Performance Evaluation of Malaria Pf/Pv Combo Test Kit at Highly Malaria-Endemic Area, Southern Ethiopia: A Cross-Sectional Study.
Conclusion: The overall performance of the kit was below the WHO standard. Further study on a large sample size is recommended to be carried out in the study area to use the test kit instead of microscopy for malaria diagnosis. Providing training on quality malaria laboratory diagnosis and availing necessary supplies for malaria diagnosis shall also be considered. PMID: 32963553 [PubMed] (Source: Journal of Tropical Medicine)
Source: Journal of Tropical Medicine - September 25, 2020 Category: Tropical Medicine Tags: J Trop Med Source Type: research

Retraction notice to <“Artemisia annua and Artemisia afra tea infusions vs. artesunate-amodiaquine (ASAQ) in treating Plasmodium falciparum malaria in a large scale, double blind, randomized clinical trial”> <[PHYTOMEDICINE 57C (2019) 49–56]>
Publication date: Available online 21 September 2020Source: PhytomedicineAuthor(s): Jérôme Munyangi, Lucile Cornet-Vernet, Michel Idumbo, Chen Lu, Pierre Lutgen, Christian Perronne, Nadège Ngombe, Jacques Bianga, Bavon Mupenda, Paul Lalukala, Guy Mergeai, Dieudonné Mumba, Melissa Towler, Pamela Weathers (Source: Phytomedicine)
Source: Phytomedicine - September 24, 2020 Category: Drugs & Pharmacology Source Type: research

Leveraging Computational Modeling to Understand Infectious Diseases
We present advances in modeling techniques that have led to fundamental disease discoveries and impacted clinical translation.Recent FindingsCombining mechanistic models and machine learning algorithms has led to improvements in the treatment ofShigella and tuberculosis through the development of novel compounds. Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the i...
Source: Current Pathobiology Reports - September 24, 2020 Category: Laboratory Medicine Source Type: research

Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia
Publication date: 22 September 2020Source: Cell Reports, Volume 32, Issue 12Author(s): Guoyue Xu, Rebekah van Bruggen, Christian O. Gualtieri, Neda Moradin, Adrien Fois, Diane Vallerand, Mariana De Sa Tavares Russo, Angelia Bassenden, Wenyun Lu, Mifong Tam, Sylvie Lesage, Hélène Girouard, Daina Zofija Avizonis, Geneviève Deblois, Josef T. Prchal, Mary Stevenson, Albert Berghuis, Tom Muir, Joshua Rabinowitz, Silvia M. Vidal (Source: Cell Reports)
Source: Cell Reports - September 23, 2020 Category: Cytology Source Type: research

Stratifying malaria receptivity in Bangladesh using archived rapid diagnostic tests
Surveillance of low-density infections and of exposure to vectors is crucial to understand where malaria elimination might be feasible, and where the risk of outbreaks is high. Archived rapid diagnostic tests ... (Source: Malaria Journal)
Source: Malaria Journal - September 23, 2020 Category: Infectious Diseases Authors: Andr é Barembaye Sagna, Mohammad Golam Kibria, Shamsun Naher, Shayla Islam, M. M. Aktaruzzaman, Mohammad Shafiul Alam and Cristian Koepfli Tags: Research Source Type: research

Viruses, Vol. 12, Pages 1062: A Sporadic and Lethal Lassa Fever Case in Forest Guinea, 2019
uraffour Elisabeth Fichet-Calvet Lassa fever is a rodent-borne disease caused by Lassa virus (LASV). It causes fever, dizziness, vertigo, fatigue, coughing, diarrhea, internal bleeding and facial edema. The disease has been known in Guinea since 1960 but only anectodical acute cases have been reported to date. In January 2019, a 35-year-old man, a wood merchant from Kissidougou, Forest Guinea, presented himself at several health centers with persistent fever, frequent vomiting and joint pain. He was repeatedly treated for severe malaria, and died three weeks later in Mamou regional hospital. Differential diagnosis id...
Source: Viruses - September 23, 2020 Category: Virology Authors: N ’Faly Magassouba Enogo Koivogui Sory Conde Moussa Kone Michel Koropogui Barr è Soropogui Ifono Kekoura Julia Hinzmann Stephan G ünther Sakoba Keita Sophie Duraffour Elisabeth Fichet-Calvet Tags: Article Source Type: research

