewayker Tegegne Amare Mekuanint Abebe Yenesew Adane Derso Source Type: research

Malaria infection and predictor factors among Chadian nomads' children
CONCLUSIONS: Malaria remains a significant public health issue in the nomadic communities of Chad. Community education and sensitization programs within nomad communities are recommended to raise awareness about malaria transmission and control methods, particularly among those living in remote rural areas. The National Malaria Control Program (NMCP) should increase both the coverage and use of long-lasting insecticidal nets (LLINs) and seasonal malaria chemoprevention (SMC) in addition to promoting treatment-seeking behaviors in nomadic communities.PMID:38549091 | PMC:PMC10979592 | DOI:10.1186/s12889-024-18454-5 (Source: Rural Remote Health)
Source: Rural Remote Health - March 29, 2024 Category: Rural Health Authors: Azoukaln é Moukénet Kebfene Moudin é Ngarkodje Ngarasta Clement Kerah Hinzoumbe Ibrahima Seck Source Type: research

Assessment of Culicidae collection methods for xenomonitoring lymphatic filariasis in malaria co-infection context in Burkina Faso
Conclusions/SignificanceThis study revealed that HLC indoor and outdoor remained the most effective collection method. Likewise, the results showed the probability to use Window Exit-Trap and PSC collection methods to sampleAnopheles infected. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 29, 2024 Category: Tropical Medicine Authors: Sanata Coulibaly Source Type: research

Efficacy of artesunate-amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in mainland Tanzania
Diversification of artemisinin-based combination therapy (ACT) is suggested as one of the strategies that can be used to contain artemisinin resistance. Artesunate-amodiaquine (ASAQ) is one of the artemisinin-... (Source: Malaria Journal)
Source: Malaria Journal - March 29, 2024 Category: Infectious Diseases Authors: Billy Ngasala, Samwel Bushukatale, Mercy Chiduo, Twilumba Makene, Lilian Mkony, Ally Mohamed, Fablizio Molteni, Frank Chacky, Ritha J. A. Njau and Richard Mwaiswelo Tags: Research Source Type: research

Optimizing malaria vector control in the Greater Mekong Subregion: a systematic review and mathematical modelling study to identify desirable intervention characteristics
In the Greater Mekong Subregion (GMS), new vector-control tools are needed to target mosquitoes that bite outside during the daytime and night-time to advance malaria elimination. (Source: Parasites and Vectors)
Source: Parasites and Vectors - March 29, 2024 Category: Microbiology Authors: Yuqian Wang, Nakul Chitnis and Emma L. Fairbanks Tags: Research Source Type: research

Population-specific variations in KCNH2 predispose patients to delayed ventricular repolarization upon dihydroartemisinin-piperaquine therapy
Antimicrob Agents Chemother. 2024 Mar 28:e0139023. doi: 10.1128/aac.01390-23. Online ahead of print.ABSTRACTDihydroartemisinin-piperaquine is efficacious for the treatment of uncomplicated malaria and its use is increasing globally. Despite the positive results in fighting malaria, inhibition of the Kv11.1 channel (hERG; encoded by the KCNH2 gene) by piperaquine has raised concerns about cardiac safety. Whether genetic factors could modulate the risk of piperaquine-mediated QT prolongations remained unclear. Here, we first profiled the genetic landscape of KCNH2 variability using data from 141,614 individuals. Overall, we ...
Source: Antimicrobial Agents and Chemotherapy - March 28, 2024 Category: Microbiology Authors: Mahamadou D Camara Yitian Zhou Antoine Dara Mamadou M T ékété Ta ís Nóbrega de Sousa S ékou Sissoko Laurent Demb élé Nouhoun Ouologuem Amadou Hamidou Togo Mohamed L Alhousseini Bakary Fofana Issaka Sagara Abdoulaye A Djimde Pedro J Gil Volker M La Source Type: research

Cancers, Vol. 16, Pages 1321: Antineoplastic Drug Synergy of Artesunate with Navitoclax in Models of High-Grade Serous Ovarian Cancer
M. Kolesar Artesunate belongs to a class of medications derived from the sweet wormwood plant (Artemisia annua) known as artemisinins. Artesunate has traditionally been used as a frontline treatment for severe malaria but has also demonstrated antineoplastic activity against various malignancies, including ovarian cancer. Data suggest that artesunate exacerbates cellular oxidative stress, triggering apoptosis. In the current study, we investigated the ability of navitoclax, an inhibitor of the antiapoptotic Bcl-2 protein family, to enhance artesunate efficacy in ovarian cancer cells. Artesunate and navitoclax both dem...
Source: Cancers - March 28, 2024 Category: Cancer & Oncology Authors: J. Robert McCorkle Rebecca Ahn Connie D. Cao Kristen S. Hill Charles S. Dietrich Jill M. Kolesar Tags: Article Source Type: research

Characterisation of the merozoite thrombospondin related anonymous protein (MTRAP) of Plasmodium berghei as a transmission-blocking antigen
CONCLUSION: Our results indicate that antibodies to PbMTRAP may reduce but are not sufficient to completely block transmission.PMID:38537036 | DOI:10.1590/0074-02760230217 (Source: Memorias do Instituto Oswaldo Cruz)
Source: Memorias do Instituto Oswaldo Cruz - March 27, 2024 Category: Infectious Diseases Authors: Xiomara Alexandra Gait án Juliana Calit Irina Dobrescu Maris é Solórzano Ramos Alba Marina Gimenez Daniel Youssef Bargieri Source Type: research