Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein
In this study, we combined structural elements from the different aryl acetamide hit subtypes and explored the structure-activity relationship. It was shown that the inclusion of an endocyclic nitrogen, to generate the tool compound WJM-715, improved aqueous solubility and modestly improved metabolic stability in rat hepatocytes. Metabolic stability in human liver microsomes remains a challenge for future development of the aryl acetamide class, which was underscored by modest systemic exposure and a short half-life in mice. The optimized aryl acetamide analogs were cross resistant to parasites with mutations in PfSTART1, ...
Source: European Journal of Medicinal Chemistry - March 30, 2024 Category: Chemistry Authors: William Nguyen Coralie Boulet Madeline G Dans Katie Loi Kate E Jarman Gabrielle M Watson Wai-Hong Tham Kate J Fairhurst Tomas Yeo David A Fidock Sergio Wittlin Mrittika Chowdury Tania F de Koning-Ward Gong Chen Dandan Yan Susan A Charman Delphine Baud Ste Source Type: research
Ready for Renascence in Mosquito: The Regulation of Gene Expression in Plasmodium Sexual Development
Acta Trop. 2024 Mar 28:107191. doi: 10.1016/j.actatropica.2024.107191. Online ahead of print.ABSTRACTMalaria remains one of the most perilous vector-borne infectious diseases for humans globally. Sexual gametocyte represents the exclusive stage at which malaria parasites are transmitted from the vertebrate to the Anopheles host. The most effective approach to prevent malaria transmission is by addressing the sexual developmental processes, that is, gametocytogenesis and gametogenesis. Thus, this review will comprehensively cover advances in the regulation of gene expression surrounding the transmissible stages, including e...
Source: Acta Tropica - March 30, 2024 Category: Infectious Diseases Authors: Cong Liu Jingjing Tang Kejia Liang Peng Liu Zhenkui Li Source Type: research
Ready for renascence in mosquito: The regulation of gene expression in Plasmodium sexual development
Acta Trop. 2024 Mar 28;254:107191. doi: 10.1016/j.actatropica.2024.107191. Online ahead of print.ABSTRACTMalaria remains one of the most perilous vector-borne infectious diseases for humans globally. Sexual gametocyte represents the exclusive stage at which malaria parasites are transmitted from the vertebrate to the Anopheles host. The feasible and effective approach to prevent malaria transmission is by addressing the sexual developmental processes, that is, gametocytogenesis and gametogenesis. Thus, this review will comprehensively cover advances in the regulation of gene expression surrounding the transmissible stages,...
Source: Acta Tropica - March 30, 2024 Category: Infectious Diseases Authors: Cong Liu Jingjing Tang Kejia Liang Peng Liu Zhenkui Li Source Type: research
Receipt of seasonal malaria chemoprevention by age-ineligible children and associated factors in nine implementation states in Nigeria
As part of implementation quality standards, community distributors are expected to ensure that only age-eligible children (aged 3 –59 months) receive seasonal malaria chemoprevention (SMC) medicines during mon... (Source: Malaria Journal)
Source: Malaria Journal - March 30, 2024 Category: Infectious Diseases Authors: Taiwo Ibinaiye, Kunle Rotimi, Ayodeji Balogun, Adaeze Aidenagbon, Chibuzo Oguoma, Christian Rassi, Kevin Baker, Olusola Oresanya and Chuks Nnaji Tags: Research Source Type: research
Malaria infection and predictor factors among Chadian nomads' children
CONCLUSIONS: Malaria remains a significant public health issue in the nomadic communities of Chad. Community education and sensitization programs within nomad communities are recommended to raise awareness about malaria transmission and control methods, particularly among those living in remote rural areas. The National Malaria Control Program (NMCP) should increase both the coverage and use of long-lasting insecticidal nets (LLINs) and seasonal malaria chemoprevention (SMC) in addition to promoting treatment-seeking behaviors in nomadic communities.PMID:38549091 | DOI:10.1186/s12889-024-18454-5 (Source: Rural Remote Health)