Impact of sugarcane irrigation on malaria vector Anopheles mosquito fauna, abundance and seasonality in Arjo-Didessa, Ethiopia
This study aimed to evaluate the impac... (Source: Malaria Journal)
Source: Malaria Journal - September 22, 2020 Category: Infectious Diseases Authors: Assalif Demissew, Dawit Hawaria, Solomon Kibret, Abebe Animut, Arega Tsegaye, Ming-Cheih Lee, Guiyun Yan and Delenasaw Yewhalaw Tags: Research Source Type: research

Correction to: N6 ‑Adenosine methylation on mRNA is recognized by YTH2 domain protein of human malaria parasite Plasmodium falciparum
An amendment to this paper has been published and can be accessed via the original article. (Source: Epigenetics and Chromatin)
Source: Epigenetics and Chromatin - September 22, 2020 Category: Genetics & Stem Cells Authors: Gayathri Govindaraju, Rajashekar Varma Kadumuri, Devadathan Valiyamangalath Sethumadhavan, C. A. Jabeena, Sreenivas Chavali and Arumugam Rajavelu Tags: Correction Source Type: research

Prevalence of and risk factors for severe malaria caused by Plasmodium and dengue virus co-infection: a systematic review and meta-analysis
ConclusionsThe present study found that there was a high prevalence of severe malaria among patients withPlasmodium and DENV co-infection. Physicians in endemic areas where these two diseases overlap should recognize that patients with this co-infection can develop either severe malaria or severe dengue with bleeding complications, but a greater risk of developing severe dengue than severe malaria was noted in patients with this co-infection.Trial registrationThe protocol of this study was registered at PROSPERO:CRD42020196792. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - September 22, 2020 Category: Infectious Diseases Source Type: research

Non-malarial febrile illness: a systematic review of published aetiological studies and case reports from Southern Asia and South-eastern Asia, 1980 –2015
In the absence of definitive diagnosis, healthcare providers are likely to prescribe empirical antibacterials to those who test negative for malaria. This problem is of critical importance in Southern Asia (SA... (Source: BMC Medicine)
Source: BMC Medicine - September 21, 2020 Category: Internal Medicine Authors: Poojan Shrestha, Prabin Dahal, Chinwe Ogbonnaa-Njoku, Debashish Das, Kasia Stepniewska, Nigel V. Thomas, Heidi Hopkins, John A. Crump, David Bell, Paul N. Newton, Elizabeth A. Ashley and Philippe J. Gu érin Tags: Research article Source Type: research

When fever is not malaria in Latin America: a systematic review
In malaria-endemic countries, febrile episodes caused by diseases other than malaria are a growing concern. However, limited knowledge of the prevalent etiologic agents and their geographic distributions restr... (Source: BMC Medicine)
Source: BMC Medicine - September 21, 2020 Category: Internal Medicine Authors: Jos é Moreira, Janaina Barros, Oscar Lapouble, Marcus V. G. Lacerda, Ingrid Felger, Patricia Brasil, Sabine Dittrich and Andre M. Siqueira Tags: Research article Source Type: research

Non-malarial febrile illness: a systematic review of published aetiological studies and case reports from Africa, 1980 –2015
The availability of reliable point-of-care tests for malaria has heralded a paradigm shift in the management of febrile illnesses away from presumptive antimalarial therapy. In the absence of a definitive diag... (Source: BMC Medicine)
Source: BMC Medicine - September 21, 2020 Category: Internal Medicine Authors: Jeanne Elven, Prabin Dahal, Elizabeth A. Ashley, Nigel V. Thomas, Poojan Shrestha, Kasia Stepniewska, John A. Crump, Paul N. Newton, David Bell, Hugh Reyburn, Heidi Hopkins and Philippe J. Gu érin Tags: Research article Source Type: research

Community perception of malaria in a vulnerable municipality in the Colombian Pacific
Malaria primarily affects populations living in poor socioeconomic conditions, with limited access to basic services, deteriorating environmental conditions, and barriers to accessing health services. Control ... (Source: Malaria Journal)
Source: Malaria Journal - September 21, 2020 Category: Infectious Diseases Authors: Carol Yovanna Rosero, Gloria Isabel Jaramillo, Franco Andr és Montenegro, César García and Arelis Alexandra Coral Tags: Research Source Type: research

Use of a Plasmodium vivax genetic barcode for genomic surveillance and parasite tracking in Sri Lanka
Sri Lanka was certified as a malaria-free nation in 2016; however, imported malaria cases continue to be reported. Evidence-based information on the genetic structure/diversity of the parasite populations is u... (Source: Malaria Journal)
Source: Malaria Journal - September 21, 2020 Category: Infectious Diseases Authors: Rajika L. Dewasurendra, Mary Lynn Baniecki, Stephen Schaffner, Yamuna Siriwardena, Jade Moon, R. Doshi, Sharmini Gunawardena, Rachel F. Daniels, Daniel Neafsey, Sarah Volkman, Naduviladath V. Chandrasekharan, Dyann F. Wirth and Nadira D. Karunaweera Tags: Research Source Type: research

