Genomic Surveillance and Characterization of Microbial Threats Facilitates Early Detection and Containment of Disease Outbreaks in West Africa.
Dr. Christian Happy, has the expertise and skills, leadership and motivation necessary to successfully conduct and oversee health research projects in West Africa. He has a broad background in molecular biology and genomics with application in infectious diseases, including malaria, Lassa fever, Ebola virus disease and HIV. Of his career accomplishments to date, the most meaningful was my use of genomics technologies for early diagnosis and confirmation (within 6 hours) of Ebola virus disease (EVD) in Nigeria. This singular action was major in containing EVD in Nigeria, and therefore saving millions of lives in Africa. Thi...
Source: Videocast - All Events - July 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: Exploring the link between Sickle Cell, α -Thalassemia, P Falciparum Malaria and Burkitt Lymphoma in Africa
Sam Mbulaiteye, MBChB, M.Phil., M.Med. Senior Investigator Infections and Immunoepidemiology Branch Division of Cancer Epidemiology and Genetics (DCEG) National Cancer Institute, NCI and Swee Lay Thein, B.S., F.R.C.P., F.R.C.Path., D.Sc., FMedSci Chief, Laboratory of Sickle Cell Genetics and Pathophysiology Chief, Sickle Cell Branch National Heart, Lung, and Blood Institute, NHLBIFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 5/10/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 8, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA Immunology Interest Group 1.11.23
Klaus Fr ü h ’ s research focuses on understanding the molecular interaction between viral pathogens and their hosts, particularly the identification and characterization of viral gene products that modulate the innate and adaptive immune responses. This knowledge is translated into the development and improvement of cytomegalovirus (CMV)-vectored vaccines which are unique in their ability to persistently maintain an immune shield of so called effector memory T cells, including highly unconventional (MHC-II and MHC-E) restricted CD8+ T cells. CMV vectored vaccines have shown protection in non-human primate models of AID...
Source: Videocast - All Events - December 13, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Clinical Center Grand Rounds: Contemporary Clinical Medicine: Great Teachers - The Pathogenesis of Pediatric Cerebral Malaria: An Ongoing Story of Serendipity and Surprises
Clinical Center Grand Rounds: Contemporary Clinical Medicine: Great TeachersFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 10/12/2022 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 7, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Neurobiology of the World ’ s Most Dangerous Animal
This is an NIH Director's Lecture. Speaker Leslie Vosshall is interested in the molecular neurobiology of mosquito host-seeking behavior. Female mosquitoes require a blood meal to complete egg development. In carrying out this innate behavior, mosquitoes spread dangerous infectious diseases such as malaria, dengue, Zika, Chikungunya, and yellow fever. Humans attract mosquitoes via multiple sensory cues including emitted body odor, heat, and carbon dioxide in the breath. The mosquito perceives differences in these cues, both between and within species, to determine which animal or human to target for blood-feeding. We have ...
Source: Videocast - All Events - November 26, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Malaria parasites growing inside an infected red blood cell
(blue) will eventually burst out in unison, with millions of other parasites lurking in red blood cells around them, a feat of timing that's coordinated by the parasite’s internal clock.
[Research supported by a U.S. National Science ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - July 21, 2020 Category: Science Source Type: video
IIG Seminar: Defining malaria vaccine responses by single B cell IG sequencing and plasma IgG proteomics
IIG Seminar
Malaria elimination is a global priority and WHO has projected that malaria deaths could double due to COVID19-related health care disruptions. Vaccines have been pivotal for campaigns to eliminate or eradicate other infectious diseases. Malaria transmission blocking vaccines (TBVs) target surface antigens expressed by parasites during their development in mosquitoes in order to interrupt transmission and contribute to malaria elimination. We collected antigen-specific memory B cells from Malian adults immunized with TBV and obtained B cell receptor IG sequences that were used to define the antibody repertoire ...
Source: Videocast - All Events - June 15, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Experimental Blood Stage Infection to Study Malaria and 2) Progress on Malaria Vaccines
For more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 4/22/2020 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - March 30, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Director's Seminar: Unraveling the mechanisms of immunity to malaria
NIH Director's Seminar Series
Approximately 500 million cases of P. falciparum malaria occur annually among the world ’ s poorest populations, claiming the lives of nearly a million children each year in Africa alone. The development of a malaria vaccine is widely viewed as a key step toward malaria control and possibly eradication, yet current malaria vaccine candidates confer only partial, short-lived protection at best. Optimism that a highly effective malaria vaccine can be developed stems in part from the observation that humans can acquire immunity to malaria through repeated P. falciparum infections. However, the...
Source: Videocast - All Events - January 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Some plumped-up prawns are doing their part to help curtail the spread of disease
New research provides a roadmap for how entrepreneurs can harness freshwater prawns' voracious appetite for snails to reduce the transmission of parasites that cause schistosomiasis -- the second most devastating parasitic disease worldwide, after malaria -- while still making a profit selling the ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - August 9, 2019 Category: Science Source Type: video
CC Grand Rounds: 1) Update on Malaria Vaccines and 2) Chemoprophylaxis Vaccination (PfSPZ-CVac) Using Pyrimethamine
CC Grand Rounds: 1) Update on Malaria Vaccines and 2) Pyrimethamine Chemoprophylaxis (PfSPZ-CVac): A Novel Whole Sporozoite Malaria Vaccine ApproachFor more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 1/16/2019 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 14, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
CC Grand Rounds: 1) Update on Malaria Vaccines and 2) Pyrimethamine Chemoprophylaxis (PfSPZ-CVac): A Novel Whole Sporozoite Malaria Vaccine Approach
For more information go tohttp://www.cc.nih.gov/about/news/grcurrent.htmlAir date: 1/16/2019 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - December 18, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Sounding the Alarm and Putting Out the Fire: New Mechanistic Insights into Inflammation Triggered by Invasive Infection
NIH Director ’ s Wednesday Afternoon Lecture Series
The Lieberman laboratory studies cytotoxic T lymphocytes and their role in infection and tumor immunity. They study the molecular pathways used by killer lymphocytes and their cytotoxic granule proteases, called granzymes, and pore-forming proteins, perforin and granulysin, to induce programmed cell death. They have defined a caspase-independent programmed cell death pathway activated by granzyme A. Recent work has identified an unexpected role for granzymes and granulysin in protection against bacteria and parasites. They recently uncovered the molecular basis for infl...
Source: Videocast - All Events - May 23, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
A cheaper, easier way to test for malaria
For many in sub-saharan Africa, finding out if a fever is due to Malaria often means trekking long miles to a clinic for a relatively pricey blood test, and anxious hours of waiting before the results come in. But the Urine Malaria Test kit developed by Fyodor Biotechnologies has begun to change ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - April 25, 2018 Category: Science Source Type: video
Mosquito Multipartite Interactions in the Fight Against Arboviruses
This event is a Stadtman Candidate Seminar in the field of Vector Biology presented by Dr. Jos é Luis Ramirez entitled “ Understanding Mosquito Multipartite Interactions in the Fight Against Arboviruses. ” This seminar is hosted by the Laboratory of Malaria and Vector Research (LMVR), Division of Intramural Research (DIR), NIAID.Air date: 2/2/2018 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - January 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