Source: Rural Remote Health - March 29, 2024 Category: Rural Health Authors: Azoukaln é Moukénet Kebfene Moudin é Ngarkodje Ngarasta Clement Kerah Hinzoumbe Ibrahima Seck Source Type: research
Effect of Malaria and < em > Schistosoma mansoni < /em > Coinfection on Selected Biochemical Profiles among Patients Attending Selected Health Institutions at Dembiya, Northwest Ethiopia
CONCLUSION: Biochemical profiles in coinfection were significantly changed as compared to healthy individuals. As a result, biochemical profile tests should be utilized to monitor and manage coinfection-related problems, as well as to reduce coinfection-related morbidity and death.PMID:38549565 | PMC:PMC10978076 | DOI:10.1155/2024/9992233 (Source: Journal of Tropical Medicine)
Source: Journal of Tropical Medicine - March 29, 2024 Category: Tropical Medicine Authors: Wagaw Abebe Wossenseged Lemma Yalewayker Tegegne Amare Mekuanint Abebe Yenesew Adane Derso Source Type: research
Malaria infection and predictor factors among Chadian nomads' children
CONCLUSIONS: Malaria remains a significant public health issue in the nomadic communities of Chad. Community education and sensitization programs within nomad communities are recommended to raise awareness about malaria transmission and control methods, particularly among those living in remote rural areas. The National Malaria Control Program (NMCP) should increase both the coverage and use of long-lasting insecticidal nets (LLINs) and seasonal malaria chemoprevention (SMC) in addition to promoting treatment-seeking behaviors in nomadic communities.PMID:38549091 | PMC:PMC10979592 | DOI:10.1186/s12889-024-18454-5 (Source: Rural Remote Health)
Source: Rural Remote Health - March 29, 2024 Category: Rural Health Authors: Azoukaln é Moukénet Kebfene Moudin é Ngarkodje Ngarasta Clement Kerah Hinzoumbe Ibrahima Seck Source Type: research
Effect of Malaria and < em > Schistosoma mansoni < /em > Coinfection on Selected Biochemical Profiles among Patients Attending Selected Health Institutions at Dembiya, Northwest Ethiopia
CONCLUSION: Biochemical profiles in coinfection were significantly changed as compared to healthy individuals. As a result, biochemical profile tests should be utilized to monitor and manage coinfection-related problems, as well as to reduce coinfection-related morbidity and death.PMID:38549565 | PMC:PMC10978076 | DOI:10.1155/2024/9992233 (Source: Journal of Tropical Medicine)
Source: Journal of Tropical Medicine - March 29, 2024 Category: Tropical Medicine Authors: Wagaw Abebe Wossenseged Lemma Yalewayker Tegegne Amare Mekuanint Abebe Yenesew Adane Derso Source Type: research
Assessment of < i > Culicidae < /i > collection methods for xenomonitoring lymphatic filariasis in malaria co-infection context in Burkina Faso
Conclusions/SignificanceThis study revealed that HLC indoor and outdoor remained the most effective collection method. Likewise, the results showed the probability to use Window Exit-Trap and PSC collection methods to sampleAnopheles infected. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 29, 2024 Category: Tropical Medicine Authors: Sanata Coulibaly Source Type: research
Efficacy of artesunate-amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in mainland Tanzania
Diversification of artemisinin-based combination therapy (ACT) is suggested as one of the strategies that can be used to contain artemisinin resistance. Artesunate-amodiaquine (ASAQ) is one of the artemisinin-... (Source: Malaria Journal)
Source: Malaria Journal - March 29, 2024 Category: Infectious Diseases Authors: Billy Ngasala, Samwel Bushukatale, Mercy Chiduo, Twilumba Makene, Lilian Mkony, Ally Mohamed, Fablizio Molteni, Frank Chacky, Ritha J. A. Njau and Richard Mwaiswelo Tags: Research Source Type: research
Optimizing malaria vector control in the Greater Mekong Subregion: a systematic review and mathematical modelling study to identify desirable intervention characteristics
In the Greater Mekong Subregion (GMS), new vector-control tools are needed to target mosquitoes that bite outside during the daytime and night-time to advance malaria elimination. (Source: Parasites and Vectors)
Source: Parasites and Vectors - March 29, 2024 Category: Microbiology Authors: Yuqian Wang, Nakul Chitnis and Emma L. Fairbanks Tags: Research Source Type: research