Purification and initial characterization of Plasmodium falciparum K+ channels, PfKch1 and PfKch2 produced in Saccharomyces cerevisiae
Resistance towards known antimalarial drugs poses a significant problem, urging for novel drugs that target vital proteins in the malaria parasite Plasmodium falciparum. However, recombinant production of malaria... (Source: Microbial Cell Factories)
Source: Microbial Cell Factories - September 21, 2020 Category: Microbiology Authors: Karen Molbaek, Maria Tejada, Christina Hoeier Ricke, Peter Scharff-Poulsen, Peter Ellekvist, Claus Helix-Nielsen, Nirbhay Kumar, Dan A. Klaerke and Per Amstrup Pedersen Tags: Research Source Type: research

The Glycocalyx and Its Role in Vascular Physiology and Vascular Related Diseases
ConclusionAs we have seen in this review, many important developments in our basic understanding of GCX structure, function and role in diseases have been described since the 2007 paper. The future is wide open for continued GCX research. (Source: Cardiovascular Engineering and Technology)
Source: Cardiovascular Engineering and Technology - September 21, 2020 Category: Cardiology Source Type: research

Clinical relevance of low-density < i > Plasmodium falciparum < /i > parasitemia in untreated febrile children: A cohort study
This study investigates the clinical presentation and outcome of untreated febrile children with LD infections attending primary care facilities in a moderately endemic area of Tanzania. Methods/findingsThis cohort study includes 2,801 febrile pediatric outpatients (median age 13.5 months [range 2 –59], female:male ratio 0.8:1.0) recruited in Dar es Salaam, Tanzania between 01 December 2014 and 28 February 2016. Treatment decisions were guided by a clinical decision support algorithm run on a mobile app, which also collected clinical data. Only standard mRDT+ cases received antimalarials. O utcomes (clinical failure,...
Source: PLoS Medicine - September 21, 2020 Category: Internal Medicine Authors: Mary-Anne Hartley Source Type: research

Structure of the Plasmodium falciparum PfSERA5 pseudo ‐zymogen
In this study we present a revised structure of the central PfSERA5E domain at a resolution of 1.2 å, and the first structure of the “zymogen” of this papain‐like domain including its cognate prodo main (PfSERA5PE) to 2.2 å resolution. PfSERA5PE is somewhat structurally similar to that of other known proenzymes, retaining the conserved overall folding and orientation of the prodomain through, and occluding, the archetypal papain‐like catalytic triad “active‐site” cleft, in the same reverse direction as conventional prodomains. Our findings are congruent with previousl...
Source: Protein Science - September 21, 2020 Category: Biochemistry Authors: Nicholas A. Smith, Oliver B. Clarke, Mihwa Lee, Anthony N. Hodder, Brian J. Smith Tags: Article Source Type: research

Methanol Fixation, but not Giemsa Staining, Inactivates Ebola and Lassa Viruses in Peripheral Blood Smears Made on Plastic Microscope Slides.
In this study, we evaluated the performance of two plastic microscope slide types that offer safe alternatives to glass slides, determined the temporal parameters required to inactivate EBOV and LASV in thin blood smears by methanol fixation, and assessed the virucidal activity of Giemsa stain. Both types of plastic microscope slides performed optimally; there were no significant differences in blood cell morphology or tinctorial properties nor were differences noted in Plasmodium ovale morphology or staining, when compared with glass slides. For both EBOV and LASV, viable viruses were not detected in thin blood smears fol...
Source: The American Journal of Tropical Medicine and Hygiene - September 21, 2020 Category: Tropical Medicine Authors: Relich RF, Feldmann H, Haddock E Tags: Am J Trop Med Hyg Source Type: research

Estimating Annual Fluctuations in Malaria Transmission Intensity and in the Use of Malaria Control Interventions in Five Sub-Saharan African Countries.
A, Sing'oei V, Sirima SB, Sylla K, Tine R, Tiono AB, Tivura M, Usuf E, Wéry S Abstract RTS,S/AS01E malaria vaccine safety, effectiveness, and impact will be assessed in pre- and post-vaccine introduction studies, comparing the occurrence of malaria cases and adverse events in vaccinated versus unvaccinated children. Because those comparisons may be confounded by potential year-to-year fluctuations in malaria transmission intensity and malaria control intervention usage, the latter should be carefully monitored to adequately adjust the analyses. This observational cross-sectional study is assessing Plasmodi...
Source: The American Journal of Tropical Medicine and Hygiene - September 21, 2020 Category: Tropical Medicine Authors: Rts S Epidemiology Epi-Mal-Study Group, Adeniji E, Asante KP, Boahen O, Compaoré G, Coulibaly B, Kaali S, Kabore Y, Lamy M, Lusingu J, Malabeja A, Mens P, Orsini M, Otieno L, Otieno W, Owusu-Agyei S, Oyieko J, Pirçon JY, Praet N, Roman F, Sie A, Sing'oe Tags: Am J Trop Med Hyg Source Type: research

Surveying Health-Related Knowledge, Attitudes, and Behaviors of U.S.-Based Residents Traveling Internationally to Visit Friends and Relatives.
Abstract U.S. residents traveling internationally to regions with increased risk of infectious diseases infrequently seek pretravel health care. First- and second-generation immigrants traveling to their countries of origin and visiting friends and relatives (VFRs) have increased risk of certain infectious diseases and are more likely to participate in high-risk activities. In an online survey of 994 U.S. residents with two foreign-born parents who went on at least one international trip to an at-risk country (defined as having a typhoid vaccine recommendation) in the prior 3 years, respondents were questioned abo...
Source: The American Journal of Tropical Medicine and Hygiene - September 21, 2020 Category: Tropical Medicine Authors: Rapheal E, Stoddard ST, Anderson KB Tags: Am J Trop Med Hyg Source Type: research

Will More of the Same Achieve Malaria Elimination? Results from an Integrated Macroeconomic Epidemiological Demographic Model.
Abstract Historic levels of funding have reduced the global burden of malaria in recent years. Questions remain, however, as to whether scaling up interventions, in parallel with economic growth, has made malaria elimination more likely today than previously. The consequences of "trying but failing" to eliminate malaria are also uncertain. Reduced malaria exposure decreases the acquisition of semi-immunity during childhood, a necessary phase of the immunological transition that occurs on the pathway to malaria elimination. During this transitional period, the risk of malaria resurgence increases as propo...
Source: The American Journal of Tropical Medicine and Hygiene - September 21, 2020 Category: Tropical Medicine Authors: Smith RD, Keogh-Brown MR, Chico RM, Bretscher MT, Drakeley C, Jensen HT Tags: Am J Trop Med Hyg Source Type: research

Parkinsonism in a patient with Plasmodium falciparum malaria
We present a case of a 53-year-old male presenting with parkinsonism after falciparum malaria. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - September 20, 2020 Category: Neurology Authors: Nadia Gandarilla-Mart ínez, Álvaro Carbayo-Viejo, Almudena Sánchez-Gómez, Francesc Valldeoriola-Serra Tags: Correspondence Source Type: research

Gene editing reveals obligate and modulatory components of the CO2 receptor complex in the malaria vector mosquito, Anopheles coluzzii.
Abstract The sensitivity to volatile carbon dioxide (CO2) produced by humans and other animals is a critical component in the host preference behaviors of the malaria vector mosquito Anopheles coluzzii. The molecular receptors responsible for the ability to sense CO2 are encoded by three putative gustatory receptor (Gr) genes (Gr22,23,24) which are expressed in a distinctive array of sensory neurons housed in maxillary palp capitate peg sensilla of An. coluzzii. Despite the identification of these components and subsequent studies, there is a paucity of understanding regarding the respective roles of these three G...
Source: Insect Biochemistry and Molecular Biology - September 20, 2020 Category: Biochemistry Authors: Liu F, Ye Z, Baker A, Sun H, Zwiebel LJ Tags: Insect Biochem Mol Biol Source Type: research

Evaluating effectiveness of screening house eaves as a potential intervention for reducing indoor vector densities and malaria prevalence in Nyabondo, western Kenya
Mosquito-proofing of houses using wire mesh screens is gaining greater recognition as a practical intervention for reducing exposure to malaria transmitting mosquitoes. Screening potentially protects all perso... (Source: Malaria Journal)
Source: Malaria Journal - September 19, 2020 Category: Infectious Diseases Authors: Peter Njoroge Ng ’ang’a, Collins Okoyo, Charles Mbogo and Clifford Maina Mutero Tags: Research Source Type: research

Rapid reduction of malaria transmission following the introduction of indoor residual spraying in previously unsprayed districts: an observational analysis of Mopti Region, Mali, in 2017
The National Malaria Control Programme (NMCP) of Mali has had recent success decreasing malaria transmission using 3rd generation indoor residual spraying (IRS) products in areas with pyrethroid resistance, pr... (Source: Malaria Journal)
Source: Malaria Journal - September 19, 2020 Category: Infectious Diseases Authors: Joseph Wagman, Idrissa Ciss é, Diakalkia Kone, Seydou Fomba, Erin Eckert, Jules Mihigo, Elie Bankineza, Mamadou Bah, Diadier Diallo, Christelle Gogue, Kenzie Tynuv, Andrew Saibu, Jason H. Richardson, Christen Fornadel, Laurence Slutsker and Molly Roberts Tags: Research Source Type: research

Rapid quantification of the malaria biomarker hemozoin by improved biocatalytically initiated precipitation atom transfer radical polymerizations
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Samuel Raccio, Jonas Pollard, Ashley Djuahdi, Sandor Balog, Michela M. Pellizzoni, Kyle Joel Rodriguez, Omar Rifaie-Graham, Nico Bruns The fight against tropical diseases such as malaria requires the development of innovative biosensing techniques. Diagnostics must be rapid and robust to ensure prompt case management and to avoid further... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - September 18, 2020 Category: Chemistry Authors: Samuel Raccio Source Type: research

Between traditional remedies and pharmaceutical drugs: prevention and treatment of “Palu” in households in Benin, West Africa
This study aimed to describe the... (Source: BMC Public Health)
Source: BMC Public Health - September 18, 2020 Category: Consumer Health News Authors: Barikissou Georgia Damien, Carine Baxerres, Edwige Apetoh and Jean-Yves Le Hesran Tags: Research article Source Type: research

Implementation of external quality assessment of microscopy for improved parasite detection and confirmatory diagnosis of malaria in Tanzanian Military health facilities
Good quality microscopy is critical for accurate detection and confirmation of malaria parasite infections. Microscopy relies on the skills of technicians to prepare and read slides, high quality reagents, and... (Source: BMC Research Notes)
Source: BMC Research Notes - September 18, 2020 Category: Research Authors: Akili K. Kalinga, Saidi Mgata, Reginald A. Kavishe, Lucas Mahikwano, Lucky Temu, Christopher Mswanya, Charles Mwanziva, George Amoo, Edwin Kamau, Brian Vesely and Deus S. Ishengoma Tags: Research note Source Type: research

Effect of sylvatic signature in the genetics of Aedes aegypti on its vector competence for viruses of public health significance
Background: Arboviral diseases are, after malaria, the most important vector-borne causes of mortality and morbidity around the world. In the last five years, dengue has continued to expand its geographic range and 390 million dengue infections occur every year (95% confidence interval 284 –528 million). Accidentally, or as a result of domestication and adaptation, some arboviruses are introduced to human settlements and if their ecological requirements (vector and hosts) are met, they can become established and cause outbreaks. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 18, 2020 Category: Infectious Diseases Authors: A. Diaz, A. Gloria-Soria, A. Payne, N. Burkett-Cadena, M. Espinosa, J. Powell, L. Kramer Tags: 0553 Source Type: research

Misdiagnosis of Babesiosis as Malaria, Equatorial Guinea, 2014
We report a case of babesiosis, caused by Babesia microti, in a missionary who worked in Equatorial Guinea but also visited rural Spain. The initial diagnosis, based on clinical features and microscopy, was malaria. The patient's recovery was delayed until she received appropriate treatment for babesiosis. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - September 18, 2020 Category: Infectious Diseases Authors: E. Padial Ramos Tags: 0530 Source Type: research

Microscopic and Submicroscopic Asymptomatic Plasmodium falciparum Infections in Ghanaian Children and Protection against Febrile Malaria [Fungal and Parasitic Infections]
This study assessed the association between baseline microscopic and submicroscopic asymptomatic P. falciparum infections and antimalarial antibody levels and whether these parasitemia modify protective associations between antibody levels and malaria in Ghanaian children. Healthy children (N = 973, aged 0.5 to 12 years) were recruited into a 50-week longitudinal malaria cohort study from January 2016 to January 2017. Baseline asymptomatic parasitemia were determined by microscopy (microscopic parasitemia) and PCR (submicroscopic parasitemia), and antibody levels against crude schizont antigens were measured by enzyme-limi...
Source: Infection and Immunity - September 18, 2020 Category: Infectious Diseases Authors: Adu, B., Issahaque, Q.-a., Sarkodie-Addo, T., Kumordjie, S., Kyei-Baafour, E., Sinclear, C. K., Eyia-Ampah, S., Owusu-Yeboa, E., Theisen, M., Dodoo, D. Tags: Fungal and Parasitic Infections Source Type: research

Importance of the Immunodominant CD8+ T Cell Epitope of Plasmodium berghei Circumsporozoite Protein in Parasite- and Vaccine-Induced Protection [Fungal and Parasitic Infections]
In this study, we characterized the importance of the immunodominant CSP-derived epitope SYIPSAEKI of Plasmodium berghei in both sporozoite- and vaccine-induced protection in murine infection models. In BALB/c mice, where SYIPSAEKI is efficiently presented in the context of the major histocompatibility complex class I (MHC-I) molecule H-2-Kd, we established that epitope-specific CD8+ T cell responses contribute to parasite killing following sporozoite immunization. Yet, sterile protection was achieved in the absence of this epitope, substantiating the concept that other antigens can be sufficient for parasite-induced prote...
Source: Infection and Immunity - September 18, 2020 Category: Infectious Diseases Authors: Gibbins, M. P., Müller, K., Glover, M., Liu, J., Putrianti, E. D., Bauza, K., Reyes-Sandoval, A., Matuschewski, K., Silvie, O., Hafalla, J. C. R. Tags: Fungal and Parasitic Infections Source Type: research

Comparative functional survival and equivalent annual cost of 3 long-lasting insecticidal net (LLIN) products in Tanzania: A randomised trial with 3-year follow up
by Lena M. Lorenz, John Bradley, Joshua Yukich, Dennis J. Massue, Zawadi Mageni Mboma, Olivier Pigeon, Jason Moore, Albert Kilian, Jo Lines, William Kisinza, Hans J. Overgaard, Sarah J. Moore BackgroundTwo billion long-lasting insecticidal nets (LLINs) have been procured for malaria control. A functional LLIN is one that is present, is in good physical condition, and remains insecticidal, thereby providing protection against vector-borne diseases through preventing bites and killing disease vectors. The World Health Organization (WHO) prequalifies LLINs that remain adequately insecticidal 3 years after deployment. Therefor...
Source: PLoS Medicine - September 18, 2020 Category: Internal Medicine Authors: Lena M. Lorenz Source Type: research

Molecules, Vol. 25, Pages 4294: Tabebuia impetiginosa: A Comprehensive Review on Traditional Uses, Phytochemistry, and Immunopharmacological Properties
Youl Cho Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from T. impetiginosa have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning T. impetiginosa, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive searc...
Source: Molecules - September 18, 2020 Category: Chemistry Authors: Jianmei Zhang Stephanie Triseptya Hunto Yoonyong Yang Jongsung Lee Jae Youl Cho Tags: Review Source Type: research

From Circulation to Cultivation: Plasmodium In Vivo versus In Vitro.
Abstract Research on Plasmodium parasites has driven breakthroughs in reducing malaria morbidity and mortality. Experimental analysis of in vivo/ex vivo versus in vitro samples serve unique roles in Plasmodium research. However, these distinctly different environments lead to discordant biology between parasites in host circulation and those under laboratory cultivation. Here, we review how in vitro factors, such as nutrient levels and physical forces, differ from those in the human host and the resulting implications for parasite growth, survival, and virulence. Additionally, we discuss the current utility of dir...
Source: Trends in Parasitology - September 18, 2020 Category: Parasitology Authors: Brown AC, Guler JL Tags: Trends Parasitol Source Type: research

Demonstration of indigenous malaria elimination through Track-Test-Treat-Track (T4) strategy in a Malaria Elimination Demonstration Project in Mandla, Madhya Pradesh
Many malaria endemic countries are heading towards malaria elimination through the use of case management and vector control strategies, which employ surveillance, improving access to early diagnosis, prompt t... (Source: Malaria Journal)
Source: Malaria Journal - September 17, 2020 Category: Infectious Diseases Authors: Praveen K. Bharti, Harsh Rajvanshi, Sekh Nisar, Himanshu Jayswar, Kalyan B. Saha, Man Mohan Shukla, Ashok K. Mishra, Ravendra K. Sharma, Aparup Das, Harpreet Kaur, Suman L. Wattal and Altaf A. Lal Tags: Research Source Type: research

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver
Wang et  al. isolate a potent neutralizing human mAb, L9 that preferentially binds NVDP minor repeats of Plasmodium falciparum circumsporozoite protein (PfCSP) on sporozoites with high affinity while cross-reacting with NANP major repeats. Their findings define the subdominant PfCSP minor repeats as neutra lizing epitopes and demonstrate that the liver is an important site for antibodies to prevent malaria. (Source: Immunity)
Source: Immunity - September 17, 2020 Category: Allergy & Immunology Authors: Lawrence T. Wang, Lais S. Pereira, Yevel Flores-Garcia, James O ’Connor, Barbara J. Flynn, Arne Schön, Nicholas K. Hurlburt, Marlon Dillon, Annie S.P. Yang, Amanda Fabra-García, Azza H. Idris, Bryan T. Mayer, Monica W. Gerber, Raphael Gottardo, Rosema Tags: Report Source Type: research

Laboratory practices for manual blood film review: Results of an IQMH patterns of practice survey.
Abstract INTRODUCTION: Examination of a blood film is the second most common hematology test, after the complete blood count. Interpretation of a peripheral blood film by trained laboratory professionals provides valuable diagnostic information. The Institute for Quality Management in Healthcare (IQMH) Hematology Scientific Committee developed a questionnaire to gather information regarding current practices for manual blood film review and reporting from laboratories participating in IQMH Morphology proficiency testing (PT) surveys. METHODS: An online survey was distributed to 174 laboratories, 97% submitted...
Source: International Journal of Laboratory Hematology - September 17, 2020 Category: Hematology Authors: Leung E, Johnston A, Olsen B, Chang H, Martin T, Wozniak M, Good D Tags: Int J Lab Hematol Source Type: research

Visceral leishmaniasis in Saudi Arabia: from hundreds of cases to zero.
Abstract The kingdom of Saudi Arabia (KSA) has succeeded in bringing the reported numbers of Visceral leishmaniasis (VL) cases from hundreds during the 1980s and 1990s to zero case in 2019. The endemicity of VL has been confined mainly to the Southwest regions, namely Jazan and Aseer regions. Leishmania donovani species have been identified as the causative species of VL, while L. infantum have been isolated only from dogs in the endemic areas. Many species of sand flies were caught in Southwest, but P. orientalis is the probable transmitter of the disease. The black rat (Rattus ratus) was found to be contributing...
Source: Acta Tropica - September 17, 2020 Category: Infectious Diseases Authors: Abuzaid AA, Aldahan MA, Helal MAA, Asiri AM, Alzahrani MH Tags: Acta Trop Source Type: research

A Case of Postmalaria Neurologic Syndrome and Pediatric Literature Review
We describe the case of a 7-year-old child who presented with an afebrile lymphocytic meningoencephalitis. The notion of a previously treated malaria episode and the absence of malaria during current episode led us postmalaria neurologic syndrome diagnosis with secondary spontaneous outcome. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - September 16, 2020 Category: Infectious Diseases Tags: Brief Reports Source Type: research

Genetic diversity and complexity of Plasmodium falciparum infections in the microenvironment among siblings of the same household in North-Central Nigeria
Plasmodium falciparum parasites are known to exhibit extensive genetic diversity in areas of high transmission intensity and infected individuals in such communities often harbour several complex mixtures of para... (Source: Malaria Journal)
Source: Malaria Journal - September 16, 2020 Category: Infectious Diseases Authors: Segun Isaac Oyedeji, Peter Usman Bassi, Samuel Adeola Oyedeji, Olusola Ojurongbe and Henrietta Oluwatoyin Awobode Tags: Research Source Type: research

Individual, community and region level predictors of insecticide-treated net use among women in Uganda: a multilevel analysis
Use of insecticide-treated net (ITN) has been identified by the World Health Organization as an effective approach for malaria prevention. The government of Uganda has instituted measures to enhance ITN supply... (Source: Malaria Journal)
Source: Malaria Journal - September 16, 2020 Category: Infectious Diseases Authors: Edward Kwabena Ameyaw, Yusuf Olushola Kareem and Sanni Yaya Tags: Research Source Type: research

An open label study of the safety and efficacy of a single dose of weekly chloroquine and azithromycin administered for malaria prophylaxis in healthy adults challenged with 7G8 chloroquine-resistant Plasmodium falciparum in a controlled human malaria infection model
Malaria remains the top infectious disease threat facing the U.S. military in many forward operating environments. Compliance with malaria chemoprophylaxis remains a critical component in preventing malaria in... (Source: Malaria Journal)
Source: Malaria Journal - September 16, 2020 Category: Infectious Diseases Authors: Jeffrey Livezey, Patrick Twomey, Meshell Morrison, Susan Cicatelli, Elizabeth H. Duncan, Melinda Hamer, Christine Lee, Jack Hutter, Kristin Mills, Jesse DeLuca, Lucas Poon, Daniel Selig, Chau Vuong, Jason Sousa, Thomas Oliver, Jason Bennett & hellip; Tags: Research Source Type: research

The Burden of Trauma in Tanzania: Analysis of Prospective Trauma Registry Data at Regional Hospitals in Tanzania
Trauma contributes significantly to the burden of disease and mortality throughout the world, particularly in low- and middle-income countries (LMICs) [1]. Globally, injuries cause over five million deaths annually; this is 32% more than deaths due to HIV, tuberculosis and malaria combined [2]. Ninety percent of injury-related deaths occur in LMICs, where there are inadequate resources to provide the appropriate care to optimise patient outcomes [3]. (Source: Injury)
Source: Injury - September 16, 2020 Category: Orthopaedics Authors: Hendry R. Sawe, Lee A. Wallis, Ellen J Weber, Juma A. Mfinanga, Timothy J. Coats, Teri A. Reynolds Source Type: research

[Editors' Choice] Can eating help treat malaria?
The identification of metabolic control of the Plasmodium life cycle may open novel avenues for malaria treatment. (Source: Science Translational Medicine)
Source: Science Translational Medicine - September 16, 2020 Category: Biomedical Science Authors: Hurley, J. M. Tags: Editors ' Choice Source Type: research

Placental Malaria
AbstractPurpose of ReviewPlacental malaria is the primary mechanism through which malaria in pregnancy causes adverse perinatal outcomes. This review summarizes recent work on the significance, pathogenesis, diagnosis, and prevention of placental malaria.Recent FindingsPlacental malaria, characterized by the accumulation ofPlasmodium-infected red blood cells in the placental intervillous space, leads to adverse perinatal outcomes such as stillbirth, low birth weight, preterm birth, and small-for-gestational-age neonates. Placental inflammatory responses may be primary drivers of these complications. Associated factors cont...
Source: Current Tropical Medicine Reports - September 16, 2020 Category: Tropical Medicine Source Type: research

Chloroquine against malaria, cancers and viral diseases.
Abstract Quinoline (QN) derivatives are often used for the prophylaxis and treatment of malaria. Chloroquine (CQ), a protonated, weakly basic drug, exerts its antimalarial effect mainly by increasing pH and accumulating in the food vacuole of the parasites. Repurposing CQ is an emerging strategy for new indications. Given the inhibition of autophagy and its immunomodulatory action, CQ shows positive efficacy against cancer and viral diseases, include Coronavirus 2019 (COVID-19). Here, we review the underlying mechanisms behind the antimalarial, anticancer and antiviral effects of CQ. We also discuss the clinical e...
Source: Drug Discovery Today - September 16, 2020 Category: Drugs & Pharmacology Authors: Zhou W, Wang H, Yang Y, Chen ZS, Zou C, Zhang J Tags: Drug Discov Today Source Type: research

Antiviral activity of chlorpromazine, fluphenazine, perphenazine, prochlorperazine, and thioridazine towards RNA-viruses. A review.
Abstract In 2020 the whole world focused on antivirus drugs towards SARS-CoV-2. Most of the researchers focused on drugs used in other viral infections or malaria. We have not seen such mobilization towards one topic in this century. The whole situation makes clear that progress needs to be made in antiviral drug development. The first step to do it is to characterize the potential antiviral activity of new or already existed drugs on the market. Phenothiazines are antipsychotic agents used previously as antiseptics, anthelminthics, and antimalarials. Up to date, they are tested for a number of other disorders inc...
Source: European Journal of Pharmacology - September 16, 2020 Category: Drugs & Pharmacology Authors: Otręba M, Kośmider L, Rzepecka-Stojko A Tags: Eur J Pharmacol Source Type: research

Childhood anemia and iron deficiency in sub-Saharan Africa - risk factors and prevention: A review.
Abstract Iron deficiency and iron deficiency anemia are public health issues recognised by the World Health Organisation, especially in sub-Saharan Africa. In some countries on this continent, the prevalence of anemia exceeds 60% in the pediatric population. Iron supplementation could prevent around one third of anemia cases in children in Africa and could decrease morbidity and mortality. A number of factors are behind this anemia, including iron deficiency caused by an inadequate diet, pica and geophagia, as well as chronic inflammation (malaria, digestive and urinary parasites, etc.). Ferritin is a good indicat...
Source: Archives de Pediatrie - September 16, 2020 Category: Pediatrics Authors: Lemoine A, Tounian P Tags: Arch Pediatr Source Type: research